IL61508A - Preparation of 4'-epidaunorubicin and 3',4'-diepidaunorubicin and intermediates used therein - Google Patents

Preparation of 4'-epidaunorubicin and 3',4'-diepidaunorubicin and intermediates used therein

Info

Publication number: IL61508A
Authority: IL; Israel
Prior art keywords: diepidaunorubicin; epidaunorubicin; preparation; intermediates used; intermediates
Prior art date: 1979-11-22

Application number

IL61508A

Other languages

English (en)

Other versions

IL61508A0 (en

Original Assignee

Erba Farmitalia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-11-22

Filing date

1980-11-18

Publication date

1983-12-30

1980-11-18 Application filed by Erba Farmitalia filed Critical Erba Farmitalia

1980-12-31 Publication of IL61508A0 publication Critical patent/IL61508A0/xx

1983-12-30 Publication of IL61508A publication Critical patent/IL61508A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL61508A 1979-11-22 1980-11-18 Preparation of 4'-epidaunorubicin and 3',4'-diepidaunorubicin and intermediates used therein IL61508A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB7940457		1979-11-22

Publications (2)

Publication Number	Publication Date
IL61508A0 IL61508A0 (en)	1980-12-31
IL61508A true IL61508A (en)	1983-12-30

Family

ID=10509359

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL61508A IL61508A (en)	1979-11-22	1980-11-18	Preparation of 4'-epidaunorubicin and 3',4'-diepidaunorubicin and intermediates used therein

Country Status (12)

Country	Link
US (1)	US4345068A (uk)
EP (1)	EP0030295B1 (uk)
JP (1)	JPS5687598A (uk)
AT (1)	AT369385B (uk)
CA (1)	CA1169421A (uk)
DE (1)	DE3063541D1 (uk)
DK (2)	DK163517C (uk)
IL (1)	IL61508A (uk)
IT (1)	IT1163001B (uk)
SU (1)	SU1181549A3 (uk)
UA (1)	UA6016A1 (uk)
YU (1)	YU296580A (uk)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3200809C2 (de) *	1981-01-21	1986-08-28	Farmitalia Carlo Erba S.p.A., Mailand/Milano	4'-Desoxy-3'-epi-daunorubicin und -doxorubicin, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
GB8414619D0 (en) *	1984-06-08	1984-07-11	Erba Farmitalia	Anthracyclines
DE3500029A1 (de) *	1985-01-02	1986-09-04	Farmitalia Carlo Erba S.p.A., Mailand/Milano	Anthracyclinester
IT1196503B (it) *	1986-07-16	1988-11-16	Erba Farmitalia	Procedimento continuo per la trasformazione di 4'-cheto-n-trifluoroacetildaunorubicina in 4'-epi-trifluoroacetildaunorubicina,internmedio per la preparazione di un composto
GB2196626B (en) *	1986-10-15	1990-09-19	Erba Farmitalia	Antitumor anthracycline glycosides, their preparation, intermediates thereof, and compositions and use therefor
GB9216962D0 (en) *	1992-08-11	1992-09-23	Erba Carlo Spa	Therapeutically active naphthalenesulfonic-pyrrolecarboxamido derivatives
US20090099346A1 (en) *	2003-07-02	2009-04-16	Victor Matvienko	Thermally stable crystalline epirubicin hydrochloride
DE04777189T1 (de) *	2003-07-02	2011-04-07	Solux Corporation, San Diego	Thermisch stabiles kristallines epirubicin-hydrochlorid und herstellungsverfahren dafür
EP1817004A2 (en) *	2004-11-15	2007-08-15	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Combination therapy associating preferably a ceramide with a cytotoxic drug
US7388083B2 (en) *	2005-03-07	2008-06-17	Solux Corporation	Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
WO2006111561A1 (en) *	2005-04-21	2006-10-26	Dsm Ip Assets B.V.	Improved microbial production of anthracyclins
RU2450013C2 (ru) *	2005-12-13	2012-05-10	Солюкс Корпорейшен	Способ получения 4-деметилдаунорубицина
US8802830B2 (en) *	2005-12-20	2014-08-12	Solux Corporation	Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) *	2008-01-08	2013-01-22	Solux Corporation	Method of aralkylation of 4′-hydroxyl group of anthracylins
EP2301943B1 (en)	2009-09-08	2014-01-08	Heraeus Precious Metals GmbH & Co. KG	Crystallization of epidaunorubicin x HCI
KR101125460B1 (ko) *	2010-03-24	2012-03-28	동아제약주식회사	에피루비신 염산염의 신규한 결정형
DE102011103751A1 (de)	2011-05-31	2012-12-06	Heraeus Precious Metals Gmbh & Co. Kg	Kristallisierung von Epirubicinhydrochlorid
CN103204888B (zh) *	2012-01-15	2016-08-17	山东新时代药业有限公司	一种盐酸表柔比星中间体的制备方法
CN105229019B (zh)	2013-07-02	2017-12-12	浙江海正药业股份有限公司	表阿霉素的制备方法及其中间体
CN103694291B (zh) *	2013-12-24	2015-06-17	深圳万乐药业有限公司	一种戊柔比星的合成方法
DE102014208194A1 (de)	2014-04-30	2015-11-05	Heraeus Deutschland GmbH & Co. KG	Aufreinigung von Epidaunorubicin
CN104098627B (zh) *	2014-07-31	2017-04-12	大连大学	一类n‑三氟乙酰表柔红霉素的硒代衍生物，其制备方法及应用
TWI712611B (zh)	2015-03-30	2020-12-11	日商明治製菓藥業股份有限公司	泛艾黴素之製造方法及其新穎之製造中間體

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1457632A (en) *	1974-03-22	1976-12-08	Farmaceutici Italia	Adriamycins
US4039663A (en) *	1975-03-19	1977-08-02	Societa' Farmaceutici Italia S.P.A.	Daunomycins, process for their uses and intermediates
GB1506200A (en) *	1975-04-30	1978-04-05	Farmaceutici Italia	Glycosides
GB1502121A (en) *	1975-08-02	1978-02-22	Farmaceutici Italia	Anthracyclines

1980
- 1980-06-30 US US06/164,088 patent/US4345068A/en not_active Expired - Lifetime
- 1980-11-17 AT AT0564080A patent/AT369385B/de not_active IP Right Cessation
- 1980-11-18 EP EP80107162A patent/EP0030295B1/de not_active Expired
- 1980-11-18 JP JP16147580A patent/JPS5687598A/ja active Granted
- 1980-11-18 IL IL61508A patent/IL61508A/xx not_active IP Right Cessation
- 1980-11-18 DE DE8080107162T patent/DE3063541D1/de not_active Expired
- 1980-11-19 CA CA000365004A patent/CA1169421A/en not_active Expired
- 1980-11-20 IT IT26127/80A patent/IT1163001B/it active
- 1980-11-21 DK DK498080A patent/DK163517C/da not_active IP Right Cessation
- 1980-11-21 SU SU803213106A patent/SU1181549A3/ru active
- 1980-11-21 UA UA3213106A patent/UA6016A1/uk unknown
- 1980-11-21 YU YU02965/80A patent/YU296580A/xx unknown
1990
- 1990-10-22 DK DK254490A patent/DK163246C/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL61508A0 (en)	1980-12-31
DK163517C (da)	1992-08-31
DK163246B (da)	1992-02-10
DK254490D0 (da)	1990-10-22
IT8026127A0 (it)	1980-11-20
CA1169421A (en)	1984-06-19
EP0030295B1 (de)	1983-05-25
US4345068A (en)	1982-08-17
JPS6328078B2 (uk)	1988-06-07
JPS5687598A (en)	1981-07-16
DK498080A (da)	1981-05-23
UA6016A1 (uk)	1994-12-29
IT1163001B (it)	1987-04-08
ATA564080A (de)	1982-05-15
DK163517B (da)	1992-03-09
YU296580A (en)	1983-02-28
AT369385B (de)	1982-12-27
SU1181549A3 (ru)	1985-09-23
DK254490A (da)	1990-10-22
EP0030295A1 (de)	1981-06-17
DK163246C (da)	1992-06-29
DE3063541D1 (en)	1983-07-07

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Legal Events

Date	Code	Title
1997-02-18	HC	Change of name of proprietor(s)
1999-04-11	KB	Patent renewed
2001-07-24	EXP	Patent expired