IL156977A - Process of making an alkali metal salt of a hydrophobic sulfonamide, some such compounds and pharmaceutical compositions comprising said compounds - Google Patents

Process of making an alkali metal salt of a hydrophobic sulfonamide, some such compounds and pharmaceutical compositions comprising said compounds

Info

Publication number: IL156977A
Authority: IL; Israel
Prior art keywords: compounds; making; alkali metal; pharmaceutical compositions; metal salt
Prior art date: 1997-04-28

Application number

IL15697798A

Other languages

English (en)

Other versions

IL156977A0 (en

Original Assignee

Encysive Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-28

Filing date

1998-04-02

Publication date

2005-03-20

1997-04-28 Priority claimed from US08/847,797 external-priority patent/US5783705A/en

1998-04-02 Application filed by Encysive Pharmaceuticals Inc filed Critical Encysive Pharmaceuticals Inc

2004-02-08 Publication of IL156977A0 publication Critical patent/IL156977A0/xx

2005-03-20 Publication of IL156977A publication Critical patent/IL156977A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C07D261/16—Benzene-sulfonamido isoxazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Ophthalmology & Optometry (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)
Rheumatology (AREA)
Immunology (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

IL15697798A 1997-04-28 1998-04-02 Process of making an alkali metal salt of a hydrophobic sulfonamide, some such compounds and pharmaceutical compositions comprising said compounds IL156977A (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US08/847,797 US5783705A (en)	1997-04-28	1997-04-28	Process of preparing alkali metal salys of hydrophobic sulfonamides
US08/938,444 US6248767B1 (en)	1997-04-28	1997-09-26	Formulation of sulfonamides for treatment of endothelin-mediated disorders
IL13131898A IL131318A (en)	1997-04-28	1998-04-02	Pharmaceutically acceptable salts of sulfonamides for treatment of endothelin-mediated disorders
PCT/US1998/006680 WO1998049162A1 (en)	1997-04-28	1998-04-02	Sulfonamides for treatment of endothelin-mediated disorders

Publications (2)

Publication Number	Publication Date
IL156977A0 IL156977A0 (en)	2004-02-08
IL156977A true IL156977A (en)	2005-03-20

Family

ID=27126732

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL13131898A IL131318A (en)	1997-04-28	1998-04-02	Pharmaceutically acceptable salts of sulfonamides for treatment of endothelin-mediated disorders
IL15697798A IL156977A (en)	1997-04-28	1998-04-02	Process of making an alkali metal salt of a hydrophobic sulfonamide, some such compounds and pharmaceutical compositions comprising said compounds

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
IL13131898A IL131318A (en)	1997-04-28	1998-04-02	Pharmaceutically acceptable salts of sulfonamides for treatment of endothelin-mediated disorders

Country Status (26)

Country	Link
US (3)	US6432994B1 (et)
EP (1)	EP0980369B1 (et)
JP (3)	JP3455233B2 (et)
CN (2)	CN1179961C (et)
AP (1)	AP9901643A0 (et)
AT (1)	ATE292129T1 (et)
AU (1)	AU749167B2 (et)
BR (1)	BR9812258A (et)
CA (2)	CA2281090C (et)
CZ (1)	CZ301452B6 (et)
DE (2)	DE69829558T2 (et)
EA (1)	EA003993B1 (et)
EE (1)	EE04156B1 (et)
ES (1)	ES2241133T3 (et)
HK (1)	HK1028033A1 (et)
HU (1)	HU227183B1 (et)
ID (1)	ID25921A (et)
IL (2)	IL131318A (et)
NO (1)	NO995221L (et)
NZ (1)	NZ336898A (et)
OA (1)	OA11167A (et)
PL (1)	PL197843B1 (et)
SG (2)	SG100767A1 (et)
SK (1)	SK143399A3 (et)
TR (3)	TR200202738T2 (et)
WO (1)	WO1998049162A1 (et)

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WO2001049289A1 (en) *	1999-12-31	2001-07-12	Texas Biotechnology Corporation	Pharmaceutical and veterinary uses of endothelin antagonists
EP1533311B1 (en) *	1999-12-31	2007-04-25	Encysive Pharmaceuticals, Inc	Sulfonamides and derivatives thereof that modulate the activity of endothelin
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1998
- 1998-04-02 WO PCT/US1998/006680 patent/WO1998049162A1/en active Application Filing
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- 1998-04-02 CZ CZ0367599A patent/CZ301452B6/cs not_active IP Right Cessation
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2000
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2001
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Also Published As

Publication number	Publication date
AU749167B2 (en)	2002-06-20
EP0980369B1 (en)	2005-03-30
CN1179961C (zh)	2004-12-15
SK143399A3 (en)	2000-05-16
SG100767A1 (en)	2003-12-26
NO995221D0 (no)	1999-10-26
ATE292129T1 (de)	2005-04-15
NZ336898A (en)	2001-10-26
JP3455233B2 (ja)	2003-10-14
PL197843B1 (pl)	2008-05-30
EP0980369A1 (en)	2000-02-23
DE69839534D1 (de)	2008-07-03
NO995221L (no)	1999-12-28
WO1998049162A1 (en)	1998-11-05
EA199900966A1 (ru)	2000-08-28
CA2496680A1 (en)	1998-11-05
JP2008074875A (ja)	2008-04-03
US6432994B1 (en)	2002-08-13
AP9901643A0 (en)	1999-10-02
TR199902401T2 (xx)	2000-08-21
TR200202738T2 (tr)	2003-03-21
OA11167A (en)	2003-04-29
ID25921A (id)	2000-11-09
CA2281090C (en)	2005-06-07
JP2003176288A (ja)	2003-06-24
CA2281090A1 (en)	1998-11-05
US6458805B2 (en)	2002-10-01
CN1253560A (zh)	2000-05-17
CZ367599A3 (cs)	2000-02-16
EE9900469A (et)	2000-06-15
BR9812258A (pt)	2000-07-25
IL131318A (en)	2004-08-31
CZ301452B6 (cs)	2010-03-10
IL131318A0 (en)	2001-01-28
HU227183B1 (en)	2010-09-28
SG100766A1 (en)	2003-12-26
JP4256150B2 (ja)	2009-04-22
EA003993B1 (ru)	2003-12-25
ES2241133T3 (es)	2005-10-16
HUP0001442A2 (hu)	2001-11-28
PL336290A1 (en)	2000-06-19
TR200101905T2 (tr)	2002-06-21
EE04156B1 (et)	2003-10-15
US6683103B2 (en)	2004-01-27
US20010039289A1 (en)	2001-11-08
CN1636994A (zh)	2005-07-13
HUP0001442A3 (en)	2001-12-28
CN1636994B (zh)	2010-05-12
HK1028033A1 (en)	2001-03-02
DE69829558D1 (de)	2005-05-04
AU6950498A (en)	1998-11-24
JP2001520643A (ja)	2001-10-30
DE69829558T2 (de)	2006-02-16
US20020091270A1 (en)	2002-07-11
IL156977A0 (en)	2004-02-08

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PL338083A1 (en)	2000-09-25	Compositions containing a metal salt and powdered metal obtained by calcination of such salt
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ZA981168B (en)	1999-08-12	Compounds and processes for making herbicidal sulfonamides.
AU5337090A (en)	1990-10-22	Alkali metal chloroisocyanurate compositions

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