IE50646B1 - Novel 4-aroylimidazol-2-ones - Google Patents

Novel 4-aroylimidazol-2-ones

Info

Publication number: IE50646B1
Authority: IE; Ireland
Prior art keywords: alkyl; hydrogen; methyl; phenyl; pharmaceutical composition
Prior art date: 1979-06-18

Application number

IE1162/80A

Other languages

English (en)

Other versions

IE801162L (en

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-06-18

Filing date

1980-06-05

Publication date

1986-06-11

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26727558&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IE50646(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1980-06-05 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1980-12-18 Publication of IE801162L publication Critical patent/IE801162L/xx

1986-06-11 Publication of IE50646B1 publication Critical patent/IE50646B1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

IE1162/80A 1979-06-18 1980-06-05 Novel 4-aroylimidazol-2-ones IE50646B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4980879A	1979-06-18	1979-06-18
US11920780A	1980-02-07	1980-02-07

Publications (2)

Publication Number	Publication Date
IE801162L IE801162L (en)	1980-12-18
IE50646B1 true IE50646B1 (en)	1986-06-11

Family

ID=26727558

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IE1162/80A IE50646B1 (en)	1979-06-18	1980-06-05	Novel 4-aroylimidazol-2-ones

Country Status (20)

Country	Link
AT (1)	AT375349B (no)
AU (1)	AU532783B2 (no)
CA (1)	CA1132554A (no)
CH (1)	CH646155A5 (no)
DE (1)	DE3021792A1 (no)
DK (1)	DK160269C (no)
ES (1)	ES8105299A1 (no)
FR (1)	FR2459233A1 (no)
GB (1)	GB2055364B (no)
HK (1)	HK61486A (no)
HU (1)	HU186736B (no)
IE (1)	IE50646B1 (no)
IL (1)	IL60243A (no)
IT (1)	IT1143922B (no)
MY (1)	MY8600709A (no)
NL (2)	NL193752C (no)
NO (1)	NO152841C (no)
NZ (1)	NZ193935A (no)
PH (1)	PH18683A (no)
SE (2)	SE447107B (no)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PH18106A (en) *	1981-02-18	1985-03-21	Merrell Dow Pharma	Novel-4-aroylimidazol-2-ones
US4405628A (en) *	1981-03-05	1983-09-20	Merrell Dow Pharmaceuticals Inc.	4-Pyridylimidazolones and method of use
US4526981A (en) *	1981-05-04	1985-07-02	Merrell Dow Pharmaceuticals Inc.	[1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates
US4371737A (en) *	1981-05-04	1983-02-01	Merrell Dow Pharmaceuticals Inc.	5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives
US4329471A (en) *	1981-05-04	1982-05-11	Merrell Dow Pharmaceuticals Inc.	4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones
US4381393A (en) *	1981-05-04	1983-04-26	Merrell Dow Pharmaceuticals Inc.	4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones
US4329470A (en) *	1981-05-04	1982-05-11	Merrell Dow Pharmaceuticals Inc.	5-(4-Phenyl 1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives
JPS57185266A (en) *	1981-05-04	1982-11-15	Merrell Dow Pharma	4-oxymethyl-5-acyl-1,3-dihydro-2h-imidazole- 2-one
US4367236A (en)	1981-11-04	1983-01-04	Merrell Dow Pharmaceuticals Inc.	Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives
US4410540A (en) *	1981-11-04	1983-10-18	Merrell Dow Pharmaceuticals Inc.	Cardiotonic 4-aroylimidazolidin-2-ones
US7772188B2 (en)	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
WO2005092333A1 (en) *	2004-03-22	2005-10-06	Myogen, Inc.	(r)-enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases
JP2007530563A (ja) *	2004-03-22	2007-11-01	ミオゲンインコーポレイティッド	（ｓ）−エノキシモンスルホキシドおよびｐｄｅ−ｉｉｉ媒介疾患の治療におけるその使用
KR20080065704A (ko)	2005-11-09	2008-07-14	콤비네이토릭스, 인코포레이티드	의학적 이상의 치료 방법들, 조성물들, 및 키트들
US7879802B2 (en)	2007-06-04	2011-02-01	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US20100120694A1 (en)	2008-06-04	2010-05-13	Synergy Pharmaceuticals, Inc.	Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2624828T3 (es)	2008-07-16	2017-07-17	Synergy Pharmaceuticals Inc.	Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
MX357121B (es)	2011-03-01	2018-06-27	Synergy Pharmaceuticals Inc Star	Proceso de preparacion de agonistas c de guanilato ciclasa.
WO2013106547A1 (en)	2012-01-10	2013-07-18	President And Fellows Of Harvard College	Beta-cell replication promoting compounds and methods of their use
US9545446B2 (en)	2013-02-25	2017-01-17	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase and their uses
CA2905438A1 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
AU2014235209B2 (en)	2013-03-15	2018-06-14	Bausch Health Ireland Limited	Guanylate cyclase receptor agonists combined with other drugs
EP3004138B1 (en)	2013-06-05	2024-03-13	Bausch Health Ireland Limited	Ultra-pure agonists of guanylate cyclase c, method of making and using same
JP6694385B2 (ja)	2013-08-09	2020-05-13	アーデリクス，インコーポレーテッド	リン酸塩輸送阻害のための化合物及び方法
US20200368223A1 (en)	2019-05-21	2020-11-26	Ardelyx, Inc.	Methods for inhibiting phosphate transport
CN114539157B (zh) *	2022-03-03	2023-12-22	曲靖师范学院	一种碘促进氧化法制备4-碘代n-芳基吡唑类化合物的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2441933A (en) *	1945-07-30	1948-05-18	Hoffmann La Roche	Substituted imidazolones and process of making them

1980
- 1980-06-04 NZ NZ193935A patent/NZ193935A/en unknown
- 1980-06-05 IE IE1162/80A patent/IE50646B1/en not_active IP Right Cessation
- 1980-06-06 IL IL60243A patent/IL60243A/xx unknown
- 1980-06-06 AU AU59118/80A patent/AU532783B2/en not_active Expired
- 1980-06-06 SE SE8004253A patent/SE447107B/sv not_active IP Right Cessation
- 1980-06-09 ES ES492255A patent/ES8105299A1/es not_active Expired
- 1980-06-11 DE DE19803021792 patent/DE3021792A1/de active Granted
- 1980-06-13 AT AT0314280A patent/AT375349B/de not_active IP Right Cessation
- 1980-06-16 PH PH24143A patent/PH18683A/en unknown
- 1980-06-16 CH CH462780A patent/CH646155A5/de not_active IP Right Cessation
- 1980-06-17 NL NL8003498A patent/NL193752C/nl not_active IP Right Cessation
- 1980-06-17 IT IT48997/80A patent/IT1143922B/it active Protection Beyond IP Right Term
- 1980-06-17 HU HU801506A patent/HU186736B/hu unknown
- 1980-06-17 FR FR8013434A patent/FR2459233A1/fr active Granted
- 1980-06-17 NO NO801796A patent/NO152841C/no unknown
- 1980-06-17 DK DK259080A patent/DK160269C/da not_active IP Right Cessation
- 1980-06-17 CA CA354,197A patent/CA1132554A/en not_active Expired
- 1980-06-18 GB GB8019898A patent/GB2055364B/en not_active Expired
1985
- 1985-03-25 SE SE8501452A patent/SE464559B/sv not_active IP Right Cessation
1986
- 1986-08-21 HK HK614/86A patent/HK61486A/xx not_active IP Right Cessation
- 1986-12-30 MY MY709/86A patent/MY8600709A/xx unknown
2000
- 2000-09-04 NL NL300015C patent/NL300015I1/nl unknown

Also Published As

Publication number	Publication date
NO152841C (no)	1985-11-27
NL193752C (nl)	2000-09-04
ES492255A0 (es)	1981-06-01
DK160269C (da)	1991-07-22
MY8600709A (en)	1986-12-31
HK61486A (en)	1986-08-29
NZ193935A (en)	1985-05-31
DK160269B (da)	1991-02-18
IE801162L (en)	1980-12-18
IL60243A0 (en)	1980-09-16
HU186736B (en)	1985-09-30
IT8048997A0 (it)	1980-06-17
SE8004253L (sv)	1980-12-19
DK259080A (da)	1980-12-19
DE3021792A1 (de)	1981-01-22
IT1143922B (it)	1986-10-29
ATA314280A (de)	1983-12-15
CH646155A5 (de)	1984-11-15
GB2055364B (en)	1983-06-08
NO801796L (no)	1980-12-19
PH18683A (en)	1985-08-29
ES8105299A1 (es)	1981-06-01
AU532783B2 (en)	1983-10-13
NL193752B (nl)	2000-05-01
SE8501452D0 (sv)	1985-03-25
NL300015I2 (nl)	2000-10-02
DE3021792C2 (no)	1989-08-10
SE464559B (sv)	1991-05-13
NL8003498A (nl)	1980-12-22
GB2055364A (en)	1981-03-04
FR2459233A1 (fr)	1981-01-09
CA1132554A (en)	1982-09-28
FR2459233B1 (no)	1983-09-23
NO152841B (no)	1985-08-19
SE447107B (sv)	1986-10-27
IL60243A (en)	1987-01-30
SE8501452L (sv)	1985-03-25
NL300015I1 (nl)	2000-11-01
AU5911880A (en)	1981-01-08
AT375349B (de)	1984-07-25

Publication	Publication Date	Title
IE50646B1 (en)	1986-06-11	Novel 4-aroylimidazol-2-ones
US4405635A (en)	1983-09-20	4-Aroylimidazol-2-ones and their use as pharmaceuticals
EP0059948B1 (en)	1985-11-13	Novel aroylimidazolones
EP0058435B1 (en)	1986-12-30	Novel 4-aroylimidazol-2-ones
EP0435177B1 (en)	1994-11-02	4-Benzyl-5-phenyl-2,4-dihydro-3H-1,2,4-triazol-3-ones and their use as anticonvulsants
JPH0223548B2 (no)	1990-05-24
US4775688A (en)	1988-10-04	5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants
EP0079050B1 (en)	1987-04-08	4-aroylimidazolidin-2-ones
EP0221485B1 (en)	1990-12-27	5-aryl-2,4-dialkyl-3h-1,2,4-triazole-3-thiones and their use as antidepressants
US4912095A (en)	1990-03-27	5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones useful as antidepressants
EP0079049B1 (en)	1987-04-01	Novel substituted alkanoylimidazol-2-one derivatives
EP0495226B1 (en)	1995-10-11	3-Aryl-5-alkylthio-4H-1,2,4-triazoles for treatment of hyperreflexia due to spinal trauma
GB2112774A (en)	1983-07-27	Imidazole derivatives
US4775689A (en)	1988-10-04	5-(naphthyl)-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants
JPS62106092A (ja)	1987-05-16	５−複素環−２，４−ジアルキル−３ｈ−１，２，４−トリアゾ−ル−３−チオン類及びそれらの抗抑鬱剤としての用途

Legal Events

Date	Code	Title	Description
1993-11-17	SPCF	Request for grant of supplementary protection certificate	Free format text: SPC 52/93:19930623
1996-03-20	SPCG	Supplementary protection certificate granted	Free format text: SPC 52/93 EXPIRES:20021027
2000-08-23	MK9A	Patent expired