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IL40917A - Process for the preparation of 4-substituted-1-(4,4- diarylbutyl)-piperidines - Google Patents

Process for the preparation of 4-substituted-1-(4,4- diarylbutyl)-piperidines

Info

Publication number
IL40917A
IL40917A IL40917A IL4091772A IL40917A IL 40917 A IL40917 A IL 40917A IL 40917 A IL40917 A IL 40917A IL 4091772 A IL4091772 A IL 4091772A IL 40917 A IL40917 A IL 40917A
Authority
IL
Israel
Prior art keywords
preparation
reacted
chloride
reduced
diarylbutyl
Prior art date
Application number
IL40917A
Other languages
Hebrew (he)
Other versions
IL40917A0 (en
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IL40917A0 publication Critical patent/IL40917A0/en
Publication of IL40917A publication Critical patent/IL40917A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64—Acyl halides
    • C07C57/72—Acyl halides containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Claims (1)

1. CLAIMS A process of preparing a compound of the wherein Z is and wherein is hydrogen is hydrogen or is is phenyl or and lower lower or whichi comprises reacting Yvlactoiie formul in which has the same meaning as above with a halobenzene form acid formula compound into a compound of formula A process according to Claim 4 for the preparation of wherein chloride is reacted with in the presence of and the thus obtained is reduced with sodium 6 A process according to Claim 4 for the preparation of wherein chloride is reacted with and the piperidinol thus obtained is with lithium aluminium A process according to Claim 4 for the preparation of wherein chloride is reacted with hydrochloride and the thus obtained is reduced with lithium aluminium A process accordin to Claim 4 for the preparation of piperidinol wherein 4 chloride is reacted with hydrochlorid and the thus obtained is reduced with lithium aluminium the insufficientOCRQuality
IL40917A 1971-11-25 1972-11-24 Process for the preparation of 4-substituted-1-(4,4- diarylbutyl)-piperidines IL40917A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9485771A JPS5527915B2 (en) 1971-11-25 1971-11-25

Publications (2)

Publication Number Publication Date
IL40917A0 IL40917A0 (en) 1973-01-30
IL40917A true IL40917A (en) 1976-10-31

Family

ID=14121686

Family Applications (1)

Application Number Title Priority Date Filing Date
IL40917A IL40917A (en) 1971-11-25 1972-11-24 Process for the preparation of 4-substituted-1-(4,4- diarylbutyl)-piperidines

Country Status (14)

Country Link
JP (1) JPS5527915B2 (en)
AR (2) AR198393A1 (en)
BG (2) BG20349A3 (en)
CA (1) CA983503A (en)
CH (1) CH579048A5 (en)
CS (1) CS168014B2 (en)
ES (1) ES408926A1 (en)
FR (1) FR2161007A1 (en)
HU (1) HU165208B (en)
IL (1) IL40917A (en)
NL (1) NL7214913A (en)
RO (2) RO63063A (en)
SU (1) SU462333A3 (en)
YU (1) YU35120B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4082755A (en) * 1977-02-14 1978-04-04 Janssen Pharmaceutica N.V. 1-[(Diarylmethyl)aminoalkyl]piperidimes
CN106187863A (en) * 2016-07-15 2016-12-07 湖南中南制药有限责任公司 The preparation method of penfluridol

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE633495A (en) * 1962-06-13

Also Published As

Publication number Publication date
RO63063A (en) 1978-07-15
YU35120B (en) 1980-09-25
NL7214913A (en) 1973-05-29
JPS5527915B2 (en) 1980-07-24
RO62760A (en) 1978-02-15
CS168014B2 (en) 1976-05-28
BG20348A3 (en) 1975-11-05
FR2161007A1 (en) 1973-07-06
BG20349A3 (en) 1975-11-05
HU165208B (en) 1974-07-27
FR2161007B1 (en) 1976-03-05
ES408926A1 (en) 1976-03-01
IL40917A0 (en) 1973-01-30
JPS4860092A (en) 1973-08-23
AR199497A1 (en) 1974-09-09
YU291672A (en) 1980-03-15
AR198393A1 (en) 1974-06-21
SU462333A3 (en) 1975-02-28
CA983503A (en) 1976-02-10
CH579048A5 (en) 1976-08-31

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