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IL41034A - 6-aza-3h-1,4-benzodiazepines and 6-aza-1,2-dihydro-3h-1,4-benzodiazepines their preparation and pharmaceutical compositions containing them - Google Patents

6-aza-3h-1,4-benzodiazepines and 6-aza-1,2-dihydro-3h-1,4-benzodiazepines their preparation and pharmaceutical compositions containing them

Info

Publication number
IL41034A
IL41034A IL41034A IL4103472A IL41034A IL 41034 A IL41034 A IL 41034A IL 41034 A IL41034 A IL 41034A IL 4103472 A IL4103472 A IL 4103472A IL 41034 A IL41034 A IL 41034A
Authority
IL
Israel
Prior art keywords
alkyl
carbon
compound according
compound
benzodiazepines
Prior art date
Application number
IL41034A
Other versions
IL41034A0 (en
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa filed Critical Degussa
Publication of IL41034A0 publication Critical patent/IL41034A0/en
Priority to IL44720A priority Critical patent/IL44720A/en
Priority to IL44888A priority patent/IL44888A/en
Publication of IL41034A publication Critical patent/IL41034A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Claims (1)

1. CLAIMS A 6 or the formula where is a R2 and are halogen or lower is alkanoyloxy or carboxyalkanoyloxy of 2 to 6 carbon lower or Z is nitrogen or is lower alkyl lower alkyl stituted with oycloalkyl of 3 to 6 carbon a lower lower alkanoyl of 2 to 6 carbon of 2 to 7 carbon mono or dl lower of 2 to 7 carbon lower substituted to 7 aeobered saturated cyclio containing 0 to 1 additional nitrogen or oxygen and A is an alk group 1 to 6 carbon where Alkyl a alkyl or two hydrogen atoms and the can also in the tautomeric or or where Alkyl is a alkyl and pharmacologically acceptable salts A compound according to Claim 1 where is alkoxy or lower is lower lower alkyl substituted with cyc alkyl of 3 to 6 carbon lower lower mono or di lower alkyl aminoalkyl of 2 to 7 carbon lower alkyl substituted a to 7 saturated ring ing 0 to 1 additional oxygen and A is an alk group with 1 to 6 or two hydrogen and the tautomeric form as defined in Claim 1 and acceptable salts compound according to Claim 1 wherein any haloge present has an atomic weight of 9 to compound according to Claim wherein is A compound according to Claim 4 wherein are fluorine or A is is is E or and is H or alkyl of 1 to 4 carbon A compound accordin to Claim wherein and are both compound according to wherein gen and is fluorine or A compound according Claim 7 wherein is in the A compound according to Claim wherein is A compound according to Claim 5 wherein is A composition having tranquilizer activity comprising an amount for such activity of a compound of Claim 1 a acceptable A method of a tranquiliaing effect in a human mammal comprising administering to the mammal an amount of the composition of Claim 1 sufficient to induce such method according to Claim 12 wherein the compound is method according to Claim 12 the compound is administered 83 insufficientOCRQuality
IL41034A 1971-12-09 1972-12-08 6-aza-3h-1,4-benzodiazepines and 6-aza-1,2-dihydro-3h-1,4-benzodiazepines their preparation and pharmaceutical compositions containing them IL41034A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL44720A IL44720A (en) 1972-12-08 1974-04-26 5-phenyl-6-aza-7-amino-1,2-dihydro-3h1,4-benzodiazepin-2-one derivatives,their preparation and pharmaceutical compositions containing them
IL44888A IL44888A (en) 1972-12-08 1974-05-23 6-aza-3h-1,4-benzodiazepines,their preparation and pharmacceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT1060471A AT333284B (en) 1971-12-09 1971-12-09 PROCESS FOR THE PREPARATION OF NEW 6-AZA-3H-1,4-BENZODIAZEPINES, THEIR OPTICAL ISOMERS AND THEIR SALTS

Publications (2)

Publication Number Publication Date
IL41034A0 IL41034A0 (en) 1973-02-28
IL41034A true IL41034A (en) 1976-10-31

Family

ID=3623479

Family Applications (1)

Application Number Title Priority Date Filing Date
IL41034A IL41034A (en) 1971-12-09 1972-12-08 6-aza-3h-1,4-benzodiazepines and 6-aza-1,2-dihydro-3h-1,4-benzodiazepines their preparation and pharmaceutical compositions containing them

Country Status (26)

Country Link
JP (4) JPS569509B2 (en)
AR (3) AR201201A1 (en)
AT (4) AT332878B (en)
AU (1) AU473253B2 (en)
BE (1) BE792541A (en)
CH (4) CH603645A5 (en)
CS (1) CS212736B2 (en)
DD (1) DD105448A5 (en)
DE (1) DE2259471C2 (en)
DK (1) DK138425B (en)
EG (1) EG10918A (en)
ES (2) ES409089A1 (en)
FI (1) FI54710C (en)
FR (1) FR2162482B1 (en)
GB (1) GB1400755A (en)
HU (1) HU169468B (en)
IL (1) IL41034A (en)
IT (1) IT1035053B (en)
NL (1) NL171986C (en)
NO (1) NO137094C (en)
PL (3) PL89682B1 (en)
RO (4) RO65263A (en)
SE (1) SE404803B (en)
SU (4) SU468423A3 (en)
YU (2) YU305972A (en)
ZA (1) ZA728497B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2364636C2 (en) * 1973-12-24 1982-11-04 Degussa Ag, 6000 Frankfurt Process for the preparation of 2-benzoyl-6-chloro-3-nitro-pyridines
DE3067662D1 (en) * 1980-01-16 1984-06-07 Lacer Sa New 2-halo-pyridines, their production and pharmaceutical compositions
JPS60132610A (en) * 1983-12-20 1985-07-15 Japan Organo Co Ltd Sludge dehydrating apparatus
JPS6219221A (en) * 1985-07-16 1987-01-28 Chiyoda Chem Eng & Constr Co Ltd Filtration method and filtration device to remove fine particles from stock solution

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3314941A (en) * 1964-06-23 1967-04-18 American Cyanamid Co Novel substituted pyridodiazepins
US3523939A (en) * 1967-07-03 1970-08-11 Hoffmann La Roche 5-(2,6-disubstituted phenyl)-1,4-benzodiazepines and methods for their preparation

Also Published As

Publication number Publication date
PL91828B1 (en) 1977-03-31
HU169468B (en) 1976-11-28
PL91876B1 (en) 1977-03-31
SU564809A3 (en) 1977-07-05
DE2259471A1 (en) 1973-06-14
CS212736B2 (en) 1982-03-26
CH603645A5 (en) 1978-08-31
SU574156A3 (en) 1977-09-25
DD105448A5 (en) 1974-04-20
ES409089A1 (en) 1975-10-16
JPS5742639B2 (en) 1982-09-09
NO137094C (en) 1977-12-28
RO65263A (en) 1983-07-07
GB1400755A (en) 1975-07-23
JPS569509B2 (en) 1981-03-02
FI54710C (en) 1979-02-12
NO137094B (en) 1977-09-19
IT1035053B (en) 1979-10-20
PL89682B1 (en) 1976-12-31
CH605946A5 (en) 1978-10-13
AU473253B2 (en) 1976-06-17
CH603644A5 (en) 1978-08-31
FR2162482A1 (en) 1973-07-20
AR200309A1 (en) 1974-10-31
JPS55147282A (en) 1980-11-17
NL7216621A (en) 1973-06-13
ES409090A1 (en) 1975-10-16
AR203311A1 (en) 1975-08-29
YU305972A (en) 1982-02-28
FR2162482B1 (en) 1976-03-05
ATA1060471A (en) 1976-03-15
CH594665A5 (en) 1978-01-13
JPS5742638B2 (en) 1982-09-09
ATA902074A (en) 1977-01-15
AT333284B (en) 1976-11-10
SU468423A3 (en) 1975-04-25
EG10918A (en) 1981-12-31
AT332878B (en) 1976-10-25
NL171986C (en) 1983-06-16
AT332877B (en) 1976-10-25
AR201201A1 (en) 1975-02-21
JPS4864096A (en) 1973-09-05
JPS5744678B2 (en) 1982-09-22
AT338798B (en) 1977-09-12
ZA728497B (en) 1973-09-26
DE2259471C2 (en) 1982-08-19
NL171986B (en) 1983-01-17
BE792541A (en) 1973-06-08
JPS5625181A (en) 1981-03-10
SE404803B (en) 1978-10-30
SU674675A3 (en) 1979-07-15
ATA902274A (en) 1976-02-15
DK138425C (en) 1979-02-12
RO62312A (en) 1977-12-15
RO65263B (en) 1983-06-30
YU116881A (en) 1984-02-29
IL41034A0 (en) 1973-02-28
JPS5625180A (en) 1981-03-10
ATA902174A (en) 1976-02-15
FI54710B (en) 1978-10-31
AU4993172A (en) 1974-06-13
RO67345A (en) 1980-07-15
RO65264A (en) 1979-08-15
DK138425B (en) 1978-09-04

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