IE790701L - Ergot alkaloids and heparin - Google Patents
Ergot alkaloids and heparinInfo
- Publication number
- IE790701L IE790701L IE790701A IE70179A IE790701L IE 790701 L IE790701 L IE 790701L IE 790701 A IE790701 A IE 790701A IE 70179 A IE70179 A IE 70179A IE 790701 L IE790701 L IE 790701L
- Authority
- IE
- Ireland
- Prior art keywords
- heparin
- mgs
- isopropyl
- hydrogen
- ergot alkaloids
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Saccharide Compounds (AREA)
Abstract
A pharmaceutical composition comprises a mixture of a hydrogenated ergot alkaloid of formula (I):- <IMAGE> wherein R is hydrogen or a C1-4 alkyl group other than t-butyl; R1 is methyl, ethyl or isopropyl; R2 is isopropyl, secbutyl, isobutyl or benzyl; and X is hydrogen or methoxy; together with heparin, the proportion of compound (I) in mgs. to heparin in international Units being 1:5000. The composition may be in unit dosage form containing 0.5 mgs. of the alkaloid and 2,500 I.U. of heparin, together with a pharmaceutical carrier or diluent for injection (eg. poly-N- vinyl-2-pyrrolidone).
[GB2015338A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19782809618 DE2809618A1 (en) | 1978-03-06 | 1978-03-06 | NEW THERAPEUTIC PREPARATION AND METHOD FOR THE PRODUCTION THEREOF |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE790701L true IE790701L (en) | 1979-09-06 |
| IE48192B1 IE48192B1 (en) | 1984-10-31 |
Family
ID=6033695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE701/79A IE48192B1 (en) | 1978-03-06 | 1979-08-08 | Pharmaceutical compositions containing an ergot alkaloid and heparin |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS54126736A (en) |
| BE (1) | BE874626R (en) |
| CH (1) | CH639271A5 (en) |
| CY (1) | CY1298A (en) |
| DE (1) | DE2809618A1 (en) |
| FR (1) | FR2419070A2 (en) |
| GB (1) | GB2015338B (en) |
| HK (1) | HK81085A (en) |
| IE (1) | IE48192B1 (en) |
| KE (1) | KE3548A (en) |
| NL (1) | NL7901702A (en) |
| NZ (1) | NZ189817A (en) |
| PH (1) | PH16800A (en) |
| SG (1) | SG49185G (en) |
| ZA (1) | ZA791032B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2945636A1 (en) * | 1979-11-12 | 1981-05-21 | Sandoz-Patent-GmbH, 7850 Lörrach | STABLE SOLUTIONS OF HYDRATED ERGOTAL CALOIDS OR YOUR SALTS AND HEPARIN OR ITS SALTS AND METHOD FOR THE PRODUCTION THEREOF |
| DE3343818A1 (en) * | 1982-12-10 | 1984-06-14 | Sandoz-Patent-GmbH, 7850 Lörrach | Therapeutic product containing hydrogenated ergot alkaloids and heparin |
| CH656533A5 (en) * | 1982-12-10 | 1986-07-15 | Sandoz Ag | THERAPEUTIC PREPARATION CONTAINING HYDRATED ERGOTAL CALOIDS AND LOW MOLECULAR HEPARINE. |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE441142B (en) * | 1975-12-04 | 1985-09-16 | Sandoz Ag | PROCEDURE FOR PREPARING A THERAPEUTIC PREPARATION WITH ANTITHROMOBOTIC PROPERTIES |
-
1978
- 1978-03-06 DE DE19782809618 patent/DE2809618A1/en not_active Withdrawn
-
1979
- 1979-02-23 CH CH184079A patent/CH639271A5/en not_active IP Right Cessation
- 1979-03-02 NL NL7901702A patent/NL7901702A/en not_active Application Discontinuation
- 1979-03-02 GB GB7907393A patent/GB2015338B/en not_active Expired
- 1979-03-02 CY CY1298A patent/CY1298A/en unknown
- 1979-03-02 PH PH22245A patent/PH16800A/en unknown
- 1979-03-05 JP JP2460879A patent/JPS54126736A/en active Pending
- 1979-03-05 NZ NZ789817A patent/NZ189817A/en unknown
- 1979-03-05 BE BE0/193847A patent/BE874626R/en not_active IP Right Cessation
- 1979-03-06 ZA ZA791032A patent/ZA791032B/en unknown
- 1979-03-06 FR FR7905752A patent/FR2419070A2/en active Granted
- 1979-08-08 IE IE701/79A patent/IE48192B1/en unknown
-
1985
- 1985-06-24 SG SG49185A patent/SG49185G/en unknown
- 1985-07-11 KE KE3548A patent/KE3548A/en unknown
- 1985-10-17 HK HK810/85A patent/HK81085A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS54126736A (en) | 1979-10-02 |
| HK81085A (en) | 1985-10-25 |
| NL7901702A (en) | 1979-09-10 |
| GB2015338A (en) | 1979-09-12 |
| KE3548A (en) | 1985-08-02 |
| DE2809618A1 (en) | 1979-09-20 |
| CY1298A (en) | 1985-10-18 |
| CH639271A5 (en) | 1983-11-15 |
| IE48192B1 (en) | 1984-10-31 |
| FR2419070A2 (en) | 1979-10-05 |
| ZA791032B (en) | 1980-10-29 |
| FR2419070B1 (en) | 1982-08-06 |
| BE874626R (en) | 1979-09-05 |
| NZ189817A (en) | 1981-04-24 |
| SG49185G (en) | 1986-01-17 |
| PH16800A (en) | 1984-03-01 |
| GB2015338B (en) | 1982-08-18 |
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