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IL218712A - Iminothiadiazine dioxide compounds, compositions comprising same and use thereof - Google Patents

Iminothiadiazine dioxide compounds, compositions comprising same and use thereof

Info

Publication number
IL218712A
IL218712A IL218712A IL21871212A IL218712A IL 218712 A IL218712 A IL 218712A IL 218712 A IL218712 A IL 218712A IL 21871212 A IL21871212 A IL 21871212A IL 218712 A IL218712 A IL 218712A
Authority
IL
Israel
Prior art keywords
compositions
same
dioxide compounds
iminothiadiazine dioxide
iminothiadiazine
Prior art date
Application number
IL218712A
Other languages
Hebrew (he)
Other versions
IL218712A0 (en
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43857101&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL218712(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of IL218712A0 publication Critical patent/IL218712A0/en
Publication of IL218712A publication Critical patent/IL218712A/en

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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    • C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
    • C—CHEMISTRY; METALLURGY
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/12—Nitrogen atoms not forming part of a nitro radical
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IL218712A 2009-10-08 2012-03-18 Iminothiadiazine dioxide compounds, compositions comprising same and use thereof IL218712A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24968509P 2009-10-08 2009-10-08
PCT/US2010/051553 WO2011044181A1 (en) 2009-10-08 2010-10-06 Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use

Publications (2)

Publication Number Publication Date
IL218712A0 IL218712A0 (en) 2012-05-31
IL218712A true IL218712A (en) 2015-07-30

Family

ID=43857101

Family Applications (3)

Application Number Title Priority Date Filing Date
IL218712A IL218712A (en) 2009-10-08 2012-03-18 Iminothiadiazine dioxide compounds, compositions comprising same and use thereof
IL230926A IL230926A (en) 2009-10-08 2014-02-11 Iminothiadiazine dioxide compounds as bace inhibitors, compositions comprising them and their use
IL239833A IL239833A0 (en) 2009-10-08 2015-07-08 Iminothiadiazine dioxide compounds, compositions comprising same and use thereof

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL230926A IL230926A (en) 2009-10-08 2014-02-11 Iminothiadiazine dioxide compounds as bace inhibitors, compositions comprising them and their use
IL239833A IL239833A0 (en) 2009-10-08 2015-07-08 Iminothiadiazine dioxide compounds, compositions comprising same and use thereof

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US (6) US8729071B2 (en)
EP (2) EP3034080B1 (en)
JP (4) JP5592494B2 (en)
KR (3) KR101646424B1 (en)
CN (2) CN102639135B (en)
AR (1) AR078534A1 (en)
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DO (1) DOP2012000067A (en)
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IL (3) IL218712A (en)
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