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IL118325A0 - Integrin receptor antagonists and pharmaceutical compositions containing them - Google Patents

Integrin receptor antagonists and pharmaceutical compositions containing them

Info

Publication number
IL118325A0
IL118325A0 IL11832596A IL11832596A IL118325A0 IL 118325 A0 IL118325 A0 IL 118325A0 IL 11832596 A IL11832596 A IL 11832596A IL 11832596 A IL11832596 A IL 11832596A IL 118325 A0 IL118325 A0 IL 118325A0
Authority
IL
Israel
Prior art keywords
pharmaceutical compositions
compositions containing
receptor antagonists
integrin receptor
integrin
Prior art date
Application number
IL11832596A
Original Assignee
Pont Merck And Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/647,132 external-priority patent/US5710159A/en
Application filed by Pont Merck And Pharmaceutical filed Critical Pont Merck And Pharmaceutical
Publication of IL118325A0 publication Critical patent/IL118325A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL11832596A 1995-05-25 1996-05-20 Integrin receptor antagonists and pharmaceutical compositions containing them IL118325A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45064695A 1995-05-25 1995-05-25
US45576895A 1995-05-31 1995-05-31
US08/647,132 US5710159A (en) 1996-05-09 1996-05-09 Integrin receptor antagonists

Publications (1)

Publication Number Publication Date
IL118325A0 true IL118325A0 (en) 1996-10-31

Family

ID=27412454

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11832596A IL118325A0 (en) 1995-05-25 1996-05-20 Integrin receptor antagonists and pharmaceutical compositions containing them

Country Status (7)

Country Link
EP (1) EP0828737A1 (en)
JP (1) JPH11506436A (en)
AU (1) AU5876296A (en)
CA (1) CA2221980A1 (en)
IL (1) IL118325A0 (en)
MX (1) MX9708840A (en)
WO (1) WO1996037492A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760028A (en) * 1995-12-22 1998-06-02 The Dupont Merck Pharmaceutical Company Integrin receptor antagonists
CA2249733A1 (en) * 1996-03-15 1997-09-18 Du Pont Pharmaceuticals Company Spirocycle integrin inhibitors
ZA972195B (en) * 1996-03-15 1998-09-14 Du Pont Merck Pharma Spirocycle integrin inhibitors
CA2250690A1 (en) * 1996-03-29 1997-10-09 G.D. Searle & Co. Cinnamic acid derivatives and their use as integrin antagonists
AU3640997A (en) * 1996-06-19 1998-01-07 Du Pont Pharmaceuticals Company Iontophoretic delivery of integrin inhibitors
US6214834B1 (en) 1997-03-28 2001-04-10 Dupont Pharmaceuticals Company Integrin inhibitor prodrugs
CA2327673C (en) 1998-04-09 2009-08-25 Meiji Seika Kaisha, Ltd. Aminopiperidine derivatives as integrin .alpha.v.beta.3 antagonists
RU2001126719A (en) * 1999-03-03 2004-02-20 Дзе Проктер Энд Гэмбл Компани (US) Digester-substituted metalloprotease inhibitors
EP1187825A1 (en) * 1999-06-07 2002-03-20 Shire Biochem Inc. Thiophene integrin inhibitors
AU6360200A (en) 1999-07-21 2001-02-13 American Home Products Corporation Bicyclic antagonists selective for the alphavbeta3 integrin
US6750219B1 (en) 1999-08-05 2004-06-15 Meiji Seika Kaisha, Ltd. Ω-amino-α-hydroxycarboxylic acid derivatives having integrin ανβ3 antagonistic activity
BR0016818A (en) * 1999-12-28 2002-10-01 Pfizer Prod Inc Non-peptidyl inhibitors of vla-4-dependent cell adhesion useful in the treatment of inflammatory, autoimmune and respiratory diseases
DE10029077A1 (en) * 2000-06-13 2001-12-20 Bayer Ag New heterocyclic-substituted thiazole derivatives, useful as total or selective herbicides, insecticides, acaricides, nematocides, ectoparasiticides or antifouling agents
KR100594544B1 (en) * 2003-08-27 2006-06-30 주식회사 엘지생명과학 Caspase inhibitors containing isoxazoline ring
GB0412553D0 (en) * 2004-06-04 2004-07-07 Univ Aberdeen Therapeutic agents for the treatment of bone conditions
WO2006090234A1 (en) * 2005-02-22 2006-08-31 Ranbaxy Laboratories Limited Heterocyclic derivatives as cell adhesion inhibitors
GB0705400D0 (en) 2007-03-21 2007-05-02 Univ Aberdeen Therapeutic compounds andm their use
GB0817208D0 (en) 2008-09-19 2008-10-29 Pimco 2664 Ltd Therapeutic apsap compounds and their use
GB0817207D0 (en) 2008-09-19 2008-10-29 Pimco 2664 Ltd therapeutic apsac compounds and their use
US9505728B2 (en) 2012-03-09 2016-11-29 Inception 2, Inc. Triazolone compounds and uses thereof
WO2014099503A1 (en) 2012-12-20 2014-06-26 Inception 2, Inc. Triazolone compounds and uses thereof
GB201311361D0 (en) 2013-06-26 2013-08-14 Pimco 2664 Ltd Compounds and their therapeutic use
CA2921420A1 (en) 2013-09-06 2015-03-12 Inception 2, Inc. Triazolone compounds and uses thereof
EP3677579A1 (en) * 2014-07-03 2020-07-08 Board of Regents, The University of Texas System Heterocyclic gls1 inhibitors
US10005733B2 (en) 2014-12-17 2018-06-26 Pimco 2664 Limited N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and N-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)-benzenesulfonamide compounds and their therapeutic use
WO2017004359A1 (en) 2015-06-30 2017-01-05 Board Of Regents, University Of Texas System Gls1 inhibitors for treating disease
EP3394039A4 (en) 2015-12-22 2019-06-12 Board of Regents, The University of Texas System SALT FORMS AND POLYMORPHS OF (R) -1- (4- (6- (2- (4- (3,3-DIFLUOROCYCLOBUTOXY) -6-METHYLPYRIDIN-2-YL) ACETAMIDO) PYRIDAZIN-3-YL) -2 -FLUOROBUTYL) -N-METHYL-1H-1,2,3-triazole-4-carboxamide
MX2019005233A (en) * 2016-11-08 2019-08-12 Squibb Bristol Myers Co Pyrrole amides as alpha v integrin inhibitors.
CN111225903B (en) 2017-10-18 2024-08-16 德州大学系统董事会 Glutaminase inhibitor therapy

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU599636B2 (en) * 1986-03-14 1990-07-26 Syntex (U.S.A.) Inc. Transglutaminase inhibitors
DE4124942A1 (en) * 1991-07-27 1993-01-28 Thomae Gmbh Dr K 5-LOW HETEROCYCLES, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENTS CONTAINING SUCH COMPOUNDS
EP0667773A4 (en) * 1992-10-14 1996-09-25 Merck & Co Inc Fibrinogen receptor antagonists.
DE69411584T2 (en) * 1993-11-24 1998-12-17 The Du Pont Merck Pharmaceutical Co., Wilmington, Del. ISOXAZOLINE DERIVATIVES APPLICABLE AS FIBRINOGEN RECEPTOR ANTAGONISTS
PL182303B1 (en) * 1993-11-24 2001-12-31 Du Pont Pharm Co Novel derivatives of isoxazoline and isoxazole having properties of fibrinogen receptor antagonists

Also Published As

Publication number Publication date
CA2221980A1 (en) 1996-11-28
WO1996037492A1 (en) 1996-11-28
EP0828737A1 (en) 1998-03-18
AU5876296A (en) 1996-12-11
JPH11506436A (en) 1999-06-08
MX9708840A (en) 1998-03-31

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