IE39332B1 - Biological extracts - Google Patents
Biological extractsInfo
- Publication number
- IE39332B1 IE39332B1 IE367/74A IE36774A IE39332B1 IE 39332 B1 IE39332 B1 IE 39332B1 IE 367/74 A IE367/74 A IE 367/74A IE 36774 A IE36774 A IE 36774A IE 39332 B1 IE39332 B1 IE 39332B1
- Authority
- IE
- Ireland
- Prior art keywords
- glycopeptide
- infra
- cells
- immunostimulating
- red
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1476422 Immunostimulating glycopeptide WELLCOME FOUNDATION Ltd 23 May 1974 [23 Feb 1973 14 Feb 1974] 9149/73 and 6759/74 Heading A5B [Also in Division C3] An immunostimulating glycopeptide capable of conferring on mammals and birds a resistance to tumours and pathogens is obtained from cell wall material of an immunostimulating bacterium of the Actinomycetaceae Family of Prevots classification. Bacteria specified include Corynebacterium parvum, C. anaerobium, C. granulosum, C. liquifaciens, C. pyogenes, C. lymphophilum, C. hepatodystrophicans, C. adamsoni, C. avidium, C. diphtheroides, C. renale cuniculi, C. acnes, C. equi and C. ovis. The glycopeptide is extracted by (a) culturing the bacteria, (b) harvesting the cells and (c) treating the cells with a biphasic extraction solvent comprising water and a phenol so as to yield the glycopeptide as an insoluble residue. The cells are generally subjected to lysis before extraction with the biphasic solvent. The glycopeptide may be recovered by centrifugation. The product is substantially insoluble in water, saline, methanol, ethanol, phenol, chloroform, dioxan, pyridine, dimethylformamide, diethylene glycol and hexane, has infra-red peptide absorption at 1550 and 1660 cm<SP>-1</SP>, infra-red carbohydrate absorption between 950 and 1100 cm<SP>-1</SP> with peak between 1050 and 1070 cm<SP>-1</SP>, has substantially no infra-red lipid absorption between 2850 and 2950 cm<SP>-1</SP> and after intravenous administration increases the liver and spleen weight of mice and increases the life expectancy of mice with tumours. The glycopeptide is combined with a carrier for use.
[GB1476422A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB914973A GB1476422A (en) | 1973-02-23 | 1973-02-23 | Biological extracts |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE39332L IE39332L (en) | 1974-08-23 |
| IE39332B1 true IE39332B1 (en) | 1978-09-13 |
Family
ID=9866339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE367/74A IE39332B1 (en) | 1973-02-23 | 1974-02-22 | Biological extracts |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS5063196A (en) |
| AU (1) | AU6591074A (en) |
| BE (1) | BE811491A (en) |
| DE (1) | DE2408724A1 (en) |
| DK (1) | DK141757B (en) |
| FR (1) | FR2218888B1 (en) |
| GB (1) | GB1476422A (en) |
| HU (1) | HU173676B (en) |
| IE (1) | IE39332B1 (en) |
| IL (1) | IL44267A (en) |
| NL (1) | NL7402455A (en) |
| ZA (1) | ZA741189B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2410476B1 (en) * | 1977-11-30 | 1980-08-22 | Inst Nat Sante Rech Med | APPLICATION OF PEPTIDOGLYCANS EXTRACTED FROM BACTERIA, PARTICULARLY BACILLUS AS MEDICAMENTS, ESPECIALLY STIMULATING ANTI-TUMOR IMMUNITY |
| JPS58874B2 (en) * | 1979-08-30 | 1983-01-08 | 株式会社 目黒研究所 | Glycoprotein WENAC and its production method |
| FR2502496A2 (en) * | 1981-03-30 | 1982-10-01 | Pasteur Institut | Aerobic bacterial fractions, esp. Corynebacterium catarrhalis - are medicaments with adjuvant, immunostimulant, antibacterial and interferon-inducing activity |
| FR2480604A1 (en) * | 1980-04-22 | 1981-10-23 | Pasteur Institut | Aerobic bacterial fractions, esp. Corynebacterium catarrhalis - are medicaments with adjuvant, immunostimulant, antibacterial and interferon-inducing activity |
| US4479935A (en) * | 1980-04-22 | 1984-10-30 | Institut Pasteur | Fractions extracted from aerobic bacteria, endowed with antitumoral, antibacterial and interferon inducing properties, and process for their preparation |
| US4871488A (en) * | 1985-04-22 | 1989-10-03 | Albany Medical College Of Union University | Reconstituting viral glycoproteins into large phospholipid vesicles |
| DK3049430T3 (en) | 2014-07-16 | 2019-04-08 | Depofarma S P A | CELL WALL FRACTION OF PROPIONIBACTERIUM GRANULOSUM WITH IMMUNO MODULATING EFFECT |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3450815A (en) * | 1964-04-24 | 1969-06-17 | Princeton Lab Inc | Method of stimulating a host defense mechanism with an actinovaccine |
| US3529057A (en) * | 1964-08-14 | 1970-09-15 | Takeda Chemical Industries Ltd | Purified periodic acid-oxidized mucopeptide of mycobacteria cell walls constituting a vaccine enhancing nonspecific host resistance against pathogenic bacterial infections |
-
1973
- 1973-02-23 GB GB914973A patent/GB1476422A/en not_active Expired
-
1974
- 1974-02-22 IE IE367/74A patent/IE39332B1/en unknown
- 1974-02-22 FR FR7406104A patent/FR2218888B1/fr not_active Expired
- 1974-02-22 DE DE19742408724 patent/DE2408724A1/en not_active Withdrawn
- 1974-02-22 BE BE141321A patent/BE811491A/en unknown
- 1974-02-22 HU HU74WE501A patent/HU173676B/en unknown
- 1974-02-22 NL NL7402455A patent/NL7402455A/xx not_active Application Discontinuation
- 1974-02-22 DK DK96174AA patent/DK141757B/en unknown
- 1974-02-22 IL IL44267A patent/IL44267A/en unknown
- 1974-02-22 AU AU65910/74A patent/AU6591074A/en not_active Expired
- 1974-02-22 JP JP49021333A patent/JPS5063196A/ja active Pending
- 1974-02-22 ZA ZA00741189A patent/ZA741189B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE811491A (en) | 1974-08-22 |
| NL7402455A (en) | 1974-08-27 |
| FR2218888B1 (en) | 1976-12-03 |
| DK141757C (en) | 1980-10-27 |
| ZA741189B (en) | 1975-09-24 |
| DK141757B (en) | 1980-06-09 |
| GB1476422A (en) | 1977-06-16 |
| IL44267A (en) | 1978-07-31 |
| FR2218888A1 (en) | 1974-09-20 |
| DE2408724A1 (en) | 1974-09-05 |
| IE39332L (en) | 1974-08-23 |
| AU6591074A (en) | 1975-08-28 |
| HU173676B (en) | 1979-07-28 |
| IL44267A0 (en) | 1974-05-16 |
| JPS5063196A (en) | 1975-05-29 |
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