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IL91117A0 - Aldehyde compounds and a process for their preparation - Google Patents

Aldehyde compounds and a process for their preparation

Info

Publication number
IL91117A0
IL91117A0 IL91117A IL9111789A IL91117A0 IL 91117 A0 IL91117 A0 IL 91117A0 IL 91117 A IL91117 A IL 91117A IL 9111789 A IL9111789 A IL 9111789A IL 91117 A0 IL91117 A0 IL 91117A0
Authority
IL
Israel
Prior art keywords
sup
formula
compounds
hydrogen atom
disclosed
Prior art date
Application number
IL91117A
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of IL91117A0 publication Critical patent/IL91117A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/33—Polycyclic acids
    • C07C63/337—Polycyclic acids with carboxyl groups bound to condensed ring systems
    • C07C63/34—Polycyclic acids with carboxyl groups bound to condensed ring systems containing two condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Lubricants (AREA)
  • Fats And Perfumes (AREA)
  • Saccharide Compounds (AREA)

Abstract

Naphthalene derivatives of the formula:whereinR<sup>1</sup> is hydrogen atom or a lower alkoxycarbonyl andR<sup>2</sup> is a lower alkoxycarbonyl, or R' and R<sup>2</sup> are combined together to form a group of the formula:each of R<sup>3</sup> and R<sup>4</sup> is a lower alkoxy, or one of R<sup>3</sup> and R<sup>4</sup> is hydrogen atom and the other is a lower alkoxy, andRing A is a substituted or unsubstituted benzene ring, and a pharmaceutically acceptable salt thereof are disclosed. Said naphthalene derivative (I) and its salt have excellent hypolipidemic activity and are useful for treatment or prophylaxis of hyperlipidemia and/or arteriosclerosis. Disclosed are also a process for the production of compounds of formula (I), the use of said compounds and the production of medicaments and pharmaceutical compositions containing compounds of formula (1) as active ingredient.
IL91117A 1985-01-10 1989-07-26 Aldehyde compounds and a process for their preparation IL91117A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP309085 1985-01-10

Publications (1)

Publication Number Publication Date
IL91117A0 true IL91117A0 (en) 1990-03-19

Family

ID=11547645

Family Applications (1)

Application Number Title Priority Date Filing Date
IL91117A IL91117A0 (en) 1985-01-10 1989-07-26 Aldehyde compounds and a process for their preparation

Country Status (18)

Country Link
US (2) US4771072A (en)
EP (1) EP0188248B1 (en)
JP (3) JPS61267541A (en)
KR (1) KR890001884B1 (en)
CN (1) CN1006464B (en)
AT (1) ATE54441T1 (en)
AU (1) AU584153B2 (en)
BG (2) BG45385A3 (en)
DD (1) DD270529A5 (en)
DE (1) DE3672501D1 (en)
ES (2) ES8705837A1 (en)
FI (1) FI87557C (en)
HU (1) HU196737B (en)
IL (1) IL91117A0 (en)
MY (1) MY101268A (en)
NO (1) NO170760C (en)
PH (1) PH22105A (en)
PT (1) PT81814B (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4644072A (en) * 1985-04-12 1987-02-17 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US5011948A (en) * 1985-04-12 1991-04-30 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
JPS6310746A (en) * 1986-07-01 1988-01-18 Tanabe Seiyaku Co Ltd Naphthalene derivative
AT388372B (en) * 1987-10-08 1989-06-12 Tanabe Seiyaku Co Novel naphthalene derivatives and pharmaceuticals containing them
JPH01135766A (en) * 1987-11-20 1989-05-29 Tanabe Seiyaku Co Ltd Biphenyl derivative
PH26342A (en) * 1988-11-29 1992-04-29 Univ Texas Microbial cellulose modified during synthesis
MY105057A (en) * 1989-01-27 1994-07-30 Tanabe Seiyaku Co A process for preparing naphthalene derivatives
US5003087A (en) * 1989-02-03 1991-03-26 Tanabe Seiyaku Co., Ltd. Process for preparing a naphthalene derivative and a synthetic intermediate thereof
EP0501578A1 (en) * 1991-02-28 1992-09-02 Merck Frosst Canada Inc. Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis
US5227399A (en) * 1991-02-28 1993-07-13 Merck Frosst Canada, Inc. Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis
US5281720A (en) * 1991-02-28 1994-01-25 Merck Frosst Canada, Inc. Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis
EP0501579A1 (en) * 1991-02-28 1992-09-02 Merck Frosst Canada Inc. Naphthalene lactones as inhibitors of leukotriene biosynthesis
ES2129733T3 (en) * 1991-10-17 1999-06-16 Shionogi & Co PROCEDURE FOR THE PREPARATION OF LIGNIN ANALOGS AND STARTING PRODUCTS FOR THESE.
US5308852A (en) * 1992-06-29 1994-05-03 Merck Frosst Canada, Inc. Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis
US5428060A (en) * 1992-08-27 1995-06-27 Merck Frosst Canada, Inc. Heteroarylnaphthalene lactones as inhibitors of leukotriene biosynthesis
US5350744A (en) * 1992-08-27 1994-09-27 Merck Frosst Canada, Inc. Phenylnaphthalene lactones as inhibitors of leukotriene biosynthesis
US5252599A (en) * 1992-08-27 1993-10-12 Merck Frosst Canada, Inc. Heteroarylnaphthalene hydroxy acids as inhibitors of leukotriene biosynthesis
US5426109A (en) * 1992-08-27 1995-06-20 Merck Frosst Canada, Inc. Phenylnaphthalene hydroxy acids
CA2121060C (en) * 1993-04-16 2004-04-06 Sachio Mori Preparation of lignan analogues
ID18046A (en) * 1996-08-20 1998-02-19 Takeda Chemical Industries Ltd COMPOUND, MIXED CYCLE, MANUFACTURE AND USE OF IT.
CA2341540A1 (en) 1998-08-25 2000-03-02 Yale University Inhibition and treatment of hepatitis b virus and flavivirus by helioxanthin and its analogs
AU3712100A (en) 1999-06-01 2000-12-18 University Of Texas Southwestern Medical Center, The Method of treating hair loss using sulfonyl thyromimetic compounds
US6680344B1 (en) 1999-06-01 2004-01-20 The University Of Texas Southwestern Medical Center Method of treating hair loss using diphenylmethane derivatives
AU3507700A (en) 1999-06-01 2000-12-18 University Of Texas Southwestern Medical Center, The Method of treating hair loss using diphenylether derivatives
SE0102168D0 (en) 2001-06-19 2001-06-19 Karolinska Innovations Ab New use and new compounds
BR0212254A (en) * 2001-08-28 2004-10-19 Sankyo Co Pharmaceutical Composition
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
EP2995317A1 (en) 2010-05-26 2016-03-16 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
SG10201909122QA (en) 2011-10-28 2019-11-28 Lumena Pharmaceuticals Inc Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
US20130108573A1 (en) 2011-10-28 2013-05-02 Lumena Pharmaceuticals, Inc. Bile Acid Recycling Inhibitors for Treatment of Hypercholemia and Cholestatic Liver Disease
AU2014229050A1 (en) 2013-03-15 2015-10-22 Lumena Pharmaceuticals Llc Bile acid recycling inhibitors for treatment of Barrett's esophagus and gastroesophageal reflux disease
BR112015023646A2 (en) 2013-03-15 2017-07-18 Lumena Pharmaceuticals Inc Recycling bile acid inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease
WO2015153653A1 (en) * 2014-03-31 2015-10-08 Ohio State Innovation Foundation Arylnaphthalene lactone derivatives and methods of making and using thereof
US10682367B2 (en) 2016-02-26 2020-06-16 Ohio State Innovation Foundation Antitumor arylnaphthalene ligand glycosides
DK3923943T3 (en) 2019-02-12 2024-08-26 Mirum Pharmaceuticals Inc Genotype and dose-dependent response to an ASBTI in patients with bile salt export pump deficiency

Also Published As

Publication number Publication date
AU5175185A (en) 1986-07-17
CN86100090A (en) 1986-08-20
PT81814B (en) 1988-07-29
ATE54441T1 (en) 1990-07-15
JPH0272170A (en) 1990-03-12
US4771072A (en) 1988-09-13
NO855355L (en) 1986-07-11
FI87557B (en) 1992-10-15
JPS61267541A (en) 1986-11-27
KR860005778A (en) 1986-08-13
EP0188248A3 (en) 1986-12-17
NO170760C (en) 1992-12-02
CN1006464B (en) 1990-01-17
NO170760B (en) 1992-08-24
PT81814A (en) 1986-02-01
FI87557C (en) 1993-01-25
BG45385A3 (en) 1989-05-15
EP0188248B1 (en) 1990-07-11
ES8705837A1 (en) 1987-05-16
EP0188248A2 (en) 1986-07-23
JPH0549668B2 (en) 1993-07-26
AU584153B2 (en) 1989-05-18
PH22105A (en) 1988-06-01
HUT42428A (en) 1987-07-28
FI860089A0 (en) 1986-01-09
US5070103A (en) 1991-12-03
KR890001884B1 (en) 1989-05-29
FI860089L (en) 1986-07-11
ES8801239A1 (en) 1987-12-16
ES550578A0 (en) 1987-05-16
BG45383A3 (en) 1989-05-15
ES557052A0 (en) 1987-12-16
DE3672501D1 (en) 1990-08-16
JPH0272136A (en) 1990-03-12
HU196737B (en) 1989-01-30
MY101268A (en) 1991-08-17
DD270529A5 (en) 1989-08-02

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