IL138770A0 - Aerosol composition - Google Patents
Aerosol compositionInfo
- Publication number
- IL138770A0 IL138770A0 IL13877099A IL13877099A IL138770A0 IL 138770 A0 IL138770 A0 IL 138770A0 IL 13877099 A IL13877099 A IL 13877099A IL 13877099 A IL13877099 A IL 13877099A IL 138770 A0 IL138770 A0 IL 138770A0
- Authority
- IL
- Israel
- Prior art keywords
- particulate material
- aerosol composition
- mum
- propellant
- particles
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9807232.5A GB9807232D0 (en) | 1998-04-03 | 1998-04-03 | Aerosol composition |
PCT/GB1999/001019 WO1999051205A1 (en) | 1998-04-03 | 1999-04-01 | Aerosol composition |
Publications (1)
Publication Number | Publication Date |
---|---|
IL138770A0 true IL138770A0 (en) | 2001-10-31 |
Family
ID=10829846
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13877099A IL138770A0 (en) | 1998-04-03 | 1999-04-01 | Aerosol composition |
Country Status (17)
Country | Link |
---|---|
US (2) | US6737044B1 (pt) |
EP (1) | EP1069887B8 (pt) |
JP (1) | JP2002510614A (pt) |
KR (1) | KR20010072563A (pt) |
CN (1) | CN1215832C (pt) |
AT (1) | ATE474555T1 (pt) |
AU (1) | AU761518B2 (pt) |
BR (1) | BR9909394A (pt) |
CA (1) | CA2327336C (pt) |
DE (1) | DE69942606D1 (pt) |
ES (1) | ES2349184T3 (pt) |
GB (1) | GB9807232D0 (pt) |
ID (1) | ID27586A (pt) |
IL (1) | IL138770A0 (pt) |
MX (1) | MXPA00009660A (pt) |
WO (1) | WO1999051205A1 (pt) |
ZA (1) | ZA200005374B (pt) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9807232D0 (en) | 1998-04-03 | 1998-06-03 | Univ Cardiff | Aerosol composition |
DE19921693A1 (de) | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika |
ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
GB9928311D0 (en) * | 1999-11-30 | 2000-01-26 | Novartis Ag | Organic compounds |
AU2001258585B2 (en) * | 2000-05-23 | 2006-12-21 | Glaxo Group Limited | Aerosol container for formulations of salmeterol xinafoate |
GB0015043D0 (en) * | 2000-06-21 | 2000-08-09 | Glaxo Group Ltd | Medicament dispenser |
US20040081627A1 (en) * | 2000-10-09 | 2004-04-29 | Jinks Phillip A | Medicinal aerosol formulations |
AU2002222304B2 (en) * | 2000-12-22 | 2004-03-18 | Glaxo Group Limited | Metered dose inhaler for salmeterol xinafoate |
DE60221640T2 (de) * | 2001-02-06 | 2008-05-21 | Innovata Biomed Ltd., St. Albans | Bimodale trockenpulverzusammensetzung zur inhalation |
IL157580A0 (en) * | 2001-03-20 | 2004-03-28 | Glaxo Group Ltd | Inhalation drug combination |
AU2002333644A1 (en) * | 2001-09-17 | 2003-04-01 | Glaxo Group Limited | Dry powder medicament formulations |
JP2006509716A (ja) * | 2002-03-12 | 2006-03-23 | マイクロドース・テクノロジーズ・インコーポレーテッド | 吸入で同時投与した薬剤を特定部位へ届ける方法 |
US20050158248A1 (en) * | 2002-08-21 | 2005-07-21 | Xian-Ming Zeng | Method of preparing dry powder inhalation compositions |
GB0219512D0 (en) * | 2002-08-21 | 2002-10-02 | Norton Healthcare Ltd | Inhalation compositions with high drug ratios |
GB0219511D0 (en) * | 2002-08-21 | 2002-10-02 | Norton Healthcare Ltd | Method of preparing dry powder inhalation compositions |
NZ538965A (en) * | 2002-08-21 | 2006-11-30 | Norton Healthcare Ltd | Dry powder inhalation compositions |
AU2003263077B2 (en) * | 2002-09-06 | 2010-04-29 | 3M Innovative Properties Company | Metering valve for a metered dose inhaler providing consistent delivery |
GB0221343D0 (en) * | 2002-09-16 | 2002-10-23 | 3M Innovative Properties Co | Aerosol dispensers and adaptors therefor |
US7497214B2 (en) * | 2002-09-16 | 2009-03-03 | 3M Innovative Properties Company | Aerosol dispensers and adaptors therefor |
WO2004073729A1 (ja) | 2003-02-21 | 2004-09-02 | Translational Research Ltd. | 薬物の経鼻投与用組成物 |
EP1607117A4 (en) | 2003-03-27 | 2007-10-24 | Bioactis Ltd | APPLICATOR FOR POWDER MEDICATION IN THE NOSE CAVE |
WO2005000712A1 (en) * | 2003-06-24 | 2005-01-06 | Cipla Limited | Pharmaceutical dispensing aid |
CN1878602A (zh) * | 2003-11-28 | 2006-12-13 | 三菱化学株式会社 | 有机化合物微粒的制造方法 |
DE102004011381A1 (de) * | 2004-03-05 | 2005-09-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Impaktionsdüse für treibgasbetriebene Dosieraerosole |
EP1755720A1 (en) * | 2004-05-20 | 2007-02-28 | Discovery Laboratories, Inc. | Methods , systems and devices for noninvasive pulmonary delivery |
GB0501956D0 (en) * | 2005-01-31 | 2005-03-09 | Arrow Internat | Nebulizer formulation |
US8028697B2 (en) | 2005-04-28 | 2011-10-04 | Trudell Medical International | Ventilator circuit and method for the use thereof |
US20060260606A1 (en) * | 2005-05-18 | 2006-11-23 | Coifman Robert E | Inhalable formulations of amphotericin B and methods and devices for delivery thereof |
US8367734B1 (en) | 2005-08-11 | 2013-02-05 | Amphastar Pharmaceuticals Inc. | Stable epinephrine suspension formulation with high inhalation delivery efficiency |
DE102006014433A1 (de) * | 2006-03-27 | 2007-10-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dosieraerosole für die Verabreichung von pharmazeutischen Zubereitungen |
US20080269347A1 (en) * | 2006-09-28 | 2008-10-30 | Azopharma, Inc. | Epinephrine formulations |
WO2008078730A1 (ja) | 2006-12-26 | 2008-07-03 | Translational Research, Ltd. | 経鼻投与用製剤 |
US20080202627A1 (en) * | 2007-02-23 | 2008-08-28 | Mas Gregory V | Dosing System and Method |
EP2230934B8 (en) | 2007-12-14 | 2012-10-24 | AeroDesigns, Inc | Delivering aerosolizable food products |
EP2100598A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
EP2100599A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
RU2463084C2 (ru) * | 2008-03-17 | 2012-10-10 | Дискавери Лабораториз, Инк. | Адаптер дыхательного контура и система проксимальной доставки аэрозоля |
EP2626098B1 (en) | 2008-10-22 | 2020-08-19 | Trudell Medical International | Modular aerosol delivery system |
PT2410981T (pt) | 2009-03-26 | 2017-05-25 | Pulmatrix Inc | Formulações em pó seco e métodos para tratar doenças pulmonares |
EP2429495A4 (en) | 2009-05-15 | 2014-01-22 | Shin Nippon Biomedical Lab Ltd | INTRANASAL PHARMACEUTICAL COMPOSITIONS WITH ENHANCED PHARMACOKINETICS |
US8827946B2 (en) | 2009-07-31 | 2014-09-09 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal granisetron and nasal applicator |
AU2010324997A1 (en) | 2009-11-24 | 2012-05-31 | Gilead Sciences, Inc. | Inhaled fosfomycin/tobramycin for the treatment of chronic obstructive pulmonary disease |
WO2011081937A1 (en) | 2009-12-15 | 2011-07-07 | Gilead Sciences, Inc. | Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy |
PH12012501114A1 (en) | 2010-01-05 | 2024-06-03 | Microdose Therapeutx Inc | Inhalation device and method |
AR081377A1 (es) | 2010-05-10 | 2012-08-29 | Gilead Sciences Inc | Compuestos de pirazolopiridina bifuncionales |
JP5807058B2 (ja) | 2010-05-10 | 2015-11-10 | ギリアード サイエンシーズ, インコーポレイテッド | 二機能キノリン誘導体 |
CN103200938B (zh) | 2010-08-30 | 2018-07-31 | 普马特里克斯营业公司 | 干燥粉末配方及用于治疗肺部疾病的方法 |
US20130164338A1 (en) | 2010-08-30 | 2013-06-27 | Pulmatrix, Inc. | Treatment of cystic fibrosis using calcium lactate, leucine and sodium chloride in a respiraple dry powder |
CN102416179B (zh) | 2010-09-28 | 2014-05-07 | 益得生物科技股份有限公司 | 用于哮喘的吸入性复方组合物 |
RU2640921C2 (ru) | 2010-09-29 | 2018-01-12 | Пулмэтрикс, Инк. | Катионы одновалентных металлов сухих порошков для ингаляций |
WO2012050945A1 (en) | 2010-09-29 | 2012-04-19 | Pulmatrix, Inc. | Cationic dry powders |
FR2971772B1 (fr) * | 2011-02-17 | 2013-03-22 | Valois Sas | Dispositif de distribution de produit fluide. |
TWI399202B (zh) | 2011-03-17 | 2013-06-21 | Intech Biopharm Ltd | 製備用於治療呼吸道疾病之定量噴霧吸入劑的製程方法 |
FR2973786B1 (fr) * | 2011-04-06 | 2014-07-04 | Valois Sas | Bague pour dispositif de distribution de produit fluide. |
EP2510928A1 (en) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium for use in improving the quality of sleep in respiratory patients |
AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
SG11201407867VA (en) | 2012-05-29 | 2014-12-30 | Parion Sciences Inc | Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases |
CA2896686A1 (en) | 2012-12-17 | 2014-06-26 | Parion Sciences, Inc. | 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds |
WO2014099676A1 (en) | 2012-12-17 | 2014-06-26 | Parion Sciences, Inc. | Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration |
NZ709197A (en) | 2012-12-17 | 2020-06-26 | Parion Sciences Inc | 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds |
AU2013388034B2 (en) | 2013-04-30 | 2019-08-15 | Vectura Inc. | Dry powder formulations and methods of use |
ES2762806T3 (es) | 2014-02-10 | 2020-05-25 | Respivant Sciences Gmbh | Tratamiento utilizando estabilizadores de mastocitos para trastornos sistémicos |
AU2015213681B2 (en) | 2014-02-10 | 2020-03-12 | Respivant Sciences Gmbh | Mast cell stabilizers for lung disease treatment |
GB201402513D0 (en) | 2014-02-13 | 2014-04-02 | Cardiff Scintigraphics Ltd | Pressurised metered dose inhalers and method of manufacture |
WO2015127315A1 (en) | 2014-02-20 | 2015-08-27 | Otitopic Inc. | Dry powder formulations for inhalation |
PL3179986T3 (pl) | 2014-07-31 | 2023-06-26 | Vectura Inc. | Suche formulacje w proszku do inhalacji |
US10265296B2 (en) | 2015-08-07 | 2019-04-23 | Respivant Sciences Gmbh | Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders |
EP3331522A1 (en) | 2015-08-07 | 2018-06-13 | Patara Pharma LLC | Methods for the treatment of mast cell related disorders with mast cell stabilizers |
CN110139646A (zh) | 2016-08-31 | 2019-08-16 | 瑞思皮万特科学有限责任公司 | 用于治疗由特发性肺纤维化引起的慢性咳嗽的色甘酸组合物 |
EP3522983A4 (en) | 2016-10-07 | 2020-06-03 | Respivant Sciences GmbH | CROMOLYNE-BASED COMPOSITIONS FOR THE TREATMENT OF PULMONARY FIBROSIS |
CN107529499B (zh) * | 2017-04-20 | 2020-06-09 | 苏州康乐辉医药科技有限公司 | 一种气雾剂药液浓度稳定装置 |
US11744967B2 (en) | 2017-09-26 | 2023-09-05 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
CN118695855A (zh) * | 2022-01-21 | 2024-09-24 | 香港大学 | 通过单次鼻内施用用于鼻和肺沉积的抗病毒剂的双重靶向粉末制剂 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3046863A1 (de) | 1980-12-12 | 1982-07-22 | Robert Bosch Gmbh, 7000 Stuttgart | Elektronisch gesteuertes kraftstoffzumesssystem fuer eine brennkraftmaschine |
GB8613811D0 (en) | 1986-06-06 | 1986-07-09 | Phares Pharm Res Nv | Composition & method |
GB8828477D0 (en) | 1988-12-06 | 1989-01-05 | Riker Laboratories Inc | Medical aerosol formulations |
JPH05508616A (ja) * | 1989-02-23 | 1993-12-02 | ローヌー プーラン ローラー インターナショナル(ホウルディングス)インコーポレイテッド | 治療用エアロゾル剤 |
CH680263A5 (pt) | 1989-07-20 | 1992-07-31 | Norman Godin | |
DK0536235T3 (da) | 1990-06-29 | 1997-04-14 | Fisons Plc | Under tryk stående aerosolpræparater |
CA2094266C (en) | 1990-10-18 | 1999-06-01 | Robert K. Schultz | Aerosol formulations of beclomethasone-17,21-dipropionate |
GB9024366D0 (en) | 1990-11-09 | 1991-01-02 | Glaxo Group Ltd | Medicaments |
EP0504112A3 (en) | 1991-03-14 | 1993-04-21 | Ciba-Geigy Ag | Pharmaceutical aerosol formulations |
EP0561166A1 (de) | 1992-03-17 | 1993-09-22 | ASTA Medica Aktiengesellschaft | Dosieraerosole enthaltend den Wirkstoff D-18024 und verwandte Strukturen |
ATE204750T1 (de) * | 1992-06-12 | 2001-09-15 | Teijin Ltd | Pharmazeutische zubereitung zur anwendung in den atemwegen |
WO1994021229A1 (en) * | 1993-03-17 | 1994-09-29 | Minnesota Mining And Manufacturing Company | Aerosol formulation containing an ester-, amide-, or mercaptoester-derived dispersing aid |
GB9404945D0 (en) * | 1994-03-15 | 1994-04-27 | Glaxo Group Ltd | Pharmaceutical composition |
GB9419269D0 (en) * | 1994-09-23 | 1994-11-09 | Unilever Plc | Aerosol |
GB9426252D0 (en) | 1994-12-24 | 1995-02-22 | Glaxo Group Ltd | Pharmaceutical composition |
GB2307842A (en) | 1995-12-05 | 1997-06-11 | Lin Chan Yen | Ventilated protective helmet |
RU2101054C1 (ru) | 1996-04-30 | 1998-01-10 | Закрытое акционерное общество "Техно-ТМ" | Аэрозолеобразующий состав для тушения пожаров и способ его получения |
GB9619968D0 (en) | 1996-09-25 | 1996-11-13 | Johnson & Johnson Professional | Hinge with locking means |
EE200000546A (et) * | 1998-03-16 | 2002-02-15 | Inhale Therapeutic Systems, Inc. | Aerosoolistatud toimeaine manustamissüsteem |
GB9807232D0 (en) | 1998-04-03 | 1998-06-03 | Univ Cardiff | Aerosol composition |
US6136294C1 (en) | 1998-09-22 | 2002-09-24 | Aeropharm Technology Inc | Amino acid stabilized medical aerosol formulation |
-
1998
- 1998-04-03 GB GBGB9807232.5A patent/GB9807232D0/en not_active Ceased
-
1999
- 1999-04-01 CA CA002327336A patent/CA2327336C/en not_active Expired - Fee Related
- 1999-04-01 BR BR9909394-4A patent/BR9909394A/pt not_active Application Discontinuation
- 1999-04-01 AU AU31620/99A patent/AU761518B2/en not_active Ceased
- 1999-04-01 KR KR1020007011018A patent/KR20010072563A/ko not_active Application Discontinuation
- 1999-04-01 US US09/647,331 patent/US6737044B1/en not_active Expired - Lifetime
- 1999-04-01 AT AT99913508T patent/ATE474555T1/de not_active IP Right Cessation
- 1999-04-01 ES ES99913508T patent/ES2349184T3/es not_active Expired - Lifetime
- 1999-04-01 CN CN998067121A patent/CN1215832C/zh not_active Expired - Fee Related
- 1999-04-01 DE DE69942606T patent/DE69942606D1/de not_active Expired - Lifetime
- 1999-04-01 JP JP2000541977A patent/JP2002510614A/ja active Pending
- 1999-04-01 ID IDW20002207A patent/ID27586A/id unknown
- 1999-04-01 EP EP99913508A patent/EP1069887B8/en not_active Expired - Lifetime
- 1999-04-01 WO PCT/GB1999/001019 patent/WO1999051205A1/en not_active Application Discontinuation
- 1999-04-01 MX MXPA00009660A patent/MXPA00009660A/es active IP Right Grant
- 1999-04-01 IL IL13877099A patent/IL138770A0/xx unknown
-
2000
- 2000-10-03 ZA ZA200005374A patent/ZA200005374B/en unknown
-
2003
- 2003-09-23 US US10/668,840 patent/US7481995B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2327336C (en) | 2008-07-08 |
WO1999051205A1 (en) | 1999-10-14 |
AU3162099A (en) | 1999-10-25 |
GB9807232D0 (en) | 1998-06-03 |
US6737044B1 (en) | 2004-05-18 |
BR9909394A (pt) | 2000-12-05 |
DE69942606D1 (de) | 2010-09-02 |
EP1069887A1 (en) | 2001-01-24 |
JP2002510614A (ja) | 2002-04-09 |
CN1303270A (zh) | 2001-07-11 |
KR20010072563A (ko) | 2001-07-31 |
ATE474555T1 (de) | 2010-08-15 |
EP1069887B1 (en) | 2010-07-21 |
ZA200005374B (en) | 2002-01-03 |
AU761518B2 (en) | 2003-06-05 |
ES2349184T3 (es) | 2010-12-28 |
CA2327336A1 (en) | 1999-10-14 |
US20050249674A1 (en) | 2005-11-10 |
CN1215832C (zh) | 2005-08-24 |
US7481995B2 (en) | 2009-01-27 |
ID27586A (id) | 2001-04-12 |
MXPA00009660A (es) | 2003-07-14 |
EP1069887B8 (en) | 2010-08-25 |
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