IE40660L - 2-deoxy-2-nicotinamido-1-o-nicotinoylglucopyranose¹derivatives - Google Patents
2-deoxy-2-nicotinamido-1-o-nicotinoylglucopyranose¹derivativesInfo
- Publication number
- IE40660L IE40660L IE750098A IE9875A IE40660L IE 40660 L IE40660 L IE 40660L IE 750098 A IE750098 A IE 750098A IE 9875 A IE9875 A IE 9875A IE 40660 L IE40660 L IE 40660L
- Authority
- IE
- Ireland
- Prior art keywords
- acetyl
- prepared
- compound
- compounds
- glucosamine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Abstract
1451181 2 - Nicotinamides - 1 - nicotinoyloxy- 0-glycopyranoses F HOFFMAN-LA ROCHE AG 24 Jan 1975 [25 Jan 1974] 3180/75 Heading C2C Novel compounds I in which R is C 1-6 alkanoyl, C 1-6 alkoxy C 1-6 alkanoyl or aryl are prepared by replacing X in a compound II where X is halogen or optionally protected hydroxy, by a nicotinoyloxy group in known manner. Compounds I (R=acetyl, propionyl, benzoyl) are prepared. Compound II (X=Cl, R=acetyl) is prepared by reacting N-nicotinoyl-D-glucosamine with acetyl chloride. Compound II (X=acetoxy, R=acetyl) is prepared by reacting 1,3,4,6- tetra - O - acetyl - D - glucosamine with nicotinic acid. Compounds I have plasma lipid-lowering activity and form with a carrier a pharmaceutical composition which may be administered orally, parenterally or rectally.
[GB1451181A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH103974A CH597253A5 (en) | 1974-01-25 | 1974-01-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE40660L true IE40660L (en) | 1975-07-25 |
| IE40660B1 IE40660B1 (en) | 1979-07-18 |
Family
ID=4201023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE98/75A IE40660B1 (en) | 1974-01-25 | 1975-01-20 | 2-deoxy-2-nicotinamido-1-nicotinoyl-glucopyranose derivatives, methods for their preparation and compositions containing them |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPS50160278A (en) |
| AR (1) | AR208532A1 (en) |
| AT (1) | AT343144B (en) |
| BE (1) | BE824729A (en) |
| CA (1) | CA1024511A (en) |
| CH (1) | CH597253A5 (en) |
| DD (1) | DD117453A5 (en) |
| DE (1) | DE2501861C2 (en) |
| DK (1) | DK143566C (en) |
| FI (1) | FI61193C (en) |
| FR (1) | FR2258861B1 (en) |
| GB (1) | GB1451181A (en) |
| HU (1) | HU170430B (en) |
| IE (1) | IE40660B1 (en) |
| IL (1) | IL46154A (en) |
| LU (1) | LU71705A1 (en) |
| NL (1) | NL7416126A (en) |
| NO (1) | NO140598C (en) |
| PH (1) | PH10795A (en) |
| SE (1) | SE412395B (en) |
| SU (1) | SU543355A3 (en) |
| YU (1) | YU36740B (en) |
| ZA (1) | ZA747566B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH640411A5 (en) * | 1978-05-26 | 1984-01-13 | Kureha Chemical Ind Co Ltd | MEDICINE FOR TREATING HYPERGLYKAEMIA, HYPERLIPAEMIA, HYPERTENSION, INFLAMMATION, PAIN, FEVER, OR TUMOR. |
| IT1140962B (en) | 1980-05-20 | 1986-10-10 | Guidotti & C Spa Labor | NICOTINIC GLUCOSAMINE DERIVATIVES, PROCEDURE FOR PREPARATION AND RELATED COMPOSITIONS |
| DE3165099D1 (en) * | 1980-11-27 | 1984-08-30 | Hoffmann La Roche | Method for the preparation of a derivative of beta-d-glucopyranose |
-
1974
- 1974-01-25 CH CH103974A patent/CH597253A5/xx not_active IP Right Cessation
- 1974-11-26 ZA ZA00747566A patent/ZA747566B/en unknown
- 1974-11-29 IL IL46154A patent/IL46154A/en unknown
- 1974-12-09 CA CA215,544A patent/CA1024511A/en not_active Expired
- 1974-12-11 NL NL7416126A patent/NL7416126A/en not_active Application Discontinuation
- 1974-12-18 YU YU3370/74A patent/YU36740B/en unknown
- 1974-12-23 AR AR257050A patent/AR208532A1/en active
- 1974-12-27 DK DK683074A patent/DK143566C/en not_active IP Right Cessation
- 1974-12-30 FI FI3785/74A patent/FI61193C/en active
-
1975
- 1975-01-02 PH PH16663A patent/PH10795A/en unknown
- 1975-01-15 HU HUHO1762A patent/HU170430B/hu unknown
- 1975-01-17 DE DE2501861A patent/DE2501861C2/en not_active Expired
- 1975-01-20 IE IE98/75A patent/IE40660B1/en unknown
- 1975-01-22 SE SE7500692A patent/SE412395B/en unknown
- 1975-01-23 FR FR7502125A patent/FR2258861B1/fr not_active Expired
- 1975-01-23 LU LU71705A patent/LU71705A1/xx unknown
- 1975-01-23 SU SU2099880A patent/SU543355A3/en active
- 1975-01-23 DD DD183779A patent/DD117453A5/xx unknown
- 1975-01-24 NO NO750228A patent/NO140598C/en unknown
- 1975-01-24 AT AT54075A patent/AT343144B/en not_active IP Right Cessation
- 1975-01-24 JP JP50010376A patent/JPS50160278A/ja active Pending
- 1975-01-24 BE BE152662A patent/BE824729A/en not_active IP Right Cessation
- 1975-01-24 GB GB318075A patent/GB1451181A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1451181A (en) | 1976-09-29 |
| DD117453A5 (en) | 1976-01-12 |
| SE412395B (en) | 1980-03-03 |
| DE2501861A1 (en) | 1975-07-31 |
| DK143566C (en) | 1982-02-08 |
| NO750228L (en) | 1975-08-18 |
| FR2258861A1 (en) | 1975-08-22 |
| HU170430B (en) | 1977-06-28 |
| SU543355A3 (en) | 1977-01-15 |
| PH10795A (en) | 1977-09-07 |
| DK683074A (en) | 1975-10-13 |
| FR2258861B1 (en) | 1978-02-03 |
| IL46154A (en) | 1977-11-30 |
| DE2501861C2 (en) | 1984-02-09 |
| DK143566B (en) | 1981-09-07 |
| SE7500692L (en) | 1975-07-28 |
| LU71705A1 (en) | 1976-12-31 |
| JPS50160278A (en) | 1975-12-25 |
| BE824729A (en) | 1975-07-24 |
| ATA54075A (en) | 1977-09-15 |
| AU7614574A (en) | 1976-06-10 |
| IE40660B1 (en) | 1979-07-18 |
| AR208532A1 (en) | 1977-02-15 |
| NO140598B (en) | 1979-06-25 |
| IL46154A0 (en) | 1975-02-10 |
| YU337074A (en) | 1982-06-18 |
| NO140598C (en) | 1979-10-03 |
| FI378574A (en) | 1975-07-26 |
| CA1024511A (en) | 1978-01-17 |
| YU36740B (en) | 1984-08-31 |
| CH597253A5 (en) | 1978-03-31 |
| AT343144B (en) | 1978-05-10 |
| FI61193C (en) | 1982-06-10 |
| ZA747566B (en) | 1975-12-31 |
| FI61193B (en) | 1982-02-26 |
| NL7416126A (en) | 1975-07-29 |
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