IL72743A - 3-(piperidinyl)-and 3-(pyrrolidinyl)1h-indazoles,a process for their preparation and pharmaceutical compositions containing them - Google Patents
3-(piperidinyl)-and 3-(pyrrolidinyl)1h-indazoles,a process for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL72743A IL72743A IL72743A IL7274384A IL72743A IL 72743 A IL72743 A IL 72743A IL 72743 A IL72743 A IL 72743A IL 7274384 A IL7274384 A IL 7274384A IL 72743 A IL72743 A IL 72743A
- Authority
- IL
- Israel
- Prior art keywords
- indazoles
- pyrrolidinyl
- piperidinyl
- preparation
- pharmaceutical compositions
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- HEEOHMKCCDUYLO-UHFFFAOYSA-N 3-pyrrolidin-1-yl-1h-indazole Chemical class C1CCCN1C1=NNC2=CC=CC=C12 HEEOHMKCCDUYLO-UHFFFAOYSA-N 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52508883A | 1983-08-22 | 1983-08-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL72743A0 IL72743A0 (en) | 1984-11-30 |
| IL72743A true IL72743A (en) | 1989-01-31 |
Family
ID=24091865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL72743A IL72743A (en) | 1983-08-22 | 1984-08-28 | 3-(piperidinyl)-and 3-(pyrrolidinyl)1h-indazoles,a process for their preparation and pharmaceutical compositions containing them |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0135781B1 (xx) |
| JP (1) | JPS60100573A (xx) |
| KR (1) | KR880002356B1 (xx) |
| AT (1) | ATE47139T1 (xx) |
| AU (1) | AU575846B2 (xx) |
| CA (1) | CA1292232C (xx) |
| DE (1) | DE3480091D1 (xx) |
| DK (1) | DK400284A (xx) |
| ES (2) | ES535289A0 (xx) |
| FI (1) | FI82242C (xx) |
| GR (1) | GR80160B (xx) |
| HU (1) | HU198036B (xx) |
| IL (1) | IL72743A (xx) |
| NZ (1) | NZ209279A (xx) |
| PH (1) | PH22032A (xx) |
| PT (1) | PT79110B (xx) |
| ZA (1) | ZA846485B (xx) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3563964D1 (en) * | 1984-10-16 | 1988-09-01 | Synthelabo | Piperidine derivatives, their preparation and their therapeutical application |
| EP0192935B1 (en) * | 1985-01-23 | 1991-02-27 | Hoechst-Roussel Pharmaceuticals Incorporated | 3-(piperidinyl)-1h-indazoles a process for their preparation and their use as medicaments |
| US4999356A (en) * | 1987-08-07 | 1991-03-12 | Hoechst-Roussel Pharmaceuticals, Inc. | 1-phenyl-3-(1-piperazinyl)-1H-indazoles |
| GB8811299D0 (en) * | 1988-05-12 | 1988-06-15 | Grayshan R | Indazole derivatives |
| US4957916A (en) * | 1988-08-05 | 1990-09-18 | Janssen Pharmaceutica N.V. | Antipsychotic 3-piperazinylbenzazole derivatives |
| NZ230045A (en) | 1988-08-05 | 1990-11-27 | Janssen Pharmaceutica Nv | 3-piperazinylbenzazole derivatives and pharmaceutical compositions |
| US5015740A (en) * | 1988-08-05 | 1991-05-14 | Janssen Pharmaceutica N.V. | Antipsychotic 3-piperazinylbenzazole derivatives |
| IL90879A0 (en) * | 1988-09-02 | 1990-02-09 | Janssen Pharmaceutica Nv | 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them |
| US5364866A (en) * | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
| US5561128A (en) * | 1989-05-19 | 1996-10-01 | Hoechst-Roussel Pharmaceuticals, Inc. | N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility |
| US5776963A (en) * | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
| ES2076253T3 (es) * | 1989-05-19 | 1995-11-01 | Hoechst Roussel Pharma | N-(ariloxialquil)-heteroarilpiperidinas y -heteroarilpiperazinas, un procedimiento para su preparacion y su uso como medicamentos. |
| DK181190D0 (da) * | 1990-07-30 | 1990-07-30 | Lundbeck & Co As H | 3-aryl-indol- eller 3-aryl-indazolderivater |
| US5051430A (en) * | 1990-09-10 | 1991-09-24 | Hoechst-Roussel Pharmaceuticals Incorporated | 3-(1H-indazol-3-yl)-4-pyridinamines |
| NZ243065A (en) * | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
| DK55192D0 (da) * | 1992-04-28 | 1992-04-28 | Lundbeck & Co As H | 1-piperazino-1,2-dihydroindenderivater |
| JPH08502508A (ja) * | 1992-10-23 | 1996-03-19 | メルク シヤープ エンド ドーム リミテツド | ドーパミンレセプターサブタイプリガンド |
| US5670522A (en) * | 1992-10-23 | 1997-09-23 | Merck Sharp & Dohme Limited | Dopamine receptor subtype ligands |
| DE4414113A1 (de) * | 1994-04-22 | 1995-10-26 | Merck Patent Gmbh | 3-Indolylpiperidine |
| US5668148A (en) * | 1995-04-20 | 1997-09-16 | Merck & Co., Inc. | Alpha1a adrenergic receptor antagonists |
| DE59713007D1 (de) | 1996-10-14 | 2009-06-25 | Bayer Healthcare Ag | Neue heterocyclylmethyl-substituierte pyrazolderivate und ihre verwendung in der behandlung von herz-kreislauf-erkrankungen |
| FR2767827A1 (fr) * | 1997-09-03 | 1999-02-26 | Adir | Nouveaux derives de l'indole et de l'indazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| IL126745A (en) * | 1997-11-04 | 2003-09-17 | Pfizer Prod Inc | Methods of preparing 4-cyano-4- (substituted indazole) cyclohexanecarboxylic acids useful as pde4 inhibitors |
| US6133290A (en) * | 1998-07-31 | 2000-10-17 | Eli Lilly And Company | 5-HT1F agonists |
| WO2004069828A1 (ja) * | 2003-02-04 | 2004-08-19 | Mitsubishi Pharma Corporation | ピペリジン化合物およびその医薬用途 |
| EP1701954A1 (en) * | 2003-12-31 | 2006-09-20 | Warner-Lambert Company LLC | N-substituted piperidine and piperazine derivatives |
| DE602005019913D1 (de) | 2004-11-29 | 2010-04-22 | Warner Lambert Co | Therapeutische pyrazoloä3,4-büpyridine und -indazole |
| ES2565611T3 (es) * | 2008-10-14 | 2016-04-05 | Entasis Therapeutics Limited | Compuestos heteroaromáticos espirocíclicos y condensados para el tratamiento de infecciones bacterianas |
| EP2790687B1 (en) | 2011-12-16 | 2018-08-29 | Poseida Therapeutics, Inc. | Trpc4 modulators for use in the treatment or prevention of pain |
| JP2015214492A (ja) * | 2012-09-07 | 2015-12-03 | 大日本住友製薬株式会社 | ３−（４−ピペリジル）−インダゾール誘導体 |
| AU2018252099B2 (en) * | 2017-04-11 | 2021-08-12 | Sunshine Lake Pharma Co., Ltd. | Fluorine-substituted indazole compounds and uses thereof |
-
1984
- 1984-08-15 HU HU843095A patent/HU198036B/hu not_active IP Right Cessation
- 1984-08-17 EP EP84109800A patent/EP0135781B1/en not_active Expired
- 1984-08-17 AT AT84109800T patent/ATE47139T1/de not_active IP Right Cessation
- 1984-08-17 DE DE8484109800T patent/DE3480091D1/de not_active Expired
- 1984-08-20 ES ES535289A patent/ES535289A0/es active Granted
- 1984-08-20 NZ NZ209279A patent/NZ209279A/en unknown
- 1984-08-20 FI FI843281A patent/FI82242C/fi not_active IP Right Cessation
- 1984-08-20 PH PH31122A patent/PH22032A/en unknown
- 1984-08-21 GR GR80160A patent/GR80160B/el unknown
- 1984-08-21 JP JP59172528A patent/JPS60100573A/ja active Granted
- 1984-08-21 DK DK400284A patent/DK400284A/da not_active Application Discontinuation
- 1984-08-21 ZA ZA846485A patent/ZA846485B/xx unknown
- 1984-08-21 CA CA000461452A patent/CA1292232C/en not_active Expired - Lifetime
- 1984-08-21 KR KR1019840005046A patent/KR880002356B1/ko not_active IP Right Cessation
- 1984-08-21 PT PT79110A patent/PT79110B/pt not_active IP Right Cessation
- 1984-08-21 AU AU32250/84A patent/AU575846B2/en not_active Ceased
- 1984-08-28 IL IL72743A patent/IL72743A/xx unknown
-
1985
- 1985-05-16 ES ES543206A patent/ES543206A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| ES8601964A1 (es) | 1985-11-01 |
| PH22032A (en) | 1988-05-13 |
| DE3480091D1 (en) | 1989-11-16 |
| DK400284D0 (da) | 1984-08-21 |
| FI82242C (fi) | 1991-02-11 |
| CA1292232C (en) | 1991-11-19 |
| FI843281A0 (fi) | 1984-08-20 |
| HUT37139A (en) | 1985-11-28 |
| ES8603867A1 (es) | 1986-01-01 |
| GR80160B (en) | 1984-12-19 |
| ES535289A0 (es) | 1985-11-01 |
| HU198036B (en) | 1989-07-28 |
| FI82242B (fi) | 1990-10-31 |
| AU575846B2 (en) | 1988-08-11 |
| KR850001748A (ko) | 1985-04-01 |
| ATE47139T1 (de) | 1989-10-15 |
| KR880002356B1 (ko) | 1988-10-29 |
| ZA846485B (en) | 1985-03-27 |
| EP0135781B1 (en) | 1989-10-11 |
| AU3225084A (en) | 1985-02-28 |
| EP0135781A1 (en) | 1985-04-03 |
| FI843281A (fi) | 1985-02-23 |
| PT79110A (en) | 1984-09-01 |
| PT79110B (en) | 1986-09-15 |
| IL72743A0 (en) | 1984-11-30 |
| DK400284A (da) | 1985-02-23 |
| NZ209279A (en) | 1988-05-30 |
| JPS60100573A (ja) | 1985-06-04 |
| ES543206A0 (es) | 1986-01-01 |
| JPH051792B2 (xx) | 1993-01-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL72743A (en) | 3-(piperidinyl)-and 3-(pyrrolidinyl)1h-indazoles,a process for their preparation and pharmaceutical compositions containing them | |
| DE3166231D1 (en) | Process for preparing 4-amino-2,2,6,6-tetramethylpiperidine | |
| EP0328251A3 (en) | 2-(2-hydroxy-3-phenoxypropylamino)ethylphenoxyacetamides and processes and intermediates for their preparation | |
| ES8405396A1 (es) | Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1,2-bencisoxazoles. | |
| EP0127167A3 (en) | 3-(4-piperidinyl)-1,2-benzisothiazoles and derivates, a process for their preparation and their use as medicaments | |
| DE3172006D1 (en) | Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof | |
| DE3162735D1 (en) | Process for preparing 2,2,6,6-tetramethyl-4-piperidone | |
| GR77706B (xx) | ||
| ZA915022B (en) | Oxazolopyridine compounds,process for preparing these and pharmaceutical compositions containing them | |
| DE3064520D1 (en) | 3-(3'-amino-2'-hydroxy-n-prop-1'-oxy)-6-isopropylidenehydrazino-pyridazines, process for their production and medicaments containing them | |
| YU49079B (sh) | Novi derivati fosfolipida i postupak za njihovu proizvodnju | |
| ZA918644B (en) | Novel compounds,pharmaceutical compositions containing them and process for preparing same | |
| HK71784A (en) | Pyridylalkylpyrimidone compounds,process for preparing them and pharmaceutical compositions containing them | |
| JPS5597438A (en) | Treatment for titanium containing raw material |