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IE40528B1 - Cephalosporin derivatives and the preparation thereof - Google Patents

Cephalosporin derivatives and the preparation thereof

Info

Publication number
IE40528B1
IE40528B1 IE2044/74A IE204474A IE40528B1 IE 40528 B1 IE40528 B1 IE 40528B1 IE 2044/74 A IE2044/74 A IE 2044/74A IE 204474 A IE204474 A IE 204474A IE 40528 B1 IE40528 B1 IE 40528B1
Authority
IE
Ireland
Prior art keywords
alkyl
denotes
denotes hydrogen
aryl
alkylthio
Prior art date
Application number
IE2044/74A
Other versions
IE40528L (en
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP11168473A external-priority patent/JPS5652910B2/ja
Priority claimed from JP11168673A external-priority patent/JPS5062990A/ja
Priority claimed from JP11168573A external-priority patent/JPS5715596B2/ja
Priority claimed from JP11493273A external-priority patent/JPS5716117B2/ja
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of IE40528L publication Critical patent/IE40528L/en
Publication of IE40528B1 publication Critical patent/IE40528B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Novel derivatives of the cephalosporin series of the formula I <IMAGE> in which R1 denotes hydrogen, hydroxy(lower)alkylthio or heterocyclic thio which is optionally substituted by a lower alkyl or alkanoyloxy(lower)alkyl, R2 denotes lower alkyl, lower alkylthio(lower)alkyl, acyl(lower)alkyl, acylamino(lower)alkyl, lower alkenyl, aryl(lower)alkenyl or lower alkynyl, R3 denotes hydrogen, lower alkyl or aryl and X denotes sulphur or sulphinyl, but R2 cannot be lower alkyl if R1 denotes hydrogen, and their esters, amides and acid anhydrides on the carboxyl group are obtained by N-acylation of a corresponding 7-amino-3-cephem-4-carboxylic acid or a corresponding derivative with a carboxylic acid R2XCH(R3)COOH or a reactive derivative thereof. The compounds and their salts have a high antibacterial action and are suitable for the treatment of infectious diseases in humans and animals. [GB1488679A]
IE2044/74A 1973-10-03 1974-10-03 Cephalosporin derivatives and the preparation thereof IE40528B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP11168473A JPS5652910B2 (en) 1973-10-03 1973-10-03
JP11168673A JPS5062990A (en) 1973-10-03 1973-10-03
JP11168573A JPS5715596B2 (en) 1973-10-03 1973-10-03
JP11493273A JPS5716117B2 (en) 1973-10-12 1973-10-12

Publications (2)

Publication Number Publication Date
IE40528L IE40528L (en) 1975-04-03
IE40528B1 true IE40528B1 (en) 1979-06-20

Family

ID=27469929

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2044/74A IE40528B1 (en) 1973-10-03 1974-10-03 Cephalosporin derivatives and the preparation thereof

Country Status (14)

Country Link
AR (1) AR207960A1 (en)
CH (1) CH610901A5 (en)
DD (1) DD114086A5 (en)
DE (1) DE2447194A1 (en)
DK (1) DK518874A (en)
ES (1) ES430658A1 (en)
FI (1) FI287774A (en)
FR (1) FR2247247B1 (en)
GB (1) GB1488679A (en)
HU (1) HU168771B (en)
IE (1) IE40528B1 (en)
NO (1) NO743582L (en)
PH (1) PH14343A (en)
SE (1) SE7412429L (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52125184A (en) 1976-03-04 1977-10-20 Toyo Jozo Co Ltd Novel cephalosporin compounds
DE2655949A1 (en) * 1976-12-10 1978-06-15 Gruenenthal Gmbh NEW CEPHALOSPORIN AND PENICILLIN DERIVATIVES, PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THESE PRODUCTS
US20100261700A1 (en) * 2009-04-09 2010-10-14 Larry Sutton Beta-lactamase inhibitors
EP3441071A1 (en) 2013-03-12 2019-02-13 Gladius Pharmaceuticals Corporation Derivatized cephalosporins

Also Published As

Publication number Publication date
DK518874A (en) 1975-06-09
DD114086A5 (en) 1975-07-12
SE7412429L (en) 1975-04-04
FI287774A (en) 1975-04-04
CH610901A5 (en) 1979-05-15
AR207960A1 (en) 1976-11-22
NO743582L (en) 1975-04-28
ES430658A1 (en) 1977-04-01
GB1488679A (en) 1977-10-12
AU7397474A (en) 1976-04-08
FR2247247A1 (en) 1975-05-09
PH14343A (en) 1981-06-03
FR2247247B1 (en) 1978-07-28
HU168771B (en) 1976-07-28
DE2447194A1 (en) 1975-04-10
IE40528L (en) 1975-04-03

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