IL42764A - S-adenosyl-2-methionine tri-p-toluene sulfonate,its preparation and therapeutic compositions containing it - Google Patents
S-adenosyl-2-methionine tri-p-toluene sulfonate,its preparation and therapeutic compositions containing itInfo
- Publication number
- IL42764A IL42764A IL42764A IL4276473A IL42764A IL 42764 A IL42764 A IL 42764A IL 42764 A IL42764 A IL 42764A IL 4276473 A IL4276473 A IL 4276473A IL 42764 A IL42764 A IL 42764A
- Authority
- IL
- Israel
- Prior art keywords
- sam
- acid
- tri
- aqueous solution
- toluensulphonate
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 8
- 230000001225 therapeutic effect Effects 0.000 title claims abstract 7
- 238000000034 method Methods 0.000 claims abstract 11
- 239000007864 aqueous solution Substances 0.000 claims abstract 9
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims abstract 6
- 230000004060 metabolic process Effects 0.000 claims abstract 5
- 150000003839 salts Chemical class 0.000 claims abstract 4
- 229960004452 methionine Drugs 0.000 claims abstract 3
- 150000001412 amines Chemical class 0.000 claims abstract 2
- 150000003943 catecholamines Chemical class 0.000 claims abstract 2
- 150000002632 lipids Chemical class 0.000 claims abstract 2
- 239000002253 acid Substances 0.000 claims 5
- 239000003937 drug carrier Substances 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 230000002969 morbid Effects 0.000 claims 3
- 239000011347 resin Substances 0.000 claims 3
- 229920005989 resin Polymers 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 125000000129 anionic group Chemical group 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Natural products CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 1
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 230000009089 cytolysis Effects 0.000 claims 1
- 235000019441 ethanol Nutrition 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910021653 sulphate ion Inorganic materials 0.000 claims 1
- 239000001117 sulphuric acid Substances 0.000 claims 1
- 235000011149 sulphuric acid Nutrition 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
- C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- General Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2779372 | 1972-08-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL42764A0 IL42764A0 (en) | 1974-01-14 |
| IL42764A true IL42764A (en) | 1976-04-30 |
Family
ID=11222342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL42764A IL42764A (en) | 1972-08-02 | 1973-07-17 | S-adenosyl-2-methionine tri-p-toluene sulfonate,its preparation and therapeutic compositions containing it |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US3893999A (sv) |
| JP (1) | JPS5235726B2 (sv) |
| AR (1) | AR195350A1 (sv) |
| AT (1) | AT341684B (sv) |
| AU (1) | AU474015B2 (sv) |
| BE (1) | BE802981A (sv) |
| CA (1) | CA1006872A (sv) |
| CH (1) | CH592112A5 (sv) |
| CS (1) | CS195254B2 (sv) |
| DD (1) | DD107461A5 (sv) |
| DE (1) | DE2336401C3 (sv) |
| DK (1) | DK131868C (sv) |
| ES (1) | ES417377A1 (sv) |
| FI (1) | FI52466C (sv) |
| FR (1) | FR2194425B1 (sv) |
| GB (1) | GB1425384A (sv) |
| HK (1) | HK31580A (sv) |
| HU (1) | HU167266B (sv) |
| IE (1) | IE37913B1 (sv) |
| IL (1) | IL42764A (sv) |
| MX (1) | MX4544E (sv) |
| NL (1) | NL152864B (sv) |
| NO (1) | NO137941C (sv) |
| PL (1) | PL87381B1 (sv) |
| RO (1) | RO63451A (sv) |
| SE (1) | SE400085B (sv) |
| SU (1) | SU646915A3 (sv) |
| YU (1) | YU36037B (sv) |
| ZA (1) | ZA734876B (sv) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE39517B1 (en) * | 1973-06-27 | 1978-10-25 | Bioresearch Sas | Double salts of s-adenosyl-l-methhionine |
| AR221676A1 (es) * | 1974-07-12 | 1981-03-13 | Bioresearch Sas | Procedimiento para la preparacion de sales estables sulfonicas y/o sulfuricas de la s-adenosil-l-metionina,particularmente utiles como donadores especificos de metilo para las reacciones bioquimicas de transferencia del grupo ch3;asi como tambien las reacciones fundamentales en el metabolismo lipilico,protilico y glucidico |
| DE2646269A1 (de) * | 1975-10-16 | 1977-04-28 | Yamasa Shoyu Kk | Stabilisierte s-adenosyl-l-methionin- zubereitung und verfahren zur herstellung derselben |
| GB2064523B (en) * | 1979-12-04 | 1983-06-29 | Kanegafuchi Chemical Ind | Stable composition of s-adenosyl-l-methionine |
| IT1137640B (it) | 1981-08-24 | 1986-09-10 | Bioresearch Srl | Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo |
| IT1137892B (it) * | 1981-08-24 | 1986-09-10 | Bioresearch Srl | Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo |
| IT1139974B (it) * | 1981-09-11 | 1986-09-24 | Bioresearch Srl | Derivati della s-adenosilmetionina,processo per la preparazione e composizioni terapeutiche che li contengono come principio attivo |
| IT1169773B (it) * | 1983-08-24 | 1987-06-03 | Bioresearch Spa | Processo per la produzione di sali stabili della solfo-adenosil-l-metionina |
| IT1169774B (it) * | 1983-08-24 | 1987-06-03 | Bioresearch Spa | Composizioni terapeutiche iniettabili contenenti sali stabili della s-adenosil-l-metionina |
| IT1173990B (it) * | 1984-05-16 | 1987-06-24 | Bioresearch Spa | Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale |
| IT1173992B (it) * | 1984-05-16 | 1987-06-24 | Bioresearch Spa | Sali stabili della solfo-adenosil-l-metionina (same) particolarmente idonei per uso farmaceutico orale |
| IT1200589B (it) * | 1985-02-14 | 1989-01-27 | Gibipharma Spa | Derivati naturali attivita farmagologica |
| ATE80165T1 (de) * | 1987-10-09 | 1992-09-15 | Vincenzo Zappia | Lipophile salze von s-adenosyl-l-methionin (sam) mit acyltaurinderivaten. |
| DE19515275A1 (de) * | 1995-04-26 | 1996-10-31 | Knoll Ag | Neue Verwendung von (S)-Adenosyl-L-methionin(SAMe) |
| US6759395B2 (en) | 2000-12-18 | 2004-07-06 | Orchid Chemicals & Pharmaceuticals, Ltd. | Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same |
| US8063024B2 (en) * | 2005-01-26 | 2011-11-22 | University Of Manitoba | Use of S-adenosylmethionine, vitamin E, and vitamin C for the treatment of oxidative liver injury and insulin resistance |
| US20090012036A1 (en) * | 2005-05-24 | 2009-01-08 | Hebert Rolland F | Stable S-adenosyl-L-methionine |
| ITMI20060629A1 (it) * | 2006-03-31 | 2007-10-01 | Daniele Giovannone | Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento |
| US20090197824A1 (en) * | 2008-01-31 | 2009-08-06 | Methylation Sciences International Srl | Extended Release Pharmaceutical Formulations of S-Adenosylmethionine |
| EP2124552A4 (en) * | 2007-01-31 | 2013-01-09 | Methylation Sciences Internat Srl | PHARMACEUTICAL FORMULATIONS WITH PROLONGED RELEASE OF S-ADENOSYLMETHIONINE |
| US20090088404A1 (en) * | 2007-01-31 | 2009-04-02 | Methylation Sciences International Srl | Extended Release Pharmaceutical Formulations of S-Adenosylmethionine |
| ITMI20071374A1 (it) * | 2007-07-10 | 2009-01-11 | Gnosis Spa | Sali stabili di s-adenosilmetionina e processo per il loro ottenimento. |
| US20100004191A1 (en) * | 2008-07-01 | 2010-01-07 | Rolland F Hebert | Compositions of S-adenosyl-L-methionine. |
| US20110027342A1 (en) * | 2009-07-28 | 2011-02-03 | Msi Methylation Sciences, Inc. | S-adenosylmethionine formulations with enhanced bioavailability |
| US8329208B2 (en) | 2009-07-28 | 2012-12-11 | Methylation Sciences International Srl | Pharmacokinetics of S-adenosylmethionine formulations |
| EP2696879A4 (en) * | 2011-04-15 | 2014-11-26 | Scimar Ltd | USE OF S-ADENOSYLMETHIONINE, VITAMIN E AND VITAMIN C IN THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DYSFUNCTION |
| SG11201503048TA (en) | 2012-10-17 | 2015-06-29 | Methylation Sciences Internat Srl | Compositions comprising s-adenosylmethionine and a gallic acid ester |
| EP2945959B1 (en) | 2013-01-16 | 2020-05-13 | Hebert Sam-E LLC | Stable indole-3-propionate salts of s-adenosyl-l-methionine |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2946781A (en) * | 1957-02-06 | 1960-07-26 | Merck & Co Inc | Process for the preparation of adenosyl homocysteine |
| US3642772A (en) * | 1968-09-04 | 1972-02-15 | Boehringer Mannheim Gmbh | Process for preparing s-adenosyl homocysteine |
-
1973
- 1973-07-16 IE IE1192/73A patent/IE37913B1/xx unknown
- 1973-07-17 IL IL42764A patent/IL42764A/en unknown
- 1973-07-17 US US380097A patent/US3893999A/en not_active Expired - Lifetime
- 1973-07-17 DE DE2336401A patent/DE2336401C3/de not_active Expired
- 1973-07-17 ZA ZA734876A patent/ZA734876B/xx unknown
- 1973-07-19 FR FR7326500A patent/FR2194425B1/fr not_active Expired
- 1973-07-19 GB GB3449973A patent/GB1425384A/en not_active Expired
- 1973-07-25 RO RO7300075582A patent/RO63451A/ro unknown
- 1973-07-26 CS CS735374A patent/CS195254B2/cs unknown
- 1973-07-26 YU YU2030/73A patent/YU36037B/xx unknown
- 1973-07-27 AR AR249310A patent/AR195350A1/es active
- 1973-07-27 AT AT664173A patent/AT341684B/de not_active IP Right Cessation
- 1973-07-27 CA CA177,689A patent/CA1006872A/en not_active Expired
- 1973-07-30 ES ES417377A patent/ES417377A1/es not_active Expired
- 1973-07-30 AU AU58680/73A patent/AU474015B2/en not_active Expired
- 1973-07-30 BE BE134028A patent/BE802981A/xx not_active IP Right Cessation
- 1973-08-01 PL PL1973164439A patent/PL87381B1/pl unknown
- 1973-08-01 MX MX737933U patent/MX4544E/es unknown
- 1973-08-01 SE SE7310587A patent/SE400085B/sv unknown
- 1973-08-01 HU HUEE2163A patent/HU167266B/hu unknown
- 1973-08-01 DK DK422773A patent/DK131868C/da not_active IP Right Cessation
- 1973-08-01 NO NO3084/73A patent/NO137941C/no unknown
- 1973-08-01 DD DD172669A patent/DD107461A5/xx unknown
- 1973-08-01 SU SU731945967A patent/SU646915A3/ru active
- 1973-08-02 CH CH1125173A patent/CH592112A5/xx not_active IP Right Cessation
- 1973-08-02 JP JP48086440A patent/JPS5235726B2/ja not_active Expired
- 1973-08-02 FI FI732438A patent/FI52466C/sv active
- 1973-08-02 NL NL737310706A patent/NL152864B/xx not_active IP Right Cessation
-
1980
- 1980-06-12 HK HK315/80A patent/HK31580A/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL42764A (en) | S-adenosyl-2-methionine tri-p-toluene sulfonate,its preparation and therapeutic compositions containing it | |
| Glinsukon et al. | Acute toxicity of capsaicin in several animal species | |
| NO147670B (no) | Analogifremgangsmaate for fremstilling av antivirale amin-derivater. | |
| EP0164998A2 (en) | Compositions and methods of enhancing transdermal and transmembrane penetration of topical and systemic agents | |
| KR100366200B1 (ko) | L-카르니틴염과이를함유한피부질환치료용화장품조성물및약제조성물 | |
| CN103145657B (zh) | 17-氢-9-去氢穿心莲内酯化物、制备方法及其制备药物用途 | |
| GB1335783A (en) | Anti-seborrhoeic compositions | |
| Gupta et al. | Antiinflammatory activity of some active principles of Lawsonia inermis leaves | |
| CN108794473A (zh) | 一种苝酰亚胺-野尻毒素衍生物及其制备方法与应用 | |
| CN102977020A (zh) | 乌头碱型生物碱及其制备方法和以该化合物为强心和抗心衰活性成分的药物组合物及用途 | |
| GB1388330A (en) | Method of preparing stable aqueous solutions of organosilicic compounds and the resulting products and applications thereof | |
| CN113929698B (zh) | 二芳基庚烷二聚体及其药物组合物与其制备方法和应用 | |
| US4185120A (en) | Topical treatment of fungal or yeast infections using p-tolyl diiodomethyl sulfone | |
| CN102030809B (zh) | 一种具有抗菌功效的茶皂苷元衍生物及其制备方法与应用 | |
| GB977214A (en) | Chemical compounds | |
| EP0214357B1 (en) | Novel chemical compound having antimycotic, cicatrizing and antiinflammatory activity | |
| US3627774A (en) | Pyridoxine pyridoxamine and pyridoxal flufenamate salts | |
| EP0096013B1 (en) | Salts of erythromycin showing a combined therapeutic activity, process for their preparation and pharmaceutical formulations containing them | |
| NO762064L (sv) | ||
| US3993776A (en) | Anorexigenic process and composition | |
| US3919424A (en) | Bronchodilator process and composition | |
| CN116120336B (zh) | 一种木瓜原花青素及其制备方法和应用 | |
| CN102675346A (zh) | 一种左旋咪唑有机酸盐，其合成方法和它的药物组合物 | |
| CN108129437B (zh) | 一种黄酮化合物及其制备方法与应用 | |
| US3461211A (en) | Lipotropic compositions and their administration |