IL134643A0 - Chimeric transcriptional activators and compositions and uses related thereto - Google Patents
Chimeric transcriptional activators and compositions and uses related theretoInfo
- Publication number
- IL134643A0 IL134643A0 IL13464397A IL13464397A IL134643A0 IL 134643 A0 IL134643 A0 IL 134643A0 IL 13464397 A IL13464397 A IL 13464397A IL 13464397 A IL13464397 A IL 13464397A IL 134643 A0 IL134643 A0 IL 134643A0
- Authority
- IL
- Israel
- Prior art keywords
- compositions
- transcriptional activators
- uses related
- chimeric transcriptional
- chimeric
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1997/015219 WO1999010508A1 (en) | 1997-08-27 | 1997-08-27 | Chimeric transcriptional activators and compositions and uses related thereto |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL134643A0 true IL134643A0 (en) | 2001-04-30 |
Family
ID=22261527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13464397A IL134643A0 (en) | 1997-08-27 | 1997-08-27 | Chimeric transcriptional activators and compositions and uses related thereto |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1003886A1 (en) |
| JP (1) | JP2001514007A (en) |
| AU (1) | AU752129B2 (en) |
| CA (1) | CA2303482A1 (en) |
| IL (1) | IL134643A0 (en) |
| WO (1) | WO1999010508A1 (en) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000078951A1 (en) * | 1999-06-18 | 2000-12-28 | Ariad Gene Therapeutics, Inc. | Chimeric oca-b transcription factors |
| EP1254179A4 (en) | 2000-01-24 | 2005-06-01 | Univ Columbia | An in vivo screen using chemical inducers of dimerization |
| AU2001241682A1 (en) * | 2000-02-24 | 2001-09-03 | The Salk Institute For Biological Studies | Gene expression system based on chimeric receptors |
| WO2001098507A1 (en) * | 2000-06-16 | 2001-12-27 | Ariad Gene Therapeutics, Inc. | Chimeric hsf transcription factors |
| ES2392508T3 (en) * | 2001-02-20 | 2012-12-11 | Intrexon Corporation | Chimeric X retinoid receptors and their use in an inducible gene expression system based on novel ecdysone receptors |
| EP1435779A4 (en) | 2001-09-24 | 2005-06-01 | Sangamo Biosciences Inc | Modulation of stem cells using zinc finger proteins |
| US7083918B2 (en) | 2002-04-24 | 2006-08-01 | The Trustees Of Columbia University In The City Of New York | Bacterial small-molecule three-hybrid system |
| EP1678315B1 (en) | 2003-09-19 | 2011-08-03 | Sangamo BioSciences, Inc. | Engineered zinc finger proteins for regulation of gene expression |
| WO2006033859A2 (en) | 2004-09-16 | 2006-03-30 | Sangamo Biosciences, Inc. | Compositions and methods for protein production |
| BR112012024934A2 (en) | 2010-03-29 | 2016-12-06 | Univ Pennsylvania | pharmacologically induced transgene ablation systems |
| US9315825B2 (en) | 2010-03-29 | 2016-04-19 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
| EP2699688A1 (en) | 2011-04-20 | 2014-02-26 | The Trustees Of The University Of Pennsylvania | Regimens and compositions for aav-mediated passive immunization of airborne pathogens |
| MA48852A (en) | 2015-05-13 | 2020-04-01 | Univ Pennsylvania | AAV-MEDIATED EXPRESSION OF ANTI-INFLUENZA ANTIBODIES AND THEIR METHODS OF USE |
| AU2017248731B2 (en) | 2016-04-15 | 2024-08-29 | The Trustees Of The University Of Pennsylvania | Compositions for treatment of wet age-related macular degeneration |
| WO2018160573A1 (en) | 2017-02-28 | 2018-09-07 | The Trustees Of The University Of Pennsylvania | Influenza vaccines based on aav vectors |
| JOP20190200A1 (en) | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | Compositions useful in treatment of spinal muscular atrophy |
| PT3589730T (en) | 2017-02-28 | 2024-02-28 | Univ Pennsylvania | Adeno-associated virus (aav) clade f vector and uses therefor |
| BR112020007405A2 (en) | 2017-10-18 | 2020-12-08 | Regenxbio Inc. | TOTALLY HUMAN HUMAN MODIFIED ANTIBODY THERAPEUTIC PRODUCTS |
| JP2021500071A (en) | 2017-10-18 | 2021-01-07 | リジェネックスバイオ インコーポレイテッド | Treatment of eye diseases and metastatic colorectal cancer with human post-translational modified VEGF-TRAP |
| KR20220004987A (en) | 2019-04-03 | 2022-01-12 | 리젠엑스바이오 인크. | Gene therapy for eye pathologies |
| US20220195462A1 (en) | 2019-04-24 | 2022-06-23 | Regenxbio Inc. | Fully-human post-translationally modified antibody therapeutics |
| TW202122419A (en) | 2019-08-26 | 2021-06-16 | 美商銳進科斯生物股份有限公司 | Treatment of diabetic retinopathy with fully-human post-translationally modified anti-vegf fab |
| EP4041292A1 (en) | 2019-10-07 | 2022-08-17 | RegenxBio Inc. | Adeno-associated virus vector pharmaceutical composition and methods |
| WO2022060915A1 (en) | 2020-09-15 | 2022-03-24 | Regenxbio Inc. | Vectorized lanadelumab and administration thereof |
| EP4214242A1 (en) | 2020-09-15 | 2023-07-26 | RegenxBio Inc. | Vectorized antibodies for anti-viral therapy |
| CA3197342A1 (en) | 2020-10-07 | 2022-04-14 | Regenxbio Inc. | Gene therapy for ocular manifestations of cln2 disease |
| WO2022094157A1 (en) | 2020-10-28 | 2022-05-05 | Regenxbio Inc. | Vectorized anti-cgrp and anti-cgrpr antibodies and administration thereof |
| CN116528892A (en) | 2020-10-28 | 2023-08-01 | 再生生物股份有限公司 | Supported anti-TNF-alpha antibodies for ocular indications |
| EP4237453A1 (en) | 2020-10-29 | 2023-09-06 | RegenxBio Inc. | Vectorized tnf-alpha antagonists for ocular indications |
| WO2022094255A2 (en) | 2020-10-29 | 2022-05-05 | Regenxbio Inc. | Vectorized factor xii antibodies and administration thereof |
| MX2023006444A (en) | 2020-12-01 | 2023-08-10 | Univ Pennsylvania | Novel compositions with tissue-specific targeting motifs and compositions containing same. |
| CN112661820B (en) * | 2020-12-31 | 2021-12-14 | 中国科学院天津工业生物技术研究所 | Rhizobium tianshanense transcription regulation protein MsiR mutant protein and application thereof in canavanine biosensor |
| AR125406A1 (en) | 2021-04-23 | 2023-07-12 | Univ Pennsylvania | NEW COMPOSITIONS WITH SELECTIVE MOTIVES FOR THE BRAIN AND COMPOSITIONS CONTAINING THEM |
| TW202325845A (en) | 2021-10-02 | 2023-07-01 | 賓州大學委員會 | Novel aav capsids and compositions containing same |
| KR20240137067A (en) | 2022-01-25 | 2024-09-19 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | AAV capsids for improved cardiac transduction and liver detargeting |
| WO2023201308A1 (en) | 2022-04-14 | 2023-10-19 | Regenxbio Inc. | Gene therapy for treating an ocular disease |
| WO2023205610A2 (en) | 2022-04-18 | 2023-10-26 | Regenxbio Inc. | Hybrid aav capsids |
| WO2023215806A2 (en) | 2022-05-03 | 2023-11-09 | Regenxbio Inc. | Vectorized anti-complement antibodies and complement agents and administration thereof |
| EP4518973A1 (en) | 2022-05-03 | 2025-03-12 | RegenxBio Inc. | Vectorized anti-tnf-alpha inhibitors for ocular indications |
| CN117467020A (en) * | 2022-07-29 | 2024-01-30 | 南京百斯杰生物工程有限公司 | Chimeric transcription activator and application thereof |
| WO2024073669A1 (en) | 2022-09-30 | 2024-04-04 | Regenxbio Inc. | Treatment of ocular diseases with recombinant viral vectors encoding anti-vegf fab |
| WO2024238859A1 (en) | 2023-05-16 | 2024-11-21 | Regenxbio Inc. | Vectorized c5 inhibitor agents and administration thereof |
| WO2024238867A1 (en) | 2023-05-16 | 2024-11-21 | Regenxbio Inc. | Vectorized anti-complement antibodies and administration thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2246300A1 (en) * | 1996-02-23 | 1997-08-28 | Ariad Pharmaceuticals, Inc. | Cell-based assay |
| WO1997044447A2 (en) * | 1996-05-03 | 1997-11-27 | President And Fellows Of Harvard College | Transcriptional activation system, activators, and uses therefor |
-
1997
- 1997-08-27 IL IL13464397A patent/IL134643A0/en unknown
- 1997-08-27 EP EP97940681A patent/EP1003886A1/en not_active Withdrawn
- 1997-08-27 WO PCT/US1997/015219 patent/WO1999010508A1/en not_active Application Discontinuation
- 1997-08-27 JP JP2000507816A patent/JP2001514007A/en not_active Withdrawn
- 1997-08-27 CA CA002303482A patent/CA2303482A1/en not_active Abandoned
- 1997-08-27 AU AU42402/97A patent/AU752129B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001514007A (en) | 2001-09-11 |
| AU752129B2 (en) | 2002-09-05 |
| EP1003886A1 (en) | 2000-05-31 |
| AU4240297A (en) | 1999-03-16 |
| CA2303482A1 (en) | 1999-03-04 |
| WO1999010508A1 (en) | 1999-03-04 |
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