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IE883387L - Process for preparing 1,5-benzothiazepines - Google Patents

Process for preparing 1,5-benzothiazepines

Info

Publication number
IE883387L
IE883387L IE883387A IE338788A IE883387L IE 883387 L IE883387 L IE 883387L IE 883387 A IE883387 A IE 883387A IE 338788 A IE338788 A IE 338788A IE 883387 L IE883387 L IE 883387L
Authority
IE
Ireland
Prior art keywords
formula
compound
lower alkyl
reaction
solvent
Prior art date
Application number
IE883387A
Other versions
IE61196B1 (en
Inventor
Hirozumi Inoue
Tsunehiro Harada
Masaaki Nagasawa
Original Assignee
Tanable Seiyaku Company Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanable Seiyaku Company Ltd filed Critical Tanable Seiyaku Company Ltd
Publication of IE883387L publication Critical patent/IE883387L/en
Publication of IE61196B1 publication Critical patent/IE61196B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE:To obtain the title compound which is used as a medicine, because of its hypotensive and cerebral and coronary vasodilative actions, readily in high yield, by intramolecular cyclization of a propionic acid derivative as a starting substance. CONSTITUTION:A propionic acid derivative of formula I (R<1> is lower alkyl, lower alkoxy; R<2> is H, lower alkanoyl; R<3>, R<4> are lower alkyl; one of R<5> and R<6> is lower alkyl, halogen, and the other is H) or its reactive derivative is subjected to intramolecular cyclization reaction in the presence or in the absence of a condensation agent or a deacidification agent in a solvent such as xylene with heat, preferably at 100-180 deg.C to give the compound of formula II. When a free form of the compound of formula I is used, the reaction is preferably carried out in a solvent in the presence of a condensation reagent, while an acid halide is used as a reactive derivative of the compound of formula I, the reaction is preferably effected in the presence of a deacidification agent. [JP1128974A]
IE338788A 1987-11-13 1988-11-11 Process for preparing 1,5-benzothiazepine derivatives IE61196B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62287943A JPH01128974A (en) 1987-11-13 1987-11-13 Production of 1,5-benzothiazepin derivative

Publications (2)

Publication Number Publication Date
IE883387L true IE883387L (en) 1989-05-13
IE61196B1 IE61196B1 (en) 1994-10-19

Family

ID=17723745

Family Applications (1)

Application Number Title Priority Date Filing Date
IE338788A IE61196B1 (en) 1987-11-13 1988-11-11 Process for preparing 1,5-benzothiazepine derivatives

Country Status (8)

Country Link
JP (1) JPH01128974A (en)
KR (1) KR890008122A (en)
DK (1) DK631888A (en)
FI (1) FI92393C (en)
FR (1) FR2623192A1 (en)
IE (1) IE61196B1 (en)
IL (1) IL88296A (en)
IT (1) IT1230633B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94295A0 (en) * 1989-05-25 1991-03-10 Fujisawa Pharmaceutical Co Thiazepine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
ZA94284B (en) * 1993-01-27 1994-08-17 Shionogi & Co Process for preparing benzothiazepine derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58201773A (en) * 1982-05-17 1983-11-24 Tokawa Tetsuo Preparation of benzothiazepine derivative
GB8315364D0 (en) * 1983-06-03 1983-07-06 Tanabe Seiyaku Co 8-chloro-1 5-benzothiazepine derivatives
JPS60109580A (en) * 1983-11-16 1985-06-15 Roller Japan Kk Production of cis-d-2-(4'-methoxyphenyl)-3-acetoxy-5-(2- dimethylaminoethyl)-2,3-dihydro-1,5-benzothiazepin-4(5h)-one or its salt
JPS60146884A (en) * 1984-01-09 1985-08-02 Nippon Chem:Kk Method for producing 1,5 benzothiazepine derivatives
GB8406318D0 (en) * 1984-03-10 1984-04-11 Tanabe Seiyaku Co 1 5-benzothiazepine derivatives
JPS61103877A (en) * 1984-10-24 1986-05-22 Tanabe Seiyaku Co Ltd Benzothiazepine derivative and its preparation
GB2167063A (en) * 1984-11-17 1986-05-21 Tanabe Seiyaku Co 6 or 9-chloro-1, 5-benzothiazepine derivatives

Also Published As

Publication number Publication date
IT1230633B (en) 1991-10-28
DK631888D0 (en) 1988-11-11
FI92393C (en) 1994-11-10
IL88296A0 (en) 1989-06-30
FI885033A (en) 1989-05-14
JPH01128974A (en) 1989-05-22
IL88296A (en) 1995-03-15
FI885033A0 (en) 1988-11-01
DK631888A (en) 1989-05-14
FR2623192A1 (en) 1989-05-19
FI92393B (en) 1994-07-29
IT8822602A0 (en) 1988-11-11
FR2623192B1 (en) 1994-07-13
IE61196B1 (en) 1994-10-19
KR890008122A (en) 1989-07-08

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Legal Events

Date Code Title Description
MM4A Patent lapsed