[go: up one dir, main page]

IL136718A0 - Method and reagents for the quantification of solid-phase reactions using fluorine nmr - Google Patents

Method and reagents for the quantification of solid-phase reactions using fluorine nmr

Info

Publication number
IL136718A0
IL136718A0 IL13671898A IL13671898A IL136718A0 IL 136718 A0 IL136718 A0 IL 136718A0 IL 13671898 A IL13671898 A IL 13671898A IL 13671898 A IL13671898 A IL 13671898A IL 136718 A0 IL136718 A0 IL 136718A0
Authority
IL
Israel
Prior art keywords
solid
quantification
reagents
phase reactions
fluorine nmr
Prior art date
Application number
IL13671898A
Original Assignee
Aventis Pharm Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1997/023920 external-priority patent/WO1998029376A1/en
Application filed by Aventis Pharm Prod Inc filed Critical Aventis Pharm Prod Inc
Publication of IL136718A0 publication Critical patent/IL136718A0/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/12—Hydrolysis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/14—Esterification
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/18—Introducing halogen atoms or halogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/18—Introducing halogen atoms or halogen-containing groups
    • C08F8/20—Halogenation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/26—Removing halogen atoms or halogen-containing groups from the molecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/34—Introducing sulfur atoms or sulfur-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2800/00—Copolymer characterised by the proportions of the comonomers expressed
    • C08F2800/20—Copolymer characterised by the proportions of the comonomers expressed as weight or mass percentages
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2810/00—Chemical modification of a polymer
    • C08F2810/20—Chemical modification of a polymer leading to a crosslinking, either explicitly or inherently
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Steroid Compounds (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Catalysts (AREA)

Abstract

This invention is directed to the use of <19>F NMR to monitor and quantitate solid-phase reactions and fluorine-containing solid-phase reagents useful therefor.
IL13671898A 1997-12-17 1998-12-14 Method and reagents for the quantification of solid-phase reactions using fluorine nmr IL136718A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/US1997/023920 WO1998029376A1 (en) 1996-12-19 1997-12-17 Process for the solid phase synthesis of aldehydes, ketones, oximes, amines and hydroxamic acid compounds
US9055898P 1998-06-24 1998-06-24
US9056398P 1998-06-24 1998-06-24
PCT/US1998/026512 WO1999031491A1 (en) 1997-12-17 1998-12-14 Method and reagents for the quantification of solid-phase reactions using fluorine nmr

Publications (1)

Publication Number Publication Date
IL136718A0 true IL136718A0 (en) 2001-06-14

Family

ID=27376603

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13671898A IL136718A0 (en) 1997-12-17 1998-12-14 Method and reagents for the quantification of solid-phase reactions using fluorine nmr

Country Status (16)

Country Link
EP (1) EP1044364B8 (en)
JP (1) JP2003522934A (en)
CN (1) CN1205468C (en)
AT (1) ATE364837T1 (en)
AU (1) AU748529C (en)
BG (1) BG65184B1 (en)
BR (1) BR9813701A (en)
CA (1) CA2315152A1 (en)
DE (1) DE69837936T2 (en)
DK (1) DK1044364T3 (en)
ES (1) ES2288310T3 (en)
HU (1) HUP0200726A2 (en)
IL (1) IL136718A0 (en)
MX (1) MXPA00006050A (en)
PL (1) PL197620B1 (en)
WO (1) WO1999031491A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1322942B1 (en) * 2000-09-27 2014-03-26 Universiteit Leiden Method for applying nmr for ligand discovery or as a drug screening tool
FR2955862B1 (en) * 2010-02-02 2012-07-13 Commissariat Energie Atomique FLUOROCARBON POLYMER MATERIAL AND METHOD FOR SYNTHESIS
CN103487455B (en) * 2013-09-24 2016-04-27 上海大学 A kind of method of hydroxy-containing compounds in Quantitative detection olive oil
CN108593696B (en) * 2018-04-26 2020-11-03 南京明捷生物医药检测有限公司 Method for determining trifluoroacetic acid residue in polypeptide by using quantitative nuclear magnetism

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5566324A (en) * 1992-12-24 1996-10-15 Ncr Corporation Computer apparatus including a main memory prefetch cache and method of operation thereof
GB9515070D0 (en) * 1995-07-22 1995-09-20 Zeneca Ltd Label
US6355490B1 (en) * 1996-09-13 2002-03-12 Jill Edie Hochlowski Attached tags for use in combinatorial chemistry synthesis

Also Published As

Publication number Publication date
WO1999031491A1 (en) 1999-06-24
AU748529C (en) 2002-10-17
ATE364837T1 (en) 2007-07-15
EP1044364A4 (en) 2004-10-06
BG65184B1 (en) 2007-05-31
CA2315152A1 (en) 1999-06-24
PL341357A1 (en) 2001-04-09
AU748529B2 (en) 2002-06-06
EP1044364B1 (en) 2007-06-13
DE69837936D1 (en) 2007-07-26
BG104614A (en) 2001-10-31
DK1044364T3 (en) 2007-09-24
CN1284165A (en) 2001-02-14
BR9813701A (en) 2000-12-12
EP1044364B8 (en) 2008-01-02
PL197620B1 (en) 2008-04-30
DE69837936T2 (en) 2008-02-28
JP2003522934A (en) 2003-07-29
MXPA00006050A (en) 2004-05-21
AU2556999A (en) 1999-07-05
CN1205468C (en) 2005-06-08
ES2288310T3 (en) 2008-01-01
EP1044364A1 (en) 2000-10-18
HUP0200726A2 (en) 2002-06-29

Similar Documents

Publication Publication Date Title
AU5926598A (en) Electronic-property probing of biological molecules at surfaces
EP0797685A4 (en) ANALYSIS OF GENE EXPRESSION BY DISPLAY OF 3&#39;-END RESTRICTION FRAGMENTS OF cDNAs
AU4157696A (en) Quantitative method for early detection of mutant alleles and diagnostic kits for carrying out the method
AU7702798A (en) Methods and apparatus for monitoring and quantifying the movement of fluid
NO20003107L (en) Process and reagents for quantification of solid phase reactions using fluorine NMR
ITMI940998A0 (en) NEW PEROXIDICALLY VULCANIZABLE FLUORELASTOMERS PARTICULARLY SUITABLE FOR THE MANUFACTURE OF O-RINGS
HK1046954A1 (en) Detection of cervical neoplasias using fluorescence spectroscopy
IL115292A0 (en) Computer based system and method of automatically generating chemical compounds
HUP9702463A3 (en) Process and compounds for the magnetorelaxometric detection of analytes and use thereof
GB9922064D0 (en) Analytical test device and method of use
AU4351997A (en) Assays for regulators of mammalian telomerase expression
AU8218591A (en) Method for reducing interference in a fluorescent assay
IL136718A0 (en) Method and reagents for the quantification of solid-phase reactions using fluorine nmr
DK0882814T3 (en) System and method for electrochemical cleavage of compounds
AUPP547398A0 (en) Predictive assessment of certain skeletal disorders
FR2770218B1 (en) PROCESS FOR THE SILYLATION OF CARBON HYDRATES
UA70937C2 (en) Method for using 19f nmr to monitor and quantitatively estimate solid-phase reactions, and fluorine-containing solid-phase reagents for the realization of the method
AU2646897A (en) Process for the preparation of fluoro compounds from the corresponding amines
AU4627896A (en) Analytical and therapeutic agents
ZA9811577B (en) Method and reagents for the quantification of solid-phase reactions using fluorine NMR.
GB2312289B (en) Biochemical Sensor &amp; Method of Use
AP2000001849A0 (en) Method and reagents for the quantification of solid-phase reactions using flourine nmr
FR2758556B1 (en) ISOMERIZATION OF HYDROFLUOROCARBONS
AU6312498A (en) Method and equipment for the evaluation of scale dissolvers
IT1283842B1 (en) IMPROVED PROCESS AND SYSTEM FOR THE PRETREATMENT OF ALUMINUM

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed