[go: up one dir, main page]

IE781636L - Anthraquinone derivatives - Google Patents

Anthraquinone derivatives

Info

Publication number
IE781636L
IE781636L IE781636A IE163678A IE781636L IE 781636 L IE781636 L IE 781636L IE 781636 A IE781636 A IE 781636A IE 163678 A IE163678 A IE 163678A IE 781636 L IE781636 L IE 781636L
Authority
IE
Ireland
Prior art keywords
alkyl
hydroxy
hydrogen
image
atom
Prior art date
Application number
IE781636A
Other versions
IE47253B1 (en
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27542240&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IE781636(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US05/903,292 external-priority patent/US4138415A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of IE781636L publication Critical patent/IE781636L/en
Publication of IE47253B1 publication Critical patent/IE47253B1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J45/00—Ion-exchange in which a complex or a chelate is formed; Use of material as complex or chelate forming ion-exchangers; Treatment of material for improving the complex or chelate forming ion-exchange properties
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G59/00—Polycondensates containing more than one epoxy group per molecule; Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups
    • C08G59/18—Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups ; e.g. general methods of curing
    • C08G59/40—Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups ; e.g. general methods of curing characterised by the curing agents used
    • C08G59/62—Alcohols or phenols
    • C08G59/621—Phenols
    • C08G59/623—Aminophenols
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G59/00—Polycondensates containing more than one epoxy group per molecule; Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups
    • C08G59/18—Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups ; e.g. general methods of curing
    • C08G59/68—Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups ; e.g. general methods of curing characterised by the catalysts used
    • C08G59/686—Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups ; e.g. general methods of curing characterised by the catalysts used containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M1/00—Liquid compositions essentially based on mineral lubricating oils or fatty oils; Their use as lubricants
    • C10M1/08—Liquid compositions essentially based on mineral lubricating oils or fatty oils; Their use as lubricants with additives
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M133/00—Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing nitrogen
    • C10M133/02—Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing nitrogen having a carbon chain of less than 30 atoms
    • C10M133/04—Amines, e.g. polyalkylene polyamines; Quaternary amines
    • C10M133/12—Amines, e.g. polyalkylene polyamines; Quaternary amines having amino groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

The invention pertains to anthraquinone derivatives of the following general formula: <IMAGE> the tautomeric forms and the pharmacologically acceptable acid-addition salts thereof, wherein A-B is selected from CH-CH and CH2-CH2; Q is a divalent optionally branched C2-C4 alkylene moiety, wherein R1 and R2 are each individually hydrogen, C1-C4 alkyl monohydroxy C2-C4 alkyl wherein the carbon atom alpha to the nitrogen atom may not bear an hydroxy group, dihydroxy C3-C6 alkyl wherein the carbon atom alpha to the nitrogen atom may not bear an hydroxy group, formyl, C2-C4 alkanoyl trifluoroacetyl and moieties of the formulae: -(CH2)n-CN, -(CH2)n-O-R and <IMAGE> wherein n is an integer from 2 to 4, inclusive, R is C1-C4 alkyl and R3 and R4 are each individually hydrogen, C1-C4 alkyl and monohydroxy C2-C4 alkyl wherein the carbon atom alpha to the nitrogen atom may not bear an hydroxy group; and R1 and R2 taken together with their associated N atom and R3 and R4 taken together with their associated N atom is morpholino, thiomorpholino, piperazino, 4-methyl-1 -piperazino or a moiety of the formula: <IMAGE> wherein m is an integer from 2 to 6, inclusive; with the proviso that the ratio of the total number of carbon atoms to the sum of the total number of oxygen atoms plus the total number of nitrogen atoms in the side chains at the 1-position and the 4-position may not exceed 4; R5 is hydrogen, hydroxy, chloro and C1-C6 alkanoyloxy; R6 is hydrogen and hydroxy; R7 is hydrogen, hydroxy, chloro, C1-C6 alkanoyloxy and a moiety of the formula <IMAGE> wherein R8 and R9 are each individually methyl, ethyl, and beta -hydroxy- ethyl; provided that when R5 is OH then one of R6 and R7 must be H, and when R5 is H then both of R6 and R7 must be H. The above-defined anthraquinone derivatives, many of which are novel per se, have a number of useful properties, including in many cases activity as anti-tumor agents. [GB2004293A]
IE1636/78A 1977-08-15 1978-08-11 Anthraquinone derivatives IE47253B1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US82487277A 1977-08-15 1977-08-15
US87317478A 1978-01-30 1978-01-30
US87304078A 1978-01-30 1978-01-30
US87304178A 1978-01-30 1978-01-30
US05/903,292 US4138415A (en) 1978-05-05 1978-05-05 1,4-Bis(aminoalkylamino)-anthraquinones and leuco derivatives thereof

Publications (2)

Publication Number Publication Date
IE781636L true IE781636L (en) 1979-02-15
IE47253B1 IE47253B1 (en) 1984-02-08

Family

ID=27542240

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1636/78A IE47253B1 (en) 1977-08-15 1978-08-11 Anthraquinone derivatives

Country Status (22)

Country Link
JP (1) JPS6463556A (en)
AR (1) AR225884A1 (en)
AT (1) AT359484B (en)
AU (1) AU527103B2 (en)
BE (1) BE869688A (en)
CH (1) CH644840A5 (en)
DD (1) DD139256A5 (en)
DE (1) DE2835661A1 (en)
DK (1) DK158836C (en)
FI (1) FI70882C (en)
FR (1) FR2400504A1 (en)
GB (1) GB2004293B (en)
GR (1) GR74415B (en)
IE (1) IE47253B1 (en)
IL (1) IL55218A (en)
IT (1) IT1107773B (en)
NL (1) NL188981C (en)
NO (2) NO148777C (en)
NZ (1) NZ187989A (en)
PL (1) PL122586B1 (en)
PT (1) PT68420A (en)
SE (1) SE445996B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4275009A (en) * 1979-05-29 1981-06-23 American Cyanamid Company 1-(Aminoalkylamino)-5,8-dihydroxy-4-substituted-anthraquinones
US4275010A (en) * 1979-10-24 1981-06-23 American Cyanamid Company 5,8-Dihydroxy-1,4-bis(guanidinylamino)anthraquinones
US4296030A (en) * 1980-04-09 1981-10-20 American Cyanamid Company Metal chelates of 1,4-bis(substituted-amino-5,8-dihydroxy-anthraquinones
US4278605A (en) * 1980-06-30 1981-07-14 American Cyanamid Company Heteroalkylenebisanthraquinones
EP0052853A1 (en) * 1980-11-24 1982-06-02 Hoechst Aktiengesellschaft Bis-aminomethyl-anthraquinone derivatives, process for their manufacture, compositions containing them and their use
EP0083683A1 (en) * 1981-10-26 1983-07-20 American Cyanamid Company Method of preparing 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones and pharmaceutical compositions containing them
ATE48942T1 (en) * 1984-02-27 1990-01-15 American Cyanamid Co USE OF 1,4 BI-SUBSTITUTED ANTHRACHINONES FOR THE MANUFACTURE OF IMMUNOSUPPRESSIVES.
EP0182135A3 (en) * 1984-11-19 1987-08-05 American Cyanamid Company Novel bis-(substituted amino) anthraquinones
US5436243A (en) * 1993-11-17 1995-07-25 Research Triangle Institute Duke University Aminoanthraquinone derivatives to combat multidrug resistance
GB9815910D0 (en) * 1998-07-21 1998-09-23 Btg Int Ltd Synthetic method
CA2550839A1 (en) * 2003-12-23 2005-07-07 Somanta Limited Antharquinone compounds as anti cancer compounds
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
AR074897A1 (en) 2008-12-23 2011-02-23 Pharmasset Inc NUCLEOSID PHOSPHORAMIDATES
AU2009329917B2 (en) 2008-12-23 2016-03-31 Gilead Pharmasset Llc Nucleoside analogs
SG194404A1 (en) 2008-12-23 2013-11-29 Gilead Pharmasset Llc Synthesis of purine nucleosides
PT2609923T (en) 2010-03-31 2017-08-30 Gilead Pharmasset Llc Process for the crystallisation of (s)-isopropyl 2-(((s)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate
DE102012203981A1 (en) * 2012-03-14 2013-09-19 Henkel Ag & Co. Kgaa Agent for dyeing and / or delustering keratin-containing fibers containing novel 1,4-diaminoanthraquinone dyes
GB201214169D0 (en) 2012-08-08 2012-09-19 Biostatus Ltd New compounds and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1422016A (en) * 1962-10-29 1965-12-24 Oreal New anthraquinone dyes and their application to hair dye
GB1157506A (en) * 1965-09-10 1969-07-09 Ilford Ltd Anthraquinone Dye Colour Couplers and their use in Colour Photographic Materials
US3700398A (en) * 1970-07-27 1972-10-24 Du Pont Process for dyeing acid-modified nylon fibers
US3646072A (en) * 1970-07-27 1972-02-29 Du Pont Turquoise biscationic anthraquinone dyes
US4051155A (en) * 1975-12-15 1977-09-27 Allied Chemical Corporation Anthraquinone dyes

Also Published As

Publication number Publication date
DK158836B (en) 1990-07-23
AT359484B (en) 1980-11-10
PL209065A1 (en) 1980-01-02
PT68420A (en) 1978-09-01
PL122586B1 (en) 1982-08-31
IT1107773B (en) 1985-11-25
CH644840A5 (en) 1984-08-31
BE869688A (en) 1979-02-12
DK158836C (en) 1991-01-14
ATA590678A (en) 1980-04-15
GB2004293A (en) 1979-03-28
DK358678A (en) 1979-02-16
FI70882C (en) 1986-10-27
IL55218A (en) 1983-03-31
IE47253B1 (en) 1984-02-08
NO820290L (en) 1979-02-16
IT7850730A0 (en) 1978-08-14
GR74415B (en) 1984-06-28
FR2400504B1 (en) 1981-06-26
FI782481A (en) 1979-02-16
NL188981C (en) 1992-12-01
NL7808475A (en) 1979-02-19
AU3877678A (en) 1980-02-14
NO782756L (en) 1979-02-16
FI70882B (en) 1986-07-18
DE2835661A1 (en) 1979-03-01
NZ187989A (en) 1981-07-13
JPH0217534B2 (en) 1990-04-20
AU527103B2 (en) 1983-02-17
AR225884A1 (en) 1982-05-14
NO150482C (en) 1984-10-24
NO148777C (en) 1984-01-25
DD139256A5 (en) 1979-12-19
DE2835661C2 (en) 1991-08-22
SE445996B (en) 1986-08-04
NO148777B (en) 1983-09-05
GB2004293B (en) 1982-06-23
FR2400504A1 (en) 1979-03-16
JPS6463556A (en) 1989-03-09
NO150482B (en) 1984-07-16
SE7807987L (en) 1979-02-16

Similar Documents

Publication Publication Date Title
IE781636L (en) Anthraquinone derivatives
ES445702A1 (en) Thieno{8 3,2-c{9 pyridine derivatives
IL113101A0 (en) Anthracycline derivatives and their preparation
ES2129279A1 (en) Organic compounds
GR3029603T3 (en) Cytotoxic stilbene derivatives and pharmaceutical composition containing them.
IE841659L (en) Allopurinol prodrugs
TW360652B (en) Acryloyl substituted disstamycin derivatives, process for preparing them, and pharmaceutical composition comprising them
MY103172A (en) Tricyclic pyridine derivatives.
HU9401150D0 (en) 3-deoxy-oligosaccharides, process for preparing them and pharmaceutical compositions containing them
IL59686A (en) 1-(aminoalkylamino)-5,8-dihydroxy-4-substituted-anthraquinones and their preparation
GR900100035A (en) Hydroxyalkanocarbonic acid derivatives preparation method and use thereof
MY141374A (en) Water soluble camptothecin derivatives
ES8104320A1 (en) Bis(4-demethoxydaunorubicin)dihydrazone derivatives and pharmacologically acceptable salts thereof
GR3023322T3 (en) 5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxobenzo alpha heptalene derivative.
ES468585A1 (en) 2-Methyl-6-alkyl-11-aminoalkyl-6,11-dihydro-5H-pyrido(2,3-B)(1,5)benzodiazepin-5-ones and salts thereof
ZA854472B (en) Benzoseleno(4,3,2-cd)indazole compositions and methods for their production and use
IL106564A0 (en) Tetrahydronaphthalene derivatives,their preparation and their application in therapy
ES473060A1 (en) Improvements in or relating to organic compounds
WO1992000740A3 (en) Bis-dioxopiperazines and their use as protection agents
ZA854473B (en) Benzopyrano(4,3,2-cd)indazole compositions and methods for their production and use

Legal Events

Date Code Title Description
MK9A Patent expired