IL202262A0 - Bicycloaniline derivative - Google Patents
Bicycloaniline derivativeInfo
- Publication number
- IL202262A0 IL202262A0 IL202262A IL20226209A IL202262A0 IL 202262 A0 IL202262 A0 IL 202262A0 IL 202262 A IL202262 A IL 202262A IL 20226209 A IL20226209 A IL 20226209A IL 202262 A0 IL202262 A0 IL 202262A0
- Authority
- IL
- Israel
- Prior art keywords
- bicycloaniline
- derivative
- bicycloaniline derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007159217 | 2007-06-15 | ||
| US96591807P | 2007-08-23 | 2007-08-23 | |
| PCT/JP2008/061182 WO2008153207A1 (fr) | 2007-06-15 | 2008-06-12 | Dérivé d'aniline bicyclique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL202262A0 true IL202262A0 (en) | 2010-06-16 |
Family
ID=40129803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL202262A IL202262A0 (en) | 2007-06-15 | 2009-11-22 | Bicycloaniline derivative |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8436004B2 (fr) |
| EP (1) | EP2168966B1 (fr) |
| JP (1) | JP5129812B2 (fr) |
| KR (1) | KR20100024932A (fr) |
| CN (1) | CN101784551A (fr) |
| AU (1) | AU2008262837B2 (fr) |
| CA (1) | CA2689429C (fr) |
| CY (1) | CY1118448T1 (fr) |
| DK (1) | DK2168966T3 (fr) |
| ES (1) | ES2608940T3 (fr) |
| HR (1) | HRP20161536T1 (fr) |
| HU (1) | HUE032403T2 (fr) |
| IL (1) | IL202262A0 (fr) |
| LT (1) | LT2168966T (fr) |
| MX (1) | MX2009013728A (fr) |
| NZ (1) | NZ581936A (fr) |
| PL (1) | PL2168966T3 (fr) |
| PT (1) | PT2168966T (fr) |
| RU (1) | RU2010101052A (fr) |
| SI (1) | SI2168966T1 (fr) |
| WO (1) | WO2008153207A1 (fr) |
| ZA (1) | ZA200908298B (fr) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009126527A1 (fr) * | 2008-04-07 | 2009-10-15 | Cv Therapeutics, Inc. | Dérivés de 2h-benzo[b][1,4]oxazin-3(4h)-one à utiliser comme inhibiteurs de la stéaroyl-coa désaturase |
| EP2303885B1 (fr) * | 2008-06-12 | 2013-07-03 | Merck Sharp & Dohme Corp. | Procédé de production de dérivés de bicycloaniline |
| AU2009325398A1 (en) | 2008-12-12 | 2010-06-17 | Msd K.K. | Dihydropyrimidopyrimidine derivative |
| AU2009325400A1 (en) * | 2008-12-12 | 2010-06-17 | Msd K.K. | Dihydropyrimidopyrimidine derivatives |
| EP2401281A4 (fr) * | 2009-02-25 | 2012-08-15 | Msd Kk | Dérivé de pyrimido-pyrimido-indazole |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| US8796289B2 (en) | 2011-07-19 | 2014-08-05 | Abbvie Inc. | Pyridazino[4,5-D]pyrimidin-5(6H)-one inhibitors of kinases |
| WO2013039854A1 (fr) | 2011-09-15 | 2013-03-21 | Merck Sharp & Dohme Corp. | Compositions et méthodes de traitement du cancer |
| ME03300B (fr) | 2012-06-13 | 2019-07-20 | Incyte Holdings Corp | Composés tricycliques substitués servant d'inhibiteurs des fgfr |
| CN103113311A (zh) * | 2012-07-19 | 2013-05-22 | 南京邮电大学 | 一类2-芳基喹唑啉或2-杂环芳基喹唑啉衍生物及其制备方法 |
| WO2014026125A1 (fr) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Dérivés de pyrazine en tant qu'inhibiteurs de fgfr |
| BR112015012295A8 (pt) | 2012-11-28 | 2023-03-14 | Merck Sharp & Dohme | Uso de um inibidor de wee1, e, kit para identificar um paciente com câncer |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| ES2892423T3 (es) | 2013-03-15 | 2022-02-04 | Celgene Car Llc | Compuestos de heteroarilo y usos de los mismos |
| JP6576325B2 (ja) | 2013-03-15 | 2019-09-18 | セルジーン シーエーアール エルエルシー | ヘテロアリール化合物およびそれらの使用 |
| AR095464A1 (es) | 2013-03-15 | 2015-10-21 | Celgene Avilomics Res Inc | Compuestos de heteroarilo y usos de los mismos |
| UA120087C2 (uk) | 2013-04-19 | 2019-10-10 | Інсайт Холдинґс Корпорейшн | Біциклічні гетероцикли як інгібітори fgfr |
| GB201322602D0 (en) | 2013-12-19 | 2014-02-05 | Almac Discovery Ltd | Pharmaceutical compounds |
| CN104725333A (zh) * | 2013-12-20 | 2015-06-24 | 北京蓝贝望生物医药科技股份有限公司 | 一种新的氮杂环庚烷衍生物的制备方法 |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| WO2016134294A1 (fr) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| UA121669C2 (uk) | 2015-02-20 | 2020-07-10 | Інсайт Корпорейшн | Біциклічні гетероцикли як інгібітори fgfr |
| WO2017031116A1 (fr) * | 2015-08-18 | 2017-02-23 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Inhibiteurs de ku70/80 à petites molécules et utilisations associées |
| WO2017091473A1 (fr) * | 2015-11-24 | 2017-06-01 | Indiana University Research & Technology Corporation | Composition de blocage de l'angiogenèse |
| MX2019007189A (es) | 2016-12-20 | 2019-10-09 | Astrazeneca Ab | Compuestos de amino-triazolopiridina y su uso en el trataniento del cancer. |
| CN110678169A (zh) | 2017-03-31 | 2020-01-10 | 西雅图遗传学公司 | Chk1-抑制剂与weel-抑制剂的组合 |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| AU2018347307A1 (en) * | 2017-10-09 | 2020-04-23 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
| WO2019074979A1 (fr) | 2017-10-09 | 2019-04-18 | Girafpharma, Llc | Composés hétérocycliques et leurs utilisations |
| CN109810111B (zh) * | 2017-11-20 | 2023-10-27 | 上海医药集团股份有限公司 | 一种吡唑酮并嘧啶类化合物、其制备方法及应用 |
| MX2020011639A (es) | 2018-05-04 | 2021-02-15 | Incyte Corp | Sales de un inhibidor de receptores de factor de crecimiento de fibroblastos (fgfr). |
| SMT202400507T1 (it) | 2018-05-04 | 2025-01-14 | Incyte Corp | Forme solide di un inibitore di fgfr e procedimenti per preparare le stesse |
| WO2020185532A1 (fr) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Méthodes de traitement du cancer au moyen d'un inhibiteur de fgfr |
| WO2020210377A1 (fr) * | 2019-04-09 | 2020-10-15 | Nuvation Bio Inc. | Composés hétérocycliques et leurs utilisations |
| AU2020271837A1 (en) | 2019-04-09 | 2021-11-18 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
| WO2020210383A1 (fr) * | 2019-04-09 | 2020-10-15 | Nuvation Bio Inc. | Composés hétérocycliques et leurs utilisations |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| CN112442049A (zh) * | 2019-09-03 | 2021-03-05 | 微境生物医药科技(上海)有限公司 | 作为Wee1抑制剂的嘧啶衍生物 |
| US12122767B2 (en) | 2019-10-01 | 2024-10-22 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| BR112022007163A2 (pt) | 2019-10-14 | 2022-08-23 | Incyte Corp | Heterociclos bicíclicos como inibidores de fgfr |
| WO2021076728A1 (fr) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr |
| US20220387468A1 (en) | 2019-10-25 | 2022-12-08 | Astrazeneca Ab | Methods of treating cancer |
| CA3163875A1 (fr) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Heterocycles tricycliques en tant qu'inhibiteurs de fgfr |
| CN115151539A (zh) | 2019-12-04 | 2022-10-04 | 因赛特公司 | Fgfr抑制剂的衍生物 |
| WO2021146424A1 (fr) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr |
| CN116888107A (zh) * | 2021-02-19 | 2023-10-13 | 微境生物医药科技(上海)有限公司 | 作为Wee-1抑制剂的稠环化合物 |
| CA3215903A1 (fr) | 2021-04-12 | 2022-10-20 | Incyte Corporation | Polytherapie comprenant un inhibiteur de fgfr et un agent de ciblage de nectine-4 |
| EP4329815A1 (fr) | 2021-04-29 | 2024-03-06 | Novartis AG | Chimères ciblant la désubiquitinase et procédés associés |
| CN117222648A (zh) * | 2021-04-30 | 2023-12-12 | 微境生物医药科技(上海)有限公司 | 作为Wee-1抑制剂的稠环化合物及其制备方法和用途 |
| TW202313611A (zh) | 2021-06-09 | 2023-04-01 | 美商英塞特公司 | 作為ｆｇｆｒ抑制劑之三環雜環 |
| AR128711A1 (es) | 2022-03-07 | 2024-06-05 | Debiopharm Int Sa | Métodos para tratar carcinoma microcítico de pulmón |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP2000001964A0 (en) * | 1998-05-26 | 2000-12-31 | Warner Lambert Co | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation. |
| AU2001233028A1 (en) * | 2000-03-06 | 2001-10-03 | Warner-Lambert Company | 5-alkylpyrido(2,3-D)pyrimidines tyrosine kinase inhibitors |
| DE10228103A1 (de) | 2002-06-24 | 2004-01-15 | Bayer Cropscience Ag | Fungizide Wirkstoffkombinationen |
| PA8577501A1 (es) * | 2002-07-25 | 2004-02-07 | Warner Lambert Co | Inhibidores de quinasas |
| TW200413381A (en) * | 2002-11-04 | 2004-08-01 | Hoffmann La Roche | Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents |
| DE50306066D1 (de) * | 2002-11-15 | 2007-02-01 | Basf Ag | Fungizide mischungen zur bekämpfung von reispathogenen |
| US7563748B2 (en) | 2003-06-23 | 2009-07-21 | Cognis Ip Management Gmbh | Alcohol alkoxylate carriers for pesticide active ingredients |
| TW200530235A (en) * | 2003-12-24 | 2005-09-16 | Renovis Inc | Bicycloheteroarylamine compounds as ion channel ligands and uses thereof |
| RU2346996C2 (ru) | 2004-06-29 | 2009-02-20 | ЮРОПИЭН НИКЕЛЬ ПиЭлСи | Усовершенствованное выщелачивание основных металлов |
| FR2873118B1 (fr) * | 2004-07-15 | 2007-11-23 | Sanofi Synthelabo | Derives de pyrido-pyrimidine, leur application en therapeutique |
| JP2008518883A (ja) | 2004-09-21 | 2008-06-05 | エフ．ホフマン−ラ ロシュ アーゲー | タンパク質キナーゼ阻害剤として有用な６−（２−アルキル−フェニル）−ピリド［２，３−ｄ］ピリミジン |
| ATE498358T1 (de) | 2005-06-29 | 2011-03-15 | Compumedics Ltd | Sensoranordnung mit leitfähiger brücke |
| NZ570530A (en) | 2006-02-14 | 2011-09-30 | Vertex Pharma | Pharmaceutical compositions comprising 6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4)diazepine derivatives |
-
2008
- 2008-06-12 RU RU2010101052/04A patent/RU2010101052A/ru not_active Application Discontinuation
- 2008-06-12 NZ NZ581936A patent/NZ581936A/en unknown
- 2008-06-12 MX MX2009013728A patent/MX2009013728A/es not_active Application Discontinuation
- 2008-06-12 ES ES08777358.6T patent/ES2608940T3/es active Active
- 2008-06-12 JP JP2009519343A patent/JP5129812B2/ja active Active
- 2008-06-12 EP EP08777358.6A patent/EP2168966B1/fr active Active
- 2008-06-12 KR KR1020097026035A patent/KR20100024932A/ko not_active Application Discontinuation
- 2008-06-12 LT LTEP08777358.6T patent/LT2168966T/lt unknown
- 2008-06-12 HU HUE08777358A patent/HUE032403T2/en unknown
- 2008-06-12 PT PT87773586T patent/PT2168966T/pt unknown
- 2008-06-12 WO PCT/JP2008/061182 patent/WO2008153207A1/fr active Application Filing
- 2008-06-12 SI SI200831719A patent/SI2168966T1/sl unknown
- 2008-06-12 CN CN200880103594A patent/CN101784551A/zh active Pending
- 2008-06-12 AU AU2008262837A patent/AU2008262837B2/en active Active
- 2008-06-12 DK DK08777358.6T patent/DK2168966T3/en active
- 2008-06-12 CA CA2689429A patent/CA2689429C/fr active Active
- 2008-06-12 PL PL08777358T patent/PL2168966T3/pl unknown
- 2008-06-12 US US12/663,729 patent/US8436004B2/en active Active
-
2009
- 2009-11-22 IL IL202262A patent/IL202262A0/en unknown
- 2009-11-24 ZA ZA200908298A patent/ZA200908298B/xx unknown
-
2016
- 2016-11-21 HR HRP20161536TT patent/HRP20161536T1/hr unknown
- 2016-12-27 CY CY20161101346T patent/CY1118448T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2010101052A (ru) | 2011-07-20 |
| AU2008262837B2 (en) | 2013-05-23 |
| CN101784551A (zh) | 2010-07-21 |
| NZ581936A (en) | 2011-08-26 |
| AU2008262837A1 (en) | 2008-12-18 |
| EP2168966A1 (fr) | 2010-03-31 |
| US20110135601A1 (en) | 2011-06-09 |
| ZA200908298B (en) | 2010-08-25 |
| DK2168966T3 (en) | 2017-01-23 |
| EP2168966A4 (fr) | 2011-02-16 |
| HRP20161536T1 (hr) | 2016-12-30 |
| HUE032403T2 (en) | 2017-09-28 |
| PL2168966T3 (pl) | 2017-06-30 |
| US8436004B2 (en) | 2013-05-07 |
| ES2608940T3 (es) | 2017-04-17 |
| CY1118448T1 (el) | 2017-06-28 |
| EP2168966B1 (fr) | 2016-09-28 |
| LT2168966T (lt) | 2017-01-10 |
| SI2168966T1 (sl) | 2017-03-31 |
| JPWO2008153207A1 (ja) | 2010-08-26 |
| CA2689429C (fr) | 2012-08-21 |
| JP5129812B2 (ja) | 2013-01-30 |
| WO2008153207A1 (fr) | 2008-12-18 |
| MX2009013728A (es) | 2010-01-25 |
| KR20100024932A (ko) | 2010-03-08 |
| CA2689429A1 (fr) | 2008-12-18 |
| PT2168966T (pt) | 2017-01-02 |
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