IL90781A0 - 5-oxygenated hmg-coa reductase inhibitors and pharmaceutical compositions containing them - Google Patents
5-oxygenated hmg-coa reductase inhibitors and pharmaceutical compositions containing themInfo
- Publication number
- IL90781A0 IL90781A0 IL90781A IL9078189A IL90781A0 IL 90781 A0 IL90781 A0 IL 90781A0 IL 90781 A IL90781 A IL 90781A IL 9078189 A IL9078189 A IL 9078189A IL 90781 A0 IL90781 A0 IL 90781A0
- Authority
- IL
- Israel
- Prior art keywords
- hmg
- coa reductase
- reductase inhibitors
- oxygenated
- pharmaceutical compositions
- Prior art date
Links
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 title abstract 2
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title abstract 2
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000003529 anticholesteremic agent Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21301088A | 1988-06-29 | 1988-06-29 | |
| US07/250,646 US4921974A (en) | 1988-09-29 | 1988-09-29 | Intermediates and processes in the preparation of 5-oxygenated HMG-COA reductase inhibitors |
| US07/322,398 US4963538A (en) | 1988-06-29 | 1989-03-13 | 5-oxygenated HMG-CoA reductase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL90781A0 true IL90781A0 (en) | 1990-01-18 |
Family
ID=27395805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL90781A IL90781A0 (en) | 1988-06-29 | 1989-06-29 | 5-oxygenated hmg-coa reductase inhibitors and pharmaceutical compositions containing them |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0349063B1 (fi) |
| JP (1) | JPH0253752A (fi) |
| KR (1) | KR910000694A (fi) |
| AT (1) | ATE127798T1 (fi) |
| AU (1) | AU619563B2 (fi) |
| CA (1) | CA1328876C (fi) |
| DE (1) | DE68924205T2 (fi) |
| DK (1) | DK319989A (fi) |
| FI (1) | FI893004A (fi) |
| HU (1) | HUT50803A (fi) |
| IL (1) | IL90781A0 (fi) |
| NO (1) | NO892677L (fi) |
| NZ (1) | NZ229671A (fi) |
| PT (1) | PT90958B (fi) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT88364A (pt) * | 1987-09-02 | 1989-07-31 | Merck & Co Inc | Process for preparing novel hmg-coa reductase inhibitors |
| US5073568A (en) * | 1988-11-14 | 1991-12-17 | Hoffmann-La Roche Inc. | Antipsoriatic agents |
| US5200549A (en) * | 1988-11-14 | 1993-04-06 | Hoffman-La Roche Inc. | Antipsoriatic agents |
| CA2036962C (en) * | 1990-02-26 | 1998-09-15 | Ann E. Decamp | Process for the desilylation of a 4-silyloxy-tetrahydro-pyran-2-one |
| US5059696A (en) * | 1990-03-15 | 1991-10-22 | Merck & Co., Inc. | Processes and intermediates for the preparation of 5-oxygenated hmg-coa reductase inhibitors |
| MY106564A (en) * | 1990-07-06 | 1995-06-30 | Squibb & Sons Inc | Sulfur-substituted mevinic acid derivatives. |
| US5286746A (en) * | 1991-12-20 | 1994-02-15 | E. R. Squibb & Sons, Inc. | Sulfur-substituted mevinic acid derivatives |
| US5369123A (en) * | 1992-10-09 | 1994-11-29 | E. R. Squibb & Sons, Inc. | Nitrogen-substituted mevinic acid derivatives useful as HMG-CoA reductase inhibitors |
| SI20159A (sl) * | 1999-02-04 | 2000-08-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Nov postopek za odstranitev sililoksi zaščitne skupine iz 4-sililoksi tetrahidro-piran-2-on-ov |
| SI21187A (sl) * | 2002-03-26 | 2003-10-31 | Krka, Tovarna Zdravil D.D., Novo Mesto | Postopek za pripravo 4-oksitetrahidropiran-2-onov |
| US20210008084A1 (en) | 2017-10-16 | 2021-01-14 | Tsinghua University | Mevalonate pathway inhibitor and pharmaceutical composition thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56150037A (en) * | 1980-04-22 | 1981-11-20 | Sankyo Co Ltd | Hydronaphthalene compound |
| JPS58188872A (ja) * | 1982-04-26 | 1983-11-04 | Suntory Ltd | オクタヒドロナフタレン誘導体及びその製造法 |
| JPS59186972A (ja) * | 1983-03-09 | 1984-10-23 | Suntory Ltd | オクタヒドロナフタレン誘導体並びにその製造法 |
| US4668699A (en) * | 1985-08-05 | 1987-05-26 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
| PT85109A (en) * | 1986-06-23 | 1987-07-01 | Merck & Co Inc | Process for the preparation of hydroxy-tetrahydropyranone derivatives or corresponding ring opened dihydroxy acids which are hmg-coa reductase inhibitors |
| PT88364A (pt) * | 1987-09-02 | 1989-07-31 | Merck & Co Inc | Process for preparing novel hmg-coa reductase inhibitors |
-
1989
- 1989-06-19 FI FI893004A patent/FI893004A/fi not_active IP Right Cessation
- 1989-06-22 AT AT89201642T patent/ATE127798T1/de not_active IP Right Cessation
- 1989-06-22 EP EP89201642A patent/EP0349063B1/en not_active Expired - Lifetime
- 1989-06-22 DE DE68924205T patent/DE68924205T2/de not_active Expired - Fee Related
- 1989-06-22 NZ NZ229671A patent/NZ229671A/xx unknown
- 1989-06-23 PT PT90958A patent/PT90958B/pt not_active IP Right Cessation
- 1989-06-27 KR KR1019890008847A patent/KR910000694A/ko not_active Application Discontinuation
- 1989-06-27 NO NO89892677A patent/NO892677L/no unknown
- 1989-06-27 CA CA000604033A patent/CA1328876C/en not_active Expired - Fee Related
- 1989-06-28 AU AU37116/89A patent/AU619563B2/en not_active Ceased
- 1989-06-28 DK DK319989A patent/DK319989A/da not_active Application Discontinuation
- 1989-06-28 HU HU893252A patent/HUT50803A/hu unknown
- 1989-06-29 JP JP1165523A patent/JPH0253752A/ja active Pending
- 1989-06-29 IL IL90781A patent/IL90781A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO892677L (no) | 1990-01-02 |
| FI893004A (fi) | 1989-12-30 |
| DE68924205T2 (de) | 1996-03-28 |
| EP0349063B1 (en) | 1995-09-13 |
| KR910000694A (ko) | 1991-01-30 |
| EP0349063A2 (en) | 1990-01-03 |
| JPH0253752A (ja) | 1990-02-22 |
| DK319989A (da) | 1990-01-02 |
| ATE127798T1 (de) | 1995-09-15 |
| CA1328876C (en) | 1994-04-26 |
| HUT50803A (en) | 1990-03-28 |
| AU619563B2 (en) | 1992-01-30 |
| PT90958A (pt) | 1989-12-29 |
| PT90958B (pt) | 1994-11-30 |
| AU3711689A (en) | 1990-01-04 |
| NO892677D0 (no) | 1989-06-27 |
| FI893004A0 (fi) | 1989-06-19 |
| DK319989D0 (da) | 1989-06-28 |
| EP0349063A3 (en) | 1990-05-09 |
| DE68924205D1 (de) | 1995-10-19 |
| NZ229671A (en) | 1991-11-26 |
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