IL105206A - Indulgent histories and decoctions containing them - Google Patents

Indulgent histories and decoctions containing them

Info

Publication number: IL105206A
Authority: IL; Israel
Prior art keywords: compound; alkyl; hydrogen; aryl; formula
Prior art date: 1992-04-07

Application number

IL10520693A

Other languages

English (en)

Hebrew (he)

Other versions

IL105206A0 (en

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-07

Filing date

1993-03-29

Publication date

1999-04-11

1993-03-29 Application filed by Pfizer filed Critical Pfizer

1993-03-29 Priority to IL12132693A priority Critical patent/IL121326A/en

1993-07-08 Publication of IL105206A0 publication Critical patent/IL105206A0/xx

1997-07-16 Priority to IL12132697A priority patent/IL121326A0/xx

1999-04-11 Publication of IL105206A publication Critical patent/IL105206A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pyrrole Compounds (AREA)

IL10520693A 1992-04-07 1993-03-29 Indulgent histories and decoctions containing them IL105206A (en)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
IL12132693A IL121326A (en)	1992-04-07	1993-03-29	N-substituted pyrolidin-2-yl methyl indole derivatives
IL12132697A IL121326A0 (en)	1992-04-07	1997-07-16	Indole derivatives

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US86473792A	1992-04-07	1992-04-07

Publications (2)

Publication Number	Publication Date
IL105206A0 IL105206A0 (en)	1993-07-08
IL105206A true IL105206A (en)	1999-04-11

Family

ID=25343950

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL10520693A IL105206A (en)	1992-04-07	1993-03-29	Indulgent histories and decoctions containing them

Country Status (26)

Country	Link
US (7)	US5747501A (cs)
EP (1)	EP0635017A1 (cs)
JP (1)	JP2644088B2 (cs)
KR (1)	KR0179072B1 (cs)
CN (2)	CN1050841C (cs)
AU (1)	AU670579B2 (cs)
BR (1)	BR9306201A (cs)
CA (1)	CA2133413C (cs)
CZ (1)	CZ281763B6 (cs)
EG (1)	EG20226A (cs)
FI (1)	FI931558A (cs)
HR (1)	HRP930752A2 (cs)
HU (1)	HUT64062A (cs)
IL (1)	IL105206A (cs)
MX (1)	MX9302011A (cs)
MY (1)	MY108909A (cs)
NO (1)	NO303388B1 (cs)
NZ (1)	NZ251086A (cs)
PL (1)	PL172405B1 (cs)
RU (1)	RU2101283C1 (cs)
SK (1)	SK280193B6 (cs)
TW (1)	TW341565B (cs)
UA (1)	UA27467C2 (cs)
WO (1)	WO1993020073A1 (cs)
YU (1)	YU48931B (cs)
ZA (1)	ZA932440B (cs)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5559246A (en) *	1990-10-15	1996-09-24	Pfizer Inc.	Indole derivatives
US5578612A (en) *	1990-10-15	1996-11-26	Pfizer Inc.	Indole derivatives
US5545644A (en) *	1990-10-15	1996-08-13	Pfizer Inc.	Indole derivatives
US5559129A (en) *	1990-10-15	1996-09-24	Pfizer Inc	Indole derivatives
US5607951A (en) *	1990-10-15	1997-03-04	Pfizer Inc	Indole derivatives
PL172405B1 (en) *	1992-04-07	1997-09-30	Pfizer	Derivatives of indole
ES2070087B1 (es) *	1993-08-13	1996-02-16	Pfizer	Derivados de indol
WO1995006636A1 (en) *	1993-08-31	1995-03-09	Pfizer Inc.	5-arylindole derivatives
WO1995032196A1 (en) *	1994-05-19	1995-11-30	Merck Sharp & Dohme Limited	Piperazine, piperidine and tetrahydropyridine derivatives of indol-3-ylalkyl as 5-ht1d-alpha agonists
GB9415575D0 (en) *	1994-08-02	1994-09-21	Merck Sharp & Dohme	Therapeutic agents
GB9417310D0 (en)	1994-08-27	1994-10-19	Pfizer Ltd	Therapeutic agents
GB9420529D0 (en)	1994-10-12	1994-11-30	Pfizer Ltd	Indoles
GB9423682D0 (en) *	1994-11-23	1995-01-11	Merck Sharp & Dohme	Therapeutic agents
US6025374A (en) *	1994-12-06	2000-02-15	Merck Sharp & Dohme, Ltd.	Azetidine, pyrrolidine and piperidine derivatives as 5HT1 receptor agonists
ES2196163T3 (es) *	1995-07-31	2003-12-16	Shionogi & Co	Derivados de pirrolidina con una actividad de inhibicion de la fosfolipasa a2.
GB9519558D0 (en) *	1995-09-26	1995-11-29	Merck Sharp & Dohme	Therapeutic agents
US6051593A (en) *	1997-06-20	2000-04-18	Sugen, Inc.	3-(cycloalkanoheteroarylidenyl)-2- indolinone protein tyrosine kinase inhibitors
JP2002519321A (ja) *	1998-06-30	2002-07-02	イーライ・リリー・アンド・カンパニー	セロトニン関連系に効果を有するピロリジン、及び、ピロリン誘導体
US6355672B1 (en) *	1998-08-07	2002-03-12	Takeda Chemical Industries, Ltd.	Benzothiepin derivatives, process for the preparation of the same and uses thereof
US5994352A (en) *	1998-11-13	1999-11-30	Pfizer Inc.	5-arylindole derivatives
US6326388B1 (en) *	1999-12-21	2001-12-04	Celgene Corporation	Substituted 1,3,4-oxadiazoles and a method of reducing TNF-alpha level
US7041697B2 (en) *	2002-09-12	2006-05-09	Wyeth	Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan
CA2635010A1 (en) *	2005-12-30	2007-07-19	Amjad Ali	Oxazolidinone derivatives as cetp inhibitors
CN102186477B (zh) *	2008-10-16	2013-07-17	奥梅-杨森制药有限公司	作为代谢型谷氨酸受体调节剂的吲哚和苯并吗啉衍生物
US20100217013A1 (en) *	2008-12-15	2010-08-26	Wenge Li	Enantioselective process for the preparation of zolmitriptan
US20140206667A1 (en)	2012-11-14	2014-07-24	Michela Gallagher	Methods and compositions for treating schizophrenia
HUE057402T2 (hu) *	2016-04-28	2022-05-28	Jiangsu Hengrui Medicine Co	Tirozinkináz inhibitor és azok származékainak elõállítási módszere
CA3166940A1 (en) *	2020-02-04	2021-08-12	Abdelmalik Slassi	3-pyrrolidine-indole derivatives as serotonergic psychedelic agents for the treatment of cns disorders

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA795239B (en) *	1978-10-12	1980-11-26	Glaxo Group Ltd	Heterocyclic compounds
BE889931A (fr) *	1980-08-12	1982-02-11	Glaxo Group Ltd	Derives indoliques, leur preparation et leurs applications en tant que medicaments
US4689336A (en) *	1981-01-02	1987-08-25	Pfizer Inc.	Hypoglycemic 5-substituted oxazolidine 2,4-diones
GB8600397D0 (en) *	1986-01-08	1986-02-12	Glaxo Group Ltd	Chemical compounds
FR2601008B1 (fr) *	1986-07-03	1990-03-30	Sanofi Sa	Procede de synthese stereospecifique de derives de l'indole
HU203330B (en) *	1987-06-10	1991-07-29	Pfizer	Process for producing oxazolidin-2-one derivatives and hypoglychemic pharmaceutical compositions containing them
GB8719167D0 (en) *	1987-08-13	1987-09-23	Glaxo Group Ltd	Chemical compounds
GB8724912D0 (en) *	1987-10-23	1987-11-25	Wellcome Found	Indole derivatives
GB8819024D0 (en) *	1988-08-10	1988-09-14	Glaxo Group Ltd	Chemical compounds
IL96891A0 (en) *	1990-01-17	1992-03-29	Merck Sharp & Dohme	Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
WO1991018897A1 (en) *	1990-06-07	1991-12-12	The Wellcome Foundation Limited	Therapeutic heterocyclic compounds
US5545644A (en)	1990-10-15	1996-08-13	Pfizer Inc.	Indole derivatives
US5578612A (en)	1990-10-15	1996-11-26	Pfizer Inc.	Indole derivatives
US5559246A (en)	1990-10-15	1996-09-24	Pfizer Inc.	Indole derivatives
US5559129A (en)	1990-10-15	1996-09-24	Pfizer Inc	Indole derivatives
US5607951A (en)	1990-10-15	1997-03-04	Pfizer Inc	Indole derivatives
DK0592438T5 (da) *	1990-10-15	1999-12-06	Pfizer Inc.	Indolderivater
US5208248A (en) *	1991-01-11	1993-05-04	Merck Sharpe & Dohme, Ltd.	Indazole-substituted five-membered heteroaromatic compounds
SK278998B6 (sk) *	1991-02-01	1998-05-06	Merck Sharp & Dohme Limited	Deriváty imidazolu, triazolu a tetrazolu, spôsob i
TW263508B (cs) *	1991-02-12	1995-11-21	Pfizer
ATE190608T1 (de)	1991-11-25	2000-04-15	Pfizer	5-(hetero- oder carbocyclylamino)-indol derivate, deren herstellung und deren verwendung als 5-ht1 agonisten
CA2083891A1 (en) *	1991-12-03	1993-06-04	Angus Murray Macleod	Heterocyclic compounds, compositions containing them and their use in therapy
US5409941A (en)	1992-02-03	1995-04-25	Pfizer Inc.	5-heteroyl indole derivatives
TW288010B (cs)	1992-03-05	1996-10-11	Pfizer
PL172405B1 (en) *	1992-04-07	1997-09-30	Pfizer	Derivatives of indole
DK0635015T3 (da)	1992-04-10	1997-03-17	Pfizer	Acylaminoindolderivater som 5-Htl agonister

1993
- 1993-03-10 PL PL93305555A patent/PL172405B1/pl not_active IP Right Cessation
- 1993-03-10 WO PCT/US1993/001967 patent/WO1993020073A1/en not_active Application Discontinuation
- 1993-03-10 SK SK1206-94A patent/SK280193B6/sk unknown
- 1993-03-10 JP JP5517443A patent/JP2644088B2/ja not_active Expired - Fee Related
- 1993-03-10 NZ NZ251086A patent/NZ251086A/en unknown
- 1993-03-10 CZ CZ942464A patent/CZ281763B6/cs not_active IP Right Cessation
- 1993-03-10 US US08/295,798 patent/US5747501A/en not_active Expired - Fee Related
- 1993-03-10 UA UA94105899A patent/UA27467C2/uk unknown
- 1993-03-10 RU RU94045897/04A patent/RU2101283C1/ru not_active IP Right Cessation
- 1993-03-10 CA CA002133413A patent/CA2133413C/en not_active Expired - Fee Related
- 1993-03-10 AU AU37898/93A patent/AU670579B2/en not_active Ceased
- 1993-03-10 KR KR1019940703552A patent/KR0179072B1/ko not_active IP Right Cessation
- 1993-03-10 EP EP93907216A patent/EP0635017A1/en not_active Ceased
- 1993-03-10 BR BR9306201A patent/BR9306201A/pt not_active Application Discontinuation
- 1993-03-29 IL IL10520693A patent/IL105206A/en not_active IP Right Cessation
- 1993-04-02 HR HR930752A patent/HRP930752A2/hr not_active Application Discontinuation
- 1993-04-05 ZA ZA932440A patent/ZA932440B/xx unknown
- 1993-04-05 MY MYPI93000616A patent/MY108909A/en unknown
- 1993-04-05 EG EG20593A patent/EG20226A/xx active
- 1993-04-06 FI FI931558A patent/FI931558A/fi not_active IP Right Cessation
- 1993-04-06 MX MX9302011A patent/MX9302011A/es unknown
- 1993-04-06 YU YU23893A patent/YU48931B/sh unknown
- 1993-04-06 HU HU9301003A patent/HUT64062A/hu unknown
- 1993-04-06 CN CN93105697A patent/CN1050841C/zh not_active Expired - Fee Related
- 1993-04-09 TW TW082102651A patent/TW341565B/zh active
1994
- 1994-10-06 NO NO943762A patent/NO303388B1/no not_active IP Right Cessation
1998
- 1998-04-14 US US09/059,799 patent/US6150388A/en not_active Expired - Fee Related
- 1998-07-08 CN CN98116024A patent/CN1083443C/zh not_active Expired - Fee Related
2000
- 2000-10-23 US US09/694,394 patent/US6387937B1/en not_active Expired - Fee Related
- 2000-10-23 US US09/694,387 patent/US6436957B1/en not_active Expired - Fee Related
- 2000-10-23 US US09/694,588 patent/US6465500B1/en not_active Expired - Fee Related
- 2000-10-23 US US09/694,809 patent/US6387941B1/en not_active Expired - Fee Related
- 2000-10-23 US US09/694,808 patent/US6410739B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
BR9306201A (pt)	1998-06-23
MX9302011A (es)	1994-03-31
CZ246494A3 (en)	1995-06-14
YU23893A (sh)	1996-10-09
IL105206A0 (en)	1993-07-08
CN1082543A (zh)	1994-02-23
US6410739B1 (en)	2002-06-25
CA2133413C (en)	2001-04-10
CN1225362A (zh)	1999-08-11
CN1050841C (zh)	2000-03-29
US6150388A (en)	2000-11-21
EP0635017A1 (en)	1995-01-25
AU3789893A (en)	1993-11-08
JP2644088B2 (ja)	1997-08-25
WO1993020073A1 (en)	1993-10-14
FI931558A (fi)	1993-10-08
US6387937B1 (en)	2002-05-14
CZ281763B6 (cs)	1997-01-15
AU670579B2 (en)	1996-07-25
HRP930752A2 (en)	1994-10-31
CA2133413A1 (en)	1993-10-14
HUT64062A (en)	1993-11-29
SK280193B6 (sk)	1999-09-10
US6436957B1 (en)	2002-08-20
MY108909A (en)	1996-11-30
NO303388B1 (no)	1998-07-06
NO943762D0 (no)	1994-10-06
NO943762L (no)	1994-10-06
KR950700906A (ko)	1995-02-20
HU9301003D0 (en)	1993-06-28
RU2101283C1 (ru)	1998-01-10
CN1083443C (zh)	2002-04-24
NZ251086A (en)	1996-09-25
YU48931B (sh)	2002-12-10
UA27467C2 (uk)	2000-09-15
US5747501A (en)	1998-05-05
TW341565B (en)	1998-10-01
RU94045897A (ru)	1996-09-10
EG20226A (en)	1997-12-31
ZA932440B (en)	1994-10-05
US6465500B1 (en)	2002-10-15
KR0179072B1 (ko)	1999-03-20
JPH07504919A (ja)	1995-06-01
FI931558A0 (fi)	1993-04-06
SK120694A3 (en)	1995-05-10
PL172405B1 (en)	1997-09-30
US6387941B1 (en)	2002-05-14

Publication	Publication Date	Title
US6436957B1 (en)	2002-08-20	Indole derivatives as 5-HT1 agonists
EP0629199B1 (en)	2002-06-05	Indole derivatives as 5-ht1 agonists
AU651637B2 (en)	1994-07-28	Indole derivatives
EP0635015B1 (en)	1997-01-29	Acylaminoindole derivatives as 5-ht1 agonists
US6380233B1 (en)	2002-04-30	Indole derivatives as 5-HT1 agonists
US5770611A (en)	1998-06-23	Indole derivatives as 5HT1 -like agonists
IL121326A (en)	2002-09-12	N-substituted pyrolidin-2-yl methyl indole derivatives
IL118910A (en)	1999-01-26	Intermediates for the synthesis of indole derivatives

Legal Events

Date	Code	Title
1999-08-17	FF	Patent granted
2000-06-01	KB	Patent renewed
2003-06-24	KB	Patent renewed
2008-01-06	MM9K	Patent not in force due to non-payment of renewal fees