IE780901L - Tetrazolyl-piperidinyl amides - Google Patents
Tetrazolyl-piperidinyl amidesInfo
- Publication number
- IE780901L IE780901L IE780901A IE90178A IE780901L IE 780901 L IE780901 L IE 780901L IE 780901 A IE780901 A IE 780901A IE 90178 A IE90178 A IE 90178A IE 780901 L IE780901 L IE 780901L
- Authority
- IE
- Ireland
- Prior art keywords
- compounds
- formula
- piperidinyl
- amides
- phenyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 7
- 239000002253 acid Substances 0.000 abstract 2
- LKRMTUUCKBQGFO-UHFFFAOYSA-N n-phenylpiperidin-4-amine Chemical class C1CNCCC1NC1=CC=CC=C1 LKRMTUUCKBQGFO-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- JXBKZAYVMSNKHA-UHFFFAOYSA-N 1h-tetrazol-1-ium-5-olate Chemical compound OC=1N=NNN=1 JXBKZAYVMSNKHA-UHFFFAOYSA-N 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- BCIIMDOZSUCSEN-UHFFFAOYSA-N piperidin-4-amine Chemical compound NC1CCNCC1 BCIIMDOZSUCSEN-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
N-Phenyl-N-(4-piperidinyl)amides have the following formula <IMAGE> in which the substituents are defined in Claim 1; the compounds can also be present as acid addition salts. The compounds of the formula I, in which Z is oxygen, are prepared by reacting a corresponding 4,5-dihydro-1H-tetrazol-5-one with a corresponding N-phenyl-N-(4-piperidinyl)amide. Compounds of the formula I, in which Z = O, are likewise obtained by N-acylating a corresponding 4-piperidinamine. Compounds in which Z = S are prepared from compounds of the formula I, in which Z = O, by reaction with a sulphurating agent. Pharmaceutical compositions having an analgesic effect contain, as the active compound component, at least one novel compound of the formula I or a pharmaceutically acceptable acid addition salt thereof.
[GB1598872A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79381477A | 1977-05-05 | 1977-05-05 | |
| US88618878A | 1978-03-13 | 1978-03-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE780901L true IE780901L (en) | 1978-11-05 |
| IE46836B1 IE46836B1 (en) | 1983-10-05 |
Family
ID=27121432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE901/78A IE46836B1 (en) | 1977-05-05 | 1978-05-04 | N-phenyl-n-(4-piperidinyl)amides |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS53149980A (en) |
| AT (1) | AT368994B (en) |
| AU (1) | AU514360B2 (en) |
| CA (1) | CA1105464A (en) |
| CH (1) | CH635585A5 (en) |
| CY (1) | CY1253A (en) |
| DE (1) | DE2819873A1 (en) |
| DK (1) | DK152211C (en) |
| ES (1) | ES469473A1 (en) |
| FI (1) | FI64364C (en) |
| FR (1) | FR2389622B1 (en) |
| GB (1) | GB1598872A (en) |
| HK (1) | HK72585A (en) |
| HU (1) | HU179204B (en) |
| IE (1) | IE46836B1 (en) |
| IL (1) | IL54639A (en) |
| IT (1) | IT1105288B (en) |
| KE (1) | KE3429A (en) |
| LU (1) | LU79575A1 (en) |
| NL (1) | NL186861C (en) |
| NO (1) | NO148747C (en) |
| NZ (1) | NZ187164A (en) |
| PH (1) | PH12831A (en) |
| SE (1) | SE437516B (en) |
| SU (1) | SU867304A3 (en) |
| YU (1) | YU40703B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6144294A (en) * | 1984-08-07 | 1986-03-03 | Nippon Denso Co Ltd | Heat exchanger |
| US5053411A (en) * | 1989-04-20 | 1991-10-01 | Anaquest, Inc. | N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds |
| USRE34201E (en) * | 1989-04-20 | 1993-03-23 | Anaquest, Inc. | N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds |
| JPH08193074A (en) * | 1994-11-18 | 1996-07-30 | Nippon Bayeragrochem Kk | Herbicidal 1-cyclopropyltetrazolinones |
| JP2000327668A (en) * | 1999-05-21 | 2000-11-28 | Nippon Bayer Agrochem Co Ltd | Tetrazolinone derivative |
| EP1246801B1 (en) * | 1999-12-06 | 2006-09-20 | Mallinckrodt Inc. | Methods for the syntheses of alfentanil, sufentanil and remifentanil |
| US20090030041A1 (en) * | 2004-09-14 | 2009-01-29 | Toshihiro Takahashi | N-substituted N-(4-piperidinyl) Amide Derivative |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3998834A (en) * | 1975-03-14 | 1976-12-21 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl)-n-phenylamides and -carbamates |
-
1978
- 1978-04-24 FR FR7812084A patent/FR2389622B1/fr not_active Expired
- 1978-04-25 PH PH21055A patent/PH12831A/en unknown
- 1978-04-27 AU AU35522/78A patent/AU514360B2/en not_active Expired
- 1978-05-02 LU LU79575A patent/LU79575A1/en unknown
- 1978-05-03 NZ NZ187164A patent/NZ187164A/en unknown
- 1978-05-03 DK DK193778A patent/DK152211C/en not_active IP Right Cessation
- 1978-05-03 NO NO781559A patent/NO148747C/en unknown
- 1978-05-03 AT AT0322078A patent/AT368994B/en not_active IP Right Cessation
- 1978-05-03 SE SE7805110A patent/SE437516B/en not_active IP Right Cessation
- 1978-05-03 GB GB17566/78A patent/GB1598872A/en not_active Expired
- 1978-05-03 CY CY1253A patent/CY1253A/en unknown
- 1978-05-04 FI FI781398A patent/FI64364C/en not_active IP Right Cessation
- 1978-05-04 IL IL54639A patent/IL54639A/en unknown
- 1978-05-04 ES ES469473A patent/ES469473A1/en not_active Expired
- 1978-05-04 IE IE901/78A patent/IE46836B1/en not_active IP Right Cessation
- 1978-05-04 IT IT49203/78A patent/IT1105288B/en active
- 1978-05-04 CA CA302,616A patent/CA1105464A/en not_active Expired
- 1978-05-04 JP JP5287378A patent/JPS53149980A/en active Granted
- 1978-05-04 HU HU78JA819A patent/HU179204B/en unknown
- 1978-05-05 CH CH492478A patent/CH635585A5/en not_active IP Right Cessation
- 1978-05-05 NL NLAANVRAGE7804844,A patent/NL186861C/en not_active IP Right Cessation
- 1978-05-05 SU SU782613447A patent/SU867304A3/en active
- 1978-05-05 YU YU1085/78A patent/YU40703B/en unknown
- 1978-05-05 DE DE19782819873 patent/DE2819873A1/en active Granted
-
1984
- 1984-07-20 KE KE3429A patent/KE3429A/en unknown
-
1985
- 1985-09-26 HK HK725/85A patent/HK72585A/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK9A | Patent expired |