IL163812A0 - Immunizing composition and method for inducing an immune response against the -secretase cleavage site of amyloid precursor protein - Google Patents

Immunizing composition and method for inducing an immune response against the -secretase cleavage site of amyloid precursor protein

Info

Publication number: IL163812A0
Authority: IL; Israel
Prior art keywords: inducing; immune response; cleavage site; response against; precursor protein
Prior art date: 2002-03-05

Application number

IL16381203A

Other languages

English (en)

Original Assignee

Univ Ramot

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-05

Filing date

2003-03-04

Publication date

2005-12-18

2003-03-04 Application filed by Univ Ramot filed Critical Univ Ramot

2005-12-18 Publication of IL163812A0 publication Critical patent/IL163812A0/xx

Links

101710137189 Amyloid-beta A4 protein Proteins 0.000 title 1
101710151993 Amyloid-beta precursor protein Proteins 0.000 title 1
102100022704 Amyloid-beta precursor protein Human genes 0.000 title 1
DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 title 1
238000003776 cleavage reaction Methods 0.000 title 1
230000028993 immune response Effects 0.000 title 1
230000003053 immunization Effects 0.000 title 1
230000001939 inductive effect Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
230000007017 scission Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0007—Nervous system antigens; Prions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
- A61K2039/645—Dendrimers; Multiple antigen peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Microbiology (AREA)
Mycology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicinal Preparation (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

IL16381203A 2002-03-05 2003-03-04 Immunizing composition and method for inducing an immune response against the -secretase cleavage site of amyloid precursor protein IL163812A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US36134402P	2002-03-05	2002-03-05
PCT/US2003/006388 WO2003076455A2 (en)	2002-03-05	2003-03-04	Immunizing composition and method for inducing an immune response against the ss-secretase cleavage site of amyloid precursor protein

Publications (1)

Publication Number	Publication Date
IL163812A0 true IL163812A0 (en)	2005-12-18

Family

ID=27805031

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
IL16381203A IL163812A0 (en)	2002-03-05	2003-03-04	Immunizing composition and method for inducing an immune response against the -secretase cleavage site of amyloid precursor protein
IL163812A IL163812A (en)	2002-03-05	2004-08-30	Immunizing composition, antigenic product and isolated antigenic peptide for inducing an immune response against beta-secretase cleavage site of amyloid the precursor protein
IL212752A IL212752A (en)	2002-03-05	2011-05-08	Molecule Targeted Against Fission Site by ß - Pre-amyloid Protein Secretion and Its Uses

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
IL163812A IL163812A (en)	2002-03-05	2004-08-30	Immunizing composition, antigenic product and isolated antigenic peptide for inducing an immune response against beta-secretase cleavage site of amyloid the precursor protein
IL212752A IL212752A (en)	2002-03-05	2011-05-08	Molecule Targeted Against Fission Site by ß - Pre-amyloid Protein Secretion and Its Uses

Country Status (8)

Country	Link
US (3)	US7494655B2 (de)
EP (2)	EP1480666B1 (de)
JP (3)	JP2005532276A (de)
AU (1)	AU2003225636A1 (de)
CA (1)	CA2477675C (de)
ES (1)	ES2392247T3 (de)
IL (3)	IL163812A0 (de)
WO (1)	WO2003076455A2 (de)

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2003
- 2003-03-04 AU AU2003225636A patent/AU2003225636A1/en not_active Abandoned
- 2003-03-04 IL IL16381203A patent/IL163812A0/xx unknown
- 2003-03-04 JP JP2003574670A patent/JP2005532276A/ja active Pending
- 2003-03-04 US US10/506,665 patent/US7494655B2/en not_active Expired - Fee Related
- 2003-03-04 EP EP03744143A patent/EP1480666B1/de not_active Expired - Lifetime
- 2003-03-04 CA CA2477675A patent/CA2477675C/en not_active Expired - Fee Related
- 2003-03-04 EP EP10185941A patent/EP2292247A3/de not_active Withdrawn
- 2003-03-04 ES ES03744143T patent/ES2392247T3/es not_active Expired - Lifetime
- 2003-03-04 WO PCT/US2003/006388 patent/WO2003076455A2/en not_active Ceased
2004
- 2004-08-30 IL IL163812A patent/IL163812A/en not_active IP Right Cessation
2007
- 2007-04-03 US US11/695,948 patent/US7854931B2/en not_active Expired - Fee Related
2010
- 2010-05-18 JP JP2010114047A patent/JP2010248197A/ja active Pending
- 2010-12-06 US US12/961,248 patent/US8613928B2/en not_active Expired - Fee Related
2011
- 2011-05-08 IL IL212752A patent/IL212752A/en not_active IP Right Cessation
2013
- 2013-05-21 JP JP2013107244A patent/JP5717210B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20060034855A1 (en)	2006-02-16
IL212752A0 (en)	2011-07-31
US20110070249A1 (en)	2011-03-24
US7854931B2 (en)	2010-12-21
WO2003076455A2 (en)	2003-09-18
AU2003225636A8 (en)	2003-09-22
EP1480666A4 (de)	2006-06-07
JP2010248197A (ja)	2010-11-04
EP1480666B1 (de)	2012-06-13
JP5717210B2 (ja)	2015-05-13
JP2005532276A (ja)	2005-10-27
WO2003076455A3 (en)	2004-04-08
US7494655B2 (en)	2009-02-24
CA2477675A1 (en)	2003-09-18
EP1480666A2 (de)	2004-12-01
US20070172484A1 (en)	2007-07-26
IL212752A (en)	2014-01-30
EP2292247A2 (de)	2011-03-09
CA2477675C (en)	2013-05-21
IL163812A (en)	2011-06-30
JP2013181034A (ja)	2013-09-12
ES2392247T3 (es)	2012-12-07
AU2003225636A1 (en)	2003-09-22
EP2292247A3 (de)	2011-10-05
US8613928B2 (en)	2013-12-24

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