IL153591A0 - N-[5-(((5-alkyl-2-oxazolyl) methyl) thio)-2-thiazolyl] carboxamide and pharmaceutical compositions containing the same - Google Patents

N-[5-(((5-alkyl-2-oxazolyl) methyl) thio)-2-thiazolyl] carboxamide and pharmaceutical compositions containing the same

Info

Publication number: IL153591A0
Authority: IL; Israel
Prior art keywords: carboxamide; oxazolyl; thiazolyl; thio; alkyl
Prior art date: 2000-07-26

Application number

IL15359101A

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-26

Filing date

2001-05-09

Publication date

2003-07-06

2000-12-01 Priority claimed from US09/727,957 external-priority patent/US6515004B1/en

2000-12-22 Priority claimed from US09/746,060 external-priority patent/US6414156B2/en

2001-05-09 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2003-07-06 Publication of IL153591A0 publication Critical patent/IL153591A0/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Dermatology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IL15359101A 2000-07-26 2001-05-09 N-[5-(((5-alkyl-2-oxazolyl) methyl) thio)-2-thiazolyl] carboxamide and pharmaceutical compositions containing the same IL153591A0 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US61662700A	2000-07-26	2000-07-26
US09/727,957 US6515004B1 (en)	1999-12-15	2000-12-01	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
US09/746,060 US6414156B2 (en)	1998-10-21	2000-12-22	Process for preparing azacycloalkanoylaminothiazoles
PCT/US2001/015081 WO2002010162A1 (en)	2000-07-26	2001-05-09	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl] carboxamide inhibitors of cyclin dependent kinases

Publications (1)

Publication Number	Publication Date
IL153591A0 true IL153591A0 (en)	2003-07-06

Family

ID=27417184

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL15359101A IL153591A0 (en)	2000-07-26	2001-05-09	N-[5-(((5-alkyl-2-oxazolyl) methyl) thio)-2-thiazolyl] carboxamide and pharmaceutical compositions containing the same
IL153591A IL153591A (en)	2000-07-26	2002-12-23	N-[5-(((5-alkyl-2-oxazolyl) methyl)thio)-2-thiazolyl] carboxamide and pharmaceutical compositions containing the same

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL153591A IL153591A (en)	2000-07-26	2002-12-23	N-[5-(((5-alkyl-2-oxazolyl) methyl)thio)-2-thiazolyl] carboxamide and pharmaceutical compositions containing the same

Country Status (26)

Country	Link
EP (1)	EP1303513A1 (en)
JP (1)	JP2004509857A (en)
KR (1)	KR20030016429A (en)
CN (1)	CN100457753C (en)
AR (1)	AR030563A1 (en)
AU (1)	AU2001259704A1 (en)
BG (1)	BG65132B1 (en)
BR (1)	BR0112674A (en)
CA (1)	CA2417254A1 (en)
CZ (1)	CZ2003237A3 (en)
EE (1)	EE200300041A (en)
EG (1)	EG24409A (en)
GE (1)	GEP20043367B (en)
HR (1)	HRP20030116A2 (en)
HU (1)	HUP0303698A2 (en)
IL (2)	IL153591A0 (en)
LV (1)	LV13037B (en)
MX (1)	MXPA03000774A (en)
MY (1)	MY129635A (en)
NO (1)	NO20030394L (en)
PL (1)	PL365170A1 (en)
SI (1)	SI21099A (en)
SK (1)	SK18392002A3 (en)
TW (1)	TWI302533B (en)
WO (1)	WO2002010162A1 (en)
YU (1)	YU4903A (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6414156B2 (en)	1998-10-21	2002-07-02	Bristol-Myers Squibb Company	Process for preparing azacycloalkanoylaminothiazoles
EP2311818B1 (en) *	2002-02-28	2013-01-16	Novartis AG	Combination of a 5-phenylthiazole compound as PI3 kinase inhibitor with an antiinflammatory, bronchodilatory or antihistamine drug
MY156407A (en)	2002-02-28	2016-02-26	Novartis Ag	5-phenylthiazole derivatives and use as p13 kinase inhibitors
PL224879B1 (en)	2002-09-04	2017-02-28	Pharmacopeia Drug Discovery Inc	Pyrazolopyrimidines as cyclin-dependent kinase inhibitors
US8673924B2 (en)	2002-09-04	2014-03-18	Merck Sharp & Dohme Corp.	Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
JP2006500391A (en)	2002-09-04	2006-01-05	シェーリング　コーポレイション	Pyrazolopyrimidines as cyclin-dependent kinase inhibitors
US8580782B2 (en)	2002-09-04	2013-11-12	Merck Sharp & Dohme Corp.	Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
WO2004026310A1 (en)	2002-09-23	2004-04-01	Schering Corporation	Novel imidazopyrazines as cyclin dependent kinase inhibitors
US6919341B2 (en)	2002-09-23	2005-07-19	Schering Corporation	Imidazopyrazines as cyclin dependent kinase inhibitors
GB0320197D0 (en) *	2003-08-28	2003-10-01	Novartis Ag	Organic compounds
EP1555264A1 (en) *	2004-01-15	2005-07-20	Sireen AG	Five-membered heterocyclic compounds as inhibitors of SRC family protein kinase.
DE102005008310A1 (en) *	2005-02-17	2006-08-24	Schering Ag	Use of CDKII inhibitors for fertility control
US7446195B2 (en)	2005-08-17	2008-11-04	Schering Corporation	High affinity thiophene-based and furan-based kinase ligands
EP1931641B1 (en)	2005-09-09	2010-08-25	Schering Corporation	NOVEL 4-CYANO, 4-AMINO, AND 4-AMINOMETHYL DERIVATIVES OF PYRAZOLO[1,5-a]PYRIDINES, PYRAZOLO[1,5-c]PYRIMIDINES AND 2H-INDAZOLE COMPOUNDS AND 5-CYANO, 5-AMINO, AND 5-AMINOMETHYL DERIVATIVES OF IMIDAZO[1,2-a]PYRIDINES, AND IMIDAZO[1,5-a]PYRAZINES COMPOUNDS AS CYCLIN DEPENDENT KINASE INHI
EP1931676B1 (en)	2005-10-06	2011-11-16	Schering Corporation	Pyrazolopyrimidines as protein kinase inhibitors
WO2007146039A2 (en) *	2006-06-06	2007-12-21	Bristol-Myers Squibb Company	Crystalline forms of n-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl] thio]-2-thiazolyl]-4-piperidinecarboxamide
US20090175852A1 (en)	2006-06-06	2009-07-09	Schering Corporation	Imidazopyrazines as protein kinase inhibitors
AR063531A1 (en)	2006-10-31	2009-01-28	Schering Corp	DERIVATIVES OF ANILINOPIPERAZINE AND PHARMACEUTICAL COMPOSITION
EP2078003B1 (en)	2006-10-31	2017-03-08	Merck Sharp & Dohme Corp.	Anilinopiperazine derivatives and methods of use thereof
TW200845962A (en)	2007-05-08	2008-12-01	Schering Corp	Methods of treatment using intravenous formulations comprising temozolomide
TW200922564A (en)	2007-09-10	2009-06-01	Curis Inc	CDK inhibitors containing a zinc binding moiety
WO2010075542A1 (en)	2008-12-23	2010-07-01	Curis, Inc.	Cdk inhibitors
WO2011025706A2 (en)	2009-08-26	2011-03-03	Schering Corporation	Heterocyclic amide compounds as protein kinase inhibitors
US20150051227A1 (en)	2012-03-30	2015-02-19	Merck Sharp & Dohme Corp.	Predictive biomarker useful for cancer therapy mediated by a cdk inhibitor
CN104693256B (en) *	2013-12-04	2018-07-10	杭州源昶医药科技有限公司	The pharmaceutical applications of gemcitabine derivative, the composition containing the derivative and the derivative

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6262096B1 (en) *	1997-11-12	2001-07-17	Bristol-Myers Squibb Company	Aminothiazole inhibitors of cyclin dependent kinases
US6040321A (en) *	1997-11-12	2000-03-21	Bristol-Myers Squibb Company	Aminothiazole inhibitors of cyclin dependent kinases
WO1999065884A1 (en) *	1998-06-18	1999-12-23	Bristol-Myers Squibb Company	Carbon substituted aminothiazole inhibitors of cyclin dependent kinases
US6414156B2 (en) *	1998-10-21	2002-07-02	Bristol-Myers Squibb Company	Process for preparing azacycloalkanoylaminothiazoles
MY125768A (en) *	1999-12-15	2006-08-30	Bristol Myers Squibb Co	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases

2001
- 2001-05-09 SK SK1839-2002A patent/SK18392002A3/en unknown
- 2001-05-09 KR KR10-2003-7001141A patent/KR20030016429A/en not_active Application Discontinuation
- 2001-05-09 WO PCT/US2001/015081 patent/WO2002010162A1/en not_active Application Discontinuation
- 2001-05-09 GE GE5063A patent/GEP20043367B/en unknown
- 2001-05-09 CA CA002417254A patent/CA2417254A1/en not_active Abandoned
- 2001-05-09 EP EP01933266A patent/EP1303513A1/en not_active Withdrawn
- 2001-05-09 HU HU0303698A patent/HUP0303698A2/en unknown
- 2001-05-09 MX MXPA03000774A patent/MXPA03000774A/en unknown
- 2001-05-09 YU YU4903A patent/YU4903A/en unknown
- 2001-05-09 PL PL01365170A patent/PL365170A1/en not_active Application Discontinuation
- 2001-05-09 CN CNB018133673A patent/CN100457753C/en not_active Expired - Fee Related
- 2001-05-09 IL IL15359101A patent/IL153591A0/en unknown
- 2001-05-09 AU AU2001259704A patent/AU2001259704A1/en not_active Abandoned
- 2001-05-09 JP JP2002515891A patent/JP2004509857A/en not_active Withdrawn
- 2001-05-09 CZ CZ2003237A patent/CZ2003237A3/en unknown
- 2001-05-09 SI SI200120051A patent/SI21099A/en not_active IP Right Cessation
- 2001-05-09 BR BR0112674-1A patent/BR0112674A/en not_active Application Discontinuation
- 2001-05-09 EE EEP200300041A patent/EE200300041A/en unknown
- 2001-05-16 TW TW090111741A patent/TWI302533B/en not_active IP Right Cessation
- 2001-05-22 MY MYPI20012414A patent/MY129635A/en unknown
- 2001-05-23 EG EG20010550A patent/EG24409A/en active
- 2001-05-24 AR ARP010102516A patent/AR030563A1/en unknown
2002
- 2002-12-23 IL IL153591A patent/IL153591A/en not_active IP Right Cessation
2003
- 2003-01-16 BG BG107468A patent/BG65132B1/en unknown
- 2003-01-24 NO NO20030394A patent/NO20030394L/en not_active Application Discontinuation
- 2003-02-19 HR HR20030116A patent/HRP20030116A2/en not_active Application Discontinuation
- 2003-02-26 LV LVP-03-24A patent/LV13037B/en unknown

Also Published As

Publication number	Publication date
MXPA03000774A (en)	2003-09-10
CA2417254A1 (en)	2002-02-07
AR030563A1 (en)	2003-08-27
KR20030016429A (en)	2003-02-26
CZ2003237A3 (en)	2003-06-18
HUP0303698A2 (en)	2004-04-28
CN100457753C (en)	2009-02-04
HRP20030116A2 (en)	2005-02-28
EE200300041A (en)	2005-04-15
BG107468A (en)	2004-01-30
PL365170A1 (en)	2004-12-27
TWI302533B (en)	2008-11-01
GEP20043367B (en)	2004-06-10
JP2004509857A (en)	2004-04-02
BG65132B1 (en)	2007-03-30
EG24409A (en)	2009-05-20
YU4903A (en)	2006-03-03
BR0112674A (en)	2003-12-30
AU2001259704A1 (en)	2002-02-13
NO20030394D0 (en)	2003-01-24
WO2002010162A1 (en)	2002-02-07
EP1303513A1 (en)	2003-04-23
CN1444584A (en)	2003-09-24
NO20030394L (en)	2003-03-03
IL153591A (en)	2009-07-20
SI21099A (en)	2003-06-30
LV13037B (en)	2003-11-20
SK18392002A3 (en)	2003-09-11
MY129635A (en)	2007-04-30

Publication	Publication Date	Title
IL153591A0 (en)	2003-07-06	N-[5-(((5-alkyl-2-oxazolyl) methyl) thio)-2-thiazolyl] carboxamide and pharmaceutical compositions containing the same
IL149755A0 (en)	2002-12-01	N-[5-[[[5-alkyl-2 oxazolyl] methyl]thio]-2-thiazolyl] carboxamide derivatives and pharmaceutical compositions containing the same
IL147939A0 (en)	2002-08-14	Oxazole and thiazole derivatives and pharmaceutical compositions containing the same
PL352282A1 (en)	2003-08-11	Derivatives of thiazoles and pharmaceutical compositions containing these derivatives
IL149757A0 (en)	2002-12-01	Aminothiazole derivatives and pharmaceutical compositions containing the same
IL160714A0 (en)	2004-08-31	Heterocyclic substituted 2-(4-phenoxy) pyridine derivatives and pharmaceutical compositions containing the same
HUP0302297A3 (en)	2007-05-02	Substituted thioacetamides and pharmaceutical compositions containing them
IL156031A0 (en)	2003-12-23	Fused heterocyclic derivatives and pharmaceutical compositions containing the same
IL158523A0 (en)	2004-05-12	Epothilone derivatives and pharmaceutical compositions containing the same
HUP0301146A3 (en)	2004-08-30	2-chlor-5-nitrophenyl carboxamide derivatives, pharmaceutical compositions containing them and their use
HUP0301178A3 (en)	2009-08-28	Glucopyranosyloxybenzylbenzene derivatives and pharmaceutical compositions containing the same
HUP0402236A3 (en)	2010-03-29	Heterocyclic compounds pharmaceutical compounds containing thereof and use thereof
IL153123A0 (en)	2003-06-24	N-ureidoheterocycloalkyl-piperidine derivatives and pharmaceutical compositions containing the same
IL156389A0 (en)	2004-01-04	Pyrazole derivatives and pharmaceutical compositions containing the same
IL154817A0 (en)	2003-10-31	Pyrazole derivatives and pharmaceutical compositions containing the same
IL145757A0 (en)	2002-07-25	Pyrazole derivatives and pharmaceutical compositions containing the same
IL145756A0 (en)	2002-07-25	Pyrazole derivatives and pharmaceutical compositions containing the same
IL157131A0 (en)	2004-02-08	Nitrogen containing heterocyclic derivatives and pharmaceutical compositions containing the same
IL145428A0 (en)	2002-06-30	Alkanoyl-substituted heterocyclic derivatives and pharmaceutical compositions containing the same
HUP0200155A2 (en)	2002-06-29	Thioamide derivatives, pharmaceutical compositions containing them and their use
IL157740A0 (en)	2004-03-28	Heterocyclic derivatives and pharmaceutical compositions containing the same
HUP0301713A3 (en)	2005-04-28	Pharmaceutical compositions containing propenone derivatives and their use
HUP0303184A3 (en)	2008-03-28	Substituted c-cyclohexylmethylamine derivatives and pharmaceutical compositions containing them
HUP0400023A2 (en)	2004-04-28	Novel heterocyclic derivatives and medicinal use thereof and pharmaceutical compositions containing them
HUP0302397A3 (en)	2007-02-28	Heterocyclic compounds and pharmaceutical compositions containing them