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IL43276A - Locking capsule - Google Patents

Locking capsule

Info

Publication number
IL43276A
IL43276A IL43276A IL4327673A IL43276A IL 43276 A IL43276 A IL 43276A IL 43276 A IL43276 A IL 43276A IL 4327673 A IL4327673 A IL 4327673A IL 43276 A IL43276 A IL 43276A
Authority
IL
Israel
Prior art keywords
section
cap
closed end
cylinder wall
locking capsule
Prior art date
Application number
IL43276A
Other languages
Hebrew (he)
Other versions
IL43276A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL43276A0 publication Critical patent/IL43276A0/en
Publication of IL43276A publication Critical patent/IL43276A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S220/00Receptacles
    • Y10S220/34Anti-tamper pharmaceutical capsules, e.g. tamper indicating or resistant

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Closures For Containers (AREA)
  • Coating Apparatus (AREA)

Abstract

A locking capsule is provided for packaging unit doses of physiologically active agents, said capsule having a body portion and a cap portion which are adapted to be telescopically joined together in a frictionally engaged pre-locking position prior to the filling thereof and to be fully telescopically joined together in a mechanically locked position when filled. [US3823843A]

Claims (20)

1. Ά locking two-piece hard capsule comprising a cap portion and a body portion, said body portion telescoping into said cap portion effecting a frictional pre-lock when said body is partially telescoped into said cap and a mechanical lock when said body is completely telescoped into said cap, said capsule comprising: 1) an essentially cylindrical cap portion having a closed end and an open end with the cylinder wall tapering generally outwardly from said closed end to said open end, said cylinder having an inside diameter at the intersection of said cylinder wall and said closed end about the same as the maximum outside diameter of the cylinder wall of the body portion which telescopes into said cap, said cap having a plurality of individual lateral ridges disposed in the same circumferential plane and extending radially inwardly from the inner surface of said cylinder wall of said cap, each lateral ridge separated from the next lateral ridge around said circumference of said cap by an area that is a lateral and longitudinal continuation of said inner surface of said wall, and a plurality of raised areas extending radially inwardly from the inner surface of the cylindrical wall of said cap, each of said raised areas disposed between the ends of a lateral ridge and extending from said lateral ridge toward said open end of said cap; and 2) an essentially cylindrical body portion having a closed end and an open end, said cylinder having an outside diameter at the open end about the same as the inside diameter of said cap, into which said body telescopes, at the intersection of the cylinder wall of said cap with the closed end thereof, and comprising a) a first section extending from said open end toward said closed end with the cylinder wall tapering generally inwardly in relation to the axial centerline of said body, b) a second section, integrally molded with said first section, extending from said first section toward said closed end in which the surface of the cylinder wall is progressively constricted inwardly in the shape of a geometric form characterized as an ogee curve, c) a third section, integrally molded with said second section, extending from a point tangent to the trailing radius of said ogee curve toward said closed end, the cylinder wall of said third section being essentially parallel to the axial center line of said body, d) a fourth section, integrally molded with said third section, extending toward said closed end from the point where a projection of the inwardly tapering cylinder wall of said first section intersects the surface of said parallel cylinder wall, said fourth section tapering inwardly at essentially the same rate as said first section, and e) a fifth section, integrally molded with said fourth section, said fifth section constituting the closed end of said body.
2. A locking capsule as defined in claim 1 wherein the plurality of lateral ridges occupy a total of from about 180 to 300 degrees of the circumference of said cap, and the lateral continuations of the inner surface of the cylinder wall between said lateral ridges occupy a total of from about 60 to about 180 degrees of the circumference of said cap.
3. A locking capsule as defined in claim 1 or 2 wherein there are three lateral ridges in the same circumferential plane of said cap, each ridge approximately equidistant from the next and extending through an arc of from 10 about 60 to about 100 degrees.
4. Ά locking capsule as defined in claim 3 wherein each lateral ridge extends through an arc of about 100 degrees.
5. A locking capsule as defined in claim 1 or 2. wherein the plurality of said raised areas disposed between the ends of said lateral ridges occupy a total lateral surface of from about 90 to about 180 degrees of the circumference of said cap, and the longitudinal dimension of each of said raised areas is from about one-tenth to about one-fourth of the total length of said cap. 20
6. A locking capsule as defined in any of claims 1 to 5 wherein there are three raised areas each of which is disposed between the ends of each of three lateral ridges, each raised area having a lateral dimension of from about 30 to about 90 degrees and a longitudinal dimension of about one-tenth to about one-fourth of the total length of said cap.
7. A locking capsule as defined in claim 6 wherein each raised area has a lateral dimension of about 30 degrees and a longitudinal dimension of about one-sixth the total length of said cap. 30
8. A locking capsule of any of claims 1 to 7 wherein said raised areas extend radially inwardly from about 0.0015 to about 0.0035 inches from the inner surface of the wall of said cap.
9. A locking capsule of any of claims 1 to 7 wherein said lateral ridges extend radially inwardly at the apex from about 0.002 to about 0.005 inches from the inner surface of the wall of said cap.
10. A locking capsule of any of claims 1 to 9 wherein said cap has three lateral ridges in the same circumferential plane extending radially inwardly at the apex about 0.003 inches and occupying about 300 degrees of the circumference of said cap, said lateral ridges disposed about one-tenth of the distance from the intersection of the cylindrical wall of said cap with said closed end and said open end and three raised areas, each extending radially inwardly about 0.002 inches, each disposed between the ends of one of said lateral ridges and extending laterally through about 30 degrees and longitudinally about one-sixth the total length of said cap.
11. A locking capsule of any of claims 1 to 10 wherein said cap has a cylinder wall tapering generally outwardly at the rate of about 0.005 to about 0.020 inch per linear inch from said closed end to said open end.
12. A locking capsule of any of claims 1 to 11 wherein said cap has a cylinder wall tapering generally outwardly at the rate of about 0.012 inch per linear inch from said closed end to said open end.
13. A locking capsule according to any of claims 1 to 12 wherein said first section of said body is from about one-thirtieth to about one-twelfth of the total length of said body, and the cylinder wall tapers inwardly from said open end toward said closed end at a rate of from about 0.005 to about 0.020 inch per linear inch.
14. Ά locking capsule according to any of claims 1 to 13 wherein said second section of said body is a constriction progressing from the point of departure from the tapered cylinder wall of said first section toward said closed end and occupying from about one-thirtieth to about one-twelfth of the total length of said body, said constriction being characterized by an ogee curve having inverted radii of about 0.050 and 0.120 inches, respectively.
15. A locking capsule according to any of claims 1 to 14 wherein the inside diameter of said body is reduced by from about 0.004 to about 0.008 inches from the intersection of said ogee curve and the trailing edge of said first section to the intersection of the trailing edge of said ogee curve and said third section.
16. A locking capsule according to any of claims 1 to 15 wherein said third section of said body occupies from about one-fifth to about three-fifths of the total length of said body, and the cylinder wall of said third section is essentially parallel with the axial center-line of said body from the intersection of said third section with the trailing edge of said ogee curve of said second section to the intersection of said third section with the leading edge of said fourth section.
17. A locking capsule according to any of claims 1 to 16 wherein said fourth section of said body comprises from about one-eighth to about two-fifths the total length of said body, and the cylinder wall tapers inwardly from the intersection of said fourth section with said third section at a rate of from about 0.005 to about 0.020 inch per linear inch.
18. Ά locking capsule according t any of claims 1 to 17 wherein said fifth section of said body comprises said closed end of said body and occupies from about one-eighth to about two-fifths of the total length of said body.
19. A locking capsule according to any of claims 1 to 18 wherein said body comprises: a) a first section beginning at said open end of said body and extending toward said closed end of said body with the cylinder wall tapering inwardly toward the axial center-line of said body at a rate of about 0.012 inch per linear inch, said first section having an outside diameter at said open end about the same as the inside diameter of said cap at the point of intersection of the cylinder wall and the closed end of said cap and occupying about one-thirtieth of the total length of said body; b) a second section integrally molded with said first section constricting the outside diameter of said body by about 0.004 inch from the trailing edge of said first section to the leading edge of said third section, said second section having the geometric form of a longitudinally extending ogee curve and occupying about one-twentieth of the total length of said body; c) a third section integrally molded with said second section, said third section occupying about two-fifths of the total length of said body and having a cylinder wall parallel to the axial center-line of said body; d) a fourth section integrally molded with said third section, said fourth section occupying about one-fourth of the total length of said body and having a cylinder wall tapering at the rate of about 0.012 inch per linear inch from the intersection of said fourth section with said third section to the intersection of said fourth section with said fifth section; and e) a fifth section integrally molded with said fourth section, said fifth section occupying about one-fourth of the total length of said body and constituting the closed end of said body, said closed end being in the geometric form of a hemisphere.
20. A locking capsule according to any of claims 1 to 19 wherein said closed end of said body is in the geometric form of a parabola.
IL43276A 1972-10-26 1973-09-19 Locking capsule IL43276A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00301045A US3823843A (en) 1972-10-26 1972-10-26 Locking capsule

Publications (2)

Publication Number Publication Date
IL43276A0 IL43276A0 (en) 1973-11-28
IL43276A true IL43276A (en) 1976-02-29

Family

ID=23161696

Family Applications (1)

Application Number Title Priority Date Filing Date
IL43276A IL43276A (en) 1972-10-26 1973-09-19 Locking capsule

Country Status (26)

Country Link
US (1) US3823843A (en)
JP (1) JPS571265B2 (en)
AT (1) AT338433B (en)
AU (1) AU468525B2 (en)
BE (1) BE806487A (en)
BG (1) BG28241A3 (en)
BR (1) BR7308349D0 (en)
CA (1) CA1017705A (en)
CH (1) CH568192A5 (en)
CS (1) CS177152B2 (en)
DD (1) DD111188A5 (en)
DE (1) DE2353103A1 (en)
DK (1) DK133852B (en)
ES (1) ES420003A1 (en)
FR (1) FR2204541B1 (en)
GB (1) GB1442121A (en)
HU (1) HU169055B (en)
IE (1) IE39685B1 (en)
IL (1) IL43276A (en)
IT (1) IT998821B (en)
NL (1) NL175713C (en)
RO (1) RO70489A (en)
SE (1) SE404906B (en)
SU (1) SU567391A3 (en)
YU (1) YU276873A (en)
ZA (1) ZA737430B (en)

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US4717040A (en) * 1987-04-15 1988-01-05 Equinox Industries Ltd. Rotationally moulded septic tank sleeves
GR1000200B (en) * 1988-12-08 1992-03-20 Su Heung Capsule Co Ltd Medicines capsule
GB9223144D0 (en) * 1992-11-05 1992-12-16 Scherer Corp R P Controlled release device
GB9223172D0 (en) * 1992-11-05 1992-12-16 Scherer Corp R P Capsule construction
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US5769267A (en) * 1995-11-09 1998-06-23 Warner-Lambert Company Container
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US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US7464706B2 (en) 1999-07-23 2008-12-16 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US7305986B1 (en) * 1999-07-23 2007-12-11 Mannkind Corporation Unit dose capsules for use in a dry powder inhaler
US6360886B1 (en) 2000-03-13 2002-03-26 Kerr Corporation Capsule for use in preparing a dental amalgam
JP4681231B2 (en) 2002-03-20 2011-05-11 マンカインド コーポレイション Inhaler
EP1786784B1 (en) 2004-08-20 2010-10-27 MannKind Corporation Catalysis of diketopiperazine synthesis
KR20150039211A (en) 2004-08-23 2015-04-09 맨카인드 코포레이션 Diketopiperazine salts, diketomorpholine salts or diketodioxane salts for drug delivery
DE102005001332A1 (en) * 2005-01-11 2006-07-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Two-piece capsule with pre-closure for holding pharmaceutical preparations for powder inhalers
US8377471B2 (en) * 2005-08-09 2013-02-19 Capsugel Belgium Nv Container
US20070036830A1 (en) * 2005-08-09 2007-02-15 Stef Vanquickenborne Container
KR101486397B1 (en) 2005-09-14 2015-01-28 맨카인드 코포레이션 Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
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US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
TWI677355B (en) 2008-06-13 2019-11-21 美商曼凱公司 A dry powder inhaler and system for drug delivery
EP2300083B1 (en) 2008-06-20 2013-05-22 MannKind Corporation An interactive apparatus and method for real-time profiling of inhalation efforts
TWI614024B (en) 2008-08-11 2018-02-11 曼凱公司 Use of ultrarapid acting insulin
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2676695A3 (en) 2009-03-11 2017-03-01 MannKind Corporation Apparatus, system and method for measuring resistance of an inhaler
SG176738A1 (en) 2009-06-12 2012-01-30 Mannkind Corp Diketopiperazine microparticles with defined specific surface areas
JP5784622B2 (en) 2009-11-03 2015-09-24 マンカインド コーポレ−ション Apparatus and method for simulating inhalation activity
AU2011271097B2 (en) 2010-06-21 2014-11-27 Mannkind Corporation Dry powder drug delivery system and methods
CN103826988B (en) 2011-04-01 2016-03-09 曼金德公司 For the blister package of pharmaceutical kit
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
CN103945859A (en) 2011-10-24 2014-07-23 曼金德公司 Methods and compositions for treating pain
CN108057154B (en) 2012-07-12 2021-04-16 曼金德公司 Dry powder drug delivery system and method
US9101546B2 (en) 2012-09-28 2015-08-11 Sci-Tech Centre Capsule for encapsulating a tablet
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US3399803A (en) * 1966-10-11 1968-09-03 Parke Davis & Co Self-locking medicament capsule
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US3664495A (en) * 1970-12-21 1972-05-23 Parke Davis & Co Locking capsule
DE7203269U (en) * 1972-01-29 1972-04-27 Agfa-Gevaert Ag ADHESIVE DEVICE FOR FOILS

Also Published As

Publication number Publication date
ZA737430B (en) 1975-04-30
DK133852C (en) 1977-01-10
BG28241A3 (en) 1980-03-25
DD111188A5 (en) 1975-02-05
BE806487A (en) 1974-04-25
NL7313620A (en) 1974-05-01
SU567391A3 (en) 1977-07-30
IE39685B1 (en) 1978-12-06
IE39685L (en) 1974-04-26
BR7308349D0 (en) 1974-09-24
ES420003A1 (en) 1976-03-01
AT338433B (en) 1977-08-25
YU276873A (en) 1982-02-28
RO70489A (en) 1981-08-17
FR2204541B1 (en) 1979-01-26
CS177152B2 (en) 1977-07-29
NL175713B (en) 1984-07-16
CA1017705A (en) 1977-09-20
CH568192A5 (en) 1975-10-31
IT998821B (en) 1976-02-20
DK133852B (en) 1976-08-02
FR2204541A1 (en) 1974-05-24
HU169055B (en) 1976-09-28
JPS571265B2 (en) 1982-01-09
ATA905473A (en) 1976-12-15
IL43276A0 (en) 1973-11-28
JPS4980228A (en) 1974-08-02
NL175713C (en) 1984-12-17
US3823843A (en) 1974-07-16
AU468525B2 (en) 1976-01-15
DE2353103A1 (en) 1974-05-09
SE404906B (en) 1978-11-06
AU6079073A (en) 1975-03-27
GB1442121A (en) 1976-07-07

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