IL40458A - Pyrimidinones,their preparation and pharmaceutical compositions containing them - Google Patents
Pyrimidinones,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL40458A IL40458A IL40458A IL4045872A IL40458A IL 40458 A IL40458 A IL 40458A IL 40458 A IL40458 A IL 40458A IL 4045872 A IL4045872 A IL 4045872A IL 40458 A IL40458 A IL 40458A
- Authority
- IL
- Israel
- Prior art keywords
- methyl
- prepared
- hydrogen
- compound
- reacting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
1377308 Substituted 5-phenoxy and 5-thiophenoxy-2-(1H)-pyrimidinones PFIZER Inc 18 Feb 1972 [29 Oct 1971] 7748/72 Heading C2C Novel compounds of the Formula I: wherein R is hydrogen or methyl, R 1 is oxygen or sulphur, R 2 is hydrogen, halogen or methyl and R 3 is hydrogen, methyl, chloro or trifluoromethyl and pharmaceutically acceptable salts thereof may be prepared by reacting a compound wherein R 6 and R 7 are C 1-3 alkyl groups, with a reagent prepared from ethanol, sodium and urea and if necessary reacting the product with an alkali metal or alkaline earth metal salt and hot methyl iodide to introduce the methyl group at R. 2 - (p - Chlorophenoxy) - 3 - dimethylaminoacrolein may be prepared by reacting potassium p-chlorophenolate, prepared in situ, with chloroacetaldehyde diethylacetal to yield pchlorophenoxyacetaldehyde diethyl acetal which on reaction with dimethyl formamide in the presence of phosphorus oxychloride cyclizes to the required intermediate. Pharmaceutical compositions of the compound I with the usual excipients show bronchodilatory activity and inhibit gastric acid secretion when administered orally, parenterally or by inhalation.
[GB1377308A]
Claims (1)
1. CLAIMS A pyrimiflxnone compound of the and the pharmaceutically acceptabl salts thereof is hydrogen or is oxygen or is halogen or and R is or methyl oxygen and is of Formula I substantially as described in Examples II II1 A process for compounds according to claim 1 comprising heating a prepared from ethan sodium urea with a compound of the wherein and as defined above and and are groups having up to 3 carbon atoms if further reacting with an or alkali earth salt and hot methyl to produce a of Formula I in which R A for 40458 as described in Example A pharmaceutical composition comprising a pharma ceutically acceptable carrier and a compound according to insufficientOCRQuality
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19400671A | 1971-10-29 | 1971-10-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL40458A0 IL40458A0 (en) | 1972-11-28 |
| IL40458A true IL40458A (en) | 1976-05-31 |
Family
ID=22715935
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL40458A IL40458A (en) | 1971-10-29 | 1972-09-28 | Pyrimidinones,their preparation and pharmaceutical compositions containing them |
| IL48790A IL48790A (en) | 1971-10-29 | 1976-01-05 | Hydroxy-pyrimidines,their preparation and pharmaceutical compositions containing them |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL48790A IL48790A (en) | 1971-10-29 | 1976-01-05 | Hydroxy-pyrimidines,their preparation and pharmaceutical compositions containing them |
Country Status (25)
| Country | Link |
|---|---|
| JP (2) | JPS5337870B2 (en) |
| AR (2) | AR198798A1 (en) |
| AT (2) | AT321308B (en) |
| AU (1) | AU467600B2 (en) |
| BE (1) | BE790125A (en) |
| CA (1) | CA980778A (en) |
| CH (2) | CH549579A (en) |
| DE (3) | DE2264374C3 (en) |
| DK (1) | DK131465B (en) |
| EG (1) | EG11013A (en) |
| ES (2) | ES407730A1 (en) |
| FI (1) | FI55503C (en) |
| FR (1) | FR2157865B1 (en) |
| GB (2) | GB1377720A (en) |
| IE (1) | IE37043B1 (en) |
| IL (2) | IL40458A (en) |
| LU (1) | LU66304A1 (en) |
| NL (1) | NL166470C (en) |
| NO (1) | NO136574C (en) |
| PH (2) | PH10129A (en) |
| PL (2) | PL89852B1 (en) |
| SE (2) | SE393376B (en) |
| SU (2) | SU498908A3 (en) |
| YU (2) | YU35125B (en) |
| ZA (1) | ZA727362B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55151912U (en) * | 1979-04-17 | 1980-11-01 | ||
| JPS5752409Y2 (en) * | 1979-11-05 | 1982-11-15 | ||
| DE3222914A1 (en) * | 1982-06-18 | 1983-12-22 | Beiersdorf Ag, 2000 Hamburg | SUBSTITUTED 5-PHENYLTHIO-6-AMINO-PYRIMIDINONE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE, AND PREPARATIONS CONTAINING THESE COMPOUNDS |
| JPH0655686B2 (en) * | 1988-08-30 | 1994-07-27 | 宇部興産株式会社 | Process for producing p-bromophenoxyacetaldehyde dialkyl acetals |
| ATE533488T1 (en) | 2005-08-22 | 2011-12-15 | Melior Pharmaceuticals I Inc | METHODS AND FORMULATIONS FOR MODULATING LYN KINASE ACTIVITY AND TREATING ASSOCIATED DISEASES |
| US8552184B2 (en) | 2008-07-03 | 2013-10-08 | Melior Pharmaceuticals I, Inc. | Compounds and methods for treating disorders related to glucose metabolism |
| US20130158055A1 (en) | 2010-05-28 | 2013-06-20 | Andrew G. Reaume | Prevention Of Pancreatic Beta Cell Degeneration |
| AU2018250795B2 (en) | 2017-04-10 | 2022-02-10 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Treatment of adipocytes |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2913462A (en) * | 1959-11-17 | Eahl h | ||
| GB951431A (en) * | 1959-03-17 | 1964-03-04 | Wellcome Found | Pyrimidine derivatives and the manufacture thereof |
-
0
- BE BE790125D patent/BE790125A/en not_active IP Right Cessation
-
1972
- 1972-02-18 GB GB5005373A patent/GB1377720A/en not_active Expired
- 1972-02-18 GB GB774872A patent/GB1377308A/en not_active Expired
- 1972-09-25 SE SE7212358A patent/SE393376B/en unknown
- 1972-09-28 IL IL40458A patent/IL40458A/en unknown
- 1972-09-28 AU AU47228/72A patent/AU467600B2/en not_active Expired
- 1972-10-02 PH PH13959A patent/PH10129A/en unknown
- 1972-10-05 DE DE2264374A patent/DE2264374C3/en not_active Expired
- 1972-10-05 DE DE2264657A patent/DE2264657C2/en not_active Expired
- 1972-10-05 DE DE2248741A patent/DE2248741C3/en not_active Expired
- 1972-10-06 AT AT858972A patent/AT321308B/en not_active IP Right Cessation
- 1972-10-06 AT AT00933/74A patent/AT320656B/en not_active IP Right Cessation
- 1972-10-12 YU YU2551/72A patent/YU35125B/en unknown
- 1972-10-12 FI FI2825/72A patent/FI55503C/en active
- 1972-10-13 NO NO3686/72A patent/NO136574C/en unknown
- 1972-10-13 SU SU1839308A patent/SU498908A3/en active
- 1972-10-16 PL PL1972174103A patent/PL89852B1/pl unknown
- 1972-10-16 DK DK510072AA patent/DK131465B/en not_active IP Right Cessation
- 1972-10-16 NL NL7213959.A patent/NL166470C/en not_active IP Right Cessation
- 1972-10-16 CH CH165674A patent/CH549579A/en not_active IP Right Cessation
- 1972-10-16 ZA ZA727362A patent/ZA727362B/en unknown
- 1972-10-16 JP JP10279972A patent/JPS5337870B2/ja not_active Expired
- 1972-10-16 FR FR7236560A patent/FR2157865B1/fr not_active Expired
- 1972-10-16 IE IE1398/72A patent/IE37043B1/en unknown
- 1972-10-16 CA CA153,956A patent/CA980778A/en not_active Expired
- 1972-10-16 PL PL1972158297A patent/PL84634B1/pl unknown
- 1972-10-16 LU LU66304A patent/LU66304A1/xx unknown
- 1972-10-16 CH CH1507872A patent/CH555832A/en not_active IP Right Cessation
- 1972-10-18 ES ES407730A patent/ES407730A1/en not_active Expired
- 1972-10-19 EG EG431/72A patent/EG11013A/en active
- 1972-10-23 AR AR244763A patent/AR198798A1/en active
-
1973
- 1973-07-12 AR AR249053A patent/AR196263A1/en active
-
1974
- 1974-03-26 SU SU2008490A patent/SU505362A3/en active
-
1975
- 1975-04-15 ES ES436624A patent/ES436624A1/en not_active Expired
- 1975-05-06 SE SE7505279A patent/SE397090B/en unknown
- 1975-11-21 PH PH17784A patent/PH11594A/en unknown
-
1976
- 1976-01-05 IL IL48790A patent/IL48790A/en unknown
-
1978
- 1978-02-08 JP JP1336078A patent/JPS53116386A/en active Granted
-
1979
- 1979-04-25 YU YU991/79A patent/YU36295B/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US3772295A (en) | Quinazoline derivatives | |
| IL40458A (en) | Pyrimidinones,their preparation and pharmaceutical compositions containing them | |
| GB1506914A (en) | 2-dihalophenylamino-2-imidazoline derivatives | |
| US3819612A (en) | 2-substituted adenosine derivatives and the production thereof | |
| GB1217661A (en) | Hydrazino-benzocinnoline and -benzo-cycloheptapyridazine derivatives and pharmaceutical compositions containing them | |
| IL33846A (en) | Derivatives of 1-thiachromone and 4-thionchromone,their preparation and pharmaceutical compositions containing them | |
| US3350400A (en) | 7-(picolylaminoalkyl)-theophylline and its salts | |
| GB1495665A (en) | Pyrimidines | |
| IL40329A (en) | Pyridine derivatives,their production and their use as antimicrobial agents | |
| GB1469006A (en) | 2-phenylhydrazinothiazolines or-thiazines and a process for the preparation thereof | |
| GB1328935A (en) | Substituted cycloalkyl lactamimides | |
| US3352864A (en) | Theophyllinyl-7-n-propane-omega sulfonic acid and salts thereof | |
| GB1337371A (en) | 3-amino-imidazo-1,5-a- pyridines processes for their preparation and pharmaceutical compositions incorporating them | |
| US4335119A (en) | Quick-acting diuretic compositions | |
| US2767172A (en) | Process for the production of n-benzylidene and n-quinolylmethylene-substituted 2-aminobenz-isothiazolones | |
| GB1174349A (en) | Novel 2-Anilinomethylimidazoline Derivatives and process for the preparation thereof | |
| US3714206A (en) | Benzo-2,3,1-diazaborines | |
| GB2122604A (en) | Substituted thiazolidinyl esters of mineral acids | |
| JPS6014038B2 (en) | Method for producing new thiazoloisoquinoline compounds | |
| US3860582A (en) | Derivatives of 4-chloro-5-sulfamoyl-anthranilic acid | |
| US4036972A (en) | 2-(N-thienylmethyl-phenylamino)-imidazolines-(2) and salts thereof | |
| ES418987A1 (en) | Phenylamidinourea derivatives processes for their preparation and compositions incorporating them | |
| US2807616A (en) | Oxazolopyrimidines and method of preparing same | |
| US3415931A (en) | Pharmaceutical composition containing theophyllinyl-7-n-propane - omega - sulfonic acid or its salts and a method of treatment | |
| GB1254270A (en) | Benzoxazepine derivatives |