IL118546A - Corn oil transesterification products - Google Patents

Corn oil transesterification products

Info

Publication number: IL118546A
Authority: IL; Israel
Prior art keywords: weight; product; glycerides; tri; mono
Prior art date: 1991-06-27

Application number

IL11854692A

Other languages

English (en)

Hebrew (he)

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-27

Filing date

1992-06-25

Publication date

1998-09-24

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697415&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL118546(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-06-25 Application filed by Novartis Ag filed Critical Novartis Ag

1998-09-24 Publication of IL118546A publication Critical patent/IL118546A/en

Links

239000002285 corn oil Substances 0.000 title claims abstract description 18
235000005687 corn oil Nutrition 0.000 title claims abstract description 18
239000000203 mixture Substances 0.000 claims abstract description 16
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims abstract description 8
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 70
150000003626 triacylglycerols Chemical class 0.000 claims description 24
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 11
IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 9
235000021313 oleic acid Nutrition 0.000 claims description 9
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 8
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 8
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 8
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 8
239000005642 Oleic acid Substances 0.000 claims description 8
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 8
150000004671 saturated fatty acids Chemical class 0.000 claims description 8
238000005809 transesterification reaction Methods 0.000 claims description 8
OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 claims description 6
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 6
OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims description 5
235000021314 Palmitic acid Nutrition 0.000 claims description 5
235000021355 Stearic acid Nutrition 0.000 claims description 5
239000002253 acid Substances 0.000 claims description 5
238000000034 method Methods 0.000 claims description 5
235000020778 linoleic acid Nutrition 0.000 claims description 4
WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 4
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 4
239000008117 stearic acid Substances 0.000 claims description 4
238000010438 heat treatment Methods 0.000 claims description 3
OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims description 3
239000003921 oil Substances 0.000 claims description 3
235000019198 oils Nutrition 0.000 claims description 3
OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims description 2
239000013543 active substance Substances 0.000 claims description 2
238000013019 agitation Methods 0.000 claims description 2
DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims description 2
235000020661 alpha-linolenic acid Nutrition 0.000 claims description 2
239000003054 catalyst Substances 0.000 claims description 2
229960004488 linolenic acid Drugs 0.000 claims description 2
KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims description 2
229920006395 saturated elastomer Polymers 0.000 claims description 2
239000003795 chemical substances by application Substances 0.000 claims 1
230000008014 freezing Effects 0.000 claims 1
238000007710 freezing Methods 0.000 claims 1
239000004615 ingredient Substances 0.000 claims 1
238000007670 refining Methods 0.000 claims 1
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract description 4
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract description 3
229930105110 Cyclosporin A Natural products 0.000 abstract description 3
108010036949 Cyclosporine Proteins 0.000 abstract description 3
229960001265 ciclosporin Drugs 0.000 abstract description 3
229930182912 cyclosporin Natural products 0.000 abstract description 3
239000004094 surface-active agent Substances 0.000 abstract description 2
238000009472 formulation Methods 0.000 abstract 2
239000002552 dosage form Substances 0.000 abstract 1
239000006186 oral dosage form Substances 0.000 abstract 1
235000014113 dietary fatty acids Nutrition 0.000 description 5
229930195729 fatty acid Natural products 0.000 description 5
239000000194 fatty acid Substances 0.000 description 5
150000004665 fatty acids Chemical class 0.000 description 5
239000007791 liquid phase Substances 0.000 description 4
239000013049 sediment Substances 0.000 description 4
238000005119 centrifugation Methods 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
125000005314 unsaturated fatty acid group Chemical group 0.000 description 3
235000021122 unsaturated fatty acids Nutrition 0.000 description 3
150000004670 unsaturated fatty acids Chemical class 0.000 description 3
239000001149 (9Z,12Z)-octadeca-9,12-dienoate Substances 0.000 description 2
230000001133 acceleration Effects 0.000 description 2
239000012071 phase Substances 0.000 description 2
239000007858 starting material Substances 0.000 description 2
235000015112 vegetable and seed oil Nutrition 0.000 description 2
239000008158 vegetable oil Substances 0.000 description 2
WTTJVINHCBCLGX-UHFFFAOYSA-N (9trans,12cis)-methyl linoleate Natural products CCCCCC=CCC=CCCCCCCCC(=O)OC WTTJVINHCBCLGX-UHFFFAOYSA-N 0.000 description 1
DVWSXZIHSUZZKJ-UHFFFAOYSA-N 18:3n-3 Natural products CCC=CCC=CCC=CCCCCCCCC(=O)OC DVWSXZIHSUZZKJ-UHFFFAOYSA-N 0.000 description 1
LNJCGNRKWOHFFV-UHFFFAOYSA-N 3-(2-hydroxyethylsulfanyl)propanenitrile Chemical compound OCCSCCC#N LNJCGNRKWOHFFV-UHFFFAOYSA-N 0.000 description 1
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
235000019489 Almond oil Nutrition 0.000 description 1
244000144730 Amygdalus persica Species 0.000 description 1
PCZLBADHCBPNCX-UHFFFAOYSA-N C(CCCCCCCCCCCCCCCCC)(=O)OC.C(CCCCCCCCCCCCCCC)(=O)OC.C(CCCCCCCCCCCCCCCCCCC)(=O)OC Chemical compound C(CCCCCCCCCCCCCCCCC)(=O)OC.C(CCCCCCCCCCCCCCC)(=O)OC.C(CCCCCCCCCCCCCCCCCCC)(=O)OC PCZLBADHCBPNCX-UHFFFAOYSA-N 0.000 description 1
239000001828 Gelatine Substances 0.000 description 1
PKIXXJPMNDDDOS-UHFFFAOYSA-N Methyl linoleate Natural products CCCCC=CCCC=CCCCCCCCC(=O)OC PKIXXJPMNDDDOS-UHFFFAOYSA-N 0.000 description 1
235000019482 Palm oil Nutrition 0.000 description 1
235000019483 Peanut oil Nutrition 0.000 description 1
235000006040 Prunus persica var persica Nutrition 0.000 description 1
235000019485 Safflower oil Nutrition 0.000 description 1
235000019486 Sunflower oil Nutrition 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000008168 almond oil Substances 0.000 description 1
239000002775 capsule Substances 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000004821 distillation Methods 0.000 description 1
QYDYPVFESGNLHU-UHFFFAOYSA-N elaidic acid methyl ester Natural products CCCCCCCCC=CCCCCCCCC(=O)OC QYDYPVFESGNLHU-UHFFFAOYSA-N 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
125000005456 glyceride group Chemical group 0.000 description 1
IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
229910052740 iodine Inorganic materials 0.000 description 1
239000011630 iodine Substances 0.000 description 1
229940049918 linoleate Drugs 0.000 description 1
-1 linolenic Chemical class 0.000 description 1
150000004702 methyl esters Chemical class 0.000 description 1
DVWSXZIHSUZZKJ-YSTUJMKBSA-N methyl linolenate Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(=O)OC DVWSXZIHSUZZKJ-YSTUJMKBSA-N 0.000 description 1
QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 description 1
229940073769 methyl oleate Drugs 0.000 description 1
229940049964 oleate Drugs 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
239000002540 palm oil Substances 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
150000002978 peroxides Chemical class 0.000 description 1
229960004063 propylene glycol Drugs 0.000 description 1
239000003813 safflower oil Substances 0.000 description 1
235000005713 safflower oil Nutrition 0.000 description 1
238000007127 saponification reaction Methods 0.000 description 1
235000003441 saturated fatty acids Nutrition 0.000 description 1
230000007928 solubilization Effects 0.000 description 1
238000005063 solubilization Methods 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
239000002600 sunflower oil Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
- C11C3/04—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fats or fatty oils
- C11C3/06—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fats or fatty oils with glycerol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Nanotechnology (AREA)
Dispersion Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Medical Informatics (AREA)
Crystallography & Structural Chemistry (AREA)
Biotechnology (AREA)
Oncology (AREA)
Wood Science & Technology (AREA)
Communicable Diseases (AREA)
Transplantation (AREA)
General Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Fats And Perfumes (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Confectionery (AREA)

IL11854692A 1991-06-27 1992-06-25 Corn oil transesterification products IL118546A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB919113872A GB9113872D0 (en)	1991-06-27	1991-06-27	Improvements in or relating to organic compounds
IL102310A IL102310A (en)	1991-06-27	1992-06-25	Pharmaceutical compositions comprising cyclosporins

Publications (1)

Publication Number	Publication Date
IL118546A true IL118546A (en)	1998-09-24

Family

ID=10697415

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
IL11854692A IL118546A (en)	1991-06-27	1992-06-25	Corn oil transesterification products
IL102310A IL102310A (en)	1991-06-27	1992-06-25	Pharmaceutical compositions comprising cyclosporins
IL11854696A IL118546A0 (en)	1991-06-27	1996-06-03	Transesterified corn oil products

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
IL102310A IL102310A (en)	1991-06-27	1992-06-25	Pharmaceutical compositions comprising cyclosporins
IL11854696A IL118546A0 (en)	1991-06-27	1996-06-03	Transesterified corn oil products

Country Status (38)

Country	Link
EP (2)	EP0539319B1 (fi)
JP (2)	JP2653958B2 (fi)
KR (3)	KR0131064B1 (fi)
CN (1)	CN1077798C (fi)
AT (1)	AT403436B (fi)
AU (1)	AU659460B2 (fi)
CA (2)	CA2175842C (fi)
CH (2)	CH685764A5 (fi)
CY (1)	CY1906A (fi)
CZ (1)	CZ281790B6 (fi)
DE (3)	DE4219526C2 (fi)
DK (2)	DK0953630T3 (fi)
EE (1)	EE03108B1 (fi)
ES (2)	ES2142818T3 (fi)
FI (2)	FI109454B (fi)
FR (2)	FR2678169B1 (fi)
GB (2)	GB9113872D0 (fi)
GR (1)	GR3032366T3 (fi)
HK (2)	HK57196A (fi)
HU (1)	HU216792B (fi)
IE (1)	IE73662B1 (fi)
IL (3)	IL118546A (fi)
IT (1)	IT1254401B (fi)
LU (1)	LU88138A1 (fi)
MX (1)	MX9203236A (fi)
MY (1)	MY109512A (fi)
NO (2)	NO303964B1 (fi)
NZ (1)	NZ243309A (fi)
PH (1)	PH30337A (fi)
PT (2)	PT953630E (fi)
RO (2)	RO111021B1 (fi)
RU (1)	RU2143919C1 (fi)
SA (1)	SA92130213B1 (fi)
SK (1)	SK278759B6 (fi)
TW (1)	TW267943B (fi)
UA (1)	UA35559C2 (fi)
UY (1)	UY23864A1 (fi)
ZA (1)	ZA924719B (fi)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9113872D0 (en) *	1991-06-27	1991-08-14	Sandoz Ag	Improvements in or relating to organic compounds
EP0589843B1 (en) *	1992-09-25	2001-11-28	Novartis AG	Pharmaceutical compositions containing cyclosporins
NZ247516A (en) *	1993-04-28	1995-02-24	Bernard Charles Sherman	Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant
CH686761A5 (de) *	1993-05-27	1996-06-28	Sandoz Ag	Galenische Formulierungen.
AT408520B (de) *	1993-05-27	2001-12-27	Novartis Erfind Verwalt Gmbh	Galenische formulierungen
GB2278780B (en) *	1993-05-27	1998-10-14	Sandoz Ltd	Macrolide formulations
EP0649651B1 (en)	1993-09-28	2000-12-13	R.P. Scherer GmbH	Soft gelatin capsule manufacture
DE4340781C3 (de) *	1993-11-30	2000-01-27	Novartis Ag	Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
EP0694308A4 (en) *	1994-02-17	1997-09-10	Shiseido Co Ltd	CYCLOSPORIN EMULSION COMPOSITION
US5891846A (en) *	1994-02-17	1999-04-06	Shiseido Company, Ltd.	Cyclosporin-containing emulsion composition
NZ270145A (en) *	1994-03-01	1996-08-27	Lilly Co Eli	Non-aqueous pharmaceutical formulation for oral administration comprising water-insoluble active agent, fatty acid solubilising agent, an oil and a surface active agent
GB9405304D0 (en) *	1994-03-16	1994-04-27	Scherer Ltd R P	Delivery systems for hydrophobic drugs
EP0679712B1 (en) *	1994-03-31	1999-06-23	Loders Croklaan B.V.	Low safa oils
GB2308545B (en) *	1994-10-26	1999-06-02	Novartis Ag	Pharmaceutical microemulsion preconcentrates
IL129547A (en)	1994-10-26	2001-01-11	Novartis Ag	Pharmaceutical compositions comprising a macrolide and an acid
DK0789580T3 (da)	1994-11-03	2002-09-09	Novartis Ag	Nye præparatformer for cyclosporin til oral administration med simpel sammensætning og høj biotilgængelighed, og fremgangsmåder til deres fremstilling
HU215966B (hu) *	1994-11-21	1999-07-28	BIOGAL Gyógyszergyár Rt.	Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum
CA2220451A1 (en) *	1995-05-17	1996-11-21	Cedars-Sinai Medical Center	Methods and compositions for improving digestion and absorption in the small intestine
WO1996036330A2 (en) *	1995-05-17	1996-11-21	Cedars-Sinai Medical Center	Compositions containing fatty acids for improving digestion and absorption in the small intestine
US6861053B1 (en)	1999-08-11	2005-03-01	Cedars-Sinai Medical Center	Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US7048906B2 (en)	1995-05-17	2006-05-23	Cedars-Sinai Medical Center	Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US6008228A (en) *	1995-06-06	1999-12-28	Hoffman-La Roche Inc.	Pharmaceutical compositions containing proteinase inhibitors
US6696413B2 (en) *	1995-06-16	2004-02-24	Hexal Ag	Pharmaceutical preparation with cyclosporin A
SE504582C2 (sv) *	1995-07-06	1997-03-10	Gs Dev Ab	Cyklosporinkomposition baserad på en L2-fas
DE19549852B4 (de)	1995-11-29	2009-06-04	Novartis Ag	Cyclosporin enthaltende Präparate
US5858401A (en)	1996-01-22	1999-01-12	Sidmak Laboratories, Inc.	Pharmaceutical composition for cyclosporines
CN1104258C (zh) *	1996-05-29	2003-04-02	周德和	用于环孢霉素a的赋形剂
US5958876A (en) *	1996-06-19	1999-09-28	Novartis Ag	Cyclosporin-containing pharmaceutical compositions
KR20040000379A (ko) *	1996-06-19	2004-01-03	노파르티스 아게	사이클로스포린-함유 연질캅셀제
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1991
- 1991-06-27 GB GB919113872A patent/GB9113872D0/en active Pending
1992
- 1992-06-12 HU HU9201975A patent/HU216792B/hu unknown
- 1992-06-15 DE DE4219526A patent/DE4219526C2/de not_active Expired - Lifetime
- 1992-06-15 DE DE4244930A patent/DE4244930C2/de not_active Expired - Lifetime
- 1992-06-15 DE DE4244986A patent/DE4244986B4/de not_active Expired - Lifetime
- 1992-06-23 DK DK99106122T patent/DK0953630T3/da active
- 1992-06-23 ES ES92810479T patent/ES2142818T3/es not_active Expired - Lifetime
- 1992-06-23 EP EP92810479A patent/EP0539319B1/en not_active Expired - Lifetime
- 1992-06-23 ES ES99106122T patent/ES2227921T3/es not_active Expired - Lifetime
- 1992-06-23 EP EP99106122A patent/EP0953630B1/en not_active Expired - Lifetime
- 1992-06-23 PT PT99106122T patent/PT953630E/pt unknown
- 1992-06-23 DK DK92810479T patent/DK0539319T3/da active
- 1992-06-23 CH CH296/94A patent/CH685764A5/de not_active IP Right Cessation
- 1992-06-23 PT PT92810479T patent/PT539319E/pt unknown
- 1992-06-23 IT ITRM920476A patent/IT1254401B/it active
- 1992-06-23 CH CH1971/92A patent/CH684163A5/de not_active IP Right Cessation
- 1992-06-24 CY CY190692A patent/CY1906A/en unknown
- 1992-06-24 FR FR9207856A patent/FR2678169B1/fr not_active Expired - Lifetime
- 1992-06-24 MX MX9203236A patent/MX9203236A/es unknown
- 1992-06-24 GB GB9213393A patent/GB2257359B/en not_active Expired - Lifetime
- 1992-06-25 MY MYPI92001199A patent/MY109512A/en unknown
- 1992-06-25 ZA ZA924719A patent/ZA924719B/xx unknown
- 1992-06-25 IL IL11854692A patent/IL118546A/en not_active IP Right Cessation
- 1992-06-25 CZ CS921977A patent/CZ281790B6/cs not_active IP Right Cessation
- 1992-06-25 NO NO922506A patent/NO303964B1/no not_active IP Right Cessation
- 1992-06-25 FI FI922958A patent/FI109454B/fi not_active IP Right Cessation
- 1992-06-25 SK SK1977-92A patent/SK278759B6/sk not_active IP Right Cessation
- 1992-06-25 IL IL102310A patent/IL102310A/xx not_active IP Right Cessation
- 1992-06-25 NZ NZ243309A patent/NZ243309A/en not_active IP Right Cessation
- 1992-06-25 AT AT0129892A patent/AT403436B/de not_active IP Right Cessation
- 1992-06-25 AU AU18527/92A patent/AU659460B2/en not_active Expired
- 1992-06-25 LU LU88138A patent/LU88138A1/fr unknown
- 1992-06-25 PH PH44558A patent/PH30337A/en unknown
- 1992-06-26 CA CA002175842A patent/CA2175842C/en not_active Expired - Lifetime
- 1992-06-26 JP JP4168946A patent/JP2653958B2/ja not_active Expired - Lifetime
- 1992-06-26 CA CA002072509A patent/CA2072509C/en not_active Expired - Lifetime
- 1992-06-26 RO RO92-0868A patent/RO111021B1/ro unknown
- 1992-06-26 KR KR1019920011198A patent/KR0131064B1/ko not_active Expired - Lifetime
- 1992-06-26 RU SU5052126/A patent/RU2143919C1/ru active
- 1992-06-29 TW TW081105112A patent/TW267943B/zh not_active IP Right Cessation
- 1992-07-01 IE IE922082A patent/IE73662B1/en not_active IP Right Cessation
- 1992-10-31 SA SA92130213A patent/SA92130213B1/ar unknown
1993
- 1993-01-01 CN CN93100563A patent/CN1077798C/zh not_active Expired - Lifetime
- 1993-02-01 FR FR9301141A patent/FR2685706A1/fr active Granted
- 1993-06-18 UA UA93003147A patent/UA35559C2/uk unknown
1994
- 1994-11-09 EE EE9400190A patent/EE03108B1/xx unknown
- 1994-11-30 UY UY23864A patent/UY23864A1/es not_active IP Right Cessation
1995
- 1995-06-14 RO RO95-01142A patent/RO111110B1/ro unknown
1996
- 1996-04-03 HK HK57196A patent/HK57196A/xx not_active IP Right Cessation
- 1996-04-03 FI FI961513A patent/FI116199B/fi not_active IP Right Cessation
- 1996-06-03 IL IL11854696A patent/IL118546A0/xx unknown
- 1996-08-22 HK HK157696A patent/HK157696A/xx not_active IP Right Cessation
- 1996-09-12 JP JP24170596A patent/JP3420897B2/ja not_active Expired - Lifetime
- 1996-10-15 NO NO19964382A patent/NO325267B1/no not_active IP Right Cessation
1997
- 1997-06-20 KR KR1019970026005A patent/KR100231385B1/ko not_active Expired - Lifetime
1998
- 1998-09-22 KR KR1019980039160A patent/KR100231384B1/ko not_active Expired - Lifetime
2000
- 2000-01-14 GR GR20000400064T patent/GR3032366T3/el unknown

Also Published As

Publication number	Publication date
DE4244930C2 (de)	1999-11-11
GB9113872D0 (en)	1991-08-14
FI922958A0 (fi)	1992-06-25
NO964382L (no)	1992-12-28
JP3420897B2 (ja)	2003-06-30
MY109512A (en)	1997-02-28
UA35559C2 (uk)	2001-04-16
IE922082A1 (en)	1992-12-30
ITRM920476A0 (it)	1992-06-23
CA2072509A1 (en)	1992-12-28
RU2143919C1 (ru)	2000-01-10
ZA924719B (en)	1993-12-27
AU659460B2 (en)	1995-05-18
DK0953630T3 (da)	2004-11-01
FI961513A0 (fi)	1996-04-03
CH685764A5 (de)	1995-09-29
CA2175842A1 (en)	1992-12-28
FI116199B (fi)	2005-10-14
CA2175842C (en)	2002-05-07
IL102310A0 (en)	1993-01-14
CN1079907A (zh)	1993-12-29
EP0539319B1 (en)	1999-12-08
EP0539319A3 (en)	1993-06-09
PH30337A (en)	1997-04-02
IE73662B1 (en)	1997-06-18
CH684163A5 (de)	1994-07-29
JPH09118894A (ja)	1997-05-06
NO922506L (no)	1992-12-28
DE4219526C2 (de)	1999-04-22
MX9203236A (es)	1992-12-01
SA92130213B1 (ar)	2004-07-24
FI109454B (fi)	2002-08-15
PT953630E (pt)	2004-11-30
CZ197792A3 (en)	1993-01-13
DE4244986B4 (de)	2008-07-24
ITRM920476A1 (it)	1993-12-23
NO303964B1 (no)	1998-10-05
SK197792A3 (en)	1994-03-09
GB9213393D0 (en)	1992-08-05
CZ281790B6 (cs)	1997-01-15
HK57196A (en)	1996-04-12
KR0131064B1 (ko)	1998-04-17
DE4219526A1 (de)	1993-03-18
JP2653958B2 (ja)	1997-09-17
GB2257359A (en)	1993-01-13
RO111021B1 (ro)	1996-06-28
RO111110B1 (ro)	1996-06-28
IT1254401B (it)	1995-09-14
FR2678169A1 (fr)	1992-12-31
SK278759B6 (sk)	1998-02-04
HU9201975D0 (en)	1992-09-28
NO922506D0 (no)	1992-06-25
FI922958L (fi)	1992-12-28
JPH05186365A (ja)	1993-07-27
AU1852792A (en)	1993-03-11
FI961513L (fi)	1996-04-03
CY1906A (en)	1992-06-24
KR930000113A (ko)	1993-01-15
DK0539319T3 (da)	2000-05-22
KR100231385B1 (en)	1999-11-15
PT539319E (pt)	2000-05-31
CA2072509C (en)	1996-07-30
HU216792B (hu)	1999-08-30
FR2685706A1 (fr)	1993-07-02
HUT62201A (en)	1993-04-28
IL102310A (en)	1997-03-18
HK157696A (en)	1996-08-30
EE03108B1 (et)	1998-08-17
FR2685706B1 (fi)	1994-12-23
NZ243309A (en)	1995-02-24
LU88138A1 (fr)	1994-03-01
TW267943B (fi)	1996-01-11
CN1077798C (zh)	2002-01-16
AT403436B (de)	1998-02-25
IL118546A0 (en)	1996-10-16
NO325267B1 (no)	2008-03-17
GR3032366T3 (en)	2000-04-27
GB2257359B (en)	1996-01-10
ES2227921T3 (es)	2005-04-01
EP0953630B1 (en)	2004-09-08
ATA129892A (de)	1997-07-15
EP0539319A2 (en)	1993-04-28
UY23864A1 (es)	1995-05-29
ES2142818T3 (es)	2000-05-01
EP0953630A1 (en)	1999-11-03
FR2678169B1 (fr)	1994-08-26
KR100231384B1 (en)	1999-11-15
NO964382D0 (no)	1996-10-15

Publication	Publication Date	Title
EP0953630B1 (en)	2004-09-08	Transesterification products of corn oil and glycerol and their use in pharmaceutical compositions
CA2366754C (en)	2009-07-14	Oral pharmaceutical compositions containing long-chain triglycerides and lipophilic surfactants
US6420355B2 (en)	2002-07-16	Pharmaceutical compositions containing cyclosporins
US6652880B1 (en)	2003-11-25	Oral pharmaceutical compositions containing long-chain triglycerides and liphophilic surfactants
CZ291214B6 (cs)	2003-01-15	Potravinářský prostředek s obsahem organického gelu
IE84659B1 (en)	2007-08-08	Transesterified corn oil products
AU688920B2 (en)	1998-03-19	Transesterified corn oil products
JPH10330250A (ja)	1998-12-15	メナテトレノン油性製剤
Kartha	1968	High‐order compositeness in randomly distributed natural fats: Glyceride structure of an arecanut fat
CY1958A (en)	1992-06-24	Transesterified corn oil products

Legal Events

Date	Code	Title
1999-01-26	FF	Patent granted
1999-07-14	KB	Patent renewed
2002-08-14	KB	Patent renewed
2006-09-05	KB	Patent renewed
2010-11-30	KB	Patent renewed
2013-02-03	EXP	Patent expired