IE44450B1 - Osmotically driven dispenser and process for making same - Google Patents

Osmotically driven dispenser and process for making same

Info

Publication number: IE44450B1
Authority: IE; Ireland
Prior art keywords: active agent; agent composition; core; dispenser; wall
Prior art date: 1975-09-08

Application number

IE1851/76A

Other languages

English (en)

Other versions

IE44450L (en

Original Assignee

Alza Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-09-08

Filing date

1976-08-19

Publication date

1981-12-02

1976-08-19 Application filed by Alza Corp filed Critical Alza Corp

1977-03-08 Publication of IE44450L publication Critical patent/IE44450L/xx

1981-12-02 Publication of IE44450B1 publication Critical patent/IE44450B1/en

Links

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239000013543 active substance Substances 0.000 claims abstract description 48
239000012530 fluid Substances 0.000 claims abstract description 38
239000012229 microporous material Substances 0.000 claims abstract description 30
230000003204 osmotic effect Effects 0.000 claims description 35
229940079593 drug Drugs 0.000 claims description 31
239000003814 drug Substances 0.000 claims description 31
239000000463 material Substances 0.000 claims description 28
239000011148 porous material Substances 0.000 claims description 26
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210000004379 membrane Anatomy 0.000 description 39
239000012528 membrane Substances 0.000 description 39
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-1 poly(vinylchloride) Polymers 0.000 description 23
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239000008103 glucose Substances 0.000 description 1
239000007952 growth promoter Substances 0.000 description 1
239000004009 herbicide Substances 0.000 description 1
IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
150000003840 hydrochlorides Chemical class 0.000 description 1
229920001477 hydrophilic polymer Polymers 0.000 description 1
238000012994 industrial processing Methods 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
150000002484 inorganic compounds Chemical class 0.000 description 1
229910010272 inorganic material Inorganic materials 0.000 description 1
CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
229960000367 inositol Drugs 0.000 description 1
239000002917 insecticide Substances 0.000 description 1
238000003780 insertion Methods 0.000 description 1
230000037431 insertion Effects 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
238000002386 leaching Methods 0.000 description 1
INHCSSUBVCNVSK-UHFFFAOYSA-L lithium sulfate Inorganic materials [Li+].[Li+].[O-]S([O-])(=O)=O INHCSSUBVCNVSK-UHFFFAOYSA-L 0.000 description 1
229910001629 magnesium chloride Inorganic materials 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
235000019341 magnesium sulphate Nutrition 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
244000005700 microbiome Species 0.000 description 1
238000000465 moulding Methods 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-M oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC([O-])=O ZQPPMHVWECSIRJ-KTKRTIGZSA-M 0.000 description 1
229940049964 oleate Drugs 0.000 description 1
229940126701 oral medication Drugs 0.000 description 1
150000002892 organic cations Chemical class 0.000 description 1
150000002894 organic compounds Chemical class 0.000 description 1
239000006072 paste Substances 0.000 description 1
239000008188 pellet Substances 0.000 description 1
239000000575 pesticide Substances 0.000 description 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
230000008635 plant growth Effects 0.000 description 1
239000002373 plant growth inhibitor Substances 0.000 description 1
239000002985 plastic film Substances 0.000 description 1
229920006255 plastic film Polymers 0.000 description 1
229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
229920000747 poly(lactic acid) Polymers 0.000 description 1
229920002492 poly(sulfone) Polymers 0.000 description 1
229920000867 polyelectrolyte Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
239000004633 polyglycolic acid Substances 0.000 description 1
239000004626 polylactic acid Substances 0.000 description 1
230000000379 polymerizing effect Effects 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
229920000098 polyolefin Polymers 0.000 description 1
229920006324 polyoxymethylene Polymers 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
229920002635 polyurethane Polymers 0.000 description 1
239000004814 polyurethane Substances 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
229920002620 polyvinyl fluoride Polymers 0.000 description 1
229920000131 polyvinylidene Polymers 0.000 description 1
229920002981 polyvinylidene fluoride Polymers 0.000 description 1
GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
238000004080 punching Methods 0.000 description 1
125000001453 quaternary ammonium group Chemical group 0.000 description 1
MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
239000000376 reactant Substances 0.000 description 1
239000013557 residual solvent Substances 0.000 description 1
230000004044 response Effects 0.000 description 1
239000003128 rodenticide Substances 0.000 description 1
YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
229960001860 salicylate Drugs 0.000 description 1
238000005070 sampling Methods 0.000 description 1
CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
238000007493 shaping process Methods 0.000 description 1
238000002791 soaking Methods 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
235000017550 sodium carbonate Nutrition 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
239000011775 sodium fluoride Substances 0.000 description 1
235000013024 sodium fluoride Nutrition 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
235000010265 sodium sulphite Nutrition 0.000 description 1
238000000935 solvent evaporation Methods 0.000 description 1
241000894007 species Species 0.000 description 1
238000005507 spraying Methods 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
230000003068 static effect Effects 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
229920001909 styrene-acrylic polymer Polymers 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
OKUCEQDKBKYEJY-UHFFFAOYSA-N tert-butyl 3-(methylamino)pyrrolidine-1-carboxylate Chemical compound CNC1CCN(C(=O)OC(C)(C)C)C1 OKUCEQDKBKYEJY-UHFFFAOYSA-N 0.000 description 1
RBTVSNLYYIMMKS-UHFFFAOYSA-N tert-butyl 3-aminoazetidine-1-carboxylate;hydrochloride Chemical compound Cl.CC(C)(C)OC(=O)N1CC(N)C1 RBTVSNLYYIMMKS-UHFFFAOYSA-N 0.000 description 1
239000012085 test solution Substances 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
229910000406 trisodium phosphate Inorganic materials 0.000 description 1
235000019801 trisodium phosphate Nutrition 0.000 description 1
229940045136 urea Drugs 0.000 description 1
210000001215 vagina Anatomy 0.000 description 1
238000000214 vapour pressure osmometry Methods 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
239000011800 void material Substances 0.000 description 1
229920003169 water-soluble polymer Polymers 0.000 description 1
238000005303 weighing Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
- A61F6/142—Wirelike structures, e.g. loops, rings, spirals
- A61F6/144—Wirelike structures, e.g. loops, rings, spirals with T-configuration
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Biomedical Technology (AREA)
Reproductive Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Ophthalmology & Optometry (AREA)
Medicinal Preparation (AREA)
Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

IE1851/76A 1975-09-08 1976-08-19 Osmotically driven dispenser and process for making same IE44450B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/611,504 US3977404A (en)	1975-09-08	1975-09-08	Osmotic device having microporous reservoir

Publications (2)

Publication Number	Publication Date
IE44450L IE44450L (en)	1977-03-08
IE44450B1 true IE44450B1 (en)	1981-12-02

Family

ID=24449267

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IE1851/76A IE44450B1 (en)	1975-09-08	1976-08-19	Osmotically driven dispenser and process for making same

Country Status (11)

Country	Link
US (1)	US3977404A (sv)
JP (1)	JPS5238015A (sv)
AU (1)	AU500192B2 (sv)
CH (1)	CH620122A5 (sv)
DE (1)	DE2640193C2 (sv)
DK (1)	DK144850C (sv)
FR (1)	FR2322585A1 (sv)
GB (1)	GB1511614A (sv)
IE (1)	IE44450B1 (sv)
IT (1)	IT1070302B (sv)
SE (1)	SE429102B (sv)

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1975
- 1975-09-08 US US05/611,504 patent/US3977404A/en not_active Expired - Lifetime
1976
- 1976-08-13 GB GB33833/76A patent/GB1511614A/en not_active Expired
- 1976-08-19 IE IE1851/76A patent/IE44450B1/en unknown
- 1976-08-25 SE SE7609404A patent/SE429102B/sv not_active IP Right Cessation
- 1976-08-26 AU AU17180/76A patent/AU500192B2/en not_active Expired
- 1976-09-07 IT IT69170/76A patent/IT1070302B/it active
- 1976-09-07 DE DE2640193A patent/DE2640193C2/de not_active Expired
- 1976-09-07 DK DK402476A patent/DK144850C/da not_active IP Right Cessation
- 1976-09-07 CH CH1133576A patent/CH620122A5/de not_active IP Right Cessation
- 1976-09-07 JP JP51107164A patent/JPS5238015A/ja active Granted
- 1976-09-08 FR FR7627006A patent/FR2322585A1/fr active Granted

Also Published As

Publication number	Publication date
JPS618042B2 (sv)	1986-03-11
DK144850C (da)	1982-11-15
CH620122A5 (sv)	1980-11-14
US3977404A (en)	1976-08-31
SE429102B (sv)	1983-08-15
DE2640193A1 (de)	1977-03-24
GB1511614A (en)	1978-05-24
DK402476A (da)	1977-03-09
JPS5238015A (en)	1977-03-24
IE44450L (en)	1977-03-08
FR2322585B1 (sv)	1980-11-07
AU500192B2 (en)	1979-05-10
AU1718076A (en)	1978-03-02
IT1070302B (it)	1985-03-29
FR2322585A1 (fr)	1977-04-01
SE7609404L (sv)	1977-03-09
DK144850B (da)	1982-06-21
DE2640193C2 (de)	1986-04-10

Publication	Publication Date	Title
IE44450B1 (en)	1981-12-02	Osmotically driven dispenser and process for making same
US4034758A (en)	1977-07-12	Osmotic therapeutic system for administering medicament
CA1092469A (en)	1980-12-30	Osmotically driven active agent dispenser and process for making same
US4217898A (en)	1980-08-19	System with microporous reservoir having surface for diffusional delivery of agent
US4235236A (en)	1980-11-25	Device for dispensing drug by combined diffusional and osmotic operations
US4160452A (en)	1979-07-10	Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina
US4298003A (en)	1981-11-03	System for delivering agent at zero order rate with emerging agent below saturation
EP0040457B1 (en)	1985-04-24	Agent dispenser with microporous releasing diffusor
US4014334A (en)	1977-03-29	Laminated osmotic system for dispensing beneficial agent
US4576604A (en)	1986-03-18	Osmotic system with instant drug availability
US4142526A (en)	1979-03-06	Osmotic releasing system with means for changing release therefrom
US3916899A (en)	1975-11-04	Osmotic dispensing device with maximum and minimum sizes for the passageway
US4036227A (en)	1977-07-19	Osmotic releasing device having a plurality of release rate patterns
US4673405A (en)	1987-06-16	Osmotic system with instant drug availability
US4285987A (en)	1981-08-25	Process for manufacturing device with dispersion zone
US3845770A (en)	1974-11-05	Osmatic dispensing device for releasing beneficial agent
US4439196A (en)	1984-03-27	Osmotic drug delivery system
US4256108A (en)	1981-03-17	Microporous-semipermeable laminated osmotic system
CA1264133A (en)	1990-01-02	Lipid osmotic pump
US4326525A (en)	1982-04-27	Osmotic device that improves delivery properties of agent in situ
US4200098A (en)	1980-04-29	Osmotic system with distribution zone for dispensing beneficial agent
US4320759A (en)	1982-03-23	Dispenser with diffuser
US4627850A (en)	1986-12-09	Osmotic capsule
US4203439A (en)	1980-05-20	Osmotic system with volume amplifier for increasing amount of agent delivered therefrom
CA1078734A (en)	1980-06-03	Controlled release article