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IL40169A - Aminoalcohol esters and salts thereof,their preparation and pharmaceutical compositions containing them - Google Patents

Aminoalcohol esters and salts thereof,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL40169A
IL40169A IL40169A IL4016972A IL40169A IL 40169 A IL40169 A IL 40169A IL 40169 A IL40169 A IL 40169A IL 4016972 A IL4016972 A IL 4016972A IL 40169 A IL40169 A IL 40169A
Authority
IL
Israel
Prior art keywords
general formula
group
phenyl
represent
formula
Prior art date
Application number
IL40169A
Other versions
IL40169A0 (en
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of IL40169A0 publication Critical patent/IL40169A0/en
Publication of IL40169A publication Critical patent/IL40169A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Claims (1)

1. CLAIMS Pharmaceutically active new eaters and salts of the general formulas and X 0 0 Y wherein n is an integer of 1 to represents hydrogen or a or branched lower represents a or branched lower alkyl group or a phenyl represents a or branched lower alkyl or a benayl X represents an amino group of the general formula wherein and each represent a lower alkenyl or phenylallyl or and may form together an alkylene X may represent further a piperidino group of the formula 24 a group of the formula or a group of the formula represents a or branched lower alkyl or haloalkyl a phenyl group optionall substituted by one or more halo hydroxy trlfluoromethyl furthe a xanthenyl 2 represents a residue of a pharmaceutically acceptable organic or mineral with the proviso and each repreaent a iaopropyl and Y stands for a propyl or phenyl group optionally having one or more other may only stand for or an isomeric group and may only stand for an isomeric or phenyl isoprppyl or butyl n is or is hydrogen or or branched alkyl group and is a or branched alkyl group or phenyl group Y may only stand for an or substituted phenyl wherein the attached to the phenyl group may be trifluoromethyl group or and form together a or Y represents a phenyl or substituted phenyl wherein the substitutents attached to the phenyl group may be trifluoromethyl grou and and g each represent or stands for hydrogen and g represents a chained or branched lower alkyl group or a phenyl n may only represent 3 or f and represent or represents hydrogen or methyl represents hydrogen or phenyl group and Y represents or 26 n may only represent 3 or or respectively if represents a xanthenyl and and are identical and represent 4 isopropyl or butyl or and form together a or may only stand for propyl or and may only stand for and its and its and its and and its and its and its and its and its and compound as claimed inclaim with special reference to the A process for the preparation of a pharmacetttically active new aminoafcohol ester salt of the formulas σ γ o wherei is an Integer of 1 to represents hydrogen or a or branched lower alkyl represents a or branched lower alkyl group or a phenyl group represents a or branched lower alkyl or a benzyl X represents an amino group of the general wherein and each represent a lower cycloalkyl 28 alkenyl phenylallyl or and may form together an alkylene may represent further a group of the iprmula a of the formula or a group of the formula t represents a branched lower or haloalkyl a phenyl group optionally substituted by one or xanthenyl represents a residue of a pharmaceutically acceptable organic or with the proviso if and represent isopropyl or butyl group and Y stands for a propyl or phenyl group optionally having one or other may only for or an isomeric group and may only stand for a isomeric phenyl or 29 and each represent a leopropyl or butyl n is 1 or is hydrogen or a or branched alkyl group and a or branched alkyl group or phenyl T ma only stand for an or substituted phenyl wherein the attached to the phenyl group may be trifluoromethyl and form together a or Ϊ represents phenyl or substituted phenyl attached to the phenyl group e ma be hydroxy trifluoromethyl and and each represent or stands for hydrogen Rg represents a chained branched lower alkyl or alkenyl group or a phenyl n may only represent or or if and represent or represents hydrogen methyl represents hydrogen or phenyl group and Y represents or trichlorophenyl n may only resent or if Y represents a xanthenyl and 30 and are identical and represent Isopropyl butyl or and form together a or may only stand for propyl or and may only stand for Characterized in that a secondary of the general formula wherein and have the same meanings as defined the formula or of the formula is with a haloalcohol of the general formula Hal OH OH wherein and n have the same meanings as defined and Hal is halogen and the obtained aminoalcohol of the general formula XIII X OH wherein and n have the same meanings as defined and X is a group of the formulas or is reacted with a reactive derivative of a carboxylic acid of the general formula Y 000H wherein Y has the same meanings as defined or a haloamine of the general formula meanings as defined is reacted with a carboxylic acid of the general formula Y COOH wherein Y has the same meanings as defined or a secondary amine of the general formula R wherein and have the same meanings as defined of the formula of the formula or of the formula is reacted with a haloalkyl ester of the general formula Hal OH CH Y wherein Ύ and Hal have the same meanings as defined or an acrylic ester of the general formula wherein has the same meanings as defined and represents a lower alkyl is reacted with a secondary amine of the general formula wherein and have the same meanings as stated the obtained aminocarboxylic ester of the general formula wherein and have the same meanings as defined and X represents a group of the general formula is the obtained aminoalcohol of the general formula X n OH wherein and n have the same meanings as defined and X represents a group of the general formula is reacted with a reactive derivative of a carboxylic acid having the general formula Y wherein Y has the same meanings as defined and the compounds of the general formula are optionally converted into the corresponding free bases of the general formula or the bases of the general formula are converted optionally into their acid addition salts or process as claimed in method characterized in that the first step is carried out in the presence of a preferably in and in the presence of an acid binding process as claimed in claim method or in claim characterized in that the reactive derivative of the carboxylic acid general formula is an acid and this reagent is preferably used i slight process as claimed in claim method characterized in that the reaction is carried out at elevated temperatures in the presence of a solvent preferably of isopropanol or and a compound of the general formula wherein Hal represents chlorine or is used as starting A process as claimed in claim method 5 characterized in that a compound of the general formula wherein Hal represents chlorine or is used as starting A process as claimed in claim method or in claim characterized in that the amine reactant is 0 used in multiple A process as claimed in claim method characterized in that the reaction is carried out in the presence of a preferably in anhydrous at elevated using anhydrous potassium carbonate 5 as acid binding A process as claimed in claim 1 method characterized in that the amine reactant of the general formula is used in multiple A process as claimed in any of claims to 20 21 substantially as hereinbefore with special reference to the A pharmaceutical product containing as active ingredient at least one compound of the general formula or optionally together with other pharmacologically active a carrier or A process for the preparation of ceutical characterized in that a compound of the general formula or is converted alone or together with other pharmacologically active into auxiliary substances in the pharmaceut For DR insufficientOCRQuality
IL40169A 1971-09-03 1972-08-21 Aminoalcohol esters and salts thereof,their preparation and pharmaceutical compositions containing them IL40169A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HURI444A HU163608B (en) 1971-09-03 1971-09-03

Publications (2)

Publication Number Publication Date
IL40169A0 IL40169A0 (en) 1972-10-29
IL40169A true IL40169A (en) 1976-04-30

Family

ID=11000874

Family Applications (1)

Application Number Title Priority Date Filing Date
IL40169A IL40169A (en) 1971-09-03 1972-08-21 Aminoalcohol esters and salts thereof,their preparation and pharmaceutical compositions containing them

Country Status (18)

Country Link
AT (1) AT323741B (en)
AU (1) AU4622172A (en)
BE (1) BE788289A (en)
CA (1) CA1008075A (en)
CH (1) CH577957A5 (en)
CS (1) CS168004B2 (en)
DD (1) DD102142A5 (en)
DE (2) DE2265580C2 (en)
DK (1) DK144821C (en)
ES (1) ES406345A1 (en)
FI (1) FI56007C (en)
GB (1) GB1407456A (en)
HU (1) HU163608B (en)
IL (1) IL40169A (en)
NL (1) NL179205C (en)
PL (1) PL90702B1 (en)
SU (1) SU631068A3 (en)
YU (1) YU35762B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004045220A1 (en) * 2004-09-17 2006-04-06 Riemser Arzneimittel Ag New medicines

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1445551A1 (en) 1964-12-10 1969-05-22 Boheringer Mannheim Gmbh Process for the preparation of new, basic substituted xanthene-9-o1-9-carboxylic acid esters and their salts
US3523950A (en) * 1967-12-13 1970-08-11 Robins Co Inc A H Certain 4 - phenyl - 1,2,3,6 - tetrahydropyridyl-n-lower alkylene-ureas and derivatives

Also Published As

Publication number Publication date
AT323741B (en) 1975-07-25
BE788289A (en) 1973-01-02
FI56007B (en) 1979-07-31
GB1407456A (en) 1975-09-24
AU4622172A (en) 1974-03-07
YU35762B (en) 1981-06-30
CS168004B2 (en) 1976-05-28
ES406345A1 (en) 1976-01-16
DK144821B (en) 1982-06-14
DE2243143C3 (en) 1982-01-21
HU163608B (en) 1973-09-27
IL40169A0 (en) 1972-10-29
NL7211966A (en) 1973-03-06
FI56007C (en) 1979-11-12
CA1008075A (en) 1977-04-05
CH577957A5 (en) 1976-07-30
YU221172A (en) 1980-10-31
DK144821C (en) 1982-11-01
DE2243143A1 (en) 1973-04-12
NL179205C (en) 1986-08-01
PL90702B1 (en) 1977-01-31
DE2243143B2 (en) 1980-10-09
DE2265580C2 (en) 1982-11-18
NL179205B (en) 1986-03-03
DD102142A5 (en) 1973-12-05
SU631068A3 (en) 1978-10-30

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