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IL286931B2 - Method for obtaining low-molecular-weight heparins by means of tangential flow filtration - Google Patents

Method for obtaining low-molecular-weight heparins by means of tangential flow filtration

Info

Publication number
IL286931B2
IL286931B2 IL286931A IL28693121A IL286931B2 IL 286931 B2 IL286931 B2 IL 286931B2 IL 286931 A IL286931 A IL 286931A IL 28693121 A IL28693121 A IL 28693121A IL 286931 B2 IL286931 B2 IL 286931B2
Authority
IL
Israel
Prior art keywords
molecular
flow filtration
tangential flow
obtaining low
weight heparins
Prior art date
Application number
IL286931A
Other languages
Hebrew (he)
Other versions
IL286931A (en
IL286931B1 (en
Inventor
Rodr?Guez Guillermo Franco
Aduriz Ibon Gutierro
Original Assignee
Laboratorios Farmac?Uticos Rovi S A
Rodr?Guez Guillermo Franco
Aduriz Ibon Gutierro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Farmac?Uticos Rovi S A, Rodr?Guez Guillermo Franco, Aduriz Ibon Gutierro filed Critical Laboratorios Farmac?Uticos Rovi S A
Publication of IL286931A publication Critical patent/IL286931A/en
Publication of IL286931B1 publication Critical patent/IL286931B1/en
Publication of IL286931B2 publication Critical patent/IL286931B2/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/16—Feed pretreatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/10—Heparin; Derivatives thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/04—Specific process operations in the feed stream; Feed pretreatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2649—Filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/10—Cross-flow filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/16—Diafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/20—Specific permeability or cut-off range

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Water Supply & Treatment (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL286931A 2019-04-26 2020-04-24 Method for obtaining low-molecular-weight heparins by means of tangential flow filtration IL286931B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES201930373 2019-04-26
CN202010078241 2020-01-23
PCT/ES2020/070263 WO2020216981A1 (en) 2019-04-26 2020-04-24 Method for obtaining low-molecular-weight heparins by means of tangential flow filtration

Publications (3)

Publication Number Publication Date
IL286931A IL286931A (en) 2021-10-31
IL286931B1 IL286931B1 (en) 2024-11-01
IL286931B2 true IL286931B2 (en) 2025-03-01

Family

ID=72941056

Family Applications (1)

Application Number Title Priority Date Filing Date
IL286931A IL286931B2 (en) 2019-04-26 2020-04-24 Method for obtaining low-molecular-weight heparins by means of tangential flow filtration

Country Status (19)

Country Link
US (1) US20220112315A1 (en)
EP (1) EP3943513A4 (en)
JP (1) JP7550787B2 (en)
KR (1) KR20220005441A (en)
AU (1) AU2020263142A1 (en)
BR (1) BR112021020048A2 (en)
CA (1) CA3134458C (en)
CL (1) CL2021002647A1 (en)
CO (1) CO2021013320A2 (en)
ES (1) ES2888148B2 (en)
GE (1) GEP20247598B (en)
IL (1) IL286931B2 (en)
MA (1) MA55388A (en)
MX (1) MX2021011671A (en)
PE (1) PE20212330A1 (en)
PH (1) PH12021552600A1 (en)
SG (1) SG11202111009WA (en)
WO (1) WO2020216981A1 (en)
ZA (1) ZA202109022B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4326782A1 (en) * 2021-05-12 2024-02-28 Nexeos Diagnostics, Inc. Methods of manufacturing a high molecular weight heparin compound
CN116284499B (en) * 2022-07-28 2024-07-23 河北常山生化药业股份有限公司 Preparation method of sheep-derived low-molecular heparin sodium
CN117946294B (en) * 2023-11-13 2024-11-19 河北常山凯库得生物技术有限公司 Preparation method of energy-saving and environment-friendly enoxaparin sodium

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090105194A1 (en) * 2005-05-09 2009-04-23 Universitetet For Miljo-Og Biovitenskap Process for the production of a low molecular weight heparin
CN102731683A (en) * 2012-07-17 2012-10-17 湖北亿诺瑞生物制药有限公司 Method of separating natural low molecular heparin from heparin waste liquor
CN103936889A (en) * 2014-03-19 2014-07-23 苏州英诺凯生物医药科技有限公司 Method for purification of enoxaparin by tangential flow filtration

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0245813B2 (en) 1986-05-16 2000-03-22 ITALFARMACO S.p.A. EDTA-free heparins, heparin fractions and fragments, processes for their preparation and pharmaceutical compositions containing them
US5767269A (en) 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
ES2161615B1 (en) 1999-07-23 2003-03-16 Rovi Lab Farmaceut Sa COMPOSITIONS OF HEPARINS OF VERY LOW MOLECULAR WEIGHT.
JP4897991B2 (en) 1999-07-23 2012-03-14 ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ Ultra low molecular weight heparin composition
JP3896420B2 (en) * 2005-04-27 2007-03-22 大学共同利用機関法人 高エネルギー加速器研究機構 All ion accelerator and its control method
JP5286089B2 (en) 2006-01-13 2013-09-11 バクスター・インターナショナル・インコーポレイテッド Method for purifying polysaccharides
ES2718275T3 (en) 2009-03-27 2019-06-28 Algenist Holdings Inc Microalgae polysaccharide compositions
CN102050888B (en) 2010-12-13 2011-12-07 河北常山生化药业股份有限公司 Method for preparing enoxaparin sodium
CN103214597B (en) 2013-05-14 2015-11-11 枣庄赛诺康生化股份有限公司 Decoloration method for enoxaparin sodium intermediate
CN103342761B (en) 2013-07-15 2016-01-06 河北常山生化药业股份有限公司 A kind of membrane sepn prepares Enoxaparin Sodium technique
CN105985454A (en) 2015-02-06 2016-10-05 苏州英诺凯生物医药科技有限公司 Method for purifying enoxaparin

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090105194A1 (en) * 2005-05-09 2009-04-23 Universitetet For Miljo-Og Biovitenskap Process for the production of a low molecular weight heparin
CN102731683A (en) * 2012-07-17 2012-10-17 湖北亿诺瑞生物制药有限公司 Method of separating natural low molecular heparin from heparin waste liquor
CN103936889A (en) * 2014-03-19 2014-07-23 苏州英诺凯生物医药科技有限公司 Method for purification of enoxaparin by tangential flow filtration

Also Published As

Publication number Publication date
SG11202111009WA (en) 2021-11-29
US20220112315A1 (en) 2022-04-14
IL286931A (en) 2021-10-31
BR112021020048A2 (en) 2021-12-07
JP7550787B2 (en) 2024-09-13
ES2888148B2 (en) 2022-11-14
JP2022530321A (en) 2022-06-29
CO2021013320A2 (en) 2022-03-18
GEP20247598B (en) 2024-02-26
ES2888148A1 (en) 2021-12-30
IL286931B1 (en) 2024-11-01
ZA202109022B (en) 2023-10-25
AU2020263142A1 (en) 2021-10-28
PH12021552600A1 (en) 2022-07-11
EP3943513A4 (en) 2022-12-21
MA55388A (en) 2022-01-26
PE20212330A1 (en) 2021-12-14
EP3943513A1 (en) 2022-01-26
KR20220005441A (en) 2022-01-13
WO2020216981A1 (en) 2020-10-29
CA3134458C (en) 2023-11-21
CL2021002647A1 (en) 2022-05-13
MX2021011671A (en) 2021-10-22
CA3134458A1 (en) 2020-10-29

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