IE43453L - 15-(1,3-benzodioxan-2-yl)-16,17,19,20-pentanor prostanoic¹acid derivatives - Google Patents
15-(1,3-benzodioxan-2-yl)-16,17,19,20-pentanor prostanoic¹acid derivativesInfo
- Publication number
- IE43453L IE43453L IE760394A IE39476A IE43453L IE 43453 L IE43453 L IE 43453L IE 760394 A IE760394 A IE 760394A IE 39476 A IE39476 A IE 39476A IE 43453 L IE43453 L IE 43453L
- Authority
- IE
- Ireland
- Prior art keywords
- formula
- compounds
- prepared
- image
- derivatives
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- FRVQEDSERBQTHX-HLRBRJAUSA-N 4h-1,3-benzodioxine;7-[(1s,2s)-2-octylcyclopentyl]heptanoic acid Chemical class C1=CC=C2OCOCC2=C1.CCCCCCCC[C@H]1CCC[C@@H]1CCCCCCC(O)=O FRVQEDSERBQTHX-HLRBRJAUSA-N 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- 230000002997 prostaglandinlike Effects 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
- C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1,3-Benzodioxane-prostanoic acid derivatives of the formula I and their antipodes and racemates <IMAGE> in which the substituents are defined in Claim 1, are prepared. These compounds are obtained by reacting lactols of the formula II with a Wittig reagent of the formula Ph3P=CH-(CH2)3-COR1 to introduce the side chain located in position 8. Likewise, the corresponding 9-keto compounds are prepared from compounds of the formula I which have a hydroxyl group in position 9. The compounds have prostaglandin-like properties and can be used for the same purposes as known prostaglandins. <IMAGE>
[GB1546442A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19752508826 DE2508826A1 (en) | 1975-02-27 | 1975-02-27 | NEW 1,3-BENZODIOXANE PROSTANIC ACID DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE43453L true IE43453L (en) | 1976-08-27 |
| IE43453B1 IE43453B1 (en) | 1981-02-25 |
Family
ID=5940126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE394/76A IE43453B1 (en) | 1975-02-27 | 1976-02-27 | New 15-(1,3-benzodioxan-2-yl)-16,17,18,19,20-pentanor prostanoic acid derivatives and process for their manufacture |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS51125393A (en) |
| AT (1) | AT351188B (en) |
| AU (1) | AU503922B2 (en) |
| BE (1) | BE839027A (en) |
| CA (1) | CA1087178A (en) |
| CH (1) | CH625236A5 (en) |
| DE (1) | DE2508826A1 (en) |
| DK (1) | DK39976A (en) |
| FR (1) | FR2302089A1 (en) |
| GB (1) | GB1546442A (en) |
| IE (1) | IE43453B1 (en) |
| LU (1) | LU74432A1 (en) |
| NL (1) | NL7601847A (en) |
| SE (1) | SE424552B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7902817L (en) * | 1978-05-03 | 1979-11-04 | Roussel Uclaf | SUBSTITUTED / 4H / 1,3-BENZODIOXINE-2-CARBOXYLIC ACID DERIVATIVES, PREPARATION AND USE OF THESE AS MEDICINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE |
| FR2460945A2 (en) * | 1979-07-06 | 1981-01-30 | Roussel Uclaf | 6-Chloro-2,4,4-tri:methyl-4H-1,3-benzodioxin-2-carboxylic acid - useful in treatment of hyperlipidaemia, angina and cardiac insufficiency |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2328131C3 (en) | 1973-05-30 | 1986-11-13 | Schering AG, 1000 Berlin und 4709 Bergkamen | New process for the production of prostaglandin-F ↓ 2 ↓↓ α ↓ and its analogues |
-
1975
- 1975-02-27 DE DE19752508826 patent/DE2508826A1/en not_active Withdrawn
-
1976
- 1976-01-30 DK DK39976*#A patent/DK39976A/en not_active Application Discontinuation
- 1976-02-11 AU AU10998/76A patent/AU503922B2/en not_active Expired
- 1976-02-20 CH CH214976A patent/CH625236A5/en not_active IP Right Cessation
- 1976-02-23 GB GB7003/76A patent/GB1546442A/en not_active Expired
- 1976-02-24 JP JP51019811A patent/JPS51125393A/en active Pending
- 1976-02-24 NL NL7601847A patent/NL7601847A/en not_active Application Discontinuation
- 1976-02-25 LU LU74432A patent/LU74432A1/xx unknown
- 1976-02-26 AT AT143276A patent/AT351188B/en not_active IP Right Cessation
- 1976-02-26 SE SE7602500A patent/SE424552B/en unknown
- 1976-02-27 CA CA246,701A patent/CA1087178A/en not_active Expired
- 1976-02-27 BE BE164720A patent/BE839027A/en not_active IP Right Cessation
- 1976-02-27 FR FR7605547A patent/FR2302089A1/en active Granted
- 1976-02-27 IE IE394/76A patent/IE43453B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA1087178A (en) | 1980-10-07 |
| GB1546442A (en) | 1979-05-23 |
| IE43453B1 (en) | 1981-02-25 |
| FR2302089B1 (en) | 1980-06-13 |
| JPS51125393A (en) | 1976-11-01 |
| DK39976A (en) | 1976-08-28 |
| BE839027A (en) | 1976-08-27 |
| NL7601847A (en) | 1976-08-31 |
| DE2508826A1 (en) | 1976-09-09 |
| CH625236A5 (en) | 1981-09-15 |
| FR2302089A1 (en) | 1976-09-24 |
| LU74432A1 (en) | 1976-08-13 |
| AU503922B2 (en) | 1979-09-27 |
| ATA143276A (en) | 1978-12-15 |
| AU1099876A (en) | 1977-08-18 |
| AT351188B (en) | 1979-07-10 |
| SE424552B (en) | 1982-07-26 |
| SE7602500L (en) | 1976-08-30 |
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