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IL162482A - Use of il6-r/il-6 chimera in the manufacture of a medicament for treatment of neuron loss - Google Patents

Use of il6-r/il-6 chimera in the manufacture of a medicament for treatment of neuron loss

Info

Publication number
IL162482A
IL162482A IL162482A IL16248204A IL162482A IL 162482 A IL162482 A IL 162482A IL 162482 A IL162482 A IL 162482A IL 16248204 A IL16248204 A IL 16248204A IL 162482 A IL162482 A IL 162482A
Authority
IL
Israel
Prior art keywords
chimera
manufacture
treatment
medicament
neuron loss
Prior art date
Application number
IL162482A
Other languages
Hebrew (he)
Inventor
Michel Revel
Shalom Haggiag
Judith Chebath
Alon Levy
Peilin Zhang
Original Assignee
Yeda Res & Dev
Michel Revel
Shalom Haggiag
Judith Chebath
Alon Levy
Peilin Zhang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev, Michel Revel, Shalom Haggiag, Judith Chebath, Alon Levy, Peilin Zhang filed Critical Yeda Res & Dev
Priority to IL162482A priority Critical patent/IL162482A/en
Publication of IL162482A publication Critical patent/IL162482A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/204—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention provides for the use of IL6R/IL6 chimera for the manufacture of medicaments for the treatment of neurological diseases and disorders.
IL162482A 2001-12-31 2004-06-13 Use of il6-r/il-6 chimera in the manufacture of a medicament for treatment of neuron loss IL162482A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL162482A IL162482A (en) 2001-12-31 2004-06-13 Use of il6-r/il-6 chimera in the manufacture of a medicament for treatment of neuron loss

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL14741201A IL147412A0 (en) 2001-12-31 2001-12-31 The use of il6r/il6 chimera in nerve cell regeneration
PCT/IL2002/001058 WO2003059376A1 (en) 2001-12-31 2002-12-31 The use of il6r/il6 chimera in nerve cell regeneration
IL162482A IL162482A (en) 2001-12-31 2004-06-13 Use of il6-r/il-6 chimera in the manufacture of a medicament for treatment of neuron loss

Publications (1)

Publication Number Publication Date
IL162482A true IL162482A (en) 2013-06-27

Family

ID=11075915

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14741201A IL147412A0 (en) 2001-12-31 2001-12-31 The use of il6r/il6 chimera in nerve cell regeneration
IL162482A IL162482A (en) 2001-12-31 2004-06-13 Use of il6-r/il-6 chimera in the manufacture of a medicament for treatment of neuron loss

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL14741201A IL147412A0 (en) 2001-12-31 2001-12-31 The use of il6r/il6 chimera in nerve cell regeneration

Country Status (8)

Country Link
US (1) US7824670B2 (en)
EP (1) EP1461066B1 (en)
JP (1) JP4685354B2 (en)
AU (1) AU2002361489B2 (en)
CA (1) CA2472203C (en)
ES (1) ES2535156T3 (en)
IL (2) IL147412A0 (en)
WO (1) WO2003059376A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2527847C (en) * 2003-06-12 2015-09-29 Yeda Research & Development Co. Ltd Enhancement of oligodendrocyte differentiation
IL157309A0 (en) 2003-08-07 2004-02-19 Applied Research Systems Method for the purification of a non-immunoglobulin protein
DK1784486T3 (en) * 2004-06-23 2012-01-16 Tissuegene Inc Nervous regeneration
SG177946A1 (en) * 2005-08-29 2012-02-28 Technion Res & Dev Foundation Media for culturing stem cells
PT2733203T (en) 2006-08-02 2019-01-23 Technion Res & Dev Foundation Methods of expanding embryonic stem cells in a suspension culture
GB0815216D0 (en) * 2008-08-21 2008-09-24 Asterion Ltd Interleukin
JP5749659B2 (en) * 2009-03-12 2015-07-15 ハーゼ インベストメンツ ウーゲー Bone morphogenetic protein 2 (BMP2) variant with reduced BMP antagonist sensitivity
WO2011041062A1 (en) * 2009-10-02 2011-04-07 University Of Southern California Cranial neural crest stem cells and culture condition that supports their growth
US20130143805A1 (en) * 2010-08-13 2013-06-06 Georgetown University Ggf2 and methods of use
RS61391B1 (en) 2012-06-08 2021-02-26 Alkermes Pharma Ireland Ltd Ligands modified by circular permutation as agonists and antagonists
WO2020006469A1 (en) * 2018-06-29 2020-01-02 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods for treating and reducing traumatic brain injury-associated impairments using sgp130
EP4196149A1 (en) * 2020-08-14 2023-06-21 Kite Pharma, Inc. Improving immune cell function

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0987198A (en) 1995-09-19 1997-03-31 Tosoh Corp Nerve cell extender
IL122818A0 (en) 1997-07-10 1998-08-16 Yeda Res & Dev Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof
IL130586A0 (en) * 1999-06-21 2000-06-01 Yeda Res & Dev IL6RIL6 chimera for the treatment of demyelinating diseases
US6749850B1 (en) * 1999-08-18 2004-06-15 The General Hospital Corporation Methods, compositions and kits for promoting recovery from damage to the central nervous system
WO2001076507A2 (en) * 2000-04-11 2001-10-18 The University Of Miami Use of oxygen carriers to improve grafted cell survival in neural transplantation
EP1317273B1 (en) 2000-09-14 2006-05-03 Ares Trading S.A. Use of il-6r/il-6 chimera in huntington's disease

Also Published As

Publication number Publication date
EP1461066A1 (en) 2004-09-29
AU2002361489B2 (en) 2008-05-08
US7824670B2 (en) 2010-11-02
JP4685354B2 (en) 2011-05-18
US20050220761A1 (en) 2005-10-06
IL147412A0 (en) 2002-08-14
AU2002361489A1 (en) 2003-07-30
EP1461066B1 (en) 2015-02-25
JP2005514442A (en) 2005-05-19
WO2003059376A1 (en) 2003-07-24
ES2535156T3 (en) 2015-05-05
CA2472203A1 (en) 2003-07-24
WO2003059376A8 (en) 2003-10-09
CA2472203C (en) 2014-02-18

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees