IE55409B1 - Neutral topical sodium fluoride gel - Google Patents
Neutral topical sodium fluoride gelInfo
- Publication number
- IE55409B1 IE55409B1 IE1811/83A IE181183A IE55409B1 IE 55409 B1 IE55409 B1 IE 55409B1 IE 1811/83 A IE1811/83 A IE 1811/83A IE 181183 A IE181183 A IE 181183A IE 55409 B1 IE55409 B1 IE 55409B1
- Authority
- IE
- Ireland
- Prior art keywords
- composition
- sodium fluoride
- gel
- fluoride
- neutral
- Prior art date
Links
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 title claims abstract description 37
- 239000011775 sodium fluoride Substances 0.000 title claims abstract description 15
- 235000013024 sodium fluoride Nutrition 0.000 title claims abstract description 15
- 230000000699 topical effect Effects 0.000 title claims abstract description 7
- 230000007935 neutral effect Effects 0.000 title abstract description 6
- 239000000203 mixture Substances 0.000 claims description 24
- 239000002562 thickening agent Substances 0.000 claims description 12
- 208000002925 dental caries Diseases 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 229920002125 Sokalan® Polymers 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 239000001488 sodium phosphate Substances 0.000 claims description 5
- 239000000230 xanthan gum Substances 0.000 claims description 5
- 229920001285 xanthan gum Polymers 0.000 claims description 5
- 229940082509 xanthan gum Drugs 0.000 claims description 5
- 235000010493 xanthan gum Nutrition 0.000 claims description 5
- 239000000796 flavoring agent Substances 0.000 claims description 4
- 239000004615 ingredient Substances 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 238000004040 coloring Methods 0.000 claims description 3
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical group [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 3
- 239000004584 polyacrylic acid Substances 0.000 claims description 3
- 239000003755 preservative agent Substances 0.000 claims description 3
- 238000011321 prophylaxis Methods 0.000 claims description 3
- 159000000000 sodium salts Chemical class 0.000 claims description 3
- 235000019800 disodium phosphate Nutrition 0.000 claims description 2
- 229910000397 disodium phosphate Inorganic materials 0.000 claims description 2
- 235000013355 food flavoring agent Nutrition 0.000 claims description 2
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 2
- 239000006172 buffering agent Substances 0.000 claims 2
- 230000002335 preservative effect Effects 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 abstract description 4
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 11
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 238000011282 treatment Methods 0.000 description 9
- 239000000463 material Substances 0.000 description 6
- 238000009472 formulation Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 239000002253 acid Substances 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 3
- 238000005530 etching Methods 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 239000003973 paint Substances 0.000 description 2
- 229910052573 porcelain Inorganic materials 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229940023014 acidulated phosphate fluoride Drugs 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 208000024693 gingival disease Diseases 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical class [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
- A61K6/65—Dyes
- A61K6/66—Photochromic dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
- A61K6/69—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dental Preparations (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Seasonings (AREA)
- Glass Compositions (AREA)
- Colloid Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A neutral topical sodium fluoride gel is disclosed which comprises a thickened aqueous solution of sodium fluoride buffered to maintain a pH of from about 5 to 9.
Description
2 2 5 ο 4 Ο 9 The invention relates to a neutral topical sodium fluoride gel composition useful for the control and prevention of dental caries when topically applied to erupted teeth.
Weutral aqueous solutions of sodium fluoride were first 5 used in the prevention of dental caries about 40 years ago. The initial clinical studies using neutral sodium fluoride were carried out by Knutson and Armstrong^^ and by Bibby^2^. In the early 1960's, acidulated phosphate fluoride ("APF") appeared to be a preferred 10 material in that some laboratory tests by Brudevalc et al.*3) indicated that the APF System gave a higher fluoride uptake, than neutral sodium fluoride. Therefore, the predominant fluoride material used by dentists, hygienists, and other dental technicians since then has 15 been the APF material. In the late 1960's, the APF material was introduced in the form of a gel. One such formulation is described by Elbreder in U.S. Patent No. 3,337,412. Another APF gel is described by Weitzman et al., in U.S. Patent No. 4,267,167.
As far as is known to the inventor, since the initial use of neutral aqueous sodium fluoride in dental caries prophylaxis, no one has proposed the use of an operator-applied topical "gel" or thickened aqueous solution thereof in dentistry. This is surprising, since, from the 25 standpoint of clinical efficacy, it now is believed that (1) Public Health Rep. 58, 1701 (1943) . (2) J. Am. Dent. Assoc. 31, 317 (1944) . (3) Arch. Oral Biol. 8, 167 (1963). 3 there is no difference between neutral sodium fluoride and APF^1*', and yet there are some disadvantages to the use of the APF gel. For instance, APF has an acid etching potential for porcelain, polymer-glass composite materials, and for metal bridge-work and orthodontic brackets. This could lead to staining, weakening, and reduction of polish.
Up to now, most professional fluoride "gel" treatments have been carried out on pre-teenage children. On these patients, the acid etching potential of APF gel is not a significant problem because they have a low incidence of porcelain, composites, metal bridgework, etc. However, the dental profession has come to..recognize that fluoride treatment would be beneficial to many more patients than pre-teenagers. For instance fluoride treatment to control and/or prevent caries is useful for those undergoing orthodontic treatment, children as well as adults.
Because of improved preventive and treatment measures, more adults are retaining their natural teeth; therefore, coronal and root dental caries is becoming a significant health problem in the adult population^1 2^. Adult patients suffering from gum disease such as gingivitis and periodontal disease would benefit from fluoride treatment to retard the formation of caries in the portions of the roots of teeth that are becoming exposed because of receding gum lines. Also, people who are handicapped, people with impaired salivary flow caused by head and neck radiation, and hemophiliacs can benefit from fluoride treatment to control dental caries. However, when fluoride gel treatment is extended to such patients, the acid etching potential of APF gel can become a significant concern.
For review, see Ripa, Inti. Dent. J. _31» 105 (1531). 2 U.S. National Center for Health Statistics data, 1971-1974. 4 The present invention is based upon the discovery that a neutral sodium fluoride gel using a specified combination of thickeners or gelling agents is particularly well adapted for use in dental caries prevention 5 and control.
The present invention provides a thickened sodium fluoride aqueous composition suitable for use in the topical prophylactic treatment of teeth, said composition comprising 75.2 to 96.1% w/w water, 1 to 5% w/w sodium 10 fluoride, and thickener consisting of xanthan gum and a water soluble salt of an acrylic acid polymer, said composition having a pH of 6 to 8.
The neutral topical sodium fluoride gel of the invention is actually a thickened solution, and is not a 15 true gel. However, because the word "gel" is widely employed in the dental profession to refer to such materials, it will be used herein, with the understanding that the invention actually relates to a thickened solution and not to a true crosslinked "gel".
The gel of the invention includes, water, sodium fluoride, thickener, and a buffer to maintain the pH between of from 6 to 8. Optionally, the composition will also contain flavoring agents, sweeteners, preservatives, and coloring agents at levels necessary to achieve the 25 desired effects. Thus, typical ranges of proportions of the ingredients are shown in the following Table I: 5 Table I Basic Formulation Ingredient % (w/· ;) Water 75.2 - 96.1 Sodium Fluoride 1.0 - 5.0 Thickener 1.0 - 20 .0 Buffer 0.5 - 1.5 Flavor 0.1 - 0.5 Sweetener 0.1 - 0.3 Preservatives 0.15 - 0.35 Coloring 0.05 - 0.15 The thickener that is employed in the invention comprises a mixture of xanthan gum and a water-soluble salt of an acrylic acid polymer, e.g. the sodium salt of polyacrylic acid.
The thickner is safe for human ingestion (FDA approved for internal use), does not bind fluoride ion or in any way significantly affect its bioavailability, and provides the desired flow characteristics to the products of this invention.
The thickener is added in a proportion sufficient to achieve a solution viscosity adequate to maintain a gel in an inverted mouthpiece tray applicator for up to about four minutes (typical time for a professionally applied fluoride treatment), and yet be fluid enough to have acceptable handling characteristics for the dental operator (e.g., when dispensing into a gel tray applicator). The thickening agent, therefore, must impart a certain degree of thixotropy to the neutral sodium fluoride formulation such that at rest the product has a thick, gel-like consistency, but under a shearing 6 force, resulting perhaps from simple agitation, the sodium fluoride gel thins or undergoes a reversible transition to a more fluid condition.
Routine experimentation will suffice to determine the exact proportion of thickener needed to impart the above characteristics. The Example, below illustrates typical proportions for the particular thickeners used.
The preferred formulation for use in the invention is shown below in Table II: Table II Preferred Formulation for the Neutral Sodium Fluoride "Gel" Composition Ingredient % (w/w) Water 87.7 Sodium Fluoride 2.0 Carbopol 934P (Polyacrylic acid) 1.2 Xanthan Gum 1.2 Sodium Hydroxide, 10¾ [aqueous] 6.5 Disodium Phosphate, Anhydrous 0.7 Flavor 0.3 Sodium Saccharin 0.1 Sodium Benzoate 0.2 Methyl Paraben 0.05 Coloring Solution 0.05 100.00 pH = 7.0 VISCOSITY = 8.5 Pa.S (85 poises) at 60 RPM and 25°C.
Carbopol 934P is polymerized acrylic acid. The aqueous sodium hydroxide is added to neutralize this material to form the sodium salt thereof. 7 The pH of the gel can be adjusted to the desired range by adding acids or bases such as phosphoric acid, hydrochloric acid, or sodium hydroxide, which form salts that are safe to ingest, or by the addition of ingestible buffering 5 agents such as sodium phosphates. Disodium phosphate and monosodium phosphate are the preferred buffers. The buffer is preferred in order to maintain the pH within the desired neutral range, since absorption of carbon dioxide from air could reduce the pH of an unbuffered gel.
The thickening agent, either alone or in combination, is employed in a proportion sufficient to impart a viscosity of from 4 to 20 Pa.S (40 to 200 poises) to the solution tested by a Brookfield Viscometer at 60 rpm and 25°C. , using Spindle No. 5. The degree of thixotropy of the gel 15 is preferably such that the Brookfield viscosity measured at 1.5 rpm and 25°C., using Spindle No. 4, is within the range of from 50 to 400 Pa.S (500 to 4,000 poises). 8 The thickened neutral sodium fluoride aqueous solutions of the invention are applied to the teeth by the dentist, hygienist, or technician in the conventional manner. This involves either a tray technique or a 5 "paint on" technique. The tray technique is preferred because of the convenience and time-saving aspects of the tray application. In this method, a gel application tray is filled approximately one-third full with the gel product. After the teeth are thoroughly dried, the 10 filled tray is inserted into the patient's mouth, and is maintained there for four minutes. The tray is then removed and the patient expectorates any excess gel remaining in the mouth. For the "paint on" technique, the teeth are isolated with cotton rolls and dried 15 thoroughly with air. A cotton applicator is then dipped into the gel and applied to the teeth, keeping the teeth covered with gel for four minutes. Once again, after the cotton rolls are removed, the patient expectorates excess gel.
Claims (9)
1. A thickened sodium fluoride aqueous composition suitable for use in topical prophylactic treatment of teeth, said composition comprising 75.2 to 96.1% w/w water, 1 to 5% w/w sodium fluoride, and thickener consisting of xanthan gum and a water soluble salt of an acrylic acid polymer, said composition having a pH of 6 to 8.
2. The composition of claim 1, further including a buffering agent.
3. The composition of claim 2, wherein the buffering agent is disodium phosphate, monosodium phosphate or a mixture thereof.
4. The composition of any one of claims 1 to 3, further including a flavoring agent, preservative or colouring agent.
5. The composition of any one of claims 1 to 4, which has a viscosity of from 4 to 20 Pa.S (40 to 200 poise) tested by a Brookfield viscometer at 60 RPM and 25°C, and a viscosity of 50 to 400 Pa.S (500 to 4000 poise) tested by a Brookfield viscometer at 1.5 RPM and 25°C.
6. The composition of any one of claims 1 to 5, wherein the thickener is xanthan gum plus the sodium salt of polyacrylic acid. 1 to 6
7. A composition according to any one of claims for use in controlling dental caries. 10
8. A method for preparing a composition according to any one of claims 1 to 7 comprising mixing said ingredients in the specified proportions and, if necessary, adjusting the pH to the specified range. 5
9. A thickened sodium fluoride aqueous composition according to claim 1, substantially as hereinbefore described and exemplified. F. R. KELLY & CO., AGENTS FOR THE APPLICANTS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40426382A | 1982-08-02 | 1982-08-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE831811L IE831811L (en) | 1984-02-02 |
| IE55409B1 true IE55409B1 (en) | 1990-09-12 |
Family
ID=23598884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1811/83A IE55409B1 (en) | 1982-08-02 | 1983-07-29 | Neutral topical sodium fluoride gel |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0102200B1 (en) |
| JP (1) | JPS5944307A (en) |
| AT (1) | ATE25332T1 (en) |
| AU (1) | AU559344B2 (en) |
| CA (1) | CA1207670A (en) |
| DE (1) | DE3369637D1 (en) |
| DK (1) | DK164770C (en) |
| ES (1) | ES524657A0 (en) |
| FI (1) | FI77370C (en) |
| GR (1) | GR78863B (en) |
| HK (1) | HK61487A (en) |
| IE (1) | IE55409B1 (en) |
| IL (1) | IL69383A0 (en) |
| MX (1) | MX158408A (en) |
| NO (1) | NO163354C (en) |
| NZ (1) | NZ204974A (en) |
| PT (1) | PT77144B (en) |
| SG (1) | SG29587G (en) |
| ZA (1) | ZA835622B (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4661341A (en) * | 1984-10-30 | 1987-04-28 | The Procter & Gamble Company | Oral compositions |
| IT1198286B (en) * | 1986-11-18 | 1988-12-21 | Apollonia Corp Srl S | FLUORINATED MOUTHWASH FOR ANTICARIE PREVENTION |
| US5094841A (en) * | 1988-07-05 | 1992-03-10 | The Trustees Of Columbia University In The City Of New York | Gel for optimum release of fluoride with antibacterial capability for use in the prevention of caries of root surface |
| US5028413A (en) * | 1990-03-21 | 1991-07-02 | Bausch & Lomb Incorporated | Novel fluoride-containing dentifrice |
| NL1004386C2 (en) * | 1996-10-30 | 1998-08-06 | Sara Lee De Nv | Oral care product. |
| US6669927B2 (en) | 1998-11-12 | 2003-12-30 | 3M Innovative Properties Company | Dental compositions |
| US6312667B1 (en) * | 1998-11-12 | 2001-11-06 | 3M Innovative Properties Company | Methods of etching hard tissue in the oral environment |
| US6312666B1 (en) | 1998-11-12 | 2001-11-06 | 3M Innovative Properties Company | Methods of whitening teeth |
| US6620405B2 (en) | 2001-11-01 | 2003-09-16 | 3M Innovative Properties Company | Delivery of hydrogel compositions as a fine mist |
| DE102006055224B4 (en) * | 2006-11-21 | 2008-09-04 | Heraeus Kulzer Gmbh | Kits, their preparation and use for whitening coating of teeth |
| GB0712113D0 (en) * | 2007-06-21 | 2007-08-01 | Glaxo Group Ltd | Novel composition |
| FR2922443B1 (en) * | 2007-10-17 | 2012-11-09 | Georgia Pacific France | COSMETIC COMPOSITION FOR IMPREGNATING A CLEANING AND / OR SKIN CARE ARTICLE |
| CN102427795A (en) | 2009-05-18 | 2012-04-25 | 高露洁-棕榄公司 | Oral compositions containing polyguanidine compounds and methods of making and using the same |
| TWI499430B (en) | 2009-12-17 | 2015-09-11 | Colgate Palmolive Co | Anti-erosion toothpaste composition |
| AR080076A1 (en) | 2010-01-29 | 2012-03-14 | Colgate Palmolive Co | ORAL CARE PRODUCT FOR SENSITIVE ENAMEL CARE |
| CN111163841B (en) * | 2017-09-29 | 2024-03-12 | 3M创新有限公司 | Oral care fluoride aqueous therapeutic compositions and methods |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3337412A (en) * | 1964-04-10 | 1967-08-22 | Charles H Elbreder | Topical fluoride-phosphate compositions and method |
| GB1450881A (en) * | 1974-03-14 | 1976-09-29 | Amalgamated Dental Co Ltd | Fluoride gels |
| CA1092512A (en) * | 1975-10-28 | 1980-12-30 | Stewart Weitzman | Dental thixotropic flucride-phosphate composition |
| DE2960420D1 (en) * | 1978-07-12 | 1981-09-24 | Beecham Group Plc | Method of inhibiting corrosion of aluminium tubes by toothpastes |
| JPS5583709A (en) * | 1978-12-20 | 1980-06-24 | Lion Corp | Fluorine-containing preparation |
| US4283385A (en) * | 1980-05-09 | 1981-08-11 | Richardson-Merrell Inc. | Dentifrices with improved soluble fluoride availability |
-
1983
- 1983-07-20 NZ NZ204974A patent/NZ204974A/en unknown
- 1983-07-29 IE IE1811/83A patent/IE55409B1/en not_active IP Right Cessation
- 1983-07-29 GR GR72084A patent/GR78863B/el unknown
- 1983-08-01 EP EP83304430A patent/EP0102200B1/en not_active Expired
- 1983-08-01 IL IL69383A patent/IL69383A0/en unknown
- 1983-08-01 DK DK351083A patent/DK164770C/en not_active IP Right Cessation
- 1983-08-01 NO NO832782A patent/NO163354C/en unknown
- 1983-08-01 JP JP58141798A patent/JPS5944307A/en active Granted
- 1983-08-01 ES ES524657A patent/ES524657A0/en active Granted
- 1983-08-01 AU AU17491/83A patent/AU559344B2/en not_active Ceased
- 1983-08-01 CA CA000433663A patent/CA1207670A/en not_active Expired
- 1983-08-01 ZA ZA835622A patent/ZA835622B/en unknown
- 1983-08-01 DE DE8383304430T patent/DE3369637D1/en not_active Expired
- 1983-08-01 FI FI832766A patent/FI77370C/en not_active IP Right Cessation
- 1983-08-01 AT AT83304430T patent/ATE25332T1/en not_active IP Right Cessation
- 1983-08-01 PT PT77144A patent/PT77144B/en not_active IP Right Cessation
- 1983-08-02 MX MX198256A patent/MX158408A/en unknown
-
1987
- 1987-03-27 SG SG295/87A patent/SG29587G/en unknown
- 1987-08-20 HK HK614/87A patent/HK61487A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK61487A (en) | 1987-08-28 |
| EP0102200A3 (en) | 1984-06-13 |
| FI832766A0 (en) | 1983-08-01 |
| JPS5944307A (en) | 1984-03-12 |
| GR78863B (en) | 1984-10-02 |
| PT77144A (en) | 1983-09-01 |
| DK164770B (en) | 1992-08-17 |
| NO832782L (en) | 1984-02-03 |
| EP0102200A2 (en) | 1984-03-07 |
| NO163354B (en) | 1990-02-05 |
| ES8602399A1 (en) | 1985-12-01 |
| DK164770C (en) | 1993-01-04 |
| NO163354C (en) | 1990-05-16 |
| SG29587G (en) | 1987-07-17 |
| AU559344B2 (en) | 1987-03-05 |
| CA1207670A (en) | 1986-07-15 |
| DE3369637D1 (en) | 1987-03-12 |
| FI77370C (en) | 1989-03-10 |
| DK351083A (en) | 1984-02-03 |
| IE831811L (en) | 1984-02-02 |
| JPH0340007B2 (en) | 1991-06-17 |
| IL69383A0 (en) | 1983-11-30 |
| ATE25332T1 (en) | 1987-02-15 |
| FI77370B (en) | 1988-11-30 |
| ZA835622B (en) | 1985-03-27 |
| EP0102200B1 (en) | 1987-02-04 |
| AU1749183A (en) | 1984-02-09 |
| DK351083D0 (en) | 1983-08-01 |
| PT77144B (en) | 1986-03-27 |
| FI832766L (en) | 1984-02-03 |
| NZ204974A (en) | 1985-10-11 |
| MX158408A (en) | 1989-01-30 |
| ES524657A0 (en) | 1985-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |