IL277240B1 - Preparative process of two 4-{[(2s)-2-{4-[5-chloro-2-(1h-1,2,3-triazol-1-yl)phenyl]-5-methoxy-2-oxopyridin-1(2h)-yl}butanoyl]amino}-2-fluorobenzamide derivatives - Google Patents

Preparative process of two 4-{[(2s)-2-{4-[5-chloro-2-(1h-1,2,3-triazol-1-yl)phenyl]-5-methoxy-2-oxopyridin-1(2h)-yl}butanoyl]amino}-2-fluorobenzamide derivatives

Info

Publication number: IL277240B1
Authority: IL; Israel
Prior art keywords: oxopyridin; butanoyl; triazol; chloro; methoxy
Prior art date: 2018-03-15

Application number

IL277240A

Other languages

Hebrew (he)

Other versions

IL277240B2 (en

IL277240A (en

Original Assignee

Bayer Ag

Bayer Pharma AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2018-03-15

Filing date

2020-09-09

Publication date

2023-09-01

2019-03-08 Application filed by Bayer Ag, Bayer Pharma AG filed Critical Bayer Ag

2020-10-29 Publication of IL277240A publication Critical patent/IL277240A/en

2023-09-01 Publication of IL277240B1 publication Critical patent/IL277240B1/en

2024-01-01 Publication of IL277240B2 publication Critical patent/IL277240B2/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

IL277240A 2018-03-15 2019-03-08 Process for the preparation of two derivatives of 4-{[(2S)-2-{4-[5-chloro-2-(1H-3,2,1-triazol-1-yl)phenyl]-5-methoxy-2-oxopyridine -1-(2H)-yl}butenoyl]amino}-2-fluorobenzamide IL277240B2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP18161983		2018-03-15
PCT/EP2019/055815 WO2019175043A1 (en)	2018-03-15	2019-03-08	Preparative process of two 4-{[(2s)-2-{4-[5-chloro-2-(1h-1,2,3-triazol-1-yl)phenyl]-5-methoxy-2-oxopyridin-1(2h)-yl}butanoyl]amino}-2-fluorobenzamide derivatives

Publications (3)

Publication Number	Publication Date
IL277240A IL277240A (en)	2020-10-29
IL277240B1 true IL277240B1 (en)	2023-09-01
IL277240B2 IL277240B2 (en)	2024-01-01

Family

ID=61683650

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL277240A IL277240B2 (en)	2018-03-15	2019-03-08	Process for the preparation of two derivatives of 4-{[(2S)-2-{4-[5-chloro-2-(1H-3,2,1-triazol-1-yl)phenyl]-5-methoxy-2-oxopyridine -1-(2H)-yl}butenoyl]amino}-2-fluorobenzamide
IL300463A IL300463A (en)	2018-03-15	2019-03-08	Preparative process of two 4-{[(2s)-2-{4-[5-chloro-2-(1h-1,2,3-triazol-1-yl)phenyl]-5-methoxy-2-oxopyridin-1(2h)-yl}butanoyl]amino}-2-fluorobenzamide derivatives

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL300463A IL300463A (en)	2018-03-15	2019-03-08	Preparative process of two 4-{[(2s)-2-{4-[5-chloro-2-(1h-1,2,3-triazol-1-yl)phenyl]-5-methoxy-2-oxopyridin-1(2h)-yl}butanoyl]amino}-2-fluorobenzamide derivatives

Country Status (28)

Country	Link
US (1)	US11542245B2 (en)
EP (2)	EP3889147A1 (en)
JP (1)	JP7287978B2 (en)
KR (1)	KR20200131241A (en)
CN (1)	CN111770917B (en)
AR (1)	AR117400A1 (en)
AU (1)	AU2019236369B2 (en)
BR (1)	BR112020018562A2 (en)
CA (1)	CA3093733A1 (en)
CL (1)	CL2020002371A1 (en)
DK (1)	DK3765452T3 (en)
ES (1)	ES2920449T3 (en)
HR (1)	HRP20220565T1 (en)
HU (1)	HUE058796T2 (en)
IL (2)	IL277240B2 (en)
JO (1)	JOP20200232B1 (en)
LT (1)	LT3765452T (en)
MX (1)	MX2020009580A (en)
PE (1)	PE20211395A1 (en)
PL (1)	PL3765452T3 (en)
PT (1)	PT3765452T (en)
RS (1)	RS63338B1 (en)
SG (1)	SG11202006710RA (en)
SI (1)	SI3765452T1 (en)
TW (1)	TWI823911B (en)
UA (1)	UA126940C2 (en)
UY (1)	UY38147A (en)
WO (1)	WO2019175043A1 (en)

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EP4304561A1 (en)	2021-03-09	2024-01-17	Bayer Aktiengesellschaft	Pharmaceutical dosage forms comprising (4s)-24-chloro-4-ethyl-73-fluoro-35-methoxy-32,5- dioxo-14-(trifluoromethyl)-32h-6-aza-3(4,1)-pyridina-1(1)-[1,2,3]triazola-2(1,2),7(1)- dibenzenaheptaphane-74-carboxamide
CA3212645A1 (en)	2021-03-09	2022-09-15	Bayer Aktiengesellschaft	Crystalline forms of (4s)-24-chloro-4-ethyl-73-fluoro-35-methoxy-32,5-dioxo-14-(trifluoromethyl)-32h-6-aza-3(4,1)-pyridina-1(1)-[1,2,3]triazola-2(1,2),7(1)-dibenzenaheptaphane-74-carboxamide
WO2022189280A1 (en)	2021-03-09	2022-09-15	Bayer Aktiengesellschaft	Solvates of (4s)-24-chloro-4-ethyl-73-fluoro-35-methoxy-32,5-dioxo-14-(trifluoro-methyl)-32 h-6- aza-3(4,1)-pyridina-1(1)-[1,2,3]triazola-2(1,2),7(1)-dibenzenaheptaphane-74-carboxamide
WO2023174399A1 (en) *	2022-03-18	2023-09-21	苏州晶云药物科技股份有限公司	Crystal form of substituted oxopyridine derivative and preparation method therefor
CN116262724A (en) *	2022-11-18	2023-06-16	成都施贝康生物医药科技有限公司	Novel oxo-pyridine compound and preparation method and application thereof
CN116262734A (en) *	2022-11-18	2023-06-16	成都施贝康生物医药科技有限公司	Novel oxo-pyridine compound and preparation method and application thereof
CN116262735A (en) *	2022-11-18	2023-06-16	成都施贝康生物医药科技有限公司	Novel oxo-pyridine compound and preparation method and application thereof
CN116262740A (en) *	2022-11-18	2023-06-16	成都施贝康生物医药科技有限公司	Novel oxo-pyridine compound and preparation method and application thereof
CN116082303B (en) *	2022-12-21	2025-02-25	成都施贝康生物医药科技有限公司	Novel oxopyridine compounds and their intermediates and applications
CN116621728A (en) *	2023-06-09	2023-08-22	成都施贝康生物医药科技有限公司	Novel preparation method and key intermediates of oxopyridine compounds
CN116751136A (en) *	2023-06-21	2023-09-15	成都施贝康生物医药科技有限公司	Novel preparation method of oxo-pyridine compound and key intermediate
CN116535392B (en) *	2023-06-26	2023-09-05	成都施贝康生物医药科技有限公司	Preparation method of oxo-pyridine compound, intermediate and application
WO2024251276A1 (en) *	2023-06-09	2024-12-12	成都施贝康生物医药科技有限公司	New method for preparing oxopyridine compound, and key intermediate and use
CN116621742A (en) *	2023-06-09	2023-08-22	成都施贝康生物医药科技有限公司	Novel preparation method of oxo-pyridine compound and key intermediate
CN116730861A (en) *	2023-06-21	2023-09-12	成都施贝康生物医药科技有限公司	Novel preparation methods and key intermediates of oxopyridine compounds
CN116874387A (en) *	2023-06-21	2023-10-13	成都施贝康生物医药科技有限公司	Novel preparation method of oxo-pyridine compound and key intermediate
CN117164561A (en) *	2023-09-07	2023-12-05	成都施贝康生物医药科技有限公司	Oxo pyrimidine compound and preparation method and application thereof
CN117164563A (en) *	2023-09-07	2023-12-05	成都施贝康生物医药科技有限公司	Novel oxo-pyrimidine compound and preparation method and application thereof
CN117164565A (en) *	2023-09-07	2023-12-05	成都施贝康生物医药科技有限公司	Novel oxo-pyrimidine compound and preparation method and application thereof
CN117164564A (en) *	2023-09-07	2023-12-05	成都施贝康生物医药科技有限公司	Novel oxopyridazine compound and preparation method and application thereof
CN117164562A (en) *	2023-09-07	2023-12-05	成都施贝康生物医药科技有限公司	Oxopyridazine compound and preparation method and application thereof
CN117164566A (en) *	2023-09-07	2023-12-05	成都施贝康生物医药科技有限公司	Novel oxopyridazine compound and preparation method and application thereof
CN117186073A (en) *	2023-09-08	2023-12-08	成都施贝康生物医药科技有限公司	New oxopyrimidine compounds and their preparation methods and uses

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2019
- 2019-03-08 KR KR1020207026104A patent/KR20200131241A/en active Pending
- 2019-03-08 JO JOP/2020/0232A patent/JOP20200232B1/en active
- 2019-03-08 WO PCT/EP2019/055815 patent/WO2019175043A1/en active Application Filing
- 2019-03-08 IL IL277240A patent/IL277240B2/en unknown
- 2019-03-08 SG SG11202006710RA patent/SG11202006710RA/en unknown
- 2019-03-08 CN CN201980016087.2A patent/CN111770917B/en active Active
- 2019-03-08 HR HRP20220565TT patent/HRP20220565T1/en unknown
- 2019-03-08 IL IL300463A patent/IL300463A/en unknown
- 2019-03-08 US US16/980,210 patent/US11542245B2/en active Active
- 2019-03-08 MX MX2020009580A patent/MX2020009580A/en unknown
- 2019-03-08 EP EP21169162.1A patent/EP3889147A1/en not_active Withdrawn
- 2019-03-08 RS RS20220611A patent/RS63338B1/en unknown
- 2019-03-08 JP JP2020548726A patent/JP7287978B2/en active Active
- 2019-03-08 AU AU2019236369A patent/AU2019236369B2/en active Active
- 2019-03-08 DK DK19708556.6T patent/DK3765452T3/en active
- 2019-03-08 ES ES19708556T patent/ES2920449T3/en active Active
- 2019-03-08 PT PT197085566T patent/PT3765452T/en unknown
- 2019-03-08 PL PL19708556.6T patent/PL3765452T3/en unknown
- 2019-03-08 PE PE2020001408A patent/PE20211395A1/en unknown
- 2019-03-08 CA CA3093733A patent/CA3093733A1/en active Pending
- 2019-03-08 HU HUE19708556A patent/HUE058796T2/en unknown
- 2019-03-08 UA UAA202006635A patent/UA126940C2/en unknown
- 2019-03-08 BR BR112020018562-0A patent/BR112020018562A2/en unknown
- 2019-03-08 EP EP19708556.6A patent/EP3765452B1/en active Active
- 2019-03-08 LT LTEPPCT/EP2019/055815T patent/LT3765452T/en unknown
- 2019-03-08 SI SI201930224T patent/SI3765452T1/en unknown
- 2019-03-13 TW TW108108373A patent/TWI823911B/en active
- 2019-03-15 UY UY38147A patent/UY38147A/en unknown
- 2019-03-15 AR ARP190100659A patent/AR117400A1/en unknown
2020
- 2020-09-14 CL CL2020002371A patent/CL2020002371A1/en unknown

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Also Published As

Publication number	Publication date
HUE058796T2 (en)	2022-09-28
PL3765452T3 (en)	2022-08-01
ES2920449T3 (en)	2022-08-04
US20210017152A1 (en)	2021-01-21
HRP20220565T1 (en)	2022-06-10
TWI823911B (en)	2023-12-01
JOP20200232A1 (en)	2020-09-14
EP3765452A1 (en)	2021-01-20
AR117400A1 (en)	2021-08-04
CA3093733A1 (en)	2019-09-19
JP2021517573A (en)	2021-07-26
AU2019236369A1 (en)	2020-07-30
AU2019236369B2 (en)	2024-04-18
JP7287978B2 (en)	2023-06-06
BR112020018562A2 (en)	2020-12-29
KR20200131241A (en)	2020-11-23
CN111770917B (en)	2023-09-26
WO2019175043A1 (en)	2019-09-19
IL277240B2 (en)	2024-01-01
MX2020009580A (en)	2020-10-05
UY38147A (en)	2019-10-01
RS63338B1 (en)	2022-07-29
CL2020002371A1 (en)	2021-01-29
UA126940C2 (en)	2023-02-22
CN111770917A (en)	2020-10-13
EP3889147A1 (en)	2021-10-06
US11542245B2 (en)	2023-01-03
IL300463A (en)	2023-04-01
RU2020133706A (en)	2022-04-18
SI3765452T1 (en)	2022-06-30
LT3765452T (en)	2022-05-25
DK3765452T3 (en)	2022-06-27
EP3765452B1 (en)	2022-04-13
PE20211395A1 (en)	2021-07-27
SG11202006710RA (en)	2020-08-28
JOP20200232B1 (en)	2023-09-17
TW202002969A (en)	2020-01-16
PT3765452T (en)	2022-06-23
IL277240A (en)	2020-10-29

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