IL65922A - Preparation of apovincaminic acid esters,certain novel optically active trans-derivatives thereof and pharmaceutical compositions containing them - Google Patents

Preparation of apovincaminic acid esters,certain novel optically active trans-derivatives thereof and pharmaceutical compositions containing them

Info

Publication number: IL65922A
Authority: IL; Israel
Prior art keywords: derivatives; preparation; pharmaceutical compositions; acid esters; optically active
Prior art date: 1981-06-12

Application number

IL65922A

Other languages

English (en)

Other versions

IL65922A0 (en

Original Assignee

Richter Gedeon Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-06-12

Filing date

1982-05-31

Publication date

1985-07-31

1982-05-31 Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet

1982-08-31 Publication of IL65922A0 publication Critical patent/IL65922A0/xx

1984-09-14 Priority to IL72955A priority Critical patent/IL72955A0/xx

1985-07-31 Publication of IL65922A publication Critical patent/IL65922A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

IL65922A 1981-06-12 1982-05-31 Preparation of apovincaminic acid esters,certain novel optically active trans-derivatives thereof and pharmaceutical compositions containing them IL65922A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
IL72955A IL72955A0 (en)	1981-06-12	1984-09-14	Racemic cis and trans hydroxy-iminooctahydroindolo(2,3-a)-quinolizine derivatives,the corresponding optically active derivatives and acid addition salts,their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU811753A HU186891B (en)	1981-06-12	1981-06-12	Process for producing esters of apovincaminic acid

Publications (2)

Publication Number	Publication Date
IL65922A0 IL65922A0 (en)	1982-08-31
IL65922A true IL65922A (en)	1985-07-31

Family

ID=10956018

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL65922A IL65922A (en)	1981-06-12	1982-05-31	Preparation of apovincaminic acid esters,certain novel optically active trans-derivatives thereof and pharmaceutical compositions containing them

Country Status (24)

Country	Link
US (1)	US4474960A (xx)
JP (2)	JPS5843971A (xx)
AT (1)	AT382619B (xx)
AU (2)	AU551445B2 (xx)
BE (1)	BE893492A (xx)
CA (1)	CA1258071A (xx)
CH (2)	CH659474A5 (xx)
DE (1)	DE3222096A1 (xx)
DK (1)	DK152651C (xx)
ES (3)	ES8400433A1 (xx)
FI (1)	FI71142C (xx)
FR (2)	FR2507605B1 (xx)
GB (2)	GB2102415B (xx)
GE (1)	GEP19970819B (xx)
GR (1)	GR76494B (xx)
HU (1)	HU186891B (xx)
IL (1)	IL65922A (xx)
IT (1)	IT1200961B (xx)
NL (1)	NL192452C (xx)
NO (1)	NO821954L (xx)
PT (1)	PT75042B (xx)
SE (2)	SE450383B (xx)
SU (2)	SU1258326A3 (xx)
ZA (1)	ZA823873B (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU182411B (en) *	1981-11-03	1984-01-30	Richter Gedeon Vegyeszet	Process for preparing eburnamonine derivatives
HU191454B (en) *	1984-10-05	1987-02-27	Richter Gedeon Vegyeszeti Gyar Rt.,Hu	Process for producing amides of oktahydro-indolo/2,3-a/quinolyzin-1-yl-alkanecarboxylic acids and pharmaceutically acceptable acid additional salts thereof
HU198207B (en) *	1985-04-19	1989-08-28	Richter Gedeon Vegyeszet	Process for production of derivatives of eburnamenin and medical compositions containing them
JPH0438474Y2 (xx) *	1986-04-30	1992-09-09
JPS63164190U (xx) *	1987-02-18	1988-10-26
IT1248881B (it) *	1989-06-21	1995-01-30	Richter Gedeon Vegyeszet	Derivati diesteri di ottaidro-indolo/2,3-a/tetraidropiramil/2,3-c/ chinolizina racemici ed otticamente attivi e procedimento per la loro preparazione
HU214600B (hu) *	1995-12-22	1998-04-28	Richter Gedeon Vegyészeti Gyár Rt.	Transz-apovinkaminsav-észter-származékok, az azokat tartalmazó gyógyszerkészítmények és eljárás ezek előállítására
EP1575916B1 (en)	2001-08-31	2013-05-22	The Rockefeller University	Phosphodiesterase activity and regulation of phosphodiesterase 1-b-mediated signaling in brain
SG178279A1 (en)	2009-08-05	2012-03-29	Intra Cellular Therapies Inc	Novel regulatory proteins and inhibitors
WO2018069312A1 (en) *	2016-10-11	2018-04-19	Deutsches Zentrum Für Neurodegenerative Erkrankungen E. V. (Dzne)	Treatment of synucleinopathies

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3770724A (en) *	1970-03-31	1973-11-06	Roussel Uclaf	Process for preparing pentacyclic alkaloids
HU163143B (xx) *	1971-05-07	1973-06-28
US4033969A (en) *	1972-06-19	1977-07-05	Agence Nationale De Valorisation De La Recherche (Anvar)	Vincamine derivatives
US4033960A (en) *	1973-07-31	1977-07-05	Bayer Aktiengesellschaft	2-Mercaptoquinoxaline-di-N-oxide products and a method for their preparation
AU499923B2 (en) *	1975-06-27	1979-05-03	Richter Gedeon Vegyeszeti Gyar N	Indoloquinolizine derivatives & their production
FR2389625B1 (xx) *	1977-05-06	1980-04-18	Roussel Uclaf
FR2459799A1 (fr) *	1979-06-22	1981-01-16	Synthelabo	Synthese de la ()-vincamine
AU532001B2 (en) *	1978-11-20	1983-09-15	Sumitomo Chemical Company, Limited	Polycyclic indole derivatives
JPS55100383A (en) *	1979-01-25	1980-07-31	Sumitomo Chem Co Ltd	Preparation of novel nitrogen-containing polycyclic compound
HU181495B (en) *	1979-05-31	1983-07-28	Richter Gedeon Vegyeszet	Process for producing hydroxy-imino-eburnane derivatives
HU180927B (en) *	1979-07-13	1983-05-30	Richter Gedeon Vegyeszet	Process for producing 1k-hydroximino-e-homoe-eburane de rivatives
FR2468605A1 (fr) *	1979-10-30	1981-05-08	Richter Gedeon Vegyeszet	Procede de preparation d'ester de l'acide apovincaminique
HU182380B (en) *	1981-09-30	1983-12-28	Richter Gedeon Vegyeszet	Process for producing esters of vincaminic acid

1981
- 1981-06-12 HU HU811753A patent/HU186891B/hu not_active IP Right Cessation
1982
- 1982-05-31 IL IL65922A patent/IL65922A/xx not_active IP Right Cessation
- 1982-06-02 ZA ZA823873A patent/ZA823873B/xx unknown
- 1982-06-02 FI FI821963A patent/FI71142C/fi not_active IP Right Cessation
- 1982-06-08 GR GR68366A patent/GR76494B/el unknown
- 1982-06-09 PT PT75042A patent/PT75042B/pt not_active IP Right Cessation
- 1982-06-09 SE SE8203580A patent/SE450383B/sv not_active IP Right Cessation
- 1982-06-10 CH CH5868/84A patent/CH659474A5/de not_active IP Right Cessation
- 1982-06-10 FR FR8210103A patent/FR2507605B1/fr not_active Expired
- 1982-06-10 CH CH3597/82A patent/CH656128A5/de not_active IP Right Cessation
- 1982-06-11 DE DE19823222096 patent/DE3222096A1/de not_active Withdrawn
- 1982-06-11 US US06/387,676 patent/US4474960A/en not_active Expired - Lifetime
- 1982-06-11 BE BE0/208331A patent/BE893492A/fr not_active IP Right Cessation
- 1982-06-11 AT AT0227182A patent/AT382619B/de not_active IP Right Cessation
- 1982-06-11 ES ES513016A patent/ES8400433A1/es not_active Expired
- 1982-06-11 SU SU3452054A patent/SU1258326A3/ru active
- 1982-06-11 GB GB08217030A patent/GB2102415B/en not_active Expired
- 1982-06-11 NO NO821954A patent/NO821954L/no unknown
- 1982-06-11 NL NL8202396A patent/NL192452C/nl not_active IP Right Cessation
- 1982-06-11 IT IT67752/82A patent/IT1200961B/it active
- 1982-06-11 AU AU84798/82A patent/AU551445B2/en not_active Ceased
- 1982-06-11 DK DK262982A patent/DK152651C/da not_active IP Right Cessation
- 1982-06-12 JP JP57099997A patent/JPS5843971A/ja active Pending
- 1982-12-14 FR FR8220957A patent/FR2515653B1/fr not_active Expired
1983
- 1983-02-22 SU SU833557652A patent/SU1376947A3/ru active
- 1983-06-11 CA CA000405030A patent/CA1258071A/en not_active Expired
- 1983-06-16 ES ES523345A patent/ES8504192A1/es not_active Expired
1984
- 1984-11-30 ES ES538125A patent/ES8604581A1/es not_active Expired
1985
- 1985-01-07 GB GB08500325A patent/GB2151629B/en not_active Expired
1986
- 1986-03-13 AU AU54712/86A patent/AU568790B2/en not_active Ceased
1987
- 1987-01-02 SE SE8700015A patent/SE461654B/sv not_active IP Right Cessation
1991
- 1991-09-26 JP JP3317577A patent/JPH0714932B2/ja not_active Expired - Lifetime
1993
- 1993-07-07 GE GEAP1993974A patent/GEP19970819B/en unknown

Also Published As

Publication number	Publication date
ES8604581A1 (es)	1986-02-01
HU186891B (en)	1985-10-28
ATA227182A (de)	1986-08-15
FI821963A0 (fi)	1982-06-02
IL65922A0 (en)	1982-08-31
SU1376947A3 (ru)	1988-02-23
FR2515653B1 (fr)	1985-12-06
JPS5843971A (ja)	1983-03-14
FR2507605A1 (fr)	1982-12-17
IT8267752A0 (it)	1982-06-11
GB2102415A (en)	1983-02-02
ES523345A0 (es)	1985-04-01
AU568790B2 (en)	1988-01-07
PT75042B (en)	1984-10-09
US4474960A (en)	1984-10-02
ES513016A0 (es)	1983-10-16
DE3222096A1 (de)	1983-01-05
FR2515653A1 (fr)	1983-05-06
FI71142B (fi)	1986-08-14
NL192452B (nl)	1997-04-01
AT382619B (de)	1987-03-25
GB2102415B (en)	1986-01-02
NL8202396A (nl)	1983-01-03
SE450383B (sv)	1987-06-22
SE8700015D0 (sv)	1987-01-02
GB2151629A (en)	1985-07-24
ES8400433A1 (es)	1983-10-16
CH656128A5 (de)	1986-06-13
JPH0714932B2 (ja)	1995-02-22
ZA823873B (en)	1983-05-25
DK152651C (da)	1988-08-22
GR76494B (xx)	1984-08-10
CH659474A5 (de)	1987-01-30
CA1258071A (en)	1989-08-01
BE893492A (fr)	1982-12-13
NL192452C (nl)	1997-08-04
GB2151629B (en)	1986-01-02
JPH0517474A (ja)	1993-01-26
PT75042A (en)	1982-07-01
ES8504192A1 (es)	1985-04-01
FR2507605B1 (fr)	1985-12-13
IT1200961B (it)	1989-01-27
GB8500325D0 (en)	1985-02-13
FI71142C (fi)	1986-11-24
SE8700015L (sv)	1987-01-02
NO821954L (no)	1982-12-13
SE8203580L (sv)	1982-12-13
GEP19970819B (en)	1997-01-30
SU1258326A3 (ru)	1986-09-15
AU8479882A (en)	1982-12-16
SE461654B (sv)	1990-03-12
DK152651B (da)	1988-04-05
DK262982A (da)	1982-12-13
AU551445B2 (en)	1986-05-01
ES538125A0 (es)	1986-02-01
AU5471286A (en)	1986-07-31

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Legal Events

Date	Code	Title	Description
1996-09-12	KB	Patent renewed
2001-06-14	RH	Patent void