IE40818L - N-heterocyclylalkylbenzamides - Google Patents
N-heterocyclylalkylbenzamidesInfo
- Publication number
- IE40818L IE40818L IE750457A IE45775A IE40818L IE 40818 L IE40818 L IE 40818L IE 750457 A IE750457 A IE 750457A IE 45775 A IE45775 A IE 45775A IE 40818 L IE40818 L IE 40818L
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- alkoxy
- benzamides
- feb
- alkenyl
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 229940054066 benzamide antipsychotics Drugs 0.000 abstract 3
- 150000003936 benzamides Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 2
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000003474 anti-emetic effect Effects 0.000 abstract 1
- 239000002111 antiemetic agent Substances 0.000 abstract 1
- 229940125683 antiemetic agent Drugs 0.000 abstract 1
- 239000003699 antiulcer agent Substances 0.000 abstract 1
- 235000010233 benzoic acid Nutrition 0.000 abstract 1
- 150000001559 benzoic acids Chemical class 0.000 abstract 1
- 125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000005544 phthalimido group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1466822 Benzamides SOC D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES DE L'ILE DE FRANCE 26 Feb 1975 [5 March 1974 7 Feb 1975] 8095/75 Heading C2C Novel benzamides of the Formula I wherein A is H, C 1-5 alkyl or C 2-5 alkenyl; X is H, C 1-5 alkoxy, C 1-5 alkyl, C 2-5 alkenyloxy or C 2-5 alkenyl; Y is H, halogen, C 1-5 alkyl, C 1-5 alkoxy, amino, alkylamino, dialkylamino, carboxylic acylamino, phthalimido, benzylamino or alkoxycarbonylamino; Z is H, halogen, C 1-5 alkoxy, C 1-5 alkylsulphonyl or NR 1 R 2 , wherein R 1 and R 2 each are H or C 1-5 alkyl or R 1 and R 2 , together with the nitrogen atom to which they are attached, form a saturated heterocyclic ring optionally containing another heteroatom; W is C 1-4 alkylene and m is 1, 2 or 3; and pharmaceutically acceptable acid addition and quaternary ammonium salts thereof are prepared by reacting the appropriate benzoic acids or reactive derivatives thereof with amines of the formula or reactive derivatives thereof, wherein R 3 is H or benzyl, followed if necessary by removal of R 3 when benzyl by reduction. Pharmaceutical compositions contain the above benzamides or acid addition or quaternary ammonium salts thereof together with pharmaceutically acceptable carriers or diluents. The compounds are anti-emetics, anti-ulcer agents and are capable of modifying the central nervous system.
[GB1466822A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7407535A FR2262966A1 (en) | 1974-03-05 | 1974-03-05 | New heterocyclic benzamide and its manufacturing process |
| FR7503800A FR2299863B1 (en) | 1975-02-07 | 1975-02-07 | Novel substituted N- (Z-pyrrolidiny alkyl) benzamides, their derivatives and process for their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE40818L true IE40818L (en) | 1975-09-05 |
| IE40818B1 IE40818B1 (en) | 1979-08-29 |
Family
ID=26218210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE457/75A IE40818B1 (en) | 1974-03-05 | 1975-03-04 | Substituted benzamides |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS6015616B2 (en) |
| AR (1) | AR206621A1 (en) |
| AT (1) | AT358570B (en) |
| BG (1) | BG24666A3 (en) |
| CA (1) | CA1047504A (en) |
| CH (1) | CH605794A5 (en) |
| CS (1) | CS189692B2 (en) |
| DD (1) | DD119420A5 (en) |
| DE (1) | DE2507989A1 (en) |
| DK (1) | DK145377C (en) |
| EG (1) | EG12577A (en) |
| ES (1) | ES435274A1 (en) |
| FI (1) | FI750620A (en) |
| GB (1) | GB1466822A (en) |
| HK (1) | HK14078A (en) |
| HU (1) | HU170637B (en) |
| IE (1) | IE40818B1 (en) |
| IL (1) | IL46696A (en) |
| LU (1) | LU71949A1 (en) |
| NL (1) | NL7502608A (en) |
| NO (1) | NO750713L (en) |
| OA (1) | OA04966A (en) |
| PH (1) | PH14197A (en) |
| PL (1) | PL97091B1 (en) |
| RO (2) | RO72844A (en) |
| SE (1) | SE411754B (en) |
| SU (1) | SU609464A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ186175A (en) * | 1977-01-27 | 1980-03-05 | Shionogi & Co | Meta-sulphonamidobenzamide derivatives |
| SE8503054D0 (en) * | 1985-06-19 | 1985-06-19 | Astra Laekemedel Ab | CATECHOLCARBOXAMIDES |
| US4772459A (en) * | 1986-09-09 | 1988-09-20 | Erbamont, Inc. | Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein |
| EP0314483A1 (en) * | 1987-10-29 | 1989-05-03 | Erbamont, Inc. | Preparation of benzamides |
| FR2699533A1 (en) * | 1992-12-21 | 1994-06-24 | Mouhtaram Mohamed | N-2-piperazinyl 4-amino:benzamide derivs. having antiemetic and antipsychotic activity |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3078497A (en) * | 1960-12-29 | 1963-02-26 | Leeds And Mieallef | Dispensing containers |
-
1975
- 1975-02-24 IL IL46696A patent/IL46696A/en unknown
- 1975-02-25 DE DE19752507989 patent/DE2507989A1/en not_active Withdrawn
- 1975-02-26 GB GB809575A patent/GB1466822A/en not_active Expired
- 1975-03-03 EG EG109/75A patent/EG12577A/en active
- 1975-03-03 LU LU71949A patent/LU71949A1/en unknown
- 1975-03-03 AT AT160775A patent/AT358570B/en not_active IP Right Cessation
- 1975-03-03 SE SE7502342A patent/SE411754B/en not_active IP Right Cessation
- 1975-03-04 OA OA55430A patent/OA04966A/en unknown
- 1975-03-04 FI FI750620A patent/FI750620A/fi not_active Application Discontinuation
- 1975-03-04 DK DK86975A patent/DK145377C/en active
- 1975-03-04 BG BG029148A patent/BG24666A3/en unknown
- 1975-03-04 ES ES435274A patent/ES435274A1/en not_active Expired
- 1975-03-04 HU HUSO1137A patent/HU170637B/hu not_active IP Right Cessation
- 1975-03-04 CA CA221,240A patent/CA1047504A/en not_active Expired
- 1975-03-04 SU SU2112487A patent/SU609464A1/en active
- 1975-03-04 NO NO750713A patent/NO750713L/no unknown
- 1975-03-04 CS CS751445A patent/CS189692B2/en unknown
- 1975-03-04 IE IE457/75A patent/IE40818B1/en unknown
- 1975-03-05 NL NL7502608A patent/NL7502608A/en not_active Application Discontinuation
- 1975-03-05 RO RO7581558A patent/RO72844A/en unknown
- 1975-03-05 JP JP50027573A patent/JPS6015616B2/en not_active Expired
- 1975-03-05 RO RO7588831A patent/RO70647A/en unknown
- 1975-03-05 PL PL1975178533A patent/PL97091B1/en unknown
- 1975-03-05 CH CH279975A patent/CH605794A5/en not_active IP Right Cessation
- 1975-03-05 DD DD184579A patent/DD119420A5/de unknown
- 1975-04-04 AR AR257837A patent/AR206621A1/en active
-
1977
- 1977-08-22 PH PH20152A patent/PH14197A/en unknown
-
1978
- 1978-03-16 HK HK140/78A patent/HK14078A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SU609464A3 (en) | 1978-05-30 |
| OA04966A (en) | 1980-10-31 |
| PL97091B1 (en) | 1978-02-28 |
| SE411754B (en) | 1980-02-04 |
| CA1047504A (en) | 1979-01-30 |
| PH14197A (en) | 1981-03-26 |
| HK14078A (en) | 1978-03-23 |
| DK86975A (en) | 1975-11-03 |
| AU7874075A (en) | 1976-09-09 |
| RO70647A (en) | 1980-04-15 |
| FI750620A (en) | 1975-09-06 |
| EG12577A (en) | 1979-09-30 |
| DK145377C (en) | 1983-04-11 |
| DD119420A5 (en) | 1976-04-20 |
| SE7502342L (en) | 1975-09-08 |
| BG24666A3 (en) | 1978-04-12 |
| JPS6015616B2 (en) | 1985-04-20 |
| NO750713L (en) | 1975-09-08 |
| DE2507989A1 (en) | 1975-09-11 |
| ES435274A1 (en) | 1976-12-16 |
| IL46696A0 (en) | 1975-04-25 |
| CS189692B2 (en) | 1979-04-30 |
| GB1466822A (en) | 1977-03-09 |
| IE40818B1 (en) | 1979-08-29 |
| ATA160775A (en) | 1980-02-15 |
| JPS50123668A (en) | 1975-09-29 |
| SU609464A1 (en) | 1978-05-30 |
| AR206621A1 (en) | 1976-08-06 |
| NL7502608A (en) | 1975-09-09 |
| IL46696A (en) | 1978-07-31 |
| CH605794A5 (en) | 1978-10-13 |
| DK145377B (en) | 1982-11-08 |
| AT358570B (en) | 1980-09-25 |
| LU71949A1 (en) | 1976-02-04 |
| HU170637B (en) | 1977-07-28 |
| RO72844A (en) | 1981-09-24 |
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