IL72033A - Oral pharmaceutical compositions containing difficultly soluble antidiabetic agents and their preparation - Google Patents

Oral pharmaceutical compositions containing difficultly soluble antidiabetic agents and their preparation

Info

Publication number: IL72033A
Authority: IL; Israel
Prior art keywords: pharmaceutical compositions; compositions containing; preparation; active substance; oral pharmaceutical
Prior art date: 1983-06-08

Application number

IL72033A

Other languages

English (en)

Other versions

IL72033A0 (en

Original Assignee

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-06-08

Filing date

1984-06-05

Publication date

1987-08-31

1984-06-05 Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K

1984-10-31 Publication of IL72033A0 publication Critical patent/IL72033A0/xx

1987-08-31 Publication of IL72033A publication Critical patent/IL72033A/xx

Links

239000003472 antidiabetic agent Substances 0.000 title 1
229940125708 antidiabetic agent Drugs 0.000 title 1
239000008203 oral pharmaceutical composition Substances 0.000 title 1
239000013543 active substance Substances 0.000 abstract 3
239000000203 mixture Substances 0.000 abstract 3
239000002904 solvent Substances 0.000 abstract 3
230000000694 effects Effects 0.000 abstract 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
230000004060 metabolic process Effects 0.000 abstract 1
239000003538 oral antidiabetic agent Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Plant Substances (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL72033A 1983-06-08 1984-06-05 Oral pharmaceutical compositions containing difficultly soluble antidiabetic agents and their preparation IL72033A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19833320583 DE3320583A1 (de)	1983-06-08	1983-06-08	Neue galenische zubereitungsformen von oralen antidiabetika und verfahren zu ihrer herstellung

Publications (2)

Publication Number	Publication Date
IL72033A0 IL72033A0 (en)	1984-10-31
IL72033A true IL72033A (en)	1987-08-31

Family

ID=6200886

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL72033A IL72033A (en)	1983-06-08	1984-06-05	Oral pharmaceutical compositions containing difficultly soluble antidiabetic agents and their preparation

Country Status (24)

Country	Link
US (2)	US4708868A (xx)
EP (1)	EP0128482B1 (xx)
JP (1)	JPS6075435A (xx)
KR (1)	KR910004572B1 (xx)
AT (1)	ATE49886T1 (xx)
AU (1)	AU562803B2 (xx)
CA (1)	CA1228300A (xx)
DD (1)	DD223360A5 (xx)
DE (2)	DE3320583A1 (xx)
DK (1)	DK162018C (xx)
ES (1)	ES533207A0 (xx)
FI (1)	FI85218C (xx)
GB (1)	GB2142235B (xx)
GR (1)	GR82363B (xx)
HK (1)	HK72287A (xx)
HU (1)	HU192407B (xx)
IE (1)	IE57792B1 (xx)
IL (1)	IL72033A (xx)
MY (1)	MY100764A (xx)
NO (1)	NO168629C (xx)
NZ (1)	NZ208416A (xx)
PT (1)	PT78711B (xx)
SG (1)	SG48087G (xx)
ZA (1)	ZA844295B (xx)

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US5312924A (en) *	1983-12-30	1994-05-17	Dr. Karl Thomae Gmbh	Phenylacetic acid benzylamides
FR2577437A1 (fr) *	1985-02-21	1986-08-22	Corbiere Jerome	Nouveau procede de solubilisation des composes chimiques et les preparations aqueuses ainsi obtenues
US5258185A (en) *	1989-08-23	1993-11-02	Bauer Kurt H	Highly active, rapidly absorbable formulations of glibenclamide, processes for the production thereof and their use
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US5688518A (en) *	1992-02-27	1997-11-18	Alza Corporation	Antidepressive therapy
US5246711A (en) *	1992-02-27	1993-09-21	Alza Corporation	Dosage form for treating dysthymia
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US6153632A (en) *	1997-02-24	2000-11-28	Rieveley; Robert B.	Method and composition for the treatment of diabetes
US6291495B1 (en)	1997-02-24	2001-09-18	Robert B. Rieveley	Method and composition for the treatment of diabetes
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ATE267589T1 (de) *	1998-04-03	2004-06-15	Egalet As	Zusammensetzung mit kontrollierter wirkstoff- freisetzung
US6099862A (en)	1998-08-31	2000-08-08	Andrx Corporation	Oral dosage form for the controlled release of a biguanide and sulfonylurea
US8236352B2 (en)	1998-10-01	2012-08-07	Alkermes Pharma Ireland Limited	Glipizide compositions
ES2379471T5 (es) †	1999-02-08	2015-05-26	Intarcia Therapeutics, Inc	Vehículos viscosos biocompatibles de fase única no acuosos y procedimientos para su preparación
US7258869B1 (en)	1999-02-08	2007-08-21	Alza Corporation	Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
CA2373962C (en) *	1999-05-21	2009-02-24	Kiyohisa Ouchi	Immediate release medicinal compositions for oral use
ES2295379T3 (es)	2001-06-29	2008-04-16	Eurand Pharmaceuticals Ltd.	Procedimiento de activacion termodinamica de medicamentos insolubles en agua cargados en polimeros reticulados.
FR2827517B1 (fr) *	2001-07-23	2003-10-24	Bioalliance Pharma	Systemes therapeutiques bioadhesifs a liberation prolongee
EP1429744A1 (en) *	2001-09-21	2004-06-23	Egalet A/S	Morphine polymer release system
EP1429739A1 (en)	2001-09-21	2004-06-23	Egalet A/S	Polymer release system
DE60224293T2 (de) *	2001-09-21	2008-12-11	Egalet A/S	Feste dispersionen mit kontrollierter freisetzung von carvedilol
US20030187074A1 (en) *	2002-03-04	2003-10-02	Javed Hussain	Oral compositions for treatment of diabetes
US20030219482A1 (en) *	2002-03-21	2003-11-27	Chaudhari Sunil Sudhakar	Multiparticulate compositions for once-a-day administration
SE526943C2 (sv) *	2002-08-26	2005-11-22	Indevex Ab	Födoämneskompositionsprodukt
EP1562552A1 (en) *	2002-11-08	2005-08-17	Egalet A/S	Controlled release carvedilol compositions
AU2003276572A1 (en) *	2002-11-15	2004-06-15	Ranbaxy Laboratories Limited	Pharmaceutical dosage forms of biguanide-sulfonylurea combinations
US7731947B2 (en)	2003-11-17	2010-06-08	Intarcia Therapeutics, Inc.	Composition and dosage form comprising an interferon particle formulation and suspending vehicle
ATE454886T1 (de) *	2003-03-26	2010-01-15	Egalet As	Matrixzubereitungen für die kontrollierte darreichung von arzneistoffen
EP2301526B1 (en) *	2003-03-26	2016-03-23	Egalet Ltd.	Morphine controlled release system
US20050202063A1 (en) *	2003-08-26	2005-09-15	Ebn International Kft	Food product
DE10341414A1 (de) *	2003-09-05	2005-03-31	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Oral zu applizierende Darreichungsform für schwerlösliche saure und amphotere Wirkstoffe
US20050053669A1 (en) *	2003-09-05	2005-03-10	Boehringer Ingelheim International Gmbh	Administration form for the oral application of poorly soluble acidic and amphorteric drugs
KR100760430B1 (ko) *	2004-12-31	2007-10-04	한미약품 주식회사	당뇨병 치료제의 경구 투여용 서방성 복합 제제 및 이의제조 방법
US11246913B2 (en)	2005-02-03	2022-02-15	Intarcia Therapeutics, Inc.	Suspension formulation comprising an insulinotropic peptide
WO2006083761A2 (en)	2005-02-03	2006-08-10	Alza Corporation	Solvent/polymer solutions as suspension vehicles
WO2006128471A2 (en) *	2005-06-03	2006-12-07	Egalet A/S	A solid pharmaceutical composition with a first fraction of a dispersion medium and a second fraction of a matrix, the latter being at least partially first exposed to gastrointestinal fluids
EP1837020A1 (en)	2006-03-24	2007-09-26	Bioalliance Pharma	Mucosal bioadhesive slow release carrier for delivering active principles
JP5143131B2 (ja)	2006-05-30	2013-02-13	インターシアセラピューティクス，インコーポレイティド	浸透圧送出システムの二片構成内部チャネル型の流れモジュレータ
JP5048773B2 (ja)	2006-08-09	2012-10-17	インターシアセラピューティクス，インコーポレイティド	浸透圧式デリバリーシステム及びピストンアセンブリー
EP2073796A1 (en) *	2006-09-29	2009-07-01	Novo Nordisk A/S	Pharmaceutical formulation comprising metformin and repaglinide
NZ577560A (en) *	2007-01-16	2012-01-12	Egalet Ltd	Use of i) a polyglycol and ii) an active drug substance for the preparation of a pharmaceutical composition for i) mitigating the risk of alcohol induced dose dumping and/or ii) reducing the risk of drug abuse
JP2010523084A (ja)	2007-03-30	2010-07-15	アンブルックス，インコーポレイテッド	修飾ｆｇｆ−２１ポリペプチド
RU2440097C2 (ru)	2007-04-23	2012-01-20	Интарсия Терапьютикс, Инк.	Способ лечения диабета ii типа и ожирения, осмотическое устройство для доставки и способ его изготовления
US8821928B2 (en)	2007-06-04	2014-09-02	Egalet Ltd.	Controlled release pharmaceutical compositions for prolonged effect
EP2240155B1 (en)	2008-02-13	2012-06-06	Intarcia Therapeutics, Inc	Devices, formulations, and methods for delivery of multiple beneficial agents
EP2393484A1 (en)	2009-02-06	2011-12-14	Egalet Ltd.	Immediate release composition resistant to abuse by intake of alcohol
EP2228066A1 (en) *	2009-03-03	2010-09-15	LEK Pharmaceuticals d.d.	Pharmaceutical compositions of sulphonylurea-based active pharmaceutical ingredient with excellent dissolution properties
EP2445487A2 (en)	2009-06-24	2012-05-02	Egalet Ltd.	Controlled release formulations
US8298561B2 (en)	2009-09-28	2012-10-30	Intarcia Therapeutics, Inc.	Rapid establishment and/or termination of substantial steady-state drug delivery
EP2438911A1 (en) *	2010-10-08	2012-04-11	LEK Pharmaceuticals d.d.	Pharmaceuticals compositions comprising sulphonylurea-class insulin secretagogue and polyethylene glycol castor oil
US20120208755A1 (en)	2011-02-16	2012-08-16	Intarcia Therapeutics, Inc.	Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
EP2877161A1 (en)	2012-07-06	2015-06-03	Egalet Ltd.	Abuse deterrent pharmaceutical compositions for controlled release
US9889085B1 (en)	2014-09-30	2018-02-13	Intarcia Therapeutics, Inc.	Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
CN114805531A (zh)	2014-10-24	2022-07-29	百时美施贵宝公司	修饰的fgf-21多肽及其用途
MX2017015504A (es)	2015-06-03	2018-05-15	Intarcia Therapeutics Inc	Sistemas de colocacion y remoción de implante.
TWI754643B (zh)	2016-05-16	2022-02-11	美商因塔希亞治療公司	升糖素受體選擇性多肽和彼之使用方法
USD860451S1 (en)	2016-06-02	2019-09-17	Intarcia Therapeutics, Inc.	Implant removal tool
USD840030S1 (en)	2016-06-02	2019-02-05	Intarcia Therapeutics, Inc.	Implant placement guide
IL307966A (en)	2017-01-03	2023-12-01	Intarcia Therapeutics Inc	Methods involving continuous administration of a GLP-1 receptor agonist and co-administration of a drug
CN115671203B (zh) *	2022-11-24	2023-10-27	广州中医药大学科技产业园有限公司	一种用于降糖降脂的中药复方提取物及其提取方法

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DE3100535A1 (de) *	1981-01-10	1982-08-12	Dr. Karl Thomae Gmbh, 7950 Biberach	"neue carbonsaeure-derivate, ihre herstellung und ihre verwendung als arzneimittel"
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1983
- 1983-06-08 DE DE19833320583 patent/DE3320583A1/de not_active Withdrawn
1984
- 1984-05-31 US US06/616,010 patent/US4708868A/en not_active Expired - Lifetime
- 1984-06-01 DE DE8484106271T patent/DE3481170D1/de not_active Expired - Lifetime
- 1984-06-01 EP EP84106271A patent/EP0128482B1/de not_active Expired - Lifetime
- 1984-06-01 AT AT84106271T patent/ATE49886T1/de not_active IP Right Cessation
- 1984-06-05 IL IL72033A patent/IL72033A/xx unknown
- 1984-06-06 DD DD84263870A patent/DD223360A5/de not_active IP Right Cessation
- 1984-06-07 ZA ZA844295A patent/ZA844295B/xx unknown
- 1984-06-07 NO NO842291A patent/NO168629C/no unknown
- 1984-06-07 FI FI842295A patent/FI85218C/fi not_active IP Right Cessation
- 1984-06-07 JP JP59117431A patent/JPS6075435A/ja active Granted
- 1984-06-07 IE IE1422/84A patent/IE57792B1/en not_active IP Right Cessation
- 1984-06-07 DK DK280884A patent/DK162018C/da not_active IP Right Cessation
- 1984-06-07 GR GR74958A patent/GR82363B/el unknown
- 1984-06-07 NZ NZ208416A patent/NZ208416A/en unknown
- 1984-06-07 CA CA000456097A patent/CA1228300A/en not_active Expired
- 1984-06-07 HU HU842207A patent/HU192407B/hu not_active IP Right Cessation
- 1984-06-07 KR KR1019840003189A patent/KR910004572B1/ko not_active Expired
- 1984-06-07 ES ES533207A patent/ES533207A0/es active Granted
- 1984-06-07 GB GB08414528A patent/GB2142235B/en not_active Expired
- 1984-06-08 PT PT78711A patent/PT78711B/pt unknown
- 1984-06-08 AU AU29241/84A patent/AU562803B2/en not_active Ceased
1987
- 1987-05-30 SG SG48087A patent/SG48087G/en unknown
- 1987-07-06 MY MYPI87000950A patent/MY100764A/en unknown
- 1987-09-30 US US07/103,524 patent/US4873080A/en not_active Expired - Lifetime
- 1987-10-07 HK HK722/87A patent/HK72287A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
IE57792B1 (en)	1993-04-07
DE3481170D1 (de)	1990-03-08
GB2142235A (en)	1985-01-16
HUT34349A (en)	1985-03-28
GR82363B (xx)	1984-12-13
EP0128482A3 (en)	1986-06-25
NO842291L (no)	1984-12-10
CA1228300A (en)	1987-10-20
IL72033A0 (en)	1984-10-31
EP0128482A2 (de)	1984-12-19
SG48087G (en)	1987-08-28
NO168629C (no)	1992-03-18
HK72287A (en)	1987-10-16
DK162018C (da)	1992-02-10
HU192407B (en)	1987-06-29
PT78711A (de)	1984-07-01
ATE49886T1 (de)	1990-02-15
KR910004572B1 (ko)	1991-07-06
ES8601697A1 (es)	1985-11-16
GB2142235B (en)	1987-04-08
ES533207A0 (es)	1985-11-16
US4873080A (en)	1989-10-10
MY100764A (en)	1991-02-15
GB8414528D0 (en)	1984-07-11
FI842295A0 (fi)	1984-06-07
AU2924184A (en)	1984-12-13
DK162018B (da)	1991-09-09
FI85218B (fi)	1991-12-13
DD223360A5 (de)	1985-06-12
AU562803B2 (en)	1987-06-18
IE841422L (en)	1984-12-08
JPS6075435A (ja)	1985-04-27
NZ208416A (en)	1987-06-30
US4708868A (en)	1987-11-24
NO168629B (no)	1991-12-09
JPH0548206B2 (xx)	1993-07-20
FI842295L (fi)	1984-12-09
DE3320583A1 (de)	1984-12-13
EP0128482B1 (de)	1990-01-31
DK280884A (da)	1984-12-09
ZA844295B (en)	1986-02-26
DK280884D0 (da)	1984-06-07
FI85218C (fi)	1992-03-25
PT78711B (de)	1986-10-21
KR850000241A (ko)	1985-02-26

Publication	Publication Date	Title
IL72033A (en)	1987-08-31	Oral pharmaceutical compositions containing difficultly soluble antidiabetic agents and their preparation
GB2142236B (en)	1987-04-08	Oral antidiabetic compositions

Legal Events

Date	Code	Title	Description
1998-12-06	KB	Patent renewed
2002-08-14	KB	Patent renewed