IL29345A - Phthalazino (2,3-b)phthalazine-5(14h),12(7h)-diones and process for their preparation - Google Patents
Phthalazino (2,3-b)phthalazine-5(14h),12(7h)-diones and process for their preparationInfo
- Publication number
- IL29345A IL29345A IL29345A IL2934568A IL29345A IL 29345 A IL29345 A IL 29345A IL 29345 A IL29345 A IL 29345A IL 2934568 A IL2934568 A IL 2934568A IL 29345 A IL29345 A IL 29345A
- Authority
- IL
- Israel
- Prior art keywords
- phthalazino
- phthalazine
- nitro
- hydrogen
- halogen
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 7
- 238000002360 preparation method Methods 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims description 13
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 229910052736 halogen Inorganic materials 0.000 claims description 5
- 150000002367 halogens Chemical class 0.000 claims description 5
- 125000001477 organic nitrogen group Chemical group 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims 4
- ZSCSUJZQCNTODA-UHFFFAOYSA-N 2-(bromomethyl)benzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1CBr ZSCSUJZQCNTODA-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- DRTWNJQJYUBAMQ-UHFFFAOYSA-N phthalazino[2,3-b]phthalazine Chemical group C1=CC=CC2=CN3N(C=C4C=CC=CC4=C3)C=C12 DRTWNJQJYUBAMQ-UHFFFAOYSA-N 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 15
- 239000000203 mixture Substances 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000012074 organic phase Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- -1 acetamido compound Chemical class 0.000 description 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- XSCHRSMBECNVNS-UHFFFAOYSA-N benzopyrazine Natural products N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 239000002026 chloroform extract Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 229960002895 phenylbutazone Drugs 0.000 description 1
- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 1
- LFSXCDWNBUNEEM-UHFFFAOYSA-N phthalazine Chemical compound C1=NN=CC2=CC=CC=C21 LFSXCDWNBUNEEM-UHFFFAOYSA-N 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4842/67A GB1199482A (en) | 1967-02-01 | 1967-02-01 | Novel-Phthalazino [2,3-b] Pthalazine Derivatives, the preparation thereof and Compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL29345A true IL29345A (en) | 1971-07-28 |
Family
ID=9784823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL29345A IL29345A (en) | 1967-02-01 | 1968-01-18 | Phthalazino (2,3-b)phthalazine-5(14h),12(7h)-diones and process for their preparation |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US3557108A (ru) |
| AT (1) | AT275530B (ru) |
| BE (1) | BE710210A (ru) |
| CH (1) | CH484153A (ru) |
| DE (1) | DE1695381B2 (ru) |
| DK (1) | DK117568B (ru) |
| ES (1) | ES350001A0 (ru) |
| FI (1) | FI47664C (ru) |
| FR (2) | FR1583197A (ru) |
| GB (1) | GB1199482A (ru) |
| IL (1) | IL29345A (ru) |
| NL (1) | NL6800912A (ru) |
| NO (1) | NO121342B (ru) |
| SE (1) | SE335348B (ru) |
| YU (1) | YU31941B (ru) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1289189A (ru) * | 1970-01-27 | 1972-09-13 | ||
| GB1412527A (en) * | 1973-04-27 | 1975-11-05 | Lepetit Spa | Method for the preparation of phthalqzino o2,3-b phthalazine-5 14h, 12 7h-dione |
-
1967
- 1967-02-01 GB GB4842/67A patent/GB1199482A/en not_active Expired
-
1968
- 1968-01-16 US US698139A patent/US3557108A/en not_active Expired - Lifetime
- 1968-01-18 IL IL29345A patent/IL29345A/en unknown
- 1968-01-19 NL NL6800912A patent/NL6800912A/xx unknown
- 1968-01-22 FI FI680167A patent/FI47664C/fi active
- 1968-01-24 DK DK26668AA patent/DK117568B/da unknown
- 1968-01-25 NO NO0322/68A patent/NO121342B/no unknown
- 1968-01-27 DE DE19681695381 patent/DE1695381B2/de active Granted
- 1968-01-30 FR FR1583197D patent/FR1583197A/fr not_active Expired
- 1968-01-31 SE SE01305/68A patent/SE335348B/xx unknown
- 1968-01-31 CH CH145068A patent/CH484153A/fr not_active IP Right Cessation
- 1968-01-31 ES ES350001A patent/ES350001A0/es active Pending
- 1968-01-31 AT AT96168A patent/AT275530B/de active
- 1968-02-01 YU YU0239/68A patent/YU31941B/xx unknown
- 1968-02-01 BE BE710210D patent/BE710210A/xx unknown
- 1968-04-29 FR FR149898A patent/FR7422M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE335348B (ru) | 1971-05-24 |
| NL6800912A (ru) | 1968-08-02 |
| YU23968A (en) | 1973-08-31 |
| DK117568B (da) | 1970-05-11 |
| DE1695381C3 (ru) | 1973-10-11 |
| AT275530B (de) | 1969-10-27 |
| BE710210A (ru) | 1968-06-17 |
| US3557108A (en) | 1971-01-19 |
| FR1583197A (ru) | 1969-10-24 |
| ES350001A0 (es) | 1969-04-16 |
| DE1695381B2 (de) | 1973-03-08 |
| FR7422M (ru) | 1969-11-12 |
| YU31941B (en) | 1974-02-28 |
| GB1199482A (en) | 1970-07-22 |
| NO121342B (ru) | 1971-02-15 |
| DE1695381A1 (de) | 1972-04-06 |
| FI47664C (fi) | 1974-02-11 |
| FI47664B (ru) | 1973-10-31 |
| CH484153A (fr) | 1970-01-15 |
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