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IL101482A0 - Substituted 2',3'-dideoxy-5-trifluoromethyluridines,and pharmaceutical compositions containing them - Google Patents

Substituted 2',3'-dideoxy-5-trifluoromethyluridines,and pharmaceutical compositions containing them

Info

Publication number
IL101482A0
IL101482A0 IL101482A IL10148292A IL101482A0 IL 101482 A0 IL101482 A0 IL 101482A0 IL 101482 A IL101482 A IL 101482A IL 10148292 A IL10148292 A IL 10148292A IL 101482 A0 IL101482 A0 IL 101482A0
Authority
IL
Israel
Prior art keywords
trifluoromethyluridines
dideoxy
substituted
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL101482A
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of IL101482A0 publication Critical patent/IL101482A0/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/10Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL101482A 1991-04-05 1992-04-03 Substituted 2',3'-dideoxy-5-trifluoromethyluridines,and pharmaceutical compositions containing them IL101482A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4110977A DE4110977A1 (en) 1991-04-05 1991-04-05 SUBSTITUTED 2 ', 3'-DIDESOXY-5-TRIFLUOROMETHYLURIDINES, METHOD OF THEIR PREPARATION AND THEIR USE IN MEDICINAL PRODUCTS

Publications (1)

Publication Number Publication Date
IL101482A0 true IL101482A0 (en) 1992-12-30

Family

ID=6428857

Family Applications (1)

Application Number Title Priority Date Filing Date
IL101482A IL101482A0 (en) 1991-04-05 1992-04-03 Substituted 2',3'-dideoxy-5-trifluoromethyluridines,and pharmaceutical compositions containing them

Country Status (15)

Country Link
EP (1) EP0507188A1 (en)
JP (1) JPH05148261A (en)
KR (1) KR920019813A (en)
CN (1) CN1065462A (en)
AU (1) AU640860B2 (en)
CA (1) CA2064916A1 (en)
CS (1) CS92092A3 (en)
DE (1) DE4110977A1 (en)
FI (1) FI921456A7 (en)
HU (1) HUT60748A (en)
IE (1) IE921083A1 (en)
IL (1) IL101482A0 (en)
NO (1) NO921086L (en)
NZ (1) NZ242205A (en)
TW (1) TW205043B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1050846C (en) * 1995-08-03 2000-03-29 中国医学科学院医药生物技术研究所 Antitumor antibiotic-Yunnan-mycin
AU2002257446A1 (en) * 2001-05-18 2002-12-03 Rakesh Kumar Antiviral nucleosides
CN100334100C (en) * 2004-01-17 2007-08-29 杭州富邦生物制药有限公司 Method for synthesizing 5-trifluoro methyl-2'-desugarized uridine
JP4603274B2 (en) * 2004-02-24 2010-12-22 三井化学株式会社 Process for producing 2'-deoxy-5-trifluoromethyluridine
WO2009119785A1 (en) * 2008-03-28 2009-10-01 浜理薬品工業株式会社 Method for purifying ethynylthymidine compound
WO2009125841A1 (en) * 2008-04-10 2009-10-15 浜理薬品工業株式会社 Process for production of ethynylthymidine compound using 5-methyluridine as starting raw material

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3048877A1 (en) * 1980-12-23 1982-07-08 Kailash Kumar Prof. Dr. 2359 Lentföhrden Gauri Pyrimidine nucleoside phosphonate derivs. - useful as antiviral agents
FI87783C (en) * 1985-05-15 1993-02-25 Wellcome Found FRAME FOR THE PREPARATION OF THERAPEUTIC ANALYTICAL BAR 2 ', 3'-DIDEOXINUCLEOSIDER
DE3650741T2 (en) * 1985-09-17 2000-10-12 The Wellcome Foundation Ltd., Greenford Combination of therapeutic nucleosides with other therapeutically active components.
CA1327000C (en) * 1987-08-07 1994-02-15 David L.J. Tyrrell Antiviral therapy for hepatitis b
SE8704298D0 (en) * 1987-11-03 1987-11-03 Astra Ab COMPOUNDS FOR USE IN THERAPY
US4900828A (en) * 1988-05-12 1990-02-13 Hoffmann-Laroche Inc. Intermediate compounds and an improved procedure for the synthesis of 2',3'-dideoxycytidine
SE8802173D0 (en) * 1988-06-10 1988-06-10 Astra Ab PYRIMIDINE DERIVATIVES
GB8823320D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds
WO1990014079A1 (en) * 1989-05-15 1990-11-29 The United States Of America, Represented By The Secretary, United States Department Of Commerce Method of treatment of hepatitis
NZ234534A (en) * 1989-07-17 1994-12-22 Univ Birmingham Pyrimidine 4'-thionucleoside derivatives and their preparation; intermediates therefor

Also Published As

Publication number Publication date
AU1219092A (en) 1992-10-08
NO921086D0 (en) 1992-03-19
HUT60748A (en) 1992-10-28
NO921086L (en) 1992-10-06
DE4110977A1 (en) 1992-10-08
CA2064916A1 (en) 1992-10-06
JPH05148261A (en) 1993-06-15
FI921456L (en) 1992-10-06
NZ242205A (en) 1993-04-28
CN1065462A (en) 1992-10-21
CS92092A3 (en) 1992-12-16
FI921456A7 (en) 1992-10-06
TW205043B (en) 1993-05-01
FI921456A0 (en) 1992-04-02
AU640860B2 (en) 1993-09-02
IE921083A1 (en) 1992-10-07
KR920019813A (en) 1992-11-20
HU9201117D0 (en) 1992-06-29
EP0507188A1 (en) 1992-10-07

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