IL83462A - Composition of slow-release microspheres and the use of biologically active proteins and peptides - Google Patents

Composition of slow-release microspheres and the use of biologically active proteins and peptides

Info

Publication number: IL83462A
Authority: IL; Israel
Prior art keywords: growth hormone; mixture; composition; fat; biologically active
Prior art date: 1986-08-11

Application number

IL8346287A

Other languages

English (en)

Hebrew (he)

Other versions

IL83462A0 (en

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-08-11

Filing date

1987-08-06

Publication date

1994-01-25

1987-08-06 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1988-01-31 Publication of IL83462A0 publication Critical patent/IL83462A0/xx

1994-01-25 Publication of IL83462A publication Critical patent/IL83462A/en

Links

239000000203 mixture Substances 0.000 title claims description 150
239000004005 microsphere Substances 0.000 title claims description 46
108090000765 processed proteins & peptides Proteins 0.000 title claims description 30
102000004196 processed proteins & peptides Human genes 0.000 title claims description 22
102000004169 proteins and genes Human genes 0.000 title claims description 19
108090000623 proteins and genes Proteins 0.000 title claims description 19
238000007911 parenteral administration Methods 0.000 title claims description 9
239000003981 vehicle Substances 0.000 claims description 38
241001465754 Metazoa Species 0.000 claims description 36
239000000122 growth hormone Substances 0.000 claims description 31
239000007788 liquid Substances 0.000 claims description 29
108010051696 Growth Hormone Proteins 0.000 claims description 26
102000018997 Growth Hormone Human genes 0.000 claims description 26
DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims description 26
238000000034 method Methods 0.000 claims description 25
108010006025 bovine growth hormone Proteins 0.000 claims description 23
241000283690 Bos taurus Species 0.000 claims description 21
230000001965 increasing effect Effects 0.000 claims description 21
235000013336 milk Nutrition 0.000 claims description 19
239000008267 milk Substances 0.000 claims description 19
210000004080 milk Anatomy 0.000 claims description 19
238000004519 manufacturing process Methods 0.000 claims description 18
239000000872 buffer Substances 0.000 claims description 17
239000003755 preservative agent Substances 0.000 claims description 16
239000004094 surface-active agent Substances 0.000 claims description 16
239000012634 fragment Substances 0.000 claims description 14
239000003102 growth factor Substances 0.000 claims description 14
229920001184 polypeptide Polymers 0.000 claims description 14
230000002335 preservative effect Effects 0.000 claims description 14
150000003839 salts Chemical class 0.000 claims description 14
108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims description 12
102000013275 Somatomedins Human genes 0.000 claims description 12
239000003381 stabilizer Substances 0.000 claims description 12
230000007935 neutral effect Effects 0.000 claims description 10
239000002245 particle Substances 0.000 claims description 9
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 9
230000036765 blood level Effects 0.000 claims description 8
238000001816 cooling Methods 0.000 claims description 7
238000009472 formulation Methods 0.000 claims description 7
239000002736 nonionic surfactant Substances 0.000 claims description 7
239000008240 homogeneous mixture Substances 0.000 claims description 6
208000021017 Weight Gain Diseases 0.000 claims description 5
239000005556 hormone Substances 0.000 claims description 5
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235000020997 lean meat Nutrition 0.000 claims description 5
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 5
235000010234 sodium benzoate Nutrition 0.000 claims description 5
239000004299 sodium benzoate Substances 0.000 claims description 5
235000019786 weight gain Nutrition 0.000 claims description 5
230000004584 weight gain Effects 0.000 claims description 5
241000271566 Aves Species 0.000 claims description 4
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XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims 1
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235000012424 soybean oil Nutrition 0.000 description 30
239000003925 fat Substances 0.000 description 26
239000001993 wax Substances 0.000 description 21
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 14
239000003921 oil Substances 0.000 description 14
235000019198 oils Nutrition 0.000 description 14
235000013365 dairy product Nutrition 0.000 description 10
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239000011159 matrix material Substances 0.000 description 8
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238000002474 experimental method Methods 0.000 description 7
235000017557 sodium bicarbonate Nutrition 0.000 description 7
238000012360 testing method Methods 0.000 description 7
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235000013871 bee wax Nutrition 0.000 description 6
239000012166 beeswax Substances 0.000 description 6
235000014113 dietary fatty acids Nutrition 0.000 description 6
239000000194 fatty acid Substances 0.000 description 6
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239000000546 pharmaceutical excipient Substances 0.000 description 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
150000004665 fatty acids Chemical class 0.000 description 5
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238000002347 injection Methods 0.000 description 5
239000007924 injection Substances 0.000 description 5
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239000007787 solid Substances 0.000 description 5
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150000003626 triacylglycerols Chemical class 0.000 description 5
241001494479 Pecora Species 0.000 description 4
150000001298 alcohols Chemical class 0.000 description 4
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230000037396 body weight Effects 0.000 description 4
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150000002500 ions Chemical class 0.000 description 4
238000002844 melting Methods 0.000 description 4
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IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 3
239000002202 Polyethylene glycol Substances 0.000 description 3
GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 3
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
230000000694 effects Effects 0.000 description 3
238000007046 ethoxylation reaction Methods 0.000 description 3
238000010348 incorporation Methods 0.000 description 3
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239000000243 solution Substances 0.000 description 3
239000000126 substance Substances 0.000 description 3
238000013268 sustained release Methods 0.000 description 3
239000012730 sustained-release form Substances 0.000 description 3
DRAWQKGUORNASA-UHFFFAOYSA-N (2-hydroxy-3-octadec-9-enoyloxypropyl) octadec-9-enoate Chemical compound CCCCCCCCC=CCCCCCCCC(=O)OCC(O)COC(=O)CCCCCCCC=CCCCCCCCC DRAWQKGUORNASA-UHFFFAOYSA-N 0.000 description 2
DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 2
IZHVBANLECCAGF-UHFFFAOYSA-N 2-hydroxy-3-(octadecanoyloxy)propyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(=O)CCCCCCCCCCCCCCCCC IZHVBANLECCAGF-UHFFFAOYSA-N 0.000 description 2
244000180278 Copernicia prunifera Species 0.000 description 2
235000010919 Copernicia prunifera Nutrition 0.000 description 2
229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
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235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
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LPQOADBMXVRBNX-UHFFFAOYSA-N ac1ldcw0 Chemical compound Cl.C1CN(C)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN3CCSC1=C32 LPQOADBMXVRBNX-UHFFFAOYSA-N 0.000 description 2
239000002253 acid Substances 0.000 description 2
239000000654 additive Substances 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
239000007975 buffered saline Substances 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
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150000002334 glycols Chemical class 0.000 description 2
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150000002430 hydrocarbons Chemical class 0.000 description 2
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239000007972 injectable composition Substances 0.000 description 2
230000003993 interaction Effects 0.000 description 2
150000002632 lipids Chemical class 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
239000000463 material Substances 0.000 description 2
239000001788 mono and diglycerides of fatty acids Substances 0.000 description 2
239000013642 negative control Substances 0.000 description 2
WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
239000003960 organic solvent Substances 0.000 description 2
229920000642 polymer Polymers 0.000 description 2
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 2
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 2
LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 description 2
239000007921 spray Substances 0.000 description 2
238000001694 spray drying Methods 0.000 description 2
235000013311 vegetables Nutrition 0.000 description 2
JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
CGYGETOMCSJHJU-UHFFFAOYSA-N 2-chloronaphthalene Chemical compound C1=CC=CC2=CC(Cl)=CC=C21 CGYGETOMCSJHJU-UHFFFAOYSA-N 0.000 description 1
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VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
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244000105624 Arachis hypogaea Species 0.000 description 1
235000010777 Arachis hypogaea Nutrition 0.000 description 1
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239000005711 Benzoic acid Substances 0.000 description 1
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239000004215 Carbon black (E152) Substances 0.000 description 1
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FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
239000004287 Dehydroacetic acid Substances 0.000 description 1
DKMROQRQHGEIOW-UHFFFAOYSA-N Diethyl succinate Chemical compound CCOC(=O)CCC(=O)OCC DKMROQRQHGEIOW-UHFFFAOYSA-N 0.000 description 1
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241001553290 Euphorbia antisyphilitica Species 0.000 description 1
244000068988 Glycine max Species 0.000 description 1
235000010469 Glycine max Nutrition 0.000 description 1
HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 description 1
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239000004166 Lanolin Substances 0.000 description 1
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235000017587 Medicago sativa ssp. sativa Nutrition 0.000 description 1
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HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
101150052863 THY1 gene Proteins 0.000 description 1
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239000010775 animal oil Substances 0.000 description 1
238000003556 assay Methods 0.000 description 1
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235000010233 benzoic acid Nutrition 0.000 description 1
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VBICKXHEKHSIBG-UHFFFAOYSA-N beta-monoglyceryl stearate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
230000001851 biosynthetic effect Effects 0.000 description 1
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KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
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239000004327 boric acid Substances 0.000 description 1
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239000004301 calcium benzoate Substances 0.000 description 1
HZQXCUSDXIKLGS-UHFFFAOYSA-L calcium;dibenzoate;trihydrate Chemical compound O.O.O.[Ca+2].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 HZQXCUSDXIKLGS-UHFFFAOYSA-L 0.000 description 1
235000013869 carnauba wax Nutrition 0.000 description 1
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POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical class CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 1
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238000000227 grinding Methods 0.000 description 1
230000003581 hormone blood level Effects 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
235000019388 lanolin Nutrition 0.000 description 1
229940039717 lanolin Drugs 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
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150000002736 metal compounds Chemical class 0.000 description 1
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QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
239000012186 ozocerite Substances 0.000 description 1
150000002942 palmitic acid derivatives Chemical class 0.000 description 1
IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
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235000020232 peanut Nutrition 0.000 description 1
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WKEDVNSFRWHDNR-UHFFFAOYSA-N salicylanilide Chemical compound OC1=CC=CC=C1C(=O)NC1=CC=CC=C1 WKEDVNSFRWHDNR-UHFFFAOYSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives

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Endocrinology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Polymers & Plastics (AREA)
Zoology (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Food Science & Technology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Reproductive Health (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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IL8346287A 1986-08-11 1987-08-06 Composition of slow-release microspheres and the use of biologically active proteins and peptides IL83462A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US89560886A	1986-08-11	1986-08-11

Publications (2)

Publication Number	Publication Date
IL83462A0 IL83462A0 (en)	1988-01-31
IL83462A true IL83462A (en)	1994-01-25

Family

ID=25404759

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL8346287A IL83462A (en)	1986-08-11	1987-08-06	Composition of slow-release microspheres and the use of biologically active proteins and peptides

Country Status (16)

Country	Link
EP (1)	EP0257368B1 (fi)
JP (1)	JP2571790B2 (fi)
AR (1)	AR243079A1 (fi)
AT (1)	ATE74009T1 (fi)
AU (1)	AU597708B2 (fi)
CA (1)	CA1296627C (fi)
DE (1)	DE3777721D1 (fi)
DK (1)	DK169123B1 (fi)
ES (1)	ES2039219T3 (fi)
FI (1)	FI873465A (fi)
GR (1)	GR3004138T3 (fi)
HU (1)	HU203662B (fi)
IE (1)	IE65146B1 (fi)
IL (1)	IL83462A (fi)
NZ (1)	NZ221391A (fi)
ZA (1)	ZA875898B (fi)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
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US4857505A (en) *	1987-03-09	1989-08-15	American Cyanamid Company	Sustained release compositions for parenteral administration and their use
GB8725427D0 (en) *	1987-10-30	1987-12-02	Lilly Industries Ltd	Somatotropin formulations
DE68924808D1 (de) *	1988-07-26	1995-12-21	Univ Rutgers	Vorrichtungen und Verfahren zur Wachstumsförderung bei Bratgeflügel.
US5106631A (en) *	1989-07-17	1992-04-21	American Cyanamid Company	Cheese production
US5188895A (en) *	1989-08-31	1993-02-23	Mitsui Petrochemical Industries, Ltd.	Split fibers, integrated split fiber articles and method for preparing the same
WO1991005548A1 (en) *	1989-10-10	1991-05-02	Pitman-Moore, Inc.	Sustained release composition for macromolecular proteins
FR2663223B1 (fr) *	1990-06-14	1994-12-02	Af Aplicaciones Far Lab	Forme galenique parenterale.
FR2663224B1 (fr) *	1990-06-14	1995-01-20	Applicationes Farmaceuticas Sa	Forme galenique parenterale.
WO1992014449A1 (en) *	1991-02-20	1992-09-03	Nova Pharmaceutical Corporation	Controlled release microparticulate delivery system for proteins
ES2136620T3 (es) *	1991-04-19	1999-12-01	Lds Technologies Inc	Formulaciones de microemulsiones convertibles.
US5688761A (en) *	1991-04-19	1997-11-18	Lds Technologies, Inc.	Convertible microemulsion formulations
DE69208765T2 (de) *	1991-07-23	1996-09-26	American Cyanamid Co	Stabile Zusammensetzungen für parenterale Verabrechung und ihre Verwendung
US5336488A (en) *	1991-08-07	1994-08-09	American Cyanamid Company	Method of treating or preventing mastitis in animals with involuting mammary glands by administering recombinant cytokines
YU87892A (sh) *	1991-10-01	1995-12-04	Eli Lilly And Company Lilly Corporate Center	Injektibilne formulacije produženog otpuštanja i postupci za njihovo dobijanje i primenu
IL103275A0 (en) *	1991-10-01	1993-02-21	Lilly Co Eli	Injectable extended release formulations and methods
WO1994008576A1 (en) *	1992-10-16	1994-04-28	Glaxo Group Limited	Taste-masking compositions of ranitidine
US5885486A (en) *	1993-03-05	1999-03-23	Pharmaciaand Upjohn Ab	Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof
US5785976A (en) *	1993-03-05	1998-07-28	Pharmacia & Upjohn Ab	Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof
AUPN366795A0 (en)	1995-06-20	1995-07-13	Peptide Technology Limited	Formulation for preventing reproductive function
CN1227490A (zh)	1996-08-07	1999-09-01	协和发酵工业株式会社	含有黄嘌呤衍生物的脂肪乳剂
JP2001058955A (ja) *	1999-06-17	2001-03-06	Inst Of Physical & Chemical Res	生理活性ペプチド徐放性製剤
FR2809309B1 (fr) *	2000-05-23	2004-06-11	Mainelab	Microspheres a liberation prolongee pour administration injectable
US6967028B2 (en)	2000-07-31	2005-11-22	Mainelab	Prolonged release microspheres for injectable administration
DE60130580T2 (de)	2000-12-27	2008-06-12	Ares Trading S.A.	Lipidmikropartikel mittels kryogenischer mikronisierung
WO2004069180A2 (en) *	2003-01-31	2004-08-19	Smithkline Beecham Corporation	Solid dispersion compositions
CN110036974A (zh) *	2019-03-18	2019-07-23	香格里拉市春树养殖农民专业合作社	一种肉牛的养殖方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS537492B2 (fi) *	1973-02-12	1978-03-18
EP0085036A1 (en) *	1982-01-18	1983-08-03	Monsanto Company	Method for improved bovine milk production
IT1190361B (it) *	1985-05-30	1988-02-16	Zambon Spa	Composizione farmaceutica in crema per uso dermale ed oftalmico

1987
- 1987-08-04 AT AT87111217T patent/ATE74009T1/de not_active IP Right Cessation
- 1987-08-04 DE DE8787111217T patent/DE3777721D1/de not_active Expired - Fee Related
- 1987-08-04 EP EP87111217A patent/EP0257368B1/en not_active Expired - Lifetime
- 1987-08-04 ES ES198787111217T patent/ES2039219T3/es not_active Expired - Lifetime
- 1987-08-06 IL IL8346287A patent/IL83462A/en not_active IP Right Cessation
- 1987-08-07 CA CA000543953A patent/CA1296627C/en not_active Expired - Fee Related
- 1987-08-10 DK DK414987A patent/DK169123B1/da not_active IP Right Cessation
- 1987-08-10 IE IE212987A patent/IE65146B1/en not_active IP Right Cessation
- 1987-08-10 AR AR87308992A patent/AR243079A1/es active
- 1987-08-10 NZ NZ221391A patent/NZ221391A/xx unknown
- 1987-08-10 AU AU76725/87A patent/AU597708B2/en not_active Ceased
- 1987-08-10 ZA ZA875898A patent/ZA875898B/xx unknown
- 1987-08-10 HU HU873619A patent/HU203662B/hu not_active IP Right Cessation
- 1987-08-10 FI FI873465A patent/FI873465A/fi not_active Application Discontinuation
- 1987-08-11 JP JP62199239A patent/JP2571790B2/ja not_active Expired - Fee Related
1992
- 1992-03-26 GR GR910401178T patent/GR3004138T3/el unknown

Also Published As

Publication number	Publication date
ZA875898B (en)	1988-02-12
HU203662B (en)	1991-09-30
DK414987D0 (da)	1987-08-10
AU597708B2 (en)	1990-06-07
CA1296627C (en)	1992-03-03
EP0257368B1 (en)	1992-03-25
JP2571790B2 (ja)	1997-01-16
ATE74009T1 (de)	1992-04-15
IE872129L (en)	1988-02-11
DK169123B1 (da)	1994-08-22
DK414987A (da)	1988-02-12
HUT45887A (en)	1988-09-28
JPS6348223A (ja)	1988-02-29
AR243079A1 (es)	1993-07-30
NZ221391A (en)	1990-08-28
FI873465A (fi)	1988-02-12
DE3777721D1 (de)	1992-04-30
EP0257368A1 (en)	1988-03-02
FI873465A0 (fi)	1987-08-10
ES2039219T3 (es)	1993-09-16
IE65146B1 (en)	1995-10-04
AU7672587A (en)	1988-02-18
GR3004138T3 (fi)	1993-03-31
IL83462A0 (en)	1988-01-31

Publication	Publication Date	Title
US4837381A (en)	1989-06-06	Compositions for parenteral administration and their use
EP0257368B1 (en)	1992-03-25	Compositions for parenteral administration and their use
EP0448930B1 (en)	1994-06-01	Stable compositions for parenteral administration and method of making same
US5739108A (en)	1998-04-14	Prolonged release of biologically active polypeptides
US4985404A (en)	1991-01-15	Prolonged release of biologically active polypeptides
US7037516B2 (en)	2006-05-02	Non-aqueous surfactant-containing formulations for extended release of somatotropin
SI9300468A (en)	1994-06-30	Injectable composition for the sustained release of biologically active compounds
NZ223010A (en)	1990-11-27	Sustained release growth hormone emulsion
US6340671B1 (en)	2002-01-22	Stable compositions for parenteral administration and their use
JPH0720422B2 (ja)	1995-03-08	ビタミン含有反芻動物用飼料添加剤
EP0314421A1 (en)	1989-05-03	Somatotropin formulations
KR100329336B1 (ko)	2002-03-22	히아루론산을 이용한 단백질 약물의 서방성 미세 입자 제형
US6719990B2 (en)	2004-04-13	Non-aqueous injectable formulations for extended release of somatotropin
NO314387B1 (no)	2003-03-17	Sinkbundet somatotropinkompleks og i det vesentlige ikke- vandig somatropinpreparat med langvarige frigivelseskarakteristika for parenteraladministrering til et dyr for vekst- og produktivitetsökning

Legal Events

Date	Code	Title
1998-02-08	KB	Patent renewed
2001-10-31	KB	Patent renewed
2006-06-18	MM9K	Patent not in force due to non-payment of renewal fees