IL102703A - N-sulfonyl indoline derivatives carrying an amide functional group, their preparation and pharmaceutical compositions containing them - Google Patents

N-sulfonyl indoline derivatives carrying an amide functional group, their preparation and pharmaceutical compositions containing them

Info

Publication number: IL102703A
Authority: IL; Israel
Prior art keywords: group; substituted; alkyl; alkyls; free
Prior art date: 1991-08-02

Application number

IL102703A

Other languages

English (en)

Other versions

IL102703A0 (en

Original Assignee

Sanofi Elf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-02

Filing date

1992-07-31

Publication date

1997-03-18

1992-07-31 Application filed by Sanofi Elf filed Critical Sanofi Elf

1992-07-31 Priority to IL11759292A priority Critical patent/IL117592A/xx

1993-01-14 Publication of IL102703A0 publication Critical patent/IL102703A0/xx

1997-03-18 Publication of IL102703A publication Critical patent/IL102703A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Hematology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)

IL102703A 1991-08-02 1992-07-31 N-sulfonyl indoline derivatives carrying an amide functional group, their preparation and pharmaceutical compositions containing them IL102703A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
IL11759292A IL117592A (en)	1991-08-02	1992-07-31	N-substituted sulfonamidobenzene compounds

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9109908A FR2679903B1 (fr)	1991-08-02	1991-08-02	Derives de la n-sulfonyl indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant.

Publications (2)

Publication Number	Publication Date
IL102703A0 IL102703A0 (en)	1993-01-14
IL102703A true IL102703A (en)	1997-03-18

Family

ID=9415909

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
IL11759292A IL117592A (en)	1991-08-02	1992-07-31	N-substituted sulfonamidobenzene compounds
IL102703A IL102703A (en)	1991-08-02	1992-07-31	N-sulfonyl indoline derivatives carrying an amide functional group, their preparation and pharmaceutical compositions containing them
IL11759296A IL117592A0 (en)	1991-08-02	1996-03-21	N-substituted sulfonamidobenzene compounds

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
IL11759292A IL117592A (en)	1991-08-02	1992-07-31	N-substituted sulfonamidobenzene compounds

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL11759296A IL117592A0 (en)	1991-08-02	1996-03-21	N-substituted sulfonamidobenzene compounds

Country Status (29)

Country	Link
EP (1)	EP0526348B1 (xx)
JP (1)	JP2633085B2 (xx)
KR (1)	KR100241583B1 (xx)
AT (1)	ATE163289T1 (xx)
AU (2)	AU658664B2 (xx)
BR (1)	BR9205336A (xx)
CA (2)	CA2206776C (xx)
CZ (1)	CZ288173B6 (xx)
DE (1)	DE69224450T2 (xx)
DK (1)	DK0526348T3 (xx)
ES (1)	ES2117038T3 (xx)
FI (2)	FI104069B1 (xx)
FR (1)	FR2679903B1 (xx)
HK (1)	HK1008741A1 (xx)
HU (2)	HUT68927A (xx)
IL (3)	IL117592A (xx)
LT (1)	LT3064B (xx)
LV (1)	LV10091B (xx)
MX (1)	MX9204487A (xx)
MY (1)	MY110517A (xx)
NO (1)	NO180047C (xx)
NZ (1)	NZ243795A (xx)
PH (1)	PH30661A (xx)
RU (1)	RU2104268C1 (xx)
SG (1)	SG47501A1 (xx)
SK (1)	SK283463B6 (xx)
UA (1)	UA27238C2 (xx)
WO (1)	WO1993003013A1 (xx)
ZA (1)	ZA925781B (xx)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2665441B1 (fr) *	1990-07-31	1992-12-04	Sanofi Sa	Derives de la n-sulfonyl indoline, leur preparation, les compositions pharmaceutiques en contenant.
FR2708608B1 (fr) *	1993-07-30	1995-10-27	Sanofi Sa	Dérivés de N-sulfonylbenzimidazolone, leur préparation, les compositions pharmaceutiques en contenant.
FR2756736B1 (fr) *	1996-12-05	1999-03-05	Sanofi Sa	Compositions pharmaceutiques contenant des derives de n-sulfonyl indoline
US6492421B1 (en)	1997-07-31	2002-12-10	Athena Neurosciences, Inc.	Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4
HUP0003921A3 (en) *	1997-07-31	2001-03-28	Wyeth Corp	Sulfonylated dipeptide compounds which inhibit leukocyte adhesion mediated by vla-4, pharmaceutical compositions comprising thereof and their use
US6362341B1 (en)	1997-07-31	2002-03-26	Athena Neurosciences, Inc.	Benzyl compounds which inhibit leukocyte adhesion mediated by VLA-4
US7030114B1 (en)	1997-07-31	2006-04-18	Elan Pharmaceuticals, Inc.	Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6291453B1 (en)	1997-07-31	2001-09-18	Athena Neurosciences, Inc.	4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4
EP1001973A1 (en) *	1997-07-31	2000-05-24	Elan Pharmaceuticals, Inc.	Compounds which inhibit leukocyte adhesion mediated by vla-4
US6559127B1 (en)	1997-07-31	2003-05-06	Athena Neurosciences, Inc.	Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6489300B1 (en)	1997-07-31	2002-12-03	Eugene D. Thorsett	Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4
PL338373A1 (en) *	1997-07-31	2000-10-23	Elan Pharm Inc	Dipeptide and its affinite compounds inhibiting adhesion of leucocytes occurring through mediation of vla-4
US6939855B2 (en)	1997-07-31	2005-09-06	Elan Pharmaceuticals, Inc.	Anti-inflammatory compositions and method
US6423688B1 (en)	1997-07-31	2002-07-23	Athena Neurosciences, Inc.	Dipeptide and related compounds which inhibit leukocyte adhesion mediated by VLA-4
US6583139B1 (en)	1997-07-31	2003-06-24	Eugene D. Thorsett	Compounds which inhibit leukocyte adhesion mediated by VLA-4
FR2775598A1 (fr)	1998-03-06	1999-09-10	Sanofi Sa	Compositions pharmaceutiques contenant en association un antagoniste selectif des recepteurs v1a de l'arginine-vasopressine et un antagoniste selectif des recepteur v2 de l'arginine-vasopressine
FR2778103A1 (fr) *	1998-04-29	1999-11-05	Sanofi Sa	Compositions pharmaceutiques contenant en association un antagoniste v1a de l'arginine-vasopressine et un antagoniste des recepteurs at1 de l'angiotensine ii
FR2786486B3 (fr) *	1998-11-16	2000-12-08	Sanofi Sa	Procede de preparation du (2s)-1-[(2r,3s)-5-chloro-3-(2- chlorophenyl)-1-(3,4-dimethoxy benzenesulfonyl)-3-hydroxy- 2,3-dihydro-1h-indole-2-carbonyl]pyrrolidine-2-carboxamide, de ses solvats et/ou hydrates
US6545003B1 (en)	1999-01-22	2003-04-08	Elan Pharmaceuticals, Inc.	Fused ring heteroaryl and heterocyclic compounds which inhibit leukocyte adhesion mediated by VLA-4
DK1144388T3 (da)	1999-01-22	2010-05-25	Elan Pharm Inc	Acyl-derivater, som behandler VLA-4-relaterede lidelser
JP2002539080A (ja) *	1999-01-25	2002-11-19	エランファーマシューティカルズ，インコーポレイテッド	Ｖｌａ−４によって媒介される白血球接着を阻害する化合物
US6436904B1 (en)	1999-01-25	2002-08-20	Elan Pharmaceuticals, Inc.	Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6407066B1 (en)	1999-01-26	2002-06-18	Elan Pharmaceuticals, Inc.	Pyroglutamic acid derivatives and related compounds which inhibit leukocyte adhesion mediated by VLA-4
FR2792834A1 (fr) *	1999-04-29	2000-11-03	Sanofi Sa	Utilisation du sr 49059, de ses solvats et/ou hydrates pharmaceutiquement acceptables, pour la preparation de medicaments utiles dans le traitement ou la prevention du phenomene de raynaud
FR2805536B1 (fr) *	2000-02-25	2002-08-23	Sanofi Synthelabo	Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
FR2805992A1 (fr) *	2000-03-08	2001-09-14	Sanofi Synthelabo	Compositions pharmaceutiques orales contenant des derives de n-sulfonylindoline
WO2002032864A1 (en)	2000-10-17	2002-04-25	Applied Research Systems Ars Holding N.V.	Pharmaceutically active sulfanilide derivatives
AU2002224115A1 (en)	2000-11-28	2002-06-11	Yamanouchi Pharmaceutical Co., Ltd.	1,4,5,6-tetrahydroimidazo(4,5-d)diazepine derivatives or salts thereof
JP4044740B2 (ja) *	2001-05-31	2008-02-06	信越化学工業株式会社	レジスト材料及びパターン形成方法
DE60207755T2 (de)	2001-12-20	2006-07-27	Applied Research Systems Ars Holding N.V.	Triazole als oxytocin-antagonisten
CA2485681C (en)	2002-05-24	2012-10-16	Millennium Pharmaceuticals, Inc.	Ccr9 inhibitors and methods of use thereof
TWI281470B (en)	2002-05-24	2007-05-21	Elan Pharm Inc	Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
TW200307671A (en)	2002-05-24	2003-12-16	Elan Pharm Inc	Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins
CA2498091C (en) *	2002-10-11	2011-03-22	Actelion Pharmaceuticals Ltd.	Sulfonylamino-acetic acid derivatives
DE60314175T2 (de)	2002-11-18	2008-01-24	Chemocentryx Inc., Mountain View	Arylsulfonamide
US7741519B2 (en)	2007-04-23	2010-06-22	Chemocentryx, Inc.	Bis-aryl sulfonamides
US7420055B2 (en)	2002-11-18	2008-09-02	Chemocentryx, Inc.	Aryl sulfonamides
US7227035B2 (en)	2002-11-18	2007-06-05	Chemocentryx	Bis-aryl sulfonamides
CA2624450C (en)	2005-09-29	2014-02-04	Elan Pharmaceuticals, Inc.	Pyrimidinyl amide compounds which inhibit leukocyte adhesion mediated by vla-4
BRPI0616643A2 (pt)	2005-09-29	2011-06-28	Elan Pharm Inc	compostos de carbamato que inibem a adesão leucocitária mediada por vla-4
EA017110B1 (ru)	2006-02-27	2012-09-28	Элан Фамэсьютикэлс, Инк.	ПИРИМИДИНИЛСУЛЬФОНАМИДНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), СПОСОБ ПОЛУЧЕНИЯ ПИРИМИДИНИЛСУЛЬФОНАМИДНЫХ СОЕДИНЕНИЙ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ, ОПОСРЕДОВАННОГО ИНТЕГРИНОМ α4, СПОСОБ СНИЖЕНИЯ И/ИЛИ ПРЕДУПРЕЖДЕНИЯ ВОСПАЛИТЕЛЬНОГО КОМПОНЕНТА ЗАБОЛЕВАНИЯ ИЛИ АУТОИММУННОГО ОТВЕТА
WO2010126914A1 (en)	2009-04-27	2010-11-04	Elan Pharmaceuticals, Inc.	Pyridinone antagonists of alpha-4 integrins
HU231206B1 (hu)	2017-12-15	2021-10-28	Richter Gedeon Nyrt.	Triazolobenzazepinek
TW201938171A (zh)	2017-12-15	2019-10-01	匈牙利商羅特格登公司	作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3838167A (en) *	1972-08-01	1974-09-24	Lilly Co Eli	Process for preparing indoles
US4479963A (en) *	1981-02-17	1984-10-30	Ciba-Geigy Corporation	1-Carboxyalkanoylindoline-2-carboxylic acids
DE3705934A1 (de) *	1987-02-25	1988-09-08	Nattermann A & Cie	Indolyl-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
FR2665441B1 (fr) *	1990-07-31	1992-12-04	Sanofi Sa	Derives de la n-sulfonyl indoline, leur preparation, les compositions pharmaceutiques en contenant.

1991
- 1991-08-02 FR FR9109908A patent/FR2679903B1/fr not_active Expired - Fee Related
1992
- 1992-07-31 KR KR1019930701034A patent/KR100241583B1/ko not_active IP Right Cessation
- 1992-07-31 WO PCT/FR1992/000758 patent/WO1993003013A1/fr active IP Right Grant
- 1992-07-31 UA UA93002340A patent/UA27238C2/uk unknown
- 1992-07-31 AU AU24758/92A patent/AU658664B2/en not_active Ceased
- 1992-07-31 LT LTIP114A patent/LT3064B/lt not_active IP Right Cessation
- 1992-07-31 SK SK426-93A patent/SK283463B6/sk unknown
- 1992-07-31 NZ NZ243795A patent/NZ243795A/en unknown
- 1992-07-31 RU RU93005168A patent/RU2104268C1/ru not_active IP Right Cessation
- 1992-07-31 PH PH44760A patent/PH30661A/en unknown
- 1992-07-31 JP JP5503337A patent/JP2633085B2/ja not_active Expired - Fee Related
- 1992-07-31 BR BR9205336A patent/BR9205336A/pt not_active Application Discontinuation
- 1992-07-31 MY MYPI92001379A patent/MY110517A/en unknown
- 1992-07-31 CA CA002206776A patent/CA2206776C/en not_active Expired - Fee Related
- 1992-07-31 ZA ZA925781A patent/ZA925781B/xx unknown
- 1992-07-31 IL IL11759292A patent/IL117592A/xx not_active IP Right Cessation
- 1992-07-31 MX MX9204487A patent/MX9204487A/es not_active IP Right Cessation
- 1992-07-31 CZ CZ1993682A patent/CZ288173B6/cs not_active IP Right Cessation
- 1992-07-31 CA CA002093221A patent/CA2093221C/en not_active Expired - Fee Related
- 1992-07-31 HU HU9300951A patent/HUT68927A/hu unknown
- 1992-07-31 LV LVP-92-87A patent/LV10091B/lv unknown
- 1992-07-31 IL IL102703A patent/IL102703A/xx not_active IP Right Cessation
- 1992-08-03 DK DK92402213T patent/DK0526348T3/da active
- 1992-08-03 AT AT92402213T patent/ATE163289T1/de not_active IP Right Cessation
- 1992-08-03 ES ES92402213T patent/ES2117038T3/es not_active Expired - Lifetime
- 1992-08-03 DE DE69224450T patent/DE69224450T2/de not_active Expired - Fee Related
- 1992-08-03 SG SG1996002367A patent/SG47501A1/en unknown
- 1992-08-03 EP EP92402213A patent/EP0526348B1/fr not_active Expired - Lifetime
1993
- 1993-04-01 NO NO931262A patent/NO180047C/no not_active IP Right Cessation
- 1993-04-01 FI FI931476A patent/FI104069B1/fi not_active IP Right Cessation
1995
- 1995-02-03 AU AU11541/95A patent/AU691223B2/en not_active Ceased
- 1995-06-28 HU HU95P/P00474P patent/HU211884A9/hu unknown
1996
- 1996-03-21 IL IL11759296A patent/IL117592A0/xx unknown
1998
- 1998-01-27 FI FI980175A patent/FI107048B/fi not_active IP Right Cessation
- 1998-07-03 HK HK98108861A patent/HK1008741A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
HUT68927A (en)	1995-08-28
LT3064B (en)	1994-10-25
ES2117038T3 (es)	1998-08-01
FI980175A (fi)	1998-01-27
PH30661A (en)	1997-09-16
SK42693A3 (en)	1993-10-06
CZ68293A3 (en)	1994-01-19
LV10091A (lv)	1994-05-10
CA2093221A1 (en)	1993-02-03
ATE163289T1 (de)	1998-03-15
JPH06501960A (ja)	1994-03-03
JP2633085B2 (ja)	1997-07-23
NO180047C (no)	1997-02-05
LTIP114A (en)	1994-06-15
HU211884A9 (en)	1995-12-28
AU658664B2 (en)	1995-04-27
CA2206776A1 (en)	1993-02-03
CA2206776C (en)	2002-02-26
EP0526348A1 (fr)	1993-02-03
IL102703A0 (en)	1993-01-14
FR2679903B1 (fr)	1993-12-03
FI104069B (fi)	1999-11-15
HU9300951D0 (en)	1993-06-28
EP0526348B1 (fr)	1998-02-18
MY110517A (en)	1998-07-31
DE69224450T2 (de)	1998-07-30
FI104069B1 (fi)	1999-11-15
FI931476A (fi)	1993-04-01
WO1993003013A1 (fr)	1993-02-18
NO931262D0 (no)	1993-04-01
AU2475892A (en)	1993-03-02
BR9205336A (pt)	1993-11-16
IL117592A0 (en)	1996-07-23
NZ243795A (en)	1995-04-27
DE69224450D1 (de)	1998-03-26
DK0526348T3 (da)	1998-11-23
LV10091B (en)	1995-04-20
CZ288173B6 (en)	2001-05-16
AU691223B2 (en)	1998-05-14
NO931262L (no)	1993-05-26
HK1008741A1 (en)	1999-05-14
MX9204487A (es)	1993-02-01
UA27238C2 (uk)	2000-08-15
FR2679903A1 (fr)	1993-02-05
ZA925781B (en)	1993-03-02
FI107048B (fi)	2001-05-31
SG47501A1 (en)	1998-04-17
CA2093221C (en)	1998-09-22
AU1154195A (en)	1995-05-04
NO180047B (no)	1996-10-28
RU2104268C1 (ru)	1998-02-10
IL117592A (en)	1999-04-11
FI980175A0 (fi)	1998-01-27
KR100241583B1 (ko)	2000-03-02
FI931476A0 (fi)	1993-04-01
SK283463B6 (sk)	2003-08-05

Publication	Publication Date	Title
IL102703A (en)	1997-03-18	N-sulfonyl indoline derivatives carrying an amide functional group, their preparation and pharmaceutical compositions containing them
NZ331319A (en)	2000-03-27	Cyclic amine derivatives that are CCR-3 receptor (chemokine receptor) antagonists, compositions containing them and methods for their use (to combat eosinophil induced diseases).
TR200400185T4 (tr)	2004-03-22	PDE 5 inhibitörleri olarak, 8-kuinolinkisantin ve 8-izokuinolinkisantin türevleri.
AR024969A1 (es)	2002-10-30	Derivados de 8-fenil-6,9-dihidro-[1,2,4]triazol[3,4-i]purin-5-ona
TR200003598T2 (tr)	2001-06-21	Amid türevleri ve nosiseptin antagonistleri
GB1495526A (en)	1977-12-21	Chroman derivatives
HUP0202799A2 (hu)	2003-01-28	Herbicid hatású izoxazolinszármazékok és azt tartalmazó készítmény
DE69525355D1 (de)	2002-03-21	1-acyl-4-aliphatische aminopiperidin verbindungen
HUP9902410A2 (hu)	1999-11-29	Amidinszármazékok, előállításuk, trombininhibitorként való alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények
DE59408213D1 (de)	1999-06-10	Pyrrolidin- und oxazolidin derivate , ihre herstellung und ihre verwendung als thrombocyten-aggregations-hemmer
EP0096517A3 (en)	1985-04-03	Aryl pyrazinones
IL99012A0 (en)	1992-07-15	N-sulfonylindoline derivatives,their preparation and pharmaceutical compositions containing them
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SE8101464L (sv)	1981-09-11	2-penem-3-karboxylsyraderivat, deras framstellning och anvendning
DE69319925D1 (de)	1998-08-27	Indol-piperazin-derivate als selektive liganden der 5ht1d und 5ht1b receptoren verwendbar als arzneimittel
FI951555A0 (fi)	1995-03-31	5H,10H-imidatso[1,2-a]indeno[1,2-e]pyratsin-4-onijohdannaiset, niiden valmistus ja niitä sisältävät lääkkeet
ES417638A1 (es)	1976-02-01	Procedimiento para preparar oxazoles 2,4,5-trisustituidos.
DE69104475D1 (de)	1994-11-10	Harnstoffderivate, ihre herstellung und deren enthaltende arzneimittel.
KR930703327A (ko)	1993-11-29	축합형 티오펜 화합물 및 그의 의약용도
KR930006024A (ko)	1993-04-20	이미다조 인돌리진 유도체 및 그의 제조방법
HUP9901290A2 (hu)	1999-08-30	Trombin inhibitor hatású polifluor-alkil-triptofánt tartalmazó tripeptidek
GB1424492A (en)	1976-02-11	Pyrazol-5-ones their preparation and their pharmaceutical use
HUP0301000A2 (hu)	2003-08-28	2-Aminotiazolin-származékok, eljárás előállításukra, a vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk NO-szintáz inhibitorokként
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1997-09-30	FF	Patent granted
1997-11-20	HP	Change in proprietorship
1998-02-08	KB	Patent renewed
1998-12-27	KB	Patent renewed
2002-02-10	HC	Change of name of proprietor(s)
2002-09-12	KB	Patent renewed
2007-07-24	MM9K	Patent not in force due to non-payment of renewal fees