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IL86157A0 - New derivatives of 1,2,5,6-tetrahydropyridine,process for preparing them,and compositions containing them - Google Patents

New derivatives of 1,2,5,6-tetrahydropyridine,process for preparing them,and compositions containing them

Info

Publication number
IL86157A0
IL86157A0 IL86157A IL8615788A IL86157A0 IL 86157 A0 IL86157 A0 IL 86157A0 IL 86157 A IL86157 A IL 86157A IL 8615788 A IL8615788 A IL 8615788A IL 86157 A0 IL86157 A0 IL 86157A0
Authority
IL
Israel
Prior art keywords
denotes
tetrahydropyridine
preparing
compositions containing
new derivatives
Prior art date
Application number
IL86157A
Other versions
IL86157A (en
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of IL86157A0 publication Critical patent/IL86157A0/en
Publication of IL86157A publication Critical patent/IL86157A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

New compounds (I): <IMAGE> in which R denotes a hydrogen, a hydroxyl or an alkyl containing up to 8 C, optionally substituted by a carboxy or R denotes an aralkyl containing up to 10 C or -COOZ, Z being an alkyl containing up to 8 C or an aralkyl containing from 7 to 10 C, R1 denotes an alkyl containing up to 8 C, R2 denotes a hydrogen or an alkyl containing up to 8 C, -COalk1 or (CH2)2N(alk2)2, alk1 and alk2 denoting an alkyl containing up to 8 C, it being understood that if R denotes an alkyl, R2 does not denote a hydrogen, and their addition salts with acids.
IL8615788A 1987-04-24 1988-04-22 Derivatives of 1,2,5,6-tetrahydropyridine, process for preparing them and pharmaceutical compositions containing them IL86157A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20260/87A IT1203971B (en) 1987-04-24 1987-04-24 1,2,5,6-TETRAHYDROPYRIDINE DERIVATIVES, THEIR PREPARATION PROCEDURE AND THEIR APPLICATION AS MEDICATIONS

Publications (2)

Publication Number Publication Date
IL86157A0 true IL86157A0 (en) 1988-11-15
IL86157A IL86157A (en) 1994-04-12

Family

ID=11165225

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8615788A IL86157A (en) 1987-04-24 1988-04-22 Derivatives of 1,2,5,6-tetrahydropyridine, process for preparing them and pharmaceutical compositions containing them

Country Status (22)

Country Link
EP (1) EP0288394B1 (en)
JP (1) JP2727192B2 (en)
KR (1) KR960012365B1 (en)
AT (1) ATE80387T1 (en)
AU (1) AU614283B2 (en)
CA (1) CA1340986C (en)
DE (1) DE3874396T2 (en)
DK (1) DK167758B1 (en)
ES (1) ES2043863T3 (en)
FI (1) FI93211C (en)
GR (1) GR3005647T3 (en)
HU (1) HU199795B (en)
IE (1) IE63172B1 (en)
IL (1) IL86157A (en)
IT (1) IT1203971B (en)
MX (1) MX11201A (en)
NZ (1) NZ224357A (en)
OA (1) OA08835A (en)
PH (1) PH25574A (en)
PT (1) PT87290B (en)
SU (1) SU1678203A3 (en)
ZA (1) ZA882595B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL81610A (en) * 1986-02-27 1990-12-23 Roussel Uclaf Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them
US4786648A (en) * 1986-12-08 1988-11-22 Warner-Lambert Company O-substituted tetrahydropyridine oxime cholinergic agents
IT1222526B (en) * 1987-08-21 1990-09-05 Roussel Maestretti Spa OXYME DERIVATIVES OF 1,2,5,6-TETRAIDROPIRIDIN-3-CARBOXALDEHYDE, THEIR PREPARATION PROCEDURE AND THEIR USE AS MEDICINAL SUBSTANCES
EP0338723B1 (en) * 1988-04-15 1993-08-04 Beecham Group Plc Novel compounds
US5278170A (en) * 1989-04-13 1994-01-11 Beecham Group P.L.C. Azabicylo oxime compounds
SG48315A1 (en) * 1989-04-13 1998-04-17 Beecham Group Plc Novel compounds
US5362739A (en) * 1990-08-24 1994-11-08 Beecham Group P.L.C. Azabicyclic compounds and pharmaceutical compositions containing them
GB9019095D0 (en) * 1990-09-01 1990-10-17 Beecham Group Plc Novel compounds
JPH06501933A (en) * 1990-10-12 1994-03-03 ビーチャム・グループ・パブリック・リミテッド・カンパニー 1,2,5,6-tetrahydropyridine oxime derivative
EP0537993A1 (en) * 1991-10-17 1993-04-21 Eli Lilly And Company Nicotinic activity of a series of arecolones and isoarecolones
WO1993011767A1 (en) * 1991-12-18 1993-06-24 Warner-Lambert Company Transdermal delivery of (e)-1,2,5,6-tetrahydro-1-methyl-3-pyridine-carboxaldehyde-o-methyloxine hcl and related compounds in the treatment of cognitive disorders and for analgesia
US5424301A (en) * 1993-02-01 1995-06-13 Warner-Lambert Company Starch stabilized o-substituted tetrahydropyridine oxime cholinergic agents
US5362860A (en) * 1993-02-01 1994-11-08 Warner-Lambert Company Neutral stabilization complex for CI-979 HCl, a cognition activator
US6250886B1 (en) 1999-09-03 2001-06-26 Chittom International, Inc. Axial flow fan and fan blade

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1258847A (en) * 1960-02-12 1961-04-21 Ciba Geigy Process for the preparation of novel pyridine derivatives, including 1-methyl-3 or 4-acetyl-1, 2, 5, 6-tetrahydropyridine oxime
IL81610A (en) * 1986-02-27 1990-12-23 Roussel Uclaf Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them
JPH0641332B2 (en) * 1986-09-17 1994-06-01 株式会社共同精機工作所 Sheet feeding device for cutting machine
US4786648A (en) * 1986-12-08 1988-11-22 Warner-Lambert Company O-substituted tetrahydropyridine oxime cholinergic agents
US4710508A (en) * 1986-12-08 1987-12-01 Warner-Lambert Company O-substituted tetrahydropyridine oxime cholinergic agents
US4798841A (en) * 1987-03-31 1989-01-17 Warner-Lambert Company Tetrahydropyridine oxime cholinergic agents and method of treatment

Also Published As

Publication number Publication date
DK216388D0 (en) 1988-04-21
EP0288394A3 (en) 1989-01-25
FI93211B (en) 1994-11-30
DK216388A (en) 1988-10-25
EP0288394B1 (en) 1992-09-09
KR890016009A (en) 1989-11-27
JPS63284160A (en) 1988-11-21
FI93211C (en) 1995-03-10
AU614283B2 (en) 1991-08-29
SU1678203A3 (en) 1991-09-15
IE63172B1 (en) 1995-03-22
MX11201A (en) 1993-10-01
ATE80387T1 (en) 1992-09-15
DE3874396D1 (en) 1992-10-15
NZ224357A (en) 1992-01-29
PH25574A (en) 1991-08-08
AU1511188A (en) 1988-10-27
HUT47248A (en) 1989-02-28
ES2043863T3 (en) 1994-01-01
CA1340986C (en) 2000-05-09
KR960012365B1 (en) 1996-09-20
PT87290A (en) 1988-05-01
IL86157A (en) 1994-04-12
IE881207L (en) 1988-10-24
EP0288394A2 (en) 1988-10-26
DE3874396T2 (en) 1993-04-22
OA08835A (en) 1989-03-31
PT87290B (en) 1992-08-31
GR3005647T3 (en) 1993-06-07
JP2727192B2 (en) 1998-03-11
ZA882595B (en) 1989-07-26
DK167758B1 (en) 1993-12-13
FI881892A (en) 1988-10-25
HU199795B (en) 1990-03-28
IT8720260A0 (en) 1987-04-24
FI881892A0 (en) 1988-04-22
IT1203971B (en) 1989-02-23

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Legal Events

Date Code Title Description
KB Patent renewed
HCE Change of name and address of proprietor(s)
MM9K Patent not in force due to non-payment of renewal fees