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IE890157L - 16-dehydro-vitamin d3 - derivatives - Google Patents

16-dehydro-vitamin d3 - derivatives

Info

Publication number
IE890157L
IE890157L IE890157A IE15789A IE890157L IE 890157 L IE890157 L IE 890157L IE 890157 A IE890157 A IE 890157A IE 15789 A IE15789 A IE 15789A IE 890157 L IE890157 L IE 890157L
Authority
IE
Ireland
Prior art keywords
dehydro
vitamin
derivatives
agents
treatment
Prior art date
Application number
IE890157A
Other versions
IE60921B1 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IE890157L publication Critical patent/IE890157L/en
Publication of IE60921B1 publication Critical patent/IE60921B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The novel compounds of the formula <IMAGE> in which R is hydrogen or hydroxyl and A is -C IDENTICAL C-; -C=CH- having the E-configuration or -CH2-CH2-, can be used as agents for the treatment of hyperproliferative skin diseases and as agents for the treatment of neoplastic diseases. [EP0325279A1]
IE15789A 1988-01-20 1989-01-19 Dehydrocholecalciferol derivatives IE60921B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14593288A 1988-01-20 1988-01-20

Publications (2)

Publication Number Publication Date
IE890157L true IE890157L (en) 1989-07-20
IE60921B1 IE60921B1 (en) 1994-09-07

Family

ID=22515181

Family Applications (1)

Application Number Title Priority Date Filing Date
IE15789A IE60921B1 (en) 1988-01-20 1989-01-19 Dehydrocholecalciferol derivatives

Country Status (23)

Country Link
EP (1) EP0325279B1 (en)
JP (1) JPH0764806B2 (en)
KR (1) KR960009119B1 (en)
AR (1) AR247551A1 (en)
AT (1) ATE74350T1 (en)
AU (1) AU622139B2 (en)
BG (1) BG60530B2 (en)
CA (1) CA1337529C (en)
DE (1) DE58901056D1 (en)
DK (1) DK169945B1 (en)
ES (1) ES2033467T3 (en)
FI (1) FI90764C (en)
GR (1) GR3004786T3 (en)
HU (1) HU201007B (en)
IE (1) IE60921B1 (en)
IL (1) IL88989A (en)
MC (1) MC1998A1 (en)
NO (1) NO175429C (en)
NZ (1) NZ227641A (en)
PH (1) PH25605A (en)
PT (1) PT89486B (en)
YU (1) YU47298B (en)
ZA (1) ZA8923B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
EP0398217B1 (en) * 1989-05-18 1994-01-12 F. Hoffmann-La Roche Ag Dehydrocholecalciferol derivatives
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
EP0580968B1 (en) * 1992-05-20 1996-08-28 F. Hoffmann-La Roche Ag Vitamin D3 fluorinated analogs
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
TW267161B (en) * 1992-11-20 1996-01-01 Hoffmann La Roche
US5401733A (en) * 1993-10-01 1995-03-28 Hoffmann-La Roche Inc. Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
TW403735B (en) * 1995-11-22 2000-09-01 Hoffmann La Roche 25-hydroxy-16-ene-26, 27-bishomo-cholecalciferol
AU708679B2 (en) * 1996-03-21 1999-08-12 F. Hoffmann-La Roche Ag 1,25-dihydroxy-16,22,23-trisdehydro-cholecalciferol derivatives
US5939408A (en) * 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
SG70009A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Vitamin d3 analogs
DE69813380T2 (en) * 1997-05-02 2003-12-04 Duphar International Research B.V., Weesp Process for the preparation of 16-dehydro vitamin D compounds
US6331642B1 (en) * 1999-07-12 2001-12-18 Hoffmann-La Roche Inc. Vitamin D3 analogs
JP4795023B2 (en) * 2004-02-03 2011-10-19 中外製薬株式会社 Method for synthesizing vitamin D compounds and synthetic intermediates thereof
US8906888B2 (en) * 2005-04-25 2014-12-09 Cytochroma Inc. Low-calcemic 16,23-diene 25-oxime analogs of 1α,25-dihydroxy vitamin D3
WO2007022433A2 (en) * 2005-08-18 2007-02-22 Bioxell S.P.A. SYNTHESIS OF 1α-FLUORO-25-HYDROXY-16-23E-DIENE-26,27-BISHOMO-20-EPI-CHOLECALCIFEROL

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1574685A (en) * 1977-03-24 1980-09-10 Wisconsin Alumni Res Found Vitamin d3 derivatives
GB2021115B (en) * 1978-05-19 1982-10-06 Wisconsin Alumni Res Found Vitamin d derivatives
US4360471A (en) * 1981-12-11 1982-11-23 Wisconsin Alumni Research Foundation 23-Dehydro-25-hydroxyvitamin D3
US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
US4505906A (en) * 1984-01-30 1985-03-19 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 isomers
US4612308A (en) * 1984-11-29 1986-09-16 Hoffmann-La Roche Inc. 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
US4898855A (en) * 1987-09-14 1990-02-06 Hoffman-La Roche Inc. Deuterated analogs of 1,25-dihydroxycholecalciferol
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
EP0398217B1 (en) * 1989-05-18 1994-01-12 F. Hoffmann-La Roche Ag Dehydrocholecalciferol derivatives

Also Published As

Publication number Publication date
NO175429B (en) 1994-07-04
HUT49317A (en) 1989-09-28
PH25605A (en) 1991-08-08
FI90764B (en) 1993-12-15
PT89486B (en) 1993-12-31
IL88989A (en) 1993-08-18
IL88989A0 (en) 1989-08-15
NZ227641A (en) 1991-06-25
YU47298B (en) 1995-01-31
HU201007B (en) 1990-09-28
MC1998A1 (en) 1990-01-26
KR960009119B1 (en) 1996-07-13
DK19789D0 (en) 1989-01-17
DK19789A (en) 1989-07-21
DE58901056D1 (en) 1992-05-07
FI890283A (en) 1989-07-21
AU2864489A (en) 1989-07-20
FI90764C (en) 1994-03-25
JPH029861A (en) 1990-01-12
IE60921B1 (en) 1994-09-07
ES2033467T3 (en) 1993-03-16
CA1337529C (en) 1995-11-07
DK169945B1 (en) 1995-04-10
NO890239L (en) 1989-07-21
ZA8923B (en) 1989-09-27
EP0325279B1 (en) 1992-04-01
KR890011838A (en) 1989-08-22
BG60530B2 (en) 1995-07-28
FI890283A0 (en) 1989-01-19
NO890239D0 (en) 1989-01-19
ATE74350T1 (en) 1992-04-15
AR247551A1 (en) 1995-01-31
EP0325279A1 (en) 1989-07-26
YU11789A (en) 1991-04-30
AU622139B2 (en) 1992-04-02
NO175429C (en) 1994-10-12
PT89486A (en) 1989-10-04
JPH0764806B2 (en) 1995-07-12
GR3004786T3 (en) 1993-04-28

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Legal Events

Date Code Title Description
MM4A Patent lapsed