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IE791024L - Cephalosporin derivatives. - Google Patents

Cephalosporin derivatives.

Info

Publication number
IE791024L
IE791024L IE791024A IE102479A IE791024L IE 791024 L IE791024 L IE 791024L IE 791024 A IE791024 A IE 791024A IE 102479 A IE102479 A IE 102479A IE 791024 L IE791024 L IE 791024L
Authority
IE
Ireland
Prior art keywords
antibiotics
appropriate
group
toxic salts
organisms
Prior art date
Application number
IE791024A
Other versions
IE49171B1 (en
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB22909/78A external-priority patent/GB1604722A/en
Priority claimed from GB22912/78A external-priority patent/GB1603989A/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of IE791024L publication Critical patent/IE791024L/en
Publication of IE49171B1 publication Critical patent/IE49171B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cephalosporin antibiotics of the general formula <IMAGE> in which R<a> and R<b>, which are identical to or different from one another, each denote a C1-4-alkyl group or R<a> and R<b>, together with the carbon atom to which they are bonded, form a C3-7-cycloalkylidine group, have a good broad spectrum antibiotic activity, this activity being unusually high against gram-negative organisms such as strains of Pseutomonas organisms. The invention also comprises non-toxic salts, non-toxic metabolically labile esters and solvates of the compounds of the formula (I) and also non-toxic salts of the already mentioned esters. Compositions are also described which contain the antibiotics according to the invention, and processes for the preparation of antibiotics of this type either by appropriate 7-N-acylation or by appropriate O-carbamoylation of the hydroxymethyl group in the 3-position. [FR2426466A1]
IE1024/79A 1978-05-26 1979-08-08 Cephalosporin antibiotics IE49171B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB22909/78A GB1604722A (en) 1978-05-26 1978-05-26 7-(2-(2-amino-4-thiozolyl)-2-oxymino-acetamido)-cephem derivatives
GB22912/78A GB1603989A (en) 1978-05-26 1978-05-26 7-(2-(2-amino-4-thiazolyl)-2-oxymino-acetamido)-cephem derivatives

Publications (2)

Publication Number Publication Date
IE791024L true IE791024L (en) 1979-11-26
IE49171B1 IE49171B1 (en) 1985-08-21

Family

ID=26256187

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1024/79A IE49171B1 (en) 1978-05-26 1979-08-08 Cephalosporin antibiotics

Country Status (9)

Country Link
AU (1) AU524735B2 (en)
CH (1) CH649297A5 (en)
DE (1) DE2921369A1 (en)
FR (1) FR2426466A1 (en)
IE (1) IE49171B1 (en)
IT (1) IT1116199B (en)
NL (1) NL7904125A (en)
NZ (1) NZ190557A (en)
SE (1) SE438859B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE878514A (en) * 1978-09-04 1980-02-29 Fujisawa Pharmaceutical Co PROCESS FOR THE PREPARATION OF 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS WITH DISUBSTITUTION IN POSITIONS 3 AND 7, NOVEL PRODUCTS THUS OBTAINED AND THEIR USE FOR THEIR ANTIBACTERIAL ACTIVITY
US4237128A (en) * 1979-04-12 1980-12-02 E. R. Squibb & Sons, Inc. 7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides

Also Published As

Publication number Publication date
DE2921369A1 (en) 1979-12-06
AU524735B2 (en) 1982-09-30
SE7904579L (en) 1979-11-27
CH649297A5 (en) 1985-05-15
FR2426466A1 (en) 1979-12-21
FR2426466B1 (en) 1983-02-04
SE438859B (en) 1985-05-13
NL7904125A (en) 1979-11-28
IT7949175A0 (en) 1979-05-25
AU4742379A (en) 1979-11-29
IE49171B1 (en) 1985-08-21
NZ190557A (en) 1982-05-25
IT1116199B (en) 1986-02-10

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