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IL299452B2 - Psychoactive alkaloid extraction and composition with controlled dephosphorylation - Google Patents

Psychoactive alkaloid extraction and composition with controlled dephosphorylation

Info

Publication number
IL299452B2
IL299452B2 IL299452A IL29945222A IL299452B2 IL 299452 B2 IL299452 B2 IL 299452B2 IL 299452 A IL299452 A IL 299452A IL 29945222 A IL29945222 A IL 29945222A IL 299452 B2 IL299452 B2 IL 299452B2
Authority
IL
Israel
Prior art keywords
dephosphorylation
composition
controlled
alkaloid extraction
psychoactive
Prior art date
Application number
IL299452A
Other languages
Hebrew (he)
Other versions
IL299452B1 (en
IL299452A (en
Original Assignee
Psilo Scientific Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA3088384A external-priority patent/CA3088384C/en
Priority claimed from CA3097246A external-priority patent/CA3097246C/en
Priority claimed from CA3101765A external-priority patent/CA3101765A1/en
Priority claimed from CA3103707A external-priority patent/CA3103707C/en
Application filed by Psilo Scientific Ltd filed Critical Psilo Scientific Ltd
Priority claimed from PCT/CA2021/050813 external-priority patent/WO2021253116A1/en
Publication of IL299452A publication Critical patent/IL299452A/en
Publication of IL299452B1 publication Critical patent/IL299452B1/en
Publication of IL299452B2 publication Critical patent/IL299452B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0215—Solid material in other stationary receptacles
    • B01D11/0253—Fluidised bed of solid materials
    • B01D11/0257—Fluidised bed of solid materials using mixing mechanisms, e.g. stirrers, jets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/028—Flow sheets
    • B01D11/0284—Multistage extraction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0288—Applications, solvents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0292—Treatment of the solvent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
IL299452A 2020-06-17 2021-06-14 Psychoactive alkaloid extraction and composition with controlled dephosphorylation IL299452B2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US202063040317P 2020-06-17 2020-06-17
US202063046089P 2020-06-30 2020-06-30
CA3088384A CA3088384C (en) 2020-06-17 2020-07-29 Extraction of psychoactive compounds from psilocybin fungus
CA3089455A CA3089455C (en) 2020-06-17 2020-08-07 Methanol-based extraction of psychoactive compounds from fungus
CA3097246A CA3097246C (en) 2020-10-23 2020-10-23 Process for obtaining a purified psychoactive alkaloid solution
CA3101765A CA3101765A1 (en) 2020-12-04 2020-12-04 Psychoactive alkaloid extraction and composition with controlled dephosphorylation
CA3103707A CA3103707C (en) 2020-12-18 2020-12-18 Standardized psychoactive alkaloid extract composition
PCT/CA2021/050813 WO2021253116A1 (en) 2020-06-17 2021-06-14 Compositions comprising psychoactive compounds from psychoactive organisms

Publications (3)

Publication Number Publication Date
IL299452A IL299452A (en) 2023-02-01
IL299452B1 IL299452B1 (en) 2024-09-01
IL299452B2 true IL299452B2 (en) 2025-01-01

Family

ID=79022851

Family Applications (9)

Application Number Title Priority Date Filing Date
IL299452A IL299452B2 (en) 2020-06-17 2021-06-14 Psychoactive alkaloid extraction and composition with controlled dephosphorylation
IL299450A IL299450A (en) 2020-06-17 2021-06-14 Dephosphorylation-controlled extraction of phosphorylatable psychoactive alkaloids
IL298561A IL298561A (en) 2020-06-17 2021-06-14 Methanol-based extraction of psychoactive compounds from fungus
IL299453A IL299453B2 (en) 2020-06-17 2021-06-14 Extraction and synthesis of psychoactive alkaloids with inhibited dephosphorylation
IL297791A IL297791A (en) 2020-06-17 2021-06-14 Compounds composed of psychoactive compounds from psychoactive organisms
IL299451A IL299451B2 (en) 2020-06-17 2021-06-14 Extraction of psychoactive alkaloid is mainly carried out using alkali
IL305632A IL305632A (en) 2020-06-17 2021-06-14 Extraction of Psychoactive compounds from Psychedelic Fungus
IL299448A IL299448A (en) 2020-06-17 2021-06-14 A process for obtaining a purified psychoactive alkaloid solution
IL299449A IL299449A (en) 2020-06-17 2021-06-14 Standard psychoactive alkaloid extract composition

Family Applications After (8)

Application Number Title Priority Date Filing Date
IL299450A IL299450A (en) 2020-06-17 2021-06-14 Dephosphorylation-controlled extraction of phosphorylatable psychoactive alkaloids
IL298561A IL298561A (en) 2020-06-17 2021-06-14 Methanol-based extraction of psychoactive compounds from fungus
IL299453A IL299453B2 (en) 2020-06-17 2021-06-14 Extraction and synthesis of psychoactive alkaloids with inhibited dephosphorylation
IL297791A IL297791A (en) 2020-06-17 2021-06-14 Compounds composed of psychoactive compounds from psychoactive organisms
IL299451A IL299451B2 (en) 2020-06-17 2021-06-14 Extraction of psychoactive alkaloid is mainly carried out using alkali
IL305632A IL305632A (en) 2020-06-17 2021-06-14 Extraction of Psychoactive compounds from Psychedelic Fungus
IL299448A IL299448A (en) 2020-06-17 2021-06-14 A process for obtaining a purified psychoactive alkaloid solution
IL299449A IL299449A (en) 2020-06-17 2021-06-14 Standard psychoactive alkaloid extract composition

Country Status (6)

Country Link
US (4) US11331357B2 (en)
EP (1) EP4161546A4 (en)
AU (7) AU2021290454B2 (en)
BR (1) BR112022025780A2 (en)
IL (9) IL299452B2 (en)
MX (1) MX2022016533A (en)

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CN114787363A (en) 2019-10-01 2022-07-22 恩派瑞安神经科学公司 Genetic engineering of fungi to modulate tryptamine expression
CA3113240C (en) 2020-12-28 2023-09-05 Psilo Scientific Ltd. Transmucosal psychoactive alkaloid composition and preparation thereof
US20220370413A1 (en) 2021-03-06 2022-11-24 Mind Medicine, Inc. Formulations of psilocin that have enhanced stability
CA3127180C (en) * 2021-08-06 2024-03-05 Psilo Scientific Ltd. Pre-evaporation standardization of extracted psychoactive compounds
CA3133547A1 (en) * 2021-10-07 2023-04-07 Psilo Scientific Ltd. Liquid-liquid extraction of purified psychoactive alkaloid
WO2023130075A2 (en) 2021-12-31 2023-07-06 Empyrean Neuroscience, Inc. Genetically modified organisms for producing psychotropic alkaloids
WO2023225186A1 (en) * 2022-05-18 2023-11-23 Chemtor, Lp Extraction of psilocybin and psilocin

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Also Published As

Publication number Publication date
IL299449A (en) 2023-02-01
AU2022291410A1 (en) 2023-02-02
US20220226405A1 (en) 2022-07-21
AU2022291413A1 (en) 2023-02-02
IL299453B1 (en) 2024-08-01
AU2023285751A1 (en) 2024-01-18
IL299452B1 (en) 2024-09-01
IL299448A (en) 2023-02-01
IL305632A (en) 2023-11-01
AU2022291413B2 (en) 2024-02-22
AU2022291411B2 (en) 2023-12-07
US20220040246A1 (en) 2022-02-10
BR112022025780A2 (en) 2023-01-10
IL299451B2 (en) 2024-12-01
AU2021290454A1 (en) 2023-01-19
IL299451B1 (en) 2024-08-01
IL299453B2 (en) 2024-12-01
MX2022016533A (en) 2023-04-05
EP4161546A4 (en) 2024-10-09
IL299450A (en) 2023-02-01
AU2022291410B2 (en) 2024-04-04
US20210393716A1 (en) 2021-12-23
US11298388B2 (en) 2022-04-12
AU2022291416B2 (en) 2024-03-28
AU2022291416A1 (en) 2023-02-02
IL299453A (en) 2023-02-01
IL297791A (en) 2022-12-01
AU2023285751B2 (en) 2024-06-06
IL298561A (en) 2023-01-01
US11331357B2 (en) 2022-05-17
IL299451A (en) 2023-02-01
AU2022291411A1 (en) 2023-02-02
US11571450B2 (en) 2023-02-07
US20220202886A1 (en) 2022-06-30
IL299452A (en) 2023-02-01
AU2021290454B2 (en) 2024-01-11
EP4161546A1 (en) 2023-04-12
US11642385B2 (en) 2023-05-09
AU2022291414A1 (en) 2023-02-02
AU2022291414B2 (en) 2023-12-07

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