IL189498A0 - Cleavage of antifolate compounds - Google Patents
Cleavage of antifolate compoundsInfo
- Publication number
- IL189498A0 IL189498A0 IL189498A IL18949808A IL189498A0 IL 189498 A0 IL189498 A0 IL 189498A0 IL 189498 A IL189498 A IL 189498A IL 18949808 A IL18949808 A IL 18949808A IL 189498 A0 IL189498 A0 IL 189498A0
- Authority
- IL
- Israel
- Prior art keywords
- cleavage
- antifolate compounds
- antifolate
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2005/003297 WO2007023243A2 (en) | 2005-08-24 | 2005-08-24 | Cleavage of antifolate compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL189498A0 true IL189498A0 (en) | 2008-06-05 |
Family
ID=36615646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL189498A IL189498A0 (en) | 2005-08-24 | 2008-02-13 | Cleavage of antifolate compounds |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1917027A2 (en) |
| AU (1) | AU2005335876A1 (en) |
| BR (1) | BRPI0520493A2 (en) |
| CA (1) | CA2619992A1 (en) |
| IL (1) | IL189498A0 (en) |
| MX (1) | MX2008002648A (en) |
| WO (1) | WO2007023243A2 (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2349274A4 (en) | 2008-09-17 | 2014-12-17 | Endocyte Inc | FOLAT RECEPTOR BINDING CONJUGATES OF ANTIFOLATES |
| JP5739820B2 (en) | 2008-12-30 | 2015-06-24 | アークル インコーポレイテッド | Substituted 5,6-dihydro-6-phenylbenzo [f] isoquinolin-2-amine compounds |
| US20170239250A1 (en) | 2016-02-19 | 2017-08-24 | Eagle Pharmaceuticals, Inc. | Pemetrexed formulations |
| MX2019001755A (en) | 2016-08-12 | 2019-05-09 | L E A F Holdings Group Llc | Polyglutamated antifolates and uses thereof. |
| WO2018031968A1 (en) | 2016-08-12 | 2018-02-15 | L.E.A.F. Holdings Group Llc | Alpha and gamma-d polyglutamated antifolates and uses thereof |
| WO2019157146A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated antifolates and uses thereof |
| EP3749316A4 (en) | 2018-02-07 | 2021-10-27 | L.E.A.F Holdings Group LLC | Alpha polyglutamated pralatrexate and uses thereof |
| CA3090509A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated methotrexate and uses thereof |
| EP3749311A4 (en) * | 2018-02-07 | 2022-07-06 | L.E.A.F Holdings Group LLC | GAMMA POLYGLUTAMATED PEMETREXED AND USES THEREOF |
| CA3090391A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated raltitrexed and uses thereof |
| US12220431B2 (en) | 2018-02-07 | 2025-02-11 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated antifolates and uses thereof |
| EP3749315A4 (en) | 2018-02-07 | 2022-06-22 | L.E.A.F Holdings Group LLC | Alpha polyglutamated raltitrexed and uses thereof |
| WO2019157121A1 (en) * | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated lometrexol and uses thereof |
| JP7491572B2 (en) | 2018-02-07 | 2024-05-28 | エル．イー．エー．エフ． ホールディングス グループ エルエルシー | Alpha polyglutamated pemetrexed and uses thereof |
| WO2019160735A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated tetrahydrofolates and uses thereof |
| EP3752157A4 (en) | 2018-02-14 | 2022-07-06 | L.E.A.F Holdings Group LLC | Gamma polyglutamated lometrexol and uses thereof |
| WO2019160736A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated pralatrexate and uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0404487D0 (en) * | 2004-02-28 | 2004-03-31 | Protherics Molecular Design Lt | Use of enzyme |
-
2005
- 2005-08-24 BR BRPI0520493-3A patent/BRPI0520493A2/en not_active Application Discontinuation
- 2005-08-24 WO PCT/GB2005/003297 patent/WO2007023243A2/en active Application Filing
- 2005-08-24 AU AU2005335876A patent/AU2005335876A1/en not_active Abandoned
- 2005-08-24 MX MX2008002648A patent/MX2008002648A/en unknown
- 2005-08-24 CA CA002619992A patent/CA2619992A1/en not_active Abandoned
- 2005-08-24 EP EP05775448A patent/EP1917027A2/en not_active Withdrawn
-
2008
- 2008-02-13 IL IL189498A patent/IL189498A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007023243A3 (en) | 2007-09-07 |
| MX2008002648A (en) | 2008-03-14 |
| CA2619992A1 (en) | 2007-03-01 |
| BRPI0520493A2 (en) | 2009-05-12 |
| AU2005335876A1 (en) | 2007-03-01 |
| EP1917027A2 (en) | 2008-05-07 |
| WO2007023243A2 (en) | 2007-03-01 |
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