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IL143920A0 - 3-heteroarylidenyl-2-indolinone derivatives and pharmaceutical compositions containing the same - Google Patents

3-heteroarylidenyl-2-indolinone derivatives and pharmaceutical compositions containing the same

Info

Publication number
IL143920A0
IL143920A0 IL14392099A IL14392099A IL143920A0 IL 143920 A0 IL143920 A0 IL 143920A0 IL 14392099 A IL14392099 A IL 14392099A IL 14392099 A IL14392099 A IL 14392099A IL 143920 A0 IL143920 A0 IL 143920A0
Authority
IL
Israel
Prior art keywords
heteroarylidenyl
same
pharmaceutical compositions
compositions containing
indolinone derivatives
Prior art date
Application number
IL14392099A
Original Assignee
Sugen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen Inc filed Critical Sugen Inc
Publication of IL143920A0 publication Critical patent/IL143920A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL14392099A 1998-12-31 1999-12-30 3-heteroarylidenyl-2-indolinone derivatives and pharmaceutical compositions containing the same IL143920A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11431398P 1998-12-31 1998-12-31
PCT/US1999/031232 WO2000038519A1 (en) 1998-12-31 1999-12-30 3-heteroarylidenyl-2-indolinone compounds for modulating protein kinase activity and for use in cancer chemotherapy

Publications (1)

Publication Number Publication Date
IL143920A0 true IL143920A0 (en) 2002-04-21

Family

ID=22354480

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14392099A IL143920A0 (en) 1998-12-31 1999-12-30 3-heteroarylidenyl-2-indolinone derivatives and pharmaceutical compositions containing the same

Country Status (10)

Country Link
EP (1) EP1139754A4 (en)
JP (1) JP2002533360A (en)
KR (1) KR20010108063A (en)
CN (1) CN1356872A (en)
AU (1) AU760964B2 (en)
BR (1) BR9916735A (en)
CA (1) CA2357042A1 (en)
IL (1) IL143920A0 (en)
MX (1) MXPA01006742A (en)
WO (1) WO2000038519A1 (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569868B2 (en) 1998-04-16 2003-05-27 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
AU1928501A (en) * 1999-11-24 2001-06-04 Sugen, Inc. Formulations for pharmaceutical agents ionizable as free acids or free bases
US6878733B1 (en) 1999-11-24 2005-04-12 Sugen, Inc. Formulations for pharmaceutical agents ionizable as free acids or free bases
DE122008000002I1 (en) * 2000-02-15 2008-04-17 Sugen Inc PYRROL SUBSTITUTED INDOLIN-2-ON PROTEIN KINASE INHIBITORS
CZ298259B6 (en) * 2000-02-28 2007-08-08 Aventis Pharma S. A. Pharmaceutical combinations containing CPT-11 and capecitabine for treating cancer
TWI270545B (en) 2000-05-24 2007-01-11 Sugen Inc Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
CA2410509A1 (en) 2000-06-02 2001-12-13 Sugen, Inc. Indolinone derivatives as protein kinase/phosphatase inhibitors
AR042586A1 (en) 2001-02-15 2005-06-29 Sugen Inc 3- (4-AMIDOPIRROL-2-ILMETILIDEN) -2-INDOLINONE AS INHIBITORS OF PROTEIN KINASE; YOUR PHARMACEUTICAL COMPOSITIONS; A METHOD FOR THE MODULATION OF THE CATALYTIC ACTIVITY OF PROTEINQUINASE; A METHOD TO TREAT OR PREVENT AN AFFECTION RELATED TO PROTEINQUINASE
US7312237B2 (en) 2001-03-14 2007-12-25 Bristol-Myers Squibb Co. Combination of epothilone analogs and chemotherapeutic agents for the treatment of prolilferative diseases
AU2002303892A1 (en) 2001-05-30 2002-12-09 Jingrong Cui 5-aralkylsulfonyl-3- (pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors
AR038957A1 (en) * 2001-08-15 2005-02-02 Pharmacia Corp COMBINATION THERAPY FOR CANCER TREATMENT
WO2003035619A1 (en) * 2001-10-25 2003-05-01 Merck & Co., Inc. Tyrosine kinase inhibitors
AU2002348020A1 (en) * 2001-10-25 2003-05-06 Merck And Co., Inc. Tyrosine kinase inhibitors
WO2003035614A2 (en) * 2001-10-25 2003-05-01 Merck & Co., Inc. Tyrosine kinase inhibitors
EP1453502A4 (en) * 2001-11-21 2007-01-10 Sugen Inc Pharmaceutical formulations comprising indolinone derivatives
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
US6797825B2 (en) 2001-12-13 2004-09-28 Abbott Laboratories Protein kinase inhibitors
IL162203A0 (en) 2001-12-27 2005-11-20 Theravance Inc Indolinone derivatives useful as protein inase inhibitors
TW200401637A (en) * 2002-06-25 2004-02-01 Wyeth Corp Use of thio-oxindole derivatives in treatment of skin disorders
IL165395A0 (en) 2002-06-25 2006-01-15 Wyeth Corp Use of thio-oxubdile derivatives in treatment of hormone-related conditions
MXPA05001277A (en) 2002-08-02 2005-10-06 Ab Science 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors.
US8450302B2 (en) 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
AU2003274576A1 (en) * 2002-11-15 2004-06-15 Warner-Lambert Company Llc Combination chemotherapy comprising a mek inhibitor and capecitabine for treating cancer
BRPI0415467A (en) 2003-10-23 2006-12-19 Ab Science 2-aminoaryloxazole compounds for the treatment of disease
CN100432071C (en) * 2004-11-05 2008-11-12 中国科学院上海药物研究所 Substituted 1H-indol-2-one compound and its preparation method and use
UA95071C2 (en) 2005-04-04 2011-07-11 Аб Сьянс Substituted oxazole derivatives and their use as tyrosine kinase inhibitors
US8246966B2 (en) 2006-08-07 2012-08-21 University Of Georgia Research Foundation, Inc. Trypanosome microsome system and uses thereof
CA2669531A1 (en) 2006-11-22 2008-06-05 University Of Georgia Research Foundation, Inc. Tyrosine kinase inhibitors as anti-kinetolastid and anti-apicomplexan agents
SG11201401795XA (en) 2011-11-11 2014-09-26 Lilly Co Eli Combination therapy for ovarian cancer
CN107517589A (en) 2015-01-08 2017-12-26 小利兰·斯坦福大学托管委员会 Provides inducible factors and cells for bone, bone marrow and cartilage
DK3288940T5 (en) 2015-04-29 2021-09-20 Janssen Pharmaceutica Nv AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS
CN105585558A (en) * 2015-12-15 2016-05-18 贵州大学 Double-alkoxy pyrimidine jointing 3-ethylenic-bond-oxoindole derivative and preparing method and application thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
AU4155697A (en) * 1996-08-23 1998-03-06 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease

Also Published As

Publication number Publication date
WO2000038519A1 (en) 2000-07-06
CA2357042A1 (en) 2000-07-06
BR9916735A (en) 2001-09-25
CN1356872A (en) 2002-07-03
AU2221500A (en) 2000-07-31
MXPA01006742A (en) 2004-04-21
JP2002533360A (en) 2002-10-08
KR20010108063A (en) 2001-12-07
AU760964B2 (en) 2003-05-22
EP1139754A1 (en) 2001-10-10
EP1139754A4 (en) 2002-12-18

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