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IL125419A0 - A process for preparing 1, 4, 7, 10-tetraazacyclododecane and its derivatives - Google Patents

A process for preparing 1, 4, 7, 10-tetraazacyclododecane and its derivatives

Info

Publication number
IL125419A0
IL125419A0 IL12541997A IL12541997A IL125419A0 IL 125419 A0 IL125419 A0 IL 125419A0 IL 12541997 A IL12541997 A IL 12541997A IL 12541997 A IL12541997 A IL 12541997A IL 125419 A0 IL125419 A0 IL 125419A0
Authority
IL
Israel
Prior art keywords
tetraazacyclododecane
derivatives
preparing
cyclotetramerization
benzylaziridine
Prior art date
Application number
IL12541997A
Other versions
IL125419A (en
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of IL125419A0 publication Critical patent/IL125419A0/en
Publication of IL125419A publication Critical patent/IL125419A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

The invention concerns a process for preparing 1,4,7,10-tetraazacyclododecane (cyclene) and its derivatives on an industrial scale by the cyclotetramerization of benzylaziridine prepared in situ.
IL12541997A 1996-02-26 1997-02-26 Process for preparing 1, 4, 7, 10 - tetraazacyclododecane and its derivatives IL125419A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19608307A DE19608307C1 (en) 1996-02-26 1996-02-26 Process for the preparation of 1,4,7,10-tetraazacyclododecane and its derivatives
PCT/EP1997/000927 WO1997031905A1 (en) 1996-02-26 1997-02-26 Process for preparing 1,4,7,10-tetraazacyclododecane and its derivatives

Publications (2)

Publication Number Publication Date
IL125419A0 true IL125419A0 (en) 1999-03-12
IL125419A IL125419A (en) 2001-01-11

Family

ID=7787168

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12541997A IL125419A (en) 1996-02-26 1997-02-26 Process for preparing 1, 4, 7, 10 - tetraazacyclododecane and its derivatives

Country Status (21)

Country Link
EP (1) EP0883610B1 (en)
JP (2) JP4745469B2 (en)
KR (1) KR100453668B1 (en)
CN (1) CN1081186C (en)
AT (1) ATE194602T1 (en)
AU (1) AU717720B2 (en)
CA (1) CA2247265C (en)
CZ (1) CZ290128B6 (en)
DE (2) DE19608307C1 (en)
DK (1) DK0883610T3 (en)
ES (1) ES2148837T3 (en)
GR (1) GR3034468T3 (en)
HK (1) HK1018618A1 (en)
IL (1) IL125419A (en)
NO (1) NO310870B1 (en)
NZ (1) NZ331520A (en)
PL (1) PL185927B1 (en)
PT (1) PT883610E (en)
SK (1) SK281972B6 (en)
WO (1) WO1997031905A1 (en)
ZA (1) ZA971672B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19608307C1 (en) * 1996-02-26 1997-08-28 Schering Ag Process for the preparation of 1,4,7,10-tetraazacyclododecane and its derivatives
CZ2005653A3 (en) * 2005-10-17 2007-01-10 Azacycles S. R. O. Process for preparing 1,4,7,10-tetraazacyclododecane and N-acyl derivatives thereof
DE102009057274B4 (en) 2009-12-02 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrol preparation using trioxobicyclo-octane
DE102010013833A1 (en) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Producing gadolinium complex of N-(hydroxymethyl-dihydroxypropyl)-triscarboxymethyl-tetraazacyclododecane useful as magnetic resonance imaging contrast agent, comprises e.g. reacting cyclic compound with dimethylformamide dimethylacetal
CN101845112B (en) * 2010-06-02 2011-09-14 华东理工大学 Preparation method of high-flexibility nuclear magnetic resonance imaging contrast agents based on high molecular nanometer particles
DE102010023105A1 (en) 2010-06-04 2011-12-08 Bayer Schering Pharma Aktiengesellschaft Gadobutrol preparation in a one-pot process using DMF-acetal and N-methylimidazole
BR112013027028B1 (en) 2011-04-21 2020-08-11 Bayer Intellectual Property Gmbh GADOBUTROL PRODUCTION PROCESS WITH HIGH PURITY
KR102067551B1 (en) * 2018-04-12 2020-01-17 (주) 에프엔지리서치 Compounds for remediating the contaminated soil or water
CN108794417A (en) * 2018-08-04 2018-11-13 许昌恒生制药有限公司 A kind of preparation method of medical diagnosis contrast agent intermediate
EP4335461A1 (en) 2022-09-09 2024-03-13 Bayer AG Combinations of contrast agents
EP4335840A1 (en) 2022-09-09 2024-03-13 Bayer Aktiengesellschaft New contrast agents for use in diagnostic imaging

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3828023A (en) * 1971-09-13 1974-08-06 Dow Chemical Co Process for preparing cyclic oligomers of n-substituted aziridines
US6693190B1 (en) * 1994-05-11 2004-02-17 Bracco International B.V. Enhanced relaxivity monomeric and multimeric compounds
JPH11511733A (en) * 1995-03-10 1999-10-12 ナイコムド サルター，インコーポレイテッド Method for producing N-arylmethyl-aziridine derivative, 1,4,7,10-tetraazacyclododecane derivative obtained from the derivative, and sulfonate of N-arylmethyl-ethanolamine as intermediate
DE19608307C1 (en) * 1996-02-26 1997-08-28 Schering Ag Process for the preparation of 1,4,7,10-tetraazacyclododecane and its derivatives

Also Published As

Publication number Publication date
NO983901D0 (en) 1998-08-25
WO1997031905A1 (en) 1997-09-04
CA2247265A1 (en) 1997-09-04
EP0883610B1 (en) 2000-07-12
ZA971672B (en) 1997-08-29
PL185927B1 (en) 2003-09-30
IL125419A (en) 2001-01-11
KR100453668B1 (en) 2004-12-16
KR19990087248A (en) 1999-12-15
CN1081186C (en) 2002-03-20
NO310870B1 (en) 2001-09-10
DE19608307C1 (en) 1997-08-28
AU1877297A (en) 1997-09-16
CN1211975A (en) 1999-03-24
GR3034468T3 (en) 2000-12-29
PL328468A1 (en) 1999-02-01
EP0883610A1 (en) 1998-12-16
CZ272198A3 (en) 2000-02-16
JP4745469B2 (en) 2011-08-10
NZ331520A (en) 2000-01-28
JP2000505467A (en) 2000-05-09
CZ290128B6 (en) 2002-06-12
PT883610E (en) 2000-10-31
NO983901L (en) 1998-08-25
SK117298A3 (en) 1999-01-11
ES2148837T3 (en) 2000-10-16
DK0883610T3 (en) 2000-09-25
ATE194602T1 (en) 2000-07-15
CA2247265C (en) 2005-06-21
DE59702009D1 (en) 2000-08-17
HK1018618A1 (en) 1999-12-30
SK281972B6 (en) 2001-09-11
JP2009185077A (en) 2009-08-20
AU717720B2 (en) 2000-03-30

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