IL159494A0 - 6-2'-(phosphonomethoxy) alkoxy pyrimidine derivatives having antiviral activity - Google Patents

6-2'-(phosphonomethoxy) alkoxy pyrimidine derivatives having antiviral activity

Info

Publication number: IL159494A0
Authority: IL; Israel
Prior art keywords: phosphonomethoxy; antiviral activity; pyrimidine derivatives; alkoxy pyrimidine; alkoxy
Prior art date: 2001-06-29

Application number

IL15949402A

Other languages

English (en)

Original Assignee

Acad Of Science Czech Republic

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-29

Filing date

2002-06-28

Publication date

2004-06-01

2002-06-28 Application filed by Acad Of Science Czech Republic filed Critical Acad Of Science Czech Republic

2004-06-01 Publication of IL159494A0 publication Critical patent/IL159494A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
Biochemistry (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Biotechnology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IL15949402A 2001-06-29 2002-06-28 6-2'-(phosphonomethoxy) alkoxy pyrimidine derivatives having antiviral activity IL159494A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US30221201P	2001-06-29	2001-06-29
PCT/CZ2002/000038 WO2003002580A1 (en)	2001-06-29	2002-06-28	6-`2-(phosphonomethoxy)alkoxy pyrimidine derivatives having antiviral activity

Publications (1)

Publication Number	Publication Date
IL159494A0 true IL159494A0 (en)	2004-06-01

Family

ID=23166777

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL15949402A IL159494A0 (en)	2001-06-29	2002-06-28	6-2'-(phosphonomethoxy) alkoxy pyrimidine derivatives having antiviral activity
IL159494A IL159494A (en)	2001-06-29	2003-12-22	Derivatives 6 – '2– (phosphonomethoxy) alkoxy pyrimidine with antiviral activity

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL159494A IL159494A (en)	2001-06-29	2003-12-22	Derivatives 6 – '2– (phosphonomethoxy) alkoxy pyrimidine with antiviral activity

Country Status (21)

Country	Link
US (2)	US6818633B2 (xx)
EP (1)	EP1406911B1 (xx)
JP (1)	JP4545434B2 (xx)
KR (1)	KR100891366B1 (xx)
CN (1)	CN1329404C (xx)
AP (1)	AP1622A (xx)
AU (1)	AU2002315625B2 (xx)
BR (1)	BRPI0210746B8 (xx)
CA (1)	CA2452036C (xx)
CZ (1)	CZ297267B6 (xx)
EA (1)	EA006020B1 (xx)
ES (1)	ES2564144T3 (xx)
HU (1)	HU230519B1 (xx)
IL (2)	IL159494A0 (xx)
MX (1)	MXPA04000138A (xx)
NO (2)	NO333788B1 (xx)
NZ (1)	NZ530685A (xx)
PL (1)	PL207187B1 (xx)
TR (1)	TR200302288T2 (xx)
WO (1)	WO2003002580A1 (xx)
ZA (1)	ZA200400236B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2527805C (en) *	2003-06-16	2012-08-21	Institute Of Organic Chemistry And Biochemistry, Academy Of Sciences Of The Czech Republic	Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs
ES2401285T3 (es)	2004-12-16	2013-04-18	The Regents Of The University Of California	Fármacos con el pulmón como diana
US20060211650A1 (en) *	2004-12-16	2006-09-21	Forest Laboratories, Inc.	Reducing carbohydrate derivatives of adamantane amines, and synthesis and methods of use thereof
WO2007014352A2 (en) *	2005-07-27	2007-02-01	Gilead Sciences, Inc.	Antiviral phosphonate conjugates for inhibition of hiv
US7473683B2 (en)	2005-09-14	2009-01-06	The Board Of Trustees Of The Leland Stanford Junior University	Nonpolar thymidine analogs
WO2007047405A1 (en) *	2005-10-13	2007-04-26	Allergan, Inc.	Ddc compositions
FR2908133B1 (fr)	2006-11-08	2012-12-14	Centre Nat Rech Scient	Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux
JP5847296B2 (ja) *	2011-05-10	2016-01-20	アラタナセラピューティクスエンヴェー	ネコレトロウイルス感染症の治療に使用するための化合物
WO2014143643A1 (en)	2013-03-15	2014-09-18	The Regents Of The University Of California, A California Corporation	Acyclic nucleoside phosphonate diesters
CN104119385B (zh) *	2014-07-24	2017-04-05	廖国超	核苷类似物的磷酸酯前药及其应用
AU2015317972B2 (en)	2014-09-15	2019-10-17	The Regents Of The University Of California	Nucleotide analogs
WO2017048956A1 (en)	2015-09-15	2017-03-23	The Regents Of The University Of California	Nucleotide analogs
EP3784680A1 (en) *	2018-04-23	2021-03-03	Centre national de la recherche scientifique	New antiviral acyclonucleoside analogues

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CS233665B1 (en)	1983-01-06	1985-03-14	Antonin Holy	Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
CS263951B1 (en)	1985-04-25	1989-05-12	Antonin Holy	9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS263952B1 (en)	1985-04-25	1989-05-12	Holy Antonin	Remedy with antiviral effect
CS264222B1 (en)	1986-07-18	1989-06-13	Holy Antonin	N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
NZ222553A (en)	1986-11-18	1991-07-26	Bristol Myers Co	Phosphonomethoxyalkylene purine and pyrimidine derivatives and pharmaceutical compositions
CA2001715C (en)	1988-11-14	1999-12-28	Muzammil M. Mansuri	Carbocyclic nucleosides and nucleotides
CA2297294C (en) *	1989-05-15	2005-11-08	Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic	Phosphonomethoxymethylpurine/pyrimidine derivatives
MY104575A (en)	1989-12-22	1994-04-30	The Wellcome Foundation Ltd	Therapeutic nucleosides.
US5302585A (en)	1990-04-20	1994-04-12	Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic	Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
SK280313B6 (sk)	1990-04-24	1999-11-08	�Stav Organick� Chemie A Biochemie Av �R	N-(3-fluór-2-fosfonylmetoxypropyl)deriváty purínov
US5356886A (en)	1990-07-19	1994-10-18	Beecham Group P.L.C.	Antiviral phosphono-alken derivatives of purines
EP0468119A1 (en)	1990-07-24	1992-01-29	Merrell Dow Pharmaceuticals Inc.	Novel carbocyclic analogs of certain nucleosides
DK0481214T3 (da)	1990-09-14	1999-02-22	Acad Of Science Czech Republic	Prolægemidler af phosphonater
US5208221A (en)	1990-11-29	1993-05-04	Bristol-Myers Squibb Company	Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
CZ284678B6 (cs)	1991-05-20	1999-01-13	Ústav Organické Chemie A Biochemie Avčr	Di(2-propyl)estery 1-fluor-2-fosfonomethoxy-3-p -toluensulfonyloxypropanů, způsob jejich přípravy a použití
EP0531597A1 (en) *	1991-09-12	1993-03-17	Merrell Dow Pharmaceuticals Inc.	Novel unsaturated acyclic phosphonate derivatives of purine and pyrimidine
DE69218968T2 (de)	1991-10-11	1997-10-09	Inst Of Organic Chemistry And	Antivirale acyclische phosphonomethoxyalkyl substituierte, alkenyl und alkynyl purin und pyrimidin-derivate
US6057305A (en)	1992-08-05	2000-05-02	Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic	Antiretroviral enantiomeric nucleotide analogs
EP0618214A1 (en) *	1993-04-01	1994-10-05	Merrell Dow Pharmaceuticals Inc.	Unsaturated phosphonate derivatives of purines and pyrimidines
JP4086314B2 (ja)	1993-09-17	2008-05-14	ギリアードサイエンシーズ，インコーポレイテッド	ヌクレオチドアナログ
US5977061A (en)	1995-04-21	1999-11-02	Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic	N6 - substituted nucleotide analagues and their use

2002
- 2002-06-28 CZ CZ20040142A patent/CZ297267B6/cs not_active IP Right Cessation
- 2002-06-28 PL PL366852A patent/PL207187B1/pl unknown
- 2002-06-28 EA EA200400117A patent/EA006020B1/ru unknown
- 2002-06-28 KR KR1020037017181A patent/KR100891366B1/ko active IP Right Grant
- 2002-06-28 CA CA002452036A patent/CA2452036C/en not_active Expired - Lifetime
- 2002-06-28 ES ES02740215.5T patent/ES2564144T3/es not_active Expired - Lifetime
- 2002-06-28 BR BRPI0210746 patent/BRPI0210746B8/pt not_active IP Right Cessation
- 2002-06-28 NZ NZ530685A patent/NZ530685A/en not_active IP Right Cessation
- 2002-06-28 CN CNB028145712A patent/CN1329404C/zh not_active Expired - Lifetime
- 2002-06-28 WO PCT/CZ2002/000038 patent/WO2003002580A1/en active IP Right Grant
- 2002-06-28 JP JP2003508961A patent/JP4545434B2/ja not_active Expired - Lifetime
- 2002-06-28 MX MXPA04000138A patent/MXPA04000138A/es active IP Right Grant
- 2002-06-28 HU HU0400345A patent/HU230519B1/hu unknown
- 2002-06-28 TR TR2003/02288T patent/TR200302288T2/xx unknown
- 2002-06-28 IL IL15949402A patent/IL159494A0/xx active IP Right Grant
- 2002-06-28 AU AU2002315625A patent/AU2002315625B2/en not_active Expired
- 2002-06-28 EP EP02740215.5A patent/EP1406911B1/en not_active Expired - Lifetime
- 2002-06-28 US US10/187,166 patent/US6818633B2/en not_active Expired - Lifetime
- 2002-06-28 AP APAP/P/2004/002953A patent/AP1622A/en active
2003
- 2003-12-22 IL IL159494A patent/IL159494A/en unknown
- 2003-12-23 NO NO20035797A patent/NO333788B1/no not_active IP Right Cessation
2004
- 2004-01-13 ZA ZA200400236A patent/ZA200400236B/en unknown
- 2004-09-21 US US10/946,421 patent/US20050038058A1/en not_active Abandoned
2013
- 2013-08-09 NO NO20131091A patent/NO335725B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
EA200400117A1 (ru)	2004-08-26
NO335725B1 (no)	2015-02-02
CN1533397A (zh)	2004-09-29
WO2003002580A1 (en)	2003-01-09
BR0210746A (pt)	2004-07-20
ZA200400236B (en)	2004-08-18
HUP0400345A2 (hu)	2004-09-28
BRPI0210746B1 (pt)	2018-09-18
US20030109499A1 (en)	2003-06-12
HUP0400345A3 (en)	2007-05-29
WO2003002580A8 (en)	2003-01-30
JP2005511490A (ja)	2005-04-28
CZ2004142A3 (cs)	2004-05-12
EP1406911B1 (en)	2016-01-06
NO333788B1 (no)	2013-09-16
CA2452036C (en)	2009-09-29
NO20035797L (no)	2004-02-24
PL207187B1 (pl)	2010-11-30
IL159494A (en)	2008-06-05
MXPA04000138A (es)	2005-06-06
PL366852A1 (en)	2005-02-07
US20050038058A1 (en)	2005-02-17
EP1406911A1 (en)	2004-04-14
JP4545434B2 (ja)	2010-09-15
ES2564144T3 (es)	2016-03-18
BRPI0210746B8 (pt)	2021-05-25
NZ530685A (en)	2006-09-29
TR200302288T2 (tr)	2004-12-21
AP1622A (en)	2006-06-16
CN1329404C (zh)	2007-08-01
BRPI0210746A8 (pt)	2018-07-10
CZ297267B6 (cs)	2006-10-11
NO20131091L (no)	2004-02-24
EA006020B1 (ru)	2005-08-25
US6818633B2 (en)	2004-11-16
CA2452036A1 (en)	2003-01-09
HU230519B1 (hu)	2016-10-28
KR100891366B1 (ko)	2009-04-02
AU2002315625B2 (en)	2008-05-01
AP2004002953A0 (en)	2004-03-31
KR20040027521A (ko)	2004-04-01

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EP1458687A4 (en)	2005-03-23	pyrimidine
IL159494A0 (en)	2004-06-01	6-2'-(phosphonomethoxy) alkoxy pyrimidine derivatives having antiviral activity
HK1070071A1 (en)	2005-06-10	New pyrimidine compounds
EP1406619A4 (en)	2005-02-02	ANTIVIRAL AND ANTIMICROBIAL GUANIDINE OR BIGUANIDINE DERIVATIVES
AU2002362806A1 (en)	2003-07-03	Pyrimidine derivatives
HRP20030362A2 (en)	2005-04-30	Pyrimidine derivatives
GB0112802D0 (en)	2001-07-18	Pyrimidine derivatives
GB0112803D0 (en)	2001-07-18	Pyrimidine derivatives
AU2002352782A8 (en)	2003-06-10	Antitumor activity of bok
DE50103649D1 (de)	2004-10-21	2-aminoalkyl-thieno[2,3-d]pyrimidine
EP1374911A4 (en)	2007-06-20	MEANS FOR MEASURING THE METABOLIZABILITY OF PYRIMIDINE
GB0119477D0 (en)	2001-10-03	Pyrimidine derivatives
GB0112809D0 (en)	2001-07-18	Pyrimidine derivatives
GB0112804D0 (en)	2001-07-18	Pyrimidine derivatives
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Legal Events

Date	Code	Title	Description
2009-02-11	FF	Patent granted
2010-04-14	FF	Patent granted